Pantheon - League of Legends Champion
Win Rate
49.5%
Pick Rate
3.8%

Pantheonvs Vayne

DFighterAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 19, 2026
MethodologyData Methodology

Pantheon vs Vayne is a very close matchup in LoL patch 26.7. Pantheon wins with a 50.0% win rate (+0.0%) over Vayne based on 14 games. Pantheon wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Pantheon build, runes, laning stats, and strategies for the Pantheon vs Vayne matchup.

Pantheon Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Pantheon performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 50.0% win rateVayne(50.0%)
Pantheon - 50.0% win rate in this matchup
Pantheon
50.0% WR
VS
Vayne vs Pantheon matchup - 50.0% win rate
Vayne
50.0% WR

Who Wins the Pantheon vs Vayne Matchup?

Pantheon wins the Pantheon vs Vayne matchup
Winner
Pantheon
Matches: 14
50.0%
Win Rate
50.0%
5.5
CS / min
5.7
778
DMG / min
851
10,388
Gold / game
11,114
148
Heal / min
283
747
DMG Mitigated / min
494
0.8
CC / min
0.4
83.3%
Early Game WR
16.7%
25.0%
Late Game WR
75.0%

Pantheon vs Vayne Matchup Summary

The Pantheon vs Vayne matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 14 recent matches analyzed, Pantheon wins with a 50.0% win rate compared to Vayne's 50.0%, giving Pantheon a 0.0 percentage point advantage. Game phase dynamics play a critical role here: Pantheon controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Pantheon needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Pantheon leads by 0.4s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Pantheon has a statistical edge, but the margin is close enough that respecting Vayne's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Pantheon vs Vayne Laning Phase Breakdown

Vayne wins the laning phase against Pantheon in League of Legends

Vayne is favored during the laning phase against Pantheon, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
5.5Pantheon
5.7Vayne
Pantheon and Vayne farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
778Pantheon
851Vayne
Vayne deals 73 more champion damage per minute than Pantheon. While noticeable in extended trades, this gap can be offset by Pantheon choosing favorable fight windows, such as engaging when Vayne's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
10,388Pantheon
11,114Vayne
Vayne earns 725 more gold per game than Pantheon, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Vayne slightly faster item completions.
Utility
0.8Pantheon
0.4Vayne
Pantheon provides 0.4 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Pantheon coordinate with their jungler and control the pace of skirmishes.
Sustain
896Pantheon
778Vayne
Pantheon heals and mitigates 118 more damage per minute than Vayne, providing moderate extra durability. This sustain edge allows Pantheon to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Vayne.

Best Pantheon Build Against Vayne

Ionian Boots of Lucidity is the optimal boots choice against Vayne, providing the mobility and stats Pantheon needs most in this matchup. The top-performing core items for Pantheon against Vayne are Eclipse, Sundered Sky and Spear of Shojin. This combination gives Pantheon an effective balance of damage, survivability, and utility for the matchup. This build has a 33.3% win rate across 3 games. While the overall matchup may be difficult, this item path gives Pantheon the best chance to compete against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Pantheon vs Vayne matchup.

Early Game vs Late Game

Early Game
Pantheon
83.3%
+66.7% advantage
Pantheon early game win ratePantheon83.3%
Vayne early game win rateVayne16.7%
Late Game
Vayne
75.0%
+50.0% advantage
Pantheon late game win ratePantheon25.0%
Vayne late game win rateVayne75.0%

Pantheon dominates the early game (first 15 minutes) with a commanding 83.3% win rate — a 66.7 percentage point lead over Vayne. This lopsided early game means Pantheon can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Pantheon. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Pantheon must aggressively press their early advantage and close out the game before Vayne reaches their scaling breakpoints. If Vayne survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Pantheon Runes Against Vayne

Precision rune tree - Pantheon primary runes vs VaynePrecision
Conqueror - best Pantheon rune vs VaynePresence of Mind - best Pantheon rune vs VayneLegend: Haste - best Pantheon rune vs VayneLast Stand - best Pantheon rune vs Vayne
Sorcery rune tree - Pantheon secondary runes vs VayneSorcery
Scorch - best Pantheon rune vs VayneTranscendence - best Pantheon rune vs Vayne
100.0% WR

The Precision primary with Sorcery secondary combination helps Pantheon maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Vayne.


Pantheon matchup data for League of Legends patch 26.7. The table below shows Pantheon's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Pantheon build, runes, laning stats, and early vs late game analysis for that specific matchup.

