Qiyana - League of Legends Champion
Win Rate
45.8%
Pick Rate
1.6%

QiyanaRunes

FAssassin
Patch26.14
Matches226,800
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Best Qiyana runes for LoL Patch 26.14 - First Strike from the Inspiration tree with Domination secondary (49.3% WR, 18.8% pick rate). Qiyana's optimal primary runes are First Strike, Magical Footwear, Triple Tonic, Cosmic Insight. Secondary tree: Sudden Impact, Ultimate Hunter.

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Qiyana performs best with First Strike as the keystone rune from the Inspiration tree. Qiyana's optimal primary runes are First Strike, Magical Footwear, Triple Tonic, Cosmic Insight. Qiyana's secondary rune tree is Domination with Sudden Impact, Ultimate Hunter. This rune setup achieves a 49.28% win rate (+3.4% win rate difference) with a 18.8% pick rate across 138 Qiyana games.
49.3%Win Rate
+3.4%WR Diff
18.8%Pick Rate
First StrikeFirst Strike

Attacks or abilities against an enemy champion within 0.25s of entering champion combat grant 10 gold and First Strike for 3 seconds, causing you to deal 7% extra damage against champions, and granting 50% (35% for ranged champions) of bonus damage dealt as gold.

Cooldown: 25 - 15s

Magical FootwearMagical Footwear

You get free Slightly Magical Footwear at 12 min, but you cannot buy boots before then. For each takedown you acquire the boots 45s sooner.

Slightly Magical Footwear grants you an additional 10 Move Speed.

Triple TonicTriple Tonic

Upon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.

Cosmic InsightCosmic Insight

+18 Summoner Spell Haste
+10 Item Haste

Sudden ImpactSudden Impact

Damaging basic attacks and abilities deal a bonus 20 - 80 True Damage based on level to enemy champions after using a dash, leap, blink, teleport, or when leaving stealth for 4s.

Cooldown: 10s

Ultimate HunterUltimate Hunter

Your ultimate gains 6 Ability Haste, plus an additional 5 Ability Haste per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

This alternative Qiyana rune build uses Electrocute as the keystone from the Domination tree. The primary runes are Electrocute, Sudden Impact, Grisly Mementos, Treasure Hunter. Qiyana's secondary rune tree is Precision with Last Stand, Presence of Mind. This setup achieves a 46.70% win rate (+0.9% win rate difference) with a 24.8% pick rate across 182 games.
46.7%Win Rate
+0.9%WR Diff
24.8%Pick Rate
ElectrocuteElectrocute

Hitting a champion with 3 separate attacks or abilities within 3s deals bonus adaptive damage.

Damage: 70 - 240 (+0.1 bonus AD, +0.05 AP) damage.
Cooldown: 20s

'We called them the Thunderlords, for to speak of their lightning was to invite disaster.'

Sudden ImpactSudden Impact

Damaging basic attacks and abilities deal a bonus 20 - 80 True Damage based on level to enemy champions after using a dash, leap, blink, teleport, or when leaving stealth for 4s.

Cooldown: 10s

Grisly MementosGrisly Mementos

Collect 1 memento on champion takedowns, up to 18 total.

Gain 6 Trinket Haste for each collected. In game modes where vision Trinkets do not exist, instead gain 3 Summoner Spell Haste.

Treasure HunterTreasure Hunter

Gain an additional 50 gold the next time you collect a Bounty Hunter stack. Increase the gold gained by 20 gold for each Bounty Hunter stack, up to 130 gold.

Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

Last StandLast Stand

Deal 5% - 11% increased damage to champions while you are below 60% health. Max damage gained at 30% health.

Presence of MindPresence of Mind

Damaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.

Takedowns restore 15% of your maximum mana or energy.

Cooldown for damage restoration: 8s

These champions share at least 4 runes with Qiyana's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Qiyana's playstyle or want to learn champions with familiar rune setups.Kassadin, Tryndamere, Talon, Fizz, Ekko and 1 other

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Qiyana Runes - Frequently Asked Questions

What are the best Qiyana runes in patch 26.14?

The best Qiyana runes in patch 26.14 use the Inspiration tree with First Strike, Magical Footwear, Triple Tonic, and Cosmic Insight, and the Domination tree with Sudden Impact and Ultimate Hunter. This rune setup achieves a 49.3% win rate with a 18.8% pick rate.

What is the win rate for Qiyana's best rune page?

Qiyana's best rune page has a 49.3% win rate in patch 26.14, which is +3.4% compared to Qiyana's average win rate. This rune setup has a 18.8% pick rate among Qiyana players.

What keystone should I use on Qiyana?

First Strike from the Inspiration tree is the best keystone rune for Qiyana in patch 26.14. This keystone synergizes well with Qiyana's kit and provides a 49.3% win rate.

What is Qiyana's primary rune tree?

Qiyana's primary rune tree is Inspiration. The optimal Inspiration runes for Qiyana are First Strike, Magical Footwear, Triple Tonic, and Cosmic Insight, with First Strike being the keystone of choice.

What is Qiyana's secondary rune tree?

Qiyana's best secondary rune tree is Domination. The recommended Domination runes are Sudden Impact and Ultimate Hunter, which complement Qiyana's Inspiration primary tree.

What are alternative rune setups for Qiyana?

An alternative Qiyana rune setup uses Electrocute from the Domination tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Qiyana's runes?

Qiyana's top rune page has a 18.8% pick rate in patch 26.14. This indicates that 18.8% of Qiyana players use the First Strike setup with Inspiration and Domination trees.