Sett - League of Legends Champion
Win Rate
48.5%
Pick Rate
3.5%

Settvs Lissandra

DFighterTank
Patch26.10
Matches683,599
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 17, 2026
MethodologyData Methodology

Sett vs Lissandra is a decisive matchup in LoL patch 26.10. Lissandra wins with a 62.5% win rate (+25.0%) over Sett based on 8 games. Lissandra holds the advantage in both the early and late game. Below you'll find the best Sett build, runes, laning stats, and strategies for the Sett vs Lissandra matchup.

Sett Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Sett performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 37.5% win rateLissandra(37.5%)
Sett - 37.5% win rate in this matchup
Sett
37.5% WR
VS
Lissandra vs Sett matchup - 62.5% win rate
Lissandra
62.5% WR

Who Wins the Sett vs Lissandra Matchup?

Lissandra wins the Sett vs Lissandra matchup
Winner
Lissandra
Matches: 8
37.5%
Win Rate
62.5%
7.4
CS / min
7.5
714
DMG / min
891
11,735
Gold / game
12,237
153
Heal / min
167
1,137
DMG Mitigated / min
500
0.8
CC / min
1.6
33.3%
Early Game WR
66.7%
40.0%
Late Game WR
60.0%

Sett vs Lissandra Matchup Summary

The Sett vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 8 recent matches analyzed, Lissandra wins with a 62.5% win rate compared to Sett's 37.5%, giving Lissandra a 25.0 percentage point advantage. Lissandra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Sett players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Sett leads by 624 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a strong advantage in this matchup. Sett players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Lissandra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Sett vs Lissandra Laning Phase Breakdown

Lissandra wins the laning phase against Sett in League of Legends

Lissandra is favored during the laning phase against Sett, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
7.4Sett
7.5Lissandra
Sett and Lissandra farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
714Sett
891Lissandra
Lissandra heavily out-damages Sett by 177 DMG/min, dominating both short trades and all-in fights. Sett should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Lissandra's sustained damage advantage take over.
Economy
11,735Sett
12,237Lissandra
Lissandra earns 502 more gold per game than Sett, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Lissandra slightly faster item completions.
Utility
0.8Sett
1.6Lissandra
Lissandra provides 0.8 seconds more crowd control per minute than Sett, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
1,291Sett
667Lissandra
Sett vastly out-sustains Lissandra, healing and mitigating 624 more damage per minute. This massive durability gap means Sett can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Sett Build Against Lissandra

Mercury's Treads is the optimal boots choice against Lissandra, providing the mobility and stats Sett needs most in this matchup. The top-performing core items for Sett against Lissandra are Stridebreaker, Hullbreaker and Overlord's Bloodmail. This combination gives Sett an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Sett vs Lissandra matchup.

Early Game vs Late Game

Early Game
Lissandra
66.7%
+33.3% advantage
Sett early game win rateSett33.3%
Lissandra early game win rateLissandra66.7%
Late Game
Lissandra
60.0%
+20.0% advantage
Sett late game win rateSett40.0%
Lissandra late game win rateLissandra60.0%

Lissandra dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Sett. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Lissandra is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Sett. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.

Lissandra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Sett players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Sett Runes Against Lissandra

Precision rune tree - Sett primary runes vs LissandraPrecision
Fleet Footwork - best Sett rune vs LissandraTriumph - best Sett rune vs LissandraLegend: Alacrity - best Sett rune vs LissandraCoup de Grace - best Sett rune vs Lissandra
Resolve rune tree - Sett secondary runes vs LissandraResolve
Second Wind - best Sett rune vs LissandraShield Bash - best Sett rune vs Lissandra
100.0% WR

The Precision and Resolve rune setup gives Sett the best tools to compete against Lissandra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Sett matchup data for League of Legends patch 26.10. The table below shows Sett's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Sett build, runes, laning stats, and early vs late game analysis for that specific matchup.

