Lissandra - League of Legends Champion
Win Rate
51.6%
Pick Rate
1.7%

Lissandravs Annie

AMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 5, 2026
MethodologyData Methodology

Lissandra vs Annie is a decisive matchup in LoL patch 26.11. Annie wins with a 53.9% win rate (+7.7%) over Lissandra based on 39 games. Annie wins the early laning phase while Lissandra scales better into the late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Annie matchup.

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Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 46.1% win rate in this matchup
Lissandra
46.1% WR
VS
Annie vs Lissandra matchup - 53.9% win rate
Annie
53.9% WR

Who Wins the Lissandra vs Annie Matchup?

Annie wins the Lissandra vs Annie matchup
Winner
Annie
Matches: 39
46.1%
Win Rate
53.9%
6.5
CS / min
5.9
773
DMG / min
948
10,883
Gold / game
11,079
132
Heal / min
70
435
DMG Mitigated / min
470
1.6
CC / min
0.9
41.2%
Early Game WR
58.8%
50.0%
Late Game WR
50.0%

Lissandra vs Annie Matchup Summary

The Lissandra vs Annie matchup is a decisive matchup in League of Legends ranked play. Based on 39 recent matches analyzed, Annie wins with a 53.9% win rate compared to Lissandra's 46.1%, giving Annie a 7.7 percentage point advantage. Game phase dynamics play a critical role here: Annie controls the early laning stage, but Lissandra outscales as the game goes longer. The matchup shifts dramatically depending on game length — Annie needs to press advantages before Lissandra reaches their power spikes, while Lissandra should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Lissandra leads by 0.7s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Annie has a strong advantage in this matchup. Lissandra players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Annie overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Annie Laning Phase Breakdown

Lissandra wins the laning phase against Annie in League of Legends

Lissandra is favored during the laning phase against Annie, winning 3 out of 5 key stat categories. Lissandra holds advantages in farming, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.5Lissandra
5.9Annie
Lissandra edges out Annie by 0.6 CS per minute — a moderate farming advantage that adds up to roughly 9 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
773Lissandra
948Annie
Annie heavily out-damages Lissandra by 175 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Annie's sustained damage advantage take over.
Economy
10,883Lissandra
11,079Annie
Lissandra and Annie generate nearly equal gold per game, with just a 196 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.6Lissandra
0.9Annie
Lissandra provides 0.7 seconds more crowd control per minute than Annie, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
567Lissandra
539Annie
Lissandra and Annie have comparable sustain profiles, with only 28 HP/min separating their healing and damage mitigation. Neither champion can out-attrition the other in lane, so trades will be decided by burst potential and ability usage rather than sustain.

Best Lissandra Build Against Annie

Spellslinger's Shoes is the optimal boots choice against Annie, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Annie are Shadowflame, Zhonya's Hourglass and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Annie matchup.

Early Game vs Late Game

Early Game
Annie
58.8%
+17.6% advantage
Lissandra early game win rateLissandra41.2%
Annie early game win rateAnnie58.8%
Late Game
Lissandra
50.0%
+0.0% advantage
Lissandra late game win rateLissandra50.0%
Annie late game win rateAnnie50.0%

Annie dominates the early game (first 15 minutes) with a commanding 58.8% win rate — a 17.6 percentage point lead over Lissandra. This lopsided early game means Annie can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Lissandra at 50.0% win rate — only 0.0 points ahead of Annie. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Annie has the edge early, but Lissandra gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Lissandra Runes Against Annie

Sorcery rune tree - Lissandra primary runes vs AnnieSorcery
Arcane Comet - best Lissandra rune vs AnnieManaflow Band - best Lissandra rune vs AnnieTranscendence - best Lissandra rune vs AnnieScorch - best Lissandra rune vs Annie
Domination rune tree - Lissandra secondary runes vs AnnieDomination
Cheap Shot - best Lissandra rune vs AnnieUltimate Hunter - best Lissandra rune vs Annie
60.0% WR

