Vayne - League of Legends Champion
Win Rate
49.1%
Pick Rate
4.7%

Vaynevs Pantheon

DMarksmanAssassin
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 6, 2026
MethodologyData Methodology

Vayne vs Pantheon is a decisive matchup in LoL patch 26.11. Vayne wins with a 56.5% win rate (+13.0%) over Pantheon based on 23 games. Pantheon wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Pantheon matchup.

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Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 56.5% win rate in this matchup
Vayne
56.5% WR
VS
Pantheon vs Vayne matchup - 43.5% win rate
Pantheon
43.5% WR

Who Wins the Vayne vs Pantheon Matchup?

Vayne wins the Vayne vs Pantheon matchup
Winner
Vayne
Matches: 23
56.5%
Win Rate
43.5%
5.7
CS / min
5.9
610
DMG / min
848
10,299
Gold / game
11,777
192
Heal / min
157
413
DMG Mitigated / min
728
0.4
CC / min
0.8
45.5%
Early Game WR
54.5%
66.7%
Late Game WR
33.3%

Vayne vs Pantheon Matchup Summary

The Vayne vs Pantheon matchup is a decisive matchup in League of Legends ranked play. Based on 23 recent matches analyzed, Vayne wins with a 56.5% win rate compared to Pantheon's 43.5%, giving Vayne a 13.0 percentage point advantage. Game phase dynamics play a critical role here: Pantheon controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Pantheon needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Pantheon leads by 0.4s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Pantheon and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Pantheon away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Pantheon Laning Phase Breakdown

Pantheon wins the laning phase against Vayne in League of Legends

Pantheon is favored during the laning phase against Vayne, winning 5 out of 5 key stat categories. Pantheon holds advantages in farming, damage, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
5.7Vayne
5.9Pantheon
Vayne and Pantheon farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
610Vayne
848Pantheon
Pantheon heavily out-damages Vayne by 238 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Pantheon's sustained damage advantage take over.
Economy
10,299Vayne
11,777Pantheon
Pantheon generates a commanding 1,479 more gold per game than Vayne. This substantial economic advantage means Pantheon consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.4Vayne
0.8Pantheon
Pantheon provides 0.4 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Pantheon coordinate with their jungler and control the pace of skirmishes.
Sustain
605Vayne
885Pantheon
Pantheon vastly out-sustains Vayne, healing and mitigating 281 more damage per minute. This massive durability gap means Pantheon can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Pantheon

Berserker's Greaves is the optimal boots choice against Pantheon, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Pantheon are Blade of The Ruined King, Guinsoo's Rageblade and Experimental Hexplate. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 75.0% win rate across 4 games — well above average and making it the top item path against Pantheon. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Pantheon matchup.

Early Game vs Late Game

Early Game
Pantheon
54.5%
+9.1% advantage
Vayne early game win rateVayne45.5%
Pantheon early game win ratePantheon54.5%
Late Game
Vayne
66.7%
+33.3% advantage
Vayne late game win rateVayne66.7%
Pantheon late game win ratePantheon33.3%

Pantheon dominates the early game (first 15 minutes) with a commanding 54.5% win rate — a 9.1 percentage point lead over Vayne. This lopsided early game means Pantheon can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Pantheon. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Pantheon must aggressively press their early advantage and close out the game before Vayne reaches their scaling breakpoints. If Vayne survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Vayne Runes Against Pantheon

Precision rune tree - Vayne primary runes vs PantheonPrecision
Press the Attack - best Vayne rune vs PantheonTriumph - best Vayne rune vs PantheonLegend: Alacrity - best Vayne rune vs PantheonCoup de Grace - best Vayne rune vs Pantheon
Inspiration rune tree - Vayne secondary runes vs PantheonInspiration
Cash Back - best Vayne rune vs PantheonBiscuit Delivery - best Vayne rune vs Pantheon
100.0% WR