Sett matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
50.69%2886.41,00012,55142.7%56.1%
51.83%2185.995512,08652.6%51.2%
48.85%2175.789811,82142.2%53.5%
42.36%2035.578412,15641.7%42.7%
46.99%1666.280011,54547.2%46.8%
48.32%1496.192511,21944.9%51.3%
53.24%1396.292811,33348.3%56.8%
52.90%1385.796611,41550.0%55.3%
45.31%1286.41,31911,74150.0%42.3%
45.45%1216.291811,96135.4%52.0%
52.21%1136.190012,35345.8%56.9%
47.42%976.51,19813,36537.8%53.3%
52.13%946.21,03912,97860.0%47.5%
50.55%916.091611,77756.8%44.7%
50.55%915.91,13012,50057.6%46.5%
53.93%896.598612,23653.9%54.0%
44.19%866.296211,28546.5%41.9%
51.76%856.31,07712,74953.7%50.0%
54.88%825.982311,04952.5%57.1%
55.56%816.178811,51956.4%54.8%
55.84%775.786210,67847.5%64.9%
55.41%746.088012,19950.0%59.5%
45.21%735.378211,15648.6%42.1%
53.52%716.191011,75658.3%48.6%
48.57%705.572311,69139.4%56.8%
51.43%705.81,11412,55154.5%50.0%
58.82%686.694411,78863.6%54.3%
48.53%686.991212,30754.5%42.9%
47.62%636.089711,49551.7%44.1%
58.06%625.890911,55151.5%65.5%
50.85%595.982411,63540.9%56.8%
57.63%596.293011,76662.1%53.3%
50.88%575.992811,67336.0%62.5%
38.18%556.01,03812,44135.0%40.0%
58.82%516.294312,57047.6%66.7%
48.94%476.498012,09753.3%41.2%
48.84%436.791812,12945.0%52.2%
44.19%435.388011,60945.0%43.5%
63.41%415.81,10312,69653.9%67.9%
50.00%385.998512,40552.4%47.1%
44.74%385.977212,58445.5%44.4%
27.78%365.666310,97226.7%28.6%
44.44%366.079412,17241.7%45.8%
42.86%356.51,03712,73146.1%40.9%
55.17%295.690813,15050.0%57.1%
28.57%285.882911,92741.7%18.8%
53.57%285.674811,00550.0%55.6%
44.44%275.678511,27650.0%41.2%
57.69%266.389213,16350.0%62.5%
60.00%256.41,06612,96371.4%55.6%
52.00%256.683310,55153.9%50.0%
36.00%256.180312,68725.0%41.2%
65.22%235.993312,14672.7%58.3%
66.67%184.981912,87142.9%81.8%
88.89%185.183311,21280.0%100.0%
47.06%174.991911,82455.6%37.5%
50.00%165.577910,41257.1%44.4%
43.75%164.888111,96533.3%50.0%
53.33%154.278512,44850.0%54.5%
64.29%143.583113,05180.0%55.6%
69.23%135.967010,93060.0%75.0%
46.15%135.51,06315,922100.0%41.7%
46.15%136.154510,31450.0%42.9%
41.67%125.879010,48150.0%25.0%
18.18%116.162811,5160.0%33.3%
54.55%115.880012,06166.7%50.0%
63.64%114.781212,44440.0%83.3%
50.00%102.61,00613,55750.0%50.0%
60.00%105.875610,78375.0%50.0%
70.00%105.692813,62366.7%71.4%
33.33%95.987011,7320.0%60.0%
33.33%95.39399,43820.0%50.0%
55.56%92.269010,36740.0%75.0%
33.33%92.36349,12420.0%50.0%
50.00%85.01,09411,204100.0%33.3%
37.50%85.089114,10850.0%33.3%
62.50%85.61,03910,80825.0%100.0%
50.00%84.989411,72350.0%50.0%
62.50%85.274710,59850.0%75.0%
62.50%82.360910,18566.7%60.0%
50.00%86.795512,99950.0%50.0%
50.00%82.184914,4480.0%66.7%
25.00%81.967310,6290.0%50.0%
37.50%87.471411,73533.3%40.0%
42.86%71.77679,98066.7%25.0%
42.86%72.164810,23375.0%0.0%
57.14%72.14659,955100.0%25.0%
71.43%72.258210,31566.7%75.0%
42.86%75.476711,6350.0%60.0%
57.14%76.27036,98360.0%50.0%
28.57%73.767810,89150.0%20.0%
33.33%64.552711,79066.7%0.0%
66.67%63.395713,92350.0%75.0%
50.00%65.377011,167100.0%25.0%
66.67%64.078611,756100.0%60.0%
33.33%63.898212,25050.0%25.0%
33.33%66.581612,28850.0%0.0%
16.67%65.65008,39120.0%0.0%
66.67%65.986016,910100.0%60.0%
33.33%61.865311,49333.3%33.3%
40.00%53.562311,8800.0%50.0%
20.00%55.07068,7130.0%100.0%
40.00%56.576214,4010.0%40.0%
20.00%52.776910,21025.0%0.0%
40.00%54.35069,7980.0%50.0%
80.00%52.655810,50750.0%100.0%
60.00%53.471213,7140.0%60.0%
40.00%52.65949,84250.0%33.3%
40.00%53.26608,74450.0%33.3%

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Sett vs Lissandra - Frequently Asked Questions

How does Sett do against Lissandra in League of Legends?

Lissandra wins the Sett vs Lissandra matchup with a 62.5% win rate compared to Sett's 37.5%, a 25.0 percentage point difference. This data is based on 8 recent ranked games in patch 26.10.

How does Sett do against Lissandra in the early game?

In the early game, Lissandra has the advantage against Sett with a 66.7% win rate versus 33.3%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Sett do against Lissandra in the late game?

In the late game, Lissandra takes over the Sett vs Lissandra matchup with a 60.0% win rate compared to 40.0%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Sett vs Lissandra matchup?

Lissandra wins the matchup against Sett with a 62.5% win rate in League of Legends patch 26.10. The 25.0 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 8 games analyzed.

What is the best Sett build against Lissandra?

The best Sett build against Lissandra includes Stridebreaker, Hullbreaker, Overlord's Bloodmail with Mercury's Treads. Check the matchup breakdown above for the full item path and build order.

What are the best Sett runes against Lissandra?

The best Sett runes against Lissandra use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Sett vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Sett counter Lissandra?

No, Sett struggles against Lissandra with only a 37.5% win rate. Lissandra has the advantage in this matchup. Sett players should focus on safe farming and avoiding extended trades to minimize Lissandra's lead.

How do I play Sett against Lissandra?

When playing Sett against Lissandra, play cautiously and avoid Lissandra's power spikes. Look for jungle assistance and team-dependent plays since Lissandra has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.