Lissandra - League of Legends Champion
Win Rate
52.3%
Pick Rate
1.9%

Lissandravs Sett

SMage
Patch26.10
Matches683,599
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 18, 2026
MethodologyData Methodology

Lissandra vs Sett is a decisive matchup in LoL patch 26.10. Lissandra wins with a 62.5% win rate (+25.0%) over Sett based on 8 games. Lissandra holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Sett matchup.

Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Sett - 62.5% win rateSett(62.5%)
Lissandra - 62.5% win rate in this matchup
Lissandra
62.5% WR
VS
Sett vs Lissandra matchup - 37.5% win rate
Sett
37.5% WR

Who Wins the Lissandra vs Sett Matchup?

Lissandra wins the Lissandra vs Sett matchup
Winner
Lissandra
Matches: 8
62.5%
Win Rate
37.5%
7.5
CS / min
7.4
891
DMG / min
714
12,237
Gold / game
11,735
167
Heal / min
153
500
DMG Mitigated / min
1,137
1.6
CC / min
0.8
66.7%
Early Game WR
33.3%
60.0%
Late Game WR
40.0%

Lissandra vs Sett Matchup Summary

The Lissandra vs Sett matchup is a decisive matchup in League of Legends ranked play. Based on 8 recent matches analyzed, Lissandra wins with a 62.5% win rate compared to Sett's 37.5%, giving Lissandra a 25.0 percentage point advantage. Lissandra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Sett players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Sett leads by 624 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra players can confidently pick into Sett and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Sett away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Sett Laning Phase Breakdown

Lissandra wins the laning phase against Sett in League of Legends

Lissandra is favored during the laning phase against Sett, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
7.5Lissandra
7.4Sett
Lissandra and Sett farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
891Lissandra
714Sett
Lissandra heavily out-damages Sett by 177 DMG/min, dominating both short trades and all-in fights. Sett should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Lissandra's sustained damage advantage take over.
Economy
12,237Lissandra
11,735Sett
Lissandra earns 502 more gold per game than Sett, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Lissandra slightly faster item completions.
Utility
1.6Lissandra
0.8Sett
Lissandra provides 0.8 seconds more crowd control per minute than Sett, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
667Lissandra
1,291Sett
Sett vastly out-sustains Lissandra, healing and mitigating 624 more damage per minute. This massive durability gap means Sett can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Lissandra Build Against Sett

Sorcerer's Shoes is the optimal boots choice against Sett, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Sett are Shadowflame, Zhonya's Hourglass and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 75.0% win rate across 4 games — well above average and making it the top item path against Sett. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Sett matchup.

Early Game vs Late Game

Early Game
Lissandra
66.7%
+33.3% advantage
Lissandra early game win rateLissandra66.7%
Sett early game win rateSett33.3%
Late Game
Lissandra
60.0%
+20.0% advantage
Lissandra late game win rateLissandra60.0%
Sett late game win rateSett40.0%

Lissandra dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Sett. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Lissandra is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Sett. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.

Lissandra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Sett players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Lissandra Runes Against Sett

Sorcery rune tree - Lissandra primary runes vs SettSorcery
Arcane Comet - best Lissandra rune vs SettManaflow Band - best Lissandra rune vs SettTranscendence - best Lissandra rune vs SettScorch - best Lissandra rune vs Sett
Domination rune tree - Lissandra secondary runes vs SettDomination
Cheap Shot - best Lissandra rune vs SettUltimate Hunter - best Lissandra rune vs Sett
100.0% WR

Running Sorcery primary with Domination secondary allows Lissandra to press their advantage against Sett, amplifying the strengths that make this a favorable matchup.


