Vayne - League of Legends Champion
Win Rate
49.5%
Pick Rate
5.3%

Vaynevs Pantheon

DMarksmanAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 22, 2026
MethodologyData Methodology

Vayne vs Pantheon is a very close matchup in LoL patch 26.7. Vayne wins with a 50.0% win rate (+0.0%) over Pantheon based on 14 games. Pantheon wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Pantheon matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Pantheon - 50.0% win ratePantheon(50.0%)
Vayne - 50.0% win rate in this matchup
Vayne
50.0% WR
VS
Pantheon vs Vayne matchup - 50.0% win rate
Pantheon
50.0% WR

Who Wins the Vayne vs Pantheon Matchup?

Vayne wins the Vayne vs Pantheon matchup
Winner
Vayne
Matches: 14
50.0%
Win Rate
50.0%
5.7
CS / min
5.5
851
DMG / min
778
11,114
Gold / game
10,388
283
Heal / min
148
494
DMG Mitigated / min
747
0.4
CC / min
0.8
16.7%
Early Game WR
83.3%
75.0%
Late Game WR
25.0%

Vayne vs Pantheon Matchup Summary

The Vayne vs Pantheon matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 14 recent matches analyzed, Vayne wins with a 50.0% win rate compared to Pantheon's 50.0%, giving Vayne a 0.0 percentage point advantage. Game phase dynamics play a critical role here: Pantheon controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Pantheon needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Pantheon leads by 0.4s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a statistical edge, but the margin is close enough that respecting Pantheon's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Pantheon Laning Phase Breakdown

Vayne wins the laning phase against Pantheon in League of Legends

Vayne is favored during the laning phase against Pantheon, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
5.7Vayne
5.5Pantheon
Vayne and Pantheon farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
851Vayne
778Pantheon
Vayne deals 73 more champion damage per minute than Pantheon. While noticeable in extended trades, this gap can be offset by Pantheon choosing favorable fight windows, such as engaging when Vayne's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
11,114Vayne
10,388Pantheon
Vayne earns 725 more gold per game than Pantheon, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Vayne slightly faster item completions.
Utility
0.4Vayne
0.8Pantheon
Pantheon provides 0.4 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Pantheon coordinate with their jungler and control the pace of skirmishes.
Sustain
778Vayne
896Pantheon
Pantheon heals and mitigates 118 more damage per minute than Vayne, providing moderate extra durability. This sustain edge allows Pantheon to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Vayne.

Best Vayne Build Against Pantheon

Berserker's Greaves is the optimal boots choice against Pantheon, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Pantheon are Blade of The Ruined King, Guinsoo's Rageblade and Experimental Hexplate. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Pantheon. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Pantheon matchup.

Early Game vs Late Game

Early Game
Pantheon
83.3%
+66.7% advantage
Vayne early game win rateVayne16.7%
Pantheon early game win ratePantheon83.3%
Late Game
Vayne
75.0%
+50.0% advantage
Vayne late game win rateVayne75.0%
Pantheon late game win ratePantheon25.0%

Pantheon dominates the early game (first 15 minutes) with a commanding 83.3% win rate — a 66.7 percentage point lead over Vayne. This lopsided early game means Pantheon can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Pantheon. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Pantheon must aggressively press their early advantage and close out the game before Vayne reaches their scaling breakpoints. If Vayne survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Vayne Runes Against Pantheon

Precision rune tree - Vayne primary runes vs PantheonPrecision
Press the Attack - best Vayne rune vs PantheonAbsorb Life - best Vayne rune vs PantheonLegend: Alacrity - best Vayne rune vs PantheonCut Down - best Vayne rune vs Pantheon
Resolve rune tree - Vayne secondary runes vs PantheonResolve
Conditioning - best Vayne rune vs PantheonOvergrowth - best Vayne rune vs Pantheon
100.0% WR

The Precision primary with Resolve secondary combination helps Vayne maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Pantheon.