Running Precision primary with Inspiration secondary allows Vayne to press their advantage against Pantheon, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.11. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
46.01%4766.078912,87544.3%47.4%
47.20%4476.079112,72545.4%48.6%
46.26%4285.779612,71544.9%47.3%
53.92%3956.085712,96853.2%54.6%
47.85%3726.289413,18946.8%48.6%
52.99%3516.284313,14252.5%53.4%
52.98%2856.390413,45646.2%58.8%
53.90%2696.387713,73748.2%58.0%
52.38%1895.988612,46846.1%58.2%
51.92%1566.591311,98950.0%53.4%
54.30%1516.185913,22758.5%51.2%
50.33%1516.180413,00743.8%55.2%
45.95%1485.978013,60345.3%46.3%
45.38%1306.177613,08138.2%50.7%
47.83%1156.481213,76538.5%52.6%
42.61%1156.178112,08234.0%49.2%
50.88%1145.886612,98941.2%58.7%
45.19%1046.489913,17548.7%43.1%
59.80%1026.585413,18963.5%56.0%
31.00%1005.563510,36011.1%47.3%
45.83%965.885713,16444.4%46.7%
50.53%956.31,12012,73751.6%50.0%
58.06%936.379613,00854.8%60.8%
44.09%935.862511,33042.4%45.0%
45.56%905.883011,35543.6%47.1%
45.98%876.385113,57237.9%50.0%
55.81%866.189910,74843.2%65.3%
55.95%846.21,29211,54651.4%59.2%
56.41%786.388313,43557.1%55.8%
54.84%625.981412,06158.3%52.6%
45.76%596.287712,77548.0%44.1%
51.92%526.091311,59248.1%56.0%
45.10%516.592112,14440.9%48.3%
52.00%506.087513,62147.8%55.6%
35.42%486.272110,98228.0%43.5%
58.33%486.198911,81064.0%52.2%
45.83%486.21,00510,83851.9%38.1%
50.00%466.297013,36447.4%51.9%
58.70%466.291413,67162.5%54.5%
54.55%446.287414,06357.1%53.3%
44.19%436.683913,74455.0%34.8%
26.19%425.987411,67823.5%28.0%
48.78%415.983611,64443.5%55.6%
52.50%405.683813,60737.5%56.3%
38.46%396.785410,96150.0%28.6%
41.03%396.07439,57128.6%55.6%
67.57%376.589811,52662.5%76.9%
45.95%375.683211,99840.0%50.0%
52.94%346.475912,24550.0%54.5%
52.94%346.41,05111,47452.6%53.3%
66.67%336.393813,52461.5%70.0%
48.48%336.478411,26950.0%46.1%
48.48%336.597913,30562.5%44.0%
40.63%325.382011,34442.1%38.5%
62.50%325.779613,16341.7%75.0%
40.63%326.267610,36931.6%53.9%
58.06%316.484912,13864.3%52.9%
53.33%305.685512,15255.6%52.4%
60.00%306.095312,30876.9%47.1%
43.33%306.664611,44137.5%50.0%
55.56%275.379211,00650.0%60.0%
48.15%276.283411,46543.8%54.5%
50.00%265.969311,80141.7%57.1%
50.00%266.171011,42146.1%53.9%
30.77%265.370011,00127.3%33.3%
50.00%265.883412,30154.5%46.7%
48.00%256.081612,91020.0%66.7%
44.00%256.475811,84450.0%38.5%
54.17%246.399112,32564.3%40.0%
45.83%246.085011,12557.1%30.0%
56.52%235.761010,29945.5%66.7%
45.45%226.573412,18438.5%55.6%
40.91%226.080612,81544.4%38.5%
42.11%196.292010,37245.5%37.5%
63.16%196.387012,58950.0%72.7%
42.11%195.881712,14257.1%33.3%
61.11%185.61,00813,43366.7%58.3%
62.50%166.188511,54762.5%62.5%
80.00%152.288517,36850.0%84.6%
53.33%156.498513,30150.0%54.5%
60.00%156.583311,24437.5%85.7%
46.67%156.687611,53050.0%42.9%
46.67%155.491613,99225.0%54.5%
42.86%146.482413,96675.0%30.0%
42.86%146.084113,4470.0%66.7%
53.85%136.584913,506100.0%33.3%
46.15%135.275011,57950.0%42.9%
66.67%125.61,02512,92880.0%57.1%
33.33%126.092711,90033.3%33.3%
54.55%115.61,00213,29850.0%57.1%
63.64%116.164210,20450.0%80.0%
54.55%112.982014,06866.7%40.0%
81.82%116.277512,783100.0%71.4%
54.55%113.484613,74333.3%62.5%
54.55%115.576111,64971.4%25.0%
45.45%115.69159,80875.0%28.6%
40.00%104.670811,73250.0%25.0%
60.00%105.782012,59750.0%62.5%
50.00%103.877113,23733.3%57.1%
40.00%105.592611,89340.0%40.0%
66.67%93.81,03913,79866.7%66.7%
33.33%96.11,07613,2730.0%50.0%
55.56%96.793013,145100.0%20.0%
33.33%96.085513,01833.3%33.3%
55.56%93.986012,86033.3%66.7%
50.00%85.887014,56550.0%50.0%
62.50%87.368411,84766.7%50.0%
50.00%83.288313,47975.0%25.0%
25.00%85.26909,10216.7%50.0%
37.50%85.85269,89450.0%25.0%
57.14%74.076010,75033.3%75.0%
71.43%73.674311,42580.0%50.0%
42.86%74.572311,69733.3%50.0%
28.57%74.567612,0460.0%40.0%
50.00%63.578115,0220.0%60.0%
33.33%66.882313,7790.0%50.0%
33.33%62.998912,89833.3%33.3%
66.67%65.91,00614,14350.0%75.0%
20.00%54.75778,99933.3%0.0%
40.00%52.161112,29050.0%0.0%
40.00%56.41,17614,5940.0%50.0%
80.00%56.21,02413,762100.0%66.7%
40.00%55.996213,2480.0%50.0%
40.00%56.06739,21850.0%0.0%
40.00%56.47269,89240.0%0.0%

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Vayne vs Pantheon - Frequently Asked Questions

How does Vayne do against Pantheon in League of Legends?

Vayne wins the Vayne vs Pantheon matchup with a 56.5% win rate compared to Pantheon's 43.5%, a 13.0 percentage point difference. This data is based on 23 recent ranked games in patch 26.11.

How does Vayne do against Pantheon in the early game?

In the early game, Pantheon has the advantage against Vayne with a 54.5% win rate versus 45.5%. Pantheon players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Pantheon in the late game?

In the late game, Vayne takes over the Vayne vs Pantheon matchup with a 66.7% win rate compared to 33.3%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Pantheon matchup?

Vayne wins the matchup against Pantheon with a 56.5% win rate in League of Legends patch 26.11. The 13.0 percentage point advantage means Vayne is significantly favored in this lane matchup based on 23 games analyzed.

What is the best Vayne build against Pantheon?

The best Vayne build against Pantheon includes Blade of The Ruined King, Guinsoo's Rageblade, Experimental Hexplate with Berserker's Greaves. This build achieves a 75.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Pantheon?

The best Vayne runes against Pantheon use the Precision primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Pantheon matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Pantheon?

Yes, Vayne has a favorable matchup against Pantheon with a 56.5% win rate. Vayne strongly counters Pantheon in lane based on current patch 26.11 data.

How do I play Vayne against Pantheon?

When playing Vayne against Pantheon, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Pantheon. Build the recommended items and runes for this specific matchup for the best results.