Lissandra matchup data for League of Legends patch 26.10. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.35%1496.677111,28049.3%54.9%
54.35%1386.883812,17660.4%50.6%
55.56%1356.779712,02060.8%52.4%
58.82%1196.585711,81445.3%69.7%
53.85%1046.691412,01655.6%52.9%
50.98%1026.672711,35753.5%49.1%
50.00%806.886711,96240.0%56.0%
47.37%765.974811,29345.5%48.8%
45.21%736.568110,57627.3%60.0%
52.17%696.996112,15155.2%50.0%
53.13%646.588712,25569.2%42.1%
42.37%596.378711,75545.0%41.0%
41.38%586.680412,36452.2%34.3%
43.14%516.991310,43742.3%44.0%
42.86%427.390910,24141.7%44.4%
47.62%426.876010,09547.8%47.4%
43.59%396.492411,96047.1%40.9%
47.37%386.773912,00953.3%43.5%
60.53%386.682310,50361.9%58.8%
54.29%356.582911,10157.9%50.0%
55.88%346.288711,52147.1%64.7%
50.00%346.793312,04433.3%59.1%
43.33%306.375411,37862.5%36.4%
43.33%306.181910,81153.9%35.3%
50.00%306.783811,58266.7%38.9%
53.33%306.476812,25175.0%45.5%
65.52%297.089411,64469.2%62.5%
57.14%286.683111,94141.7%68.8%
50.00%286.680410,04369.2%33.3%
48.15%276.790212,52950.0%47.4%
40.74%277.088912,17457.1%35.0%
46.15%266.980410,29062.5%20.0%
30.77%266.793811,90144.4%23.5%
46.15%266.978211,53466.7%35.3%
29.17%245.895512,91442.9%23.5%
63.64%226.780410,92969.2%55.6%
61.90%216.279511,32762.5%61.5%
52.38%216.884811,51866.7%41.7%
45.00%207.185310,18254.5%33.3%
57.89%196.189310,29954.5%62.5%
33.33%186.465611,45037.5%30.0%
55.56%185.679210,17166.7%44.4%
17.65%175.868812,21714.3%20.0%
43.75%163.559310,75350.0%41.7%
68.75%166.588012,43080.0%63.6%
64.29%147.090011,20040.0%77.8%
42.86%147.176211,12255.6%20.0%
57.14%146.887914,155100.0%45.5%
46.15%136.683211,21450.0%40.0%
41.67%126.385814,250100.0%36.4%
75.00%125.977512,474100.0%66.7%
36.36%116.788512,71725.0%42.9%
72.73%116.678011,31550.0%85.7%
81.82%117.892313,197100.0%66.7%
70.00%106.681311,36880.0%60.0%
33.33%97.577010,76266.7%16.7%
33.33%96.773911,320100.0%14.3%
44.44%96.975912,01160.0%25.0%
50.00%83.780812,85866.7%40.0%
37.50%87.391710,19520.0%66.7%
62.50%87.589112,23766.7%60.0%
50.00%87.31,05311,45750.0%50.0%
25.00%81.54948,3330.0%40.0%
50.00%82.75139,630100.0%33.3%
50.00%87.01,06011,42833.3%60.0%
62.50%86.091112,81766.7%60.0%
25.00%87.080111,32920.0%33.3%
50.00%86.11,00311,85340.0%66.7%
12.50%85.575810,4670.0%14.3%
57.14%72.462312,2880.0%57.1%
42.86%71.85527,24760.0%0.0%
28.57%76.783812,06833.3%25.0%
57.14%76.57077,45375.0%33.3%
28.57%77.01,20012,84850.0%20.0%
71.43%77.094211,67033.3%100.0%
50.00%67.596513,326100.0%25.0%
83.33%67.61,02412,158100.0%66.7%
33.33%65.176510,856100.0%20.0%
33.33%66.278310,96850.0%25.0%
66.67%64.367711,77250.0%75.0%
83.33%66.51,01112,025100.0%75.0%
60.00%56.28127,81460.0%0.0%
80.00%56.994810,95466.7%100.0%
0.00%56.675011,4390.0%0.0%
40.00%56.880213,193100.0%25.0%
20.00%56.692910,16050.0%0.0%
40.00%56.992711,982100.0%25.0%

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Lissandra vs Sett - Frequently Asked Questions

How does Lissandra do against Sett in League of Legends?

Lissandra wins the Lissandra vs Sett matchup with a 62.5% win rate compared to Sett's 37.5%, a 25.0 percentage point difference. This data is based on 8 recent ranked games in patch 26.10.

How does Lissandra do against Sett in the early game?

In the early game, Lissandra has the advantage against Sett with a 66.7% win rate versus 33.3%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Sett in the late game?

In the late game, Lissandra takes over the Lissandra vs Sett matchup with a 60.0% win rate compared to 40.0%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Sett matchup?

Lissandra wins the matchup against Sett with a 62.5% win rate in League of Legends patch 26.10. The 25.0 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 8 games analyzed.

What is the best Lissandra build against Sett?

The best Lissandra build against Sett includes Shadowflame, Zhonya's Hourglass, Malignance with Sorcerer's Shoes. This build achieves a 75.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Sett?

The best Lissandra runes against Sett use the Sorcery primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Sett matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Sett?

Yes, Lissandra has a favorable matchup against Sett with a 62.5% win rate. Lissandra strongly counters Sett in lane based on current patch 26.10 data.

How do I play Lissandra against Sett?

When playing Lissandra against Sett, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.