Pantheon matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
58.41%1135.792412,05259.6%57.4%
55.45%1012.266610,63658.7%52.7%
53.26%921.56479,84044.9%62.8%
46.67%751.565210,93146.4%46.8%
41.67%721.66499,78033.3%47.6%
50.00%701.771010,58150.0%50.0%
42.42%665.690212,13554.8%31.4%
43.94%661.567111,03844.0%43.9%
49.21%635.485711,60648.0%50.0%
49.12%571.670410,80747.8%50.0%
47.37%571.570310,35343.5%50.0%
50.00%562.077811,16956.5%45.5%
44.44%541.67049,86544.4%44.4%
34.62%532.683710,60131.8%36.7%
46.15%525.11,01011,32153.9%38.5%
55.77%521.969811,14947.8%62.1%
54.90%514.575310,22557.1%52.2%
52.00%501.475410,29950.0%53.9%
44.90%493.599312,72550.0%41.4%
54.17%481.669810,33044.8%68.4%
51.06%471.463810,34740.0%59.3%
44.68%471.566710,84041.2%46.7%
44.68%473.183412,34025.0%54.8%
62.22%455.790812,11276.2%50.0%
53.33%455.283210,86654.5%52.2%
43.18%443.982311,88459.1%27.3%
60.00%404.888112,23961.1%59.1%
38.46%394.882010,68341.7%33.3%
46.15%391.464310,29858.8%36.4%
48.65%376.088310,81755.0%41.2%
48.65%371.46269,62257.9%38.9%
64.86%371.467610,13060.0%70.6%
61.11%361.571911,89541.7%70.8%
55.56%361.665210,26263.2%47.1%
44.44%361.670711,96345.5%44.0%
44.12%341.779512,15344.4%43.8%
55.88%345.890211,58850.0%62.5%
58.82%344.372411,54260.0%57.9%
48.48%334.397012,37546.1%50.0%
36.36%331.370612,11737.5%35.3%
48.48%331.273010,88063.6%40.9%
50.00%322.661910,71150.0%50.0%
50.00%321.470512,15242.9%55.6%
41.94%314.183111,03947.1%35.7%
41.94%311.163011,81343.8%40.0%
43.33%300.871911,88550.0%37.5%
60.00%304.282610,99247.6%88.9%
58.62%296.081711,36656.3%61.5%
37.93%293.690412,39630.8%43.8%
64.29%281.465611,34258.8%72.7%
28.57%281.364510,29723.1%33.3%
53.57%283.595912,66746.7%61.5%
35.71%282.879511,27236.4%35.3%
67.86%283.385212,31191.7%50.0%
71.43%285.493410,33258.8%90.9%
40.74%272.467410,07450.0%30.8%
44.44%271.378813,06550.0%42.1%
59.26%275.897813,28463.6%56.3%
34.62%265.280211,23127.3%40.0%
61.54%264.794212,05250.0%68.8%
36.00%255.580611,62935.7%36.4%
40.00%254.786012,90222.2%50.0%
44.00%255.494712,17033.3%50.0%
48.00%251.575410,78446.7%50.0%
50.00%243.688412,43360.0%42.9%
62.50%245.21,05411,77369.2%54.5%
78.26%235.387412,15066.7%85.7%
65.22%231.672910,82442.9%75.0%
52.17%233.276411,68758.3%45.5%
47.83%235.61,00812,81571.4%37.5%
43.48%234.681710,08653.9%30.0%
50.00%222.876612,87833.3%56.3%
68.18%221.373712,61257.1%73.3%
31.82%220.957610,80528.6%37.5%
68.18%225.893011,31375.0%64.3%
36.36%225.592310,31038.5%33.3%
52.38%215.386311,60366.7%46.7%
61.90%210.976913,778100.0%50.0%
50.00%204.679210,43560.0%40.0%
45.00%200.965111,60940.0%50.0%
65.00%201.669011,34970.0%60.0%
60.00%204.486912,85550.0%64.3%
45.00%204.589211,05011.1%72.7%
31.58%191.77069,04733.3%28.6%
15.79%191.567212,0110.0%21.4%
61.11%180.884112,79655.6%66.7%
44.44%183.285211,57566.7%33.3%
52.94%171.474610,74950.0%55.6%
47.06%172.174312,92850.0%45.5%
52.94%175.889610,11455.6%50.0%
41.18%170.878412,29442.9%40.0%
56.25%165.487612,95180.0%45.5%
37.50%165.675111,85937.5%37.5%
37.50%162.692111,55325.0%50.0%
43.75%165.893011,76237.5%50.0%
56.25%160.875213,67150.0%58.3%
31.25%165.496113,86360.0%18.2%
53.33%154.37499,87355.6%50.0%
53.33%153.585512,53525.0%63.6%
60.00%155.485013,56975.0%54.5%
78.57%145.699812,48260.0%88.9%
50.00%145.577810,38883.3%25.0%
64.29%141.46179,82762.5%66.7%
35.71%143.371210,50250.0%16.7%
57.14%145.21,09512,66960.0%55.6%
35.71%141.469612,14866.7%12.5%
21.43%144.459010,07320.0%22.2%
28.57%144.689713,67016.7%37.5%
38.46%131.069112,32833.3%42.9%
53.85%130.979313,16350.0%57.1%
38.46%132.26069,51333.3%50.0%
30.77%134.985912,26940.0%25.0%
53.85%134.374810,89462.5%40.0%
16.67%124.880411,72825.0%12.5%
72.73%114.379311,72562.5%100.0%
27.27%113.179212,11150.0%14.3%
54.55%110.859911,12475.0%42.9%
50.00%103.782513,04366.7%42.9%
20.00%101.86309,68616.7%25.0%
50.00%104.795512,05920.0%80.0%
60.00%105.079911,78833.3%71.4%
50.00%105.91,11013,42325.0%66.7%
40.00%106.094512,69450.0%33.3%
60.00%105.08028,26260.0%60.0%
55.56%95.079612,02866.7%50.0%
55.56%95.190910,91157.1%50.0%
44.44%95.490811,48133.3%50.0%
44.44%95.573611,74333.3%66.7%
62.50%85.291713,9590.0%71.4%
62.50%80.968612,33360.0%66.7%
50.00%85.71,06510,83950.0%50.0%
50.00%81.274513,6060.0%66.7%
62.50%82.882811,415100.0%50.0%
57.14%74.47229,13340.0%100.0%
57.14%71.388411,11425.0%100.0%
57.14%73.272611,82250.0%66.7%
85.71%72.275812,01775.0%100.0%
42.86%72.895114,45850.0%40.0%
42.86%74.391714,1130.0%50.0%
57.14%70.774613,01950.0%60.0%
42.86%71.777912,46450.0%40.0%
33.33%63.789912,43350.0%0.0%
50.00%64.477412,32650.0%50.0%
50.00%64.868312,816100.0%25.0%
50.00%60.879312,58966.7%33.3%
33.33%65.066711,57250.0%25.0%
33.33%60.975011,6580.0%50.0%
83.33%60.679613,3340.0%100.0%
100.00%52.490212,862100.0%100.0%
40.00%51.964013,3560.0%50.0%
40.00%54.171012,55766.7%0.0%
80.00%54.47578,94366.7%100.0%