Vayne matchup data for League of Legends patch 26.7. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.02%3576.081713,23145.3%52.0%
52.47%3246.289813,59649.3%55.2%
48.09%3146.283212,81944.0%52.7%
49.01%3025.982512,93747.5%50.3%
52.94%2726.083913,07152.8%53.1%
45.37%2276.496014,25446.9%44.2%
50.00%2226.493713,71750.0%50.0%
52.71%2036.585613,74148.9%56.0%
52.32%1516.582813,28755.4%49.4%
58.39%1496.695312,70051.6%63.5%
51.30%1155.881313,71761.5%42.9%
47.71%1096.088213,23938.2%57.4%
55.67%976.488012,62559.6%51.1%
51.55%976.380612,73552.5%50.0%
50.00%945.983213,59546.7%53.1%
36.36%886.279012,98330.0%41.7%
47.44%786.692813,28446.3%48.6%
61.33%756.692412,10266.7%55.6%
55.56%726.185813,24745.2%63.4%
57.35%686.085313,57456.0%58.1%
36.76%686.288112,39436.7%36.8%
52.54%596.383712,51848.5%57.7%
42.37%596.287012,82834.4%51.9%
38.60%575.760511,22540.0%37.0%
37.50%565.560110,77030.4%42.4%
43.40%536.21,04512,46744.4%42.3%
44.00%506.188613,06147.8%40.7%
53.06%496.11,21413,80450.0%55.2%
65.91%446.186913,29266.7%65.4%
56.82%445.692114,04761.1%53.9%
43.18%445.799611,54831.3%50.0%
50.00%406.384813,58435.3%60.9%
55.00%405.989314,58823.1%70.4%
57.50%406.395114,24860.0%56.7%
48.72%396.595213,49157.9%40.0%
57.89%386.01,02912,41355.0%61.1%
42.11%386.192313,74144.4%40.0%
54.05%377.092811,69252.4%56.3%
40.54%375.880412,22541.2%40.0%
40.00%355.71,14111,80838.9%41.2%
55.88%346.585611,12557.9%53.3%
50.00%326.098613,59966.7%43.5%
66.67%306.289612,54050.0%81.3%
56.67%306.298113,89653.9%58.8%
48.28%296.785812,18028.6%66.7%
55.17%296.31,02413,69462.5%46.1%
51.85%275.798412,39145.5%56.3%
61.54%266.185111,71961.5%61.5%
64.00%256.080811,77055.6%68.8%
44.00%256.892712,26342.9%45.5%
33.33%246.483511,60541.7%25.0%
56.52%235.592112,42462.5%53.3%
43.48%236.383712,92160.0%30.8%
40.91%226.678811,10141.7%40.0%
52.38%215.992313,47740.0%63.6%
60.00%205.290914,35220.0%73.3%
47.37%196.91,00811,89263.6%25.0%
50.00%186.273213,04560.0%37.5%
50.00%186.21,05312,78455.6%44.4%
44.44%186.483711,79542.9%45.5%
50.00%185.875412,37328.6%63.6%
76.47%176.91,02114,29680.0%75.0%
29.41%176.982911,89737.5%22.2%
41.18%176.086215,19160.0%33.3%
43.75%166.083811,77362.5%25.0%
56.25%166.690711,52757.1%55.6%
37.50%165.465913,20816.7%50.0%
68.75%166.793713,92583.3%60.0%
53.33%155.968611,41937.5%71.4%
73.33%156.485112,62177.8%66.7%
50.00%145.785111,11416.7%75.0%
42.86%144.364512,05114.3%71.4%
53.85%133.388514,16275.0%44.4%
53.85%135.71,05513,76250.0%55.6%
58.33%125.656210,02757.1%60.0%
25.00%124.586213,08325.0%25.0%
50.00%126.378413,32833.3%66.7%
27.27%116.277113,46233.3%25.0%
63.64%116.387415,82666.7%62.5%
36.36%116.665110,70650.0%20.0%
45.45%115.591912,62950.0%40.0%
72.73%116.474510,85071.4%75.0%
45.45%116.01,06414,50840.0%50.0%
70.00%106.699613,49075.0%66.7%
40.00%106.887613,21633.3%50.0%
55.56%96.393712,28633.3%100.0%
44.44%96.21,07715,702100.0%28.6%
33.33%96.877411,06920.0%50.0%
25.00%85.569310,37825.0%25.0%
50.00%85.99738,78533.3%100.0%
37.50%81.983414,72733.3%40.0%
42.86%75.690112,809100.0%20.0%
0.00%76.655810,7000.0%0.0%
42.86%74.665114,53850.0%40.0%
71.43%76.168213,12675.0%66.7%
57.14%75.588812,31625.0%100.0%
57.14%75.489512,10050.0%66.7%
42.86%74.077311,64333.3%50.0%
57.14%72.51,31315,57625.0%100.0%
33.33%64.65709,10525.0%50.0%
66.67%65.91,08915,49350.0%75.0%
50.00%65.776213,18250.0%50.0%
50.00%61.989114,832100.0%40.0%
16.67%65.384410,4420.0%33.3%
0.00%65.979510,7240.0%0.0%
83.33%66.196311,361100.0%50.0%
50.00%66.380413,574100.0%40.0%
40.00%54.793914,778100.0%0.0%
60.00%51.71,19517,6480.0%75.0%
20.00%51.56919,37833.3%0.0%
60.00%55.31,10015,380100.0%50.0%
20.00%56.891512,5530.0%33.3%
40.00%56.51,02117,6030.0%40.0%

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Vayne vs Pantheon - Frequently Asked Questions

How does Vayne do against Pantheon in League of Legends?

Vayne wins the Vayne vs Pantheon matchup with a 50.0% win rate compared to Pantheon's 50.0%, a 0.0 percentage point difference. This data is based on 14 recent ranked games in patch 26.7.

How does Vayne do against Pantheon in the early game?

In the early game, Pantheon has the advantage against Vayne with a 83.3% win rate versus 16.7%. Pantheon players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Pantheon in the late game?

In the late game, Vayne takes over the Vayne vs Pantheon matchup with a 75.0% win rate compared to 25.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Pantheon matchup?

Vayne wins the matchup against Pantheon with a 50.0% win rate in League of Legends patch 26.7. The 0.0 percentage point advantage means Vayne is slightly favored in this lane matchup based on 14 games analyzed.

What is the best Vayne build against Pantheon?

The best Vayne build against Pantheon includes Blade of The Ruined King, Guinsoo's Rageblade, Experimental Hexplate with Berserker's Greaves. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Pantheon?

The best Vayne runes against Pantheon use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Pantheon matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Pantheon?

Yes, Vayne has a favorable matchup against Pantheon with a 50.0% win rate. Vayne slightly edges out Pantheon in lane based on current patch 26.7 data.

How do I play Vayne against Pantheon?

When playing Vayne against Pantheon, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Pantheon. Build the recommended items and runes for this specific matchup for the best results.