
Settvs Vayne
Sett vs Vayne is a moderate matchup in LoL patch 26.19. Sett wins with a 51.2% win rate (+2.3%) over Vayne based on 43 games. Sett wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Sett build, runes, laning stats, and strategies for the Sett vs Vayne matchup.
Sett Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Sett performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.


Who wins Sett vs Vayne?
Sett wins 45.5% of these games. With this many games the true rate is most likely between 34.8% and 56.5% (95% range).
- Expected
- 52.9% From both champions' overall Top win rates
- Matchup effect
- −7.5 pts Observed minus expected
- Sample
- 77 games Lane: Top
- vs patch 26.18
- −18.2 pts A real change since last patch
Lane: Top · Ranked Solo/Duo & Flex · North America server · All ranks · Patch 26.19 · Sep 24 – Sep 28
They also met in another lane (Bot): 4 games, Sett won 25.0%.
Key takeaways
- Current data slightly favors Vayne, but the sample is too limited for a strong conclusion: Sett wins 45.5% of 77 games (95% range 34.8–56.5%).
- Both champions' overall Top win rates predict 52.9% for Sett; the result is within the margin of error of that, so this matchup mostly reflects the two champions' general strength.
- Neither side reliably wins the lane: the average gold difference at 15 minutes is 209, within the margin of error (77 games).
- Sett players pick Doran's Blade + Health Potion much less often against Vayne: 41.5% of their other Top games, 19.5% here.
How we calculate this
Games: ranked Solo/Duo and Flex games on the North America server from the patch shown. Remakes (games under 5 minutes) are excluded.
A game only counts when Sett and Vayne played the same position on opposite teams, so roaming, lane swaps within a team or a champion merely being in the same game never count as this matchup.
The 95% range is a Wilson score interval. Confidence comes from how wide that range is: within ±3 points is very high, ±5 high, ±8 moderate, anything wider low. Below 20 games a matchup is not classified at all.
Expected win rate combines both champions’ win rates in this lane (same games and filters) with the log5 formula: E = A(1−B) / (A(1−B) + B(1−A)). Matchup effect = observed − expected.
"What changes" compares Sett's choices in this matchup with the same champion's other games in the same lane, and lists a change only when it is at least 3 points and statistically significant (two-proportion z-test, |z| ≥ 2, 20+ games).
Results are not split by rank: the sample per rank is too small for honest per-rank matchup numbers.
Sett vs Vayne Laning Stats
At 15 minutes
Whole-game averages
Sett vs Vayne Win Rate by Game Length
Sett's win rate against Vayne by game length. The dot is the win rate, the bar its 95% range and the dashed line the champion's usual win rate at that length. Lengths with fewer than 25 games are left blank.
No game length stands out: Sett's results against Vayne in short and long games are within the margin of error of each other.
Sett vs Vayne Power Spikes
Who is ahead at each stage, measured from these games. A stage reads "Even" when the difference is inside the margin of error, and "Insufficient data" when there are too few games to tell.
- Lane (15 min)EvenSett gold at 15: −209
- First itemVayneSett: 15.5 min · Vayne: 14.6 min
- Games under 20 minInsufficient data
- 20–30 min gamesInsufficient data
- 30+ min gamesEvenSett wins 40.9% of 44 games
What Sett Changes Against Vayne
Choices Sett players make noticeably more or less often in this matchup than in their other Top games.

Doran's Blade + Health PotionStarting itemsUsually41.5%vs Vayne19.5%−22.1 pts
Doran's Shield + Health PotionStarting itemsUsually15.6%vs Vayne37.7%+22.0 pts51.7% WR here
Mercury's TreadsBootsUsually25.7%vs Vayne5.2%−20.5 pts
Plated SteelcapsBootsUsually48.7%vs Vayne68.8%+20.1 pts43.4% WR here
Flash + IgniteSummoner spellsUsually86.0%vs Vayne71.4%−14.5 pts41.8% WR here
Usually24.6%vs Vayne13.0%−11.6 pts
StridebreakerItemUsually79.0%vs Vayne89.6%+10.6 pts46.4% WR here

Doran's Blade + Health Potion + Stealth WardStarting itemsUsually22.1%vs Vayne11.7%−10.4 pts
Best Sett Build vs