Lissandra - League of Legends Champion
Win Rate
50.2%
Pick Rate
1.7%

Lissandravs Annie

BMage
Patch26.14
Matches226,800
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Lissandra vs Annie is a decisive matchup in LoL patch 26.14. Annie wins with a 66.7% win rate (+33.3%) over Lissandra based on 6 games. Lissandra wins the early laning phase while Annie scales better into the late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Annie matchup.

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Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 33.3% win rate in this matchup
Lissandra
33.3% WR
VS
Annie vs Lissandra matchup - 66.7% win rate
Annie
66.7% WR

Who Wins the Lissandra vs Annie Matchup?

Annie wins the Lissandra vs Annie matchup
Winner
Annie
Matches: 6
33.3%
Win Rate
66.7%
6.7
CS / min
5.7
1,027
DMG / min
1,090
15,069
Gold / game
14,481
152
Heal / min
90
566
DMG Mitigated / min
438
2.0
CC / min
1.0
0.0%
Early Game WR
0.0%
33.3%
Late Game WR
66.7%

Lissandra vs Annie Matchup Summary

The Lissandra vs Annie matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Annie wins with a 66.7% win rate compared to Lissandra's 33.3%, giving Annie a 33.3 percentage point advantage. Game phase dynamics play a critical role here: Lissandra controls the early laning stage, but Annie outscales as the game goes longer. The matchup shifts dramatically depending on game length — Lissandra needs to press advantages before Annie reaches their power spikes, while Annie should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Lissandra leads by 1.0s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Annie has a strong advantage in this matchup. Lissandra players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Annie overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Annie Laning Phase Breakdown

Lissandra wins the laning phase against Annie in League of Legends

Lissandra is favored during the laning phase against Annie, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.7Lissandra
5.7Annie
Lissandra significantly out-farms Annie by 1.0 CS per minute, accumulating an estimated 16 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Annie players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
1,027Lissandra
1,090Annie
Annie deals 63 more champion damage per minute than Lissandra. While noticeable in extended trades, this gap can be offset by Lissandra choosing favorable fight windows, such as engaging when Annie's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
15,069Lissandra
14,481Annie
Lissandra earns 588 more gold per game than Annie, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Lissandra slightly faster item completions.
Utility
2.0Lissandra
1.0Annie
Lissandra brings significantly more crowd control than Annie, with 1.0 more seconds of CC per minute. This large utility gap makes Lissandra far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Annie should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
718Lissandra
528Annie
Lissandra vastly out-sustains Annie, healing and mitigating 190 more damage per minute. This massive durability gap means Lissandra can absorb significant punishment and remain in lane while Annie is forced to recall. Building grievous wounds early is essential for Annie, and focusing on burst trade patterns rather than sustained fights is critical.

Best Lissandra Build Against Annie

Spellslinger's Shoes is the optimal boots choice against Annie, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Annie are Shadowflame, Zhonya's Hourglass and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Annie matchup.

Early Game vs Late Game

Early Game
Lissandra
0.0%
+0.0% advantage
Lissandra early game win rateLissandra0.0%
Annie early game win rateAnnie0.0%
Late Game
Annie
66.7%
+33.3% advantage
Lissandra late game win rateLissandra33.3%
Annie late game win rateAnnie66.7%

The early game (first 15 minutes) is a toss-up between Lissandra and Annie, with Lissandra holding a razor-thin 0.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Annie is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Lissandra. Extended games heavily favor Annie, whose kit and scaling make them a dominant force in team fights and objective control.