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Pantheon vs Vayne - Frequently Asked Questions

How does Pantheon do against Vayne in League of Legends?

Pantheon wins the Pantheon vs Vayne matchup with a 50.0% win rate compared to Vayne's 50.0%, a 0.0 percentage point difference. This data is based on 14 recent ranked games in patch 26.7.

How does Pantheon do against Vayne in the early game?

In the early game, Pantheon has the advantage against Vayne with a 83.3% win rate versus 16.7%. Pantheon players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Pantheon do against Vayne in the late game?

In the late game, Vayne takes over the Pantheon vs Vayne matchup with a 75.0% win rate compared to 25.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Pantheon vs Vayne matchup?

Pantheon wins the matchup against Vayne with a 50.0% win rate in League of Legends patch 26.7. The 0.0 percentage point advantage means Pantheon is slightly favored in this lane matchup based on 14 games analyzed.

What is the best Pantheon build against Vayne?

The best Pantheon build against Vayne includes Eclipse, Sundered Sky, Spear of Shojin with Ionian Boots of Lucidity. This build achieves a 33.3% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Pantheon runes against Vayne?

The best Pantheon runes against Vayne use the Precision primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Pantheon vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Pantheon counter Vayne?

Yes, Pantheon has a favorable matchup against Vayne with a 50.0% win rate. Pantheon slightly edges out Vayne in lane based on current patch 26.7 data.

How do I play Pantheon against Vayne?

When playing Pantheon against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.