The Sorcery and Domination rune setup gives Lissandra the best tools to compete against Annie in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Lissandra matchup data for League of Legends patch 26.11. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
58.02%1316.885811,86355.0%60.6%
61.60%1256.791812,36268.6%56.8%
54.47%1236.988112,08353.1%55.4%
54.95%1116.874811,41055.8%54.2%
51.52%996.684011,78453.5%50.0%
50.00%986.985712,17845.0%53.5%
55.56%816.992811,72160.5%51.2%
44.74%766.878111,74844.1%45.2%
57.53%736.785911,06161.5%52.9%
52.86%706.487411,10854.3%51.4%
48.53%687.090811,10755.0%39.3%
53.73%676.178010,94653.1%54.3%
48.28%586.778112,35453.9%43.8%
41.07%566.774210,62436.7%46.1%
58.93%566.573210,32060.6%56.5%
53.70%546.488811,71551.9%55.6%
52.08%486.888112,08468.2%38.5%
55.32%476.384311,46055.6%55.2%
51.16%436.883412,58750.0%51.9%
43.59%396.482510,76435.0%52.6%
46.15%396.577310,88341.2%50.0%
39.47%386.680212,13937.5%40.9%
56.76%376.374210,61842.1%72.2%
56.76%376.878712,41658.8%55.0%
56.76%376.880811,53576.9%45.8%
32.43%377.080410,61129.4%35.0%
48.65%377.083812,68066.7%40.0%
33.33%336.992311,15131.3%35.3%
66.67%306.784412,08075.0%61.1%
65.52%296.986511,46770.6%58.3%
53.57%286.785811,89133.3%63.2%
61.54%267.193811,18175.0%40.0%
37.50%246.470111,94744.4%33.3%
58.33%247.382212,59060.0%57.1%
50.00%227.076411,84454.5%45.5%
54.55%226.61,01413,02066.7%50.0%
31.82%226.768410,84522.2%38.5%
33.33%216.874611,90044.4%25.0%
57.14%215.782310,46554.5%60.0%
73.68%196.980510,70775.0%72.7%
57.89%196.985412,58375.0%45.5%
61.11%187.488713,06550.0%70.0%
38.89%187.294812,87866.7%25.0%
58.82%176.51,06612,41342.9%70.0%
62.50%166.268611,07572.7%40.0%
56.25%166.892312,01450.0%57.1%
66.67%156.984213,080100.0%54.5%
64.29%146.190813,43275.0%60.0%
50.00%144.254910,94350.0%50.0%
64.29%146.779211,67883.3%50.0%
57.14%147.01,08911,13070.0%25.0%
53.85%136.693411,37550.0%57.1%
58.33%127.51,05412,44966.7%50.0%
63.64%116.090612,08133.3%100.0%
45.45%115.590412,09425.0%57.1%
63.64%112.682511,48750.0%71.4%
30.00%105.47418,70242.9%0.0%
70.00%107.194411,75183.3%50.0%
70.00%106.21,13613,233100.0%50.0%
50.00%106.889914,6330.0%62.5%
70.00%106.481112,0790.0%87.5%
55.56%96.281411,09650.0%66.7%
33.33%96.885511,75450.0%20.0%
66.67%96.578212,16033.3%83.3%
22.22%92.55189,7830.0%40.0%
85.71%77.71,15311,498100.0%66.7%
71.43%76.482813,449100.0%66.7%
57.14%77.384211,22350.0%66.7%
100.00%78.28329,161100.0%100.0%
57.14%72.986810,35560.0%50.0%
42.86%77.48559,99550.0%33.3%
57.14%77.080513,44150.0%66.7%
50.00%66.469210,47333.3%66.7%
33.33%66.78659,25050.0%0.0%
50.00%65.784212,7490.0%50.0%
80.00%56.88199,894100.0%66.7%
60.00%57.671711,88250.0%66.7%
60.00%57.593814,8270.0%75.0%
40.00%52.155411,1230.0%40.0%
60.00%56.576611,909100.0%50.0%
40.00%56.95498,21433.3%50.0%
80.00%53.669512,683100.0%50.0%
60.00%52.24318,35366.7%50.0%
60.00%57.51,17014,036100.0%33.3%
40.00%55.596514,4230.0%40.0%
80.00%57.31,24116,644100.0%75.0%
80.00%56.388712,12650.0%100.0%
60.00%56.074710,44750.0%100.0%
20.00%56.67479,3500.0%33.3%

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Lissandra vs Annie - Frequently Asked Questions

How does Lissandra do against Annie in League of Legends?

Annie wins the Lissandra vs Annie matchup with a 53.9% win rate compared to Lissandra's 46.1%, a 7.7 percentage point difference. This data is based on 39 recent ranked games in patch 26.11.

How does Lissandra do against Annie in the early game?

In the early game, Annie has the advantage against Lissandra with a 58.8% win rate versus 41.2%. Annie players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Annie in the late game?

In the late game, Lissandra takes over the Lissandra vs Annie matchup with a 50.0% win rate compared to 50.0%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Annie matchup?

Annie wins the matchup against Lissandra with a 53.9% win rate in League of Legends patch 26.11. The 7.7 percentage point advantage means Annie is significantly favored in this lane matchup based on 39 games analyzed.

What is the best Lissandra build against Annie?

The best Lissandra build against Annie includes Shadowflame, Zhonya's Hourglass, Malignance with Spellslinger's Shoes. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Annie?

The best Lissandra runes against Annie use the Sorcery primary tree with Domination secondary. This rune setup achieves a 60.0% win rate in the Lissandra vs Annie matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Annie?

No, Lissandra struggles against Annie with only a 46.1% win rate. Annie has the advantage in this matchup. Lissandra players should focus on safe farming and avoiding extended trades to minimize Annie's lead.

How do I play Lissandra against Annie?

When playing Lissandra against Annie, play cautiously and avoid Annie's power spikes. Focus on safe farming — you outscale Annie in the late game. Use the matchup-specific build and runes above to optimize your chances.