The power dynamics shift as the game progresses — Lissandra has the edge early, but Annie gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Lissandra Runes Against Annie

Domination rune tree - Lissandra primary runes vs AnnieDomination
Electrocute - best Lissandra rune vs AnnieCheap Shot - best Lissandra rune vs AnnieGrisly Mementos - best Lissandra rune vs AnnieUltimate Hunter - best Lissandra rune vs Annie
Sorcery rune tree - Lissandra secondary runes vs AnnieSorcery
Manaflow Band - best Lissandra rune vs AnnieTranscendence - best Lissandra rune vs Annie
33.3% WR

The Domination and Sorcery rune setup gives Lissandra the best tools to compete against Annie in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Lissandra matchup data for League of Legends patch 26.14. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
62.22%456.484911,48773.7%53.9%
65.00%407.190012,18566.7%63.6%
47.06%346.689111,06457.1%40.0%
58.06%316.979110,55552.9%64.3%
55.56%276.884213,85877.8%44.4%
51.85%276.390310,35241.7%60.0%
44.00%256.473011,99228.6%50.0%
52.00%256.694112,41350.0%52.9%
47.83%236.88059,91335.7%66.7%
45.45%226.977111,01946.1%44.4%
28.57%216.769011,05228.6%28.6%
45.00%206.078912,2360.0%60.0%
50.00%206.783512,83340.0%53.3%
42.11%196.584710,93833.3%46.1%
52.94%176.475311,19533.3%63.6%
57.14%146.378810,31971.4%42.9%
50.00%146.793912,13040.0%55.6%
57.14%146.773910,99757.1%57.1%
45.45%117.090111,16360.0%33.3%
45.45%117.187812,49250.0%42.9%
45.45%114.57409,87540.0%50.0%
60.00%107.093011,03360.0%60.0%
40.00%106.370710,52750.0%25.0%
44.44%96.695112,88850.0%42.9%
55.56%96.481011,06466.7%50.0%
33.33%97.369511,41550.0%28.6%
25.00%86.570212,0800.0%28.6%
62.50%86.71,01613,65375.0%50.0%
75.00%87.11,06413,712100.0%66.7%
75.00%86.278110,08833.3%100.0%
85.71%77.496113,984100.0%80.0%
57.14%75.597511,52366.7%50.0%
14.29%76.383312,1060.0%16.7%
71.43%76.667610,12666.7%75.0%
66.67%67.181812,647100.0%60.0%
83.33%66.999013,827100.0%75.0%
50.00%66.07047,95666.7%33.3%
33.33%66.91,05110,52633.3%33.3%
33.33%66.71,02715,0690.0%33.3%
40.00%56.987412,25150.0%33.3%
40.00%55.16269,32550.0%33.3%
40.00%54.91,02512,6540.0%50.0%
20.00%53.774610,6910.0%50.0%
20.00%56.271812,3140.0%20.0%
40.00%51.75585,76550.0%0.0%

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Lissandra vs Annie - Frequently Asked Questions

How does Lissandra do against Annie in League of Legends?

Annie wins the Lissandra vs Annie matchup with a 66.7% win rate compared to Lissandra's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.14.

How does Lissandra do against Annie in the early game?

In the early game, Lissandra has the advantage against Annie with a 0.0% win rate versus 0.0%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Annie in the late game?

In the late game, Annie takes over the Lissandra vs Annie matchup with a 66.7% win rate compared to 33.3%. Annie scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Annie matchup?

Annie wins the matchup against Lissandra with a 66.7% win rate in League of Legends patch 26.14. The 33.3 percentage point advantage means Annie is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Lissandra build against Annie?

The best Lissandra build against Annie includes Shadowflame, Zhonya's Hourglass, Malignance with Spellslinger's Shoes. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Annie?

The best Lissandra runes against Annie use the Domination primary tree with Sorcery secondary. This rune setup achieves a 33.3% win rate in the Lissandra vs Annie matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Annie?

No, Lissandra struggles against Annie with only a 33.3% win rate. Annie has the advantage in this matchup. Lissandra players should focus on safe farming and avoiding extended trades to minimize Annie's lead.

How do I play Lissandra against Annie?

When playing Lissandra against Annie, play cautiously and avoid Annie's power spikes. Look for jungle assistance and team-dependent plays since Annie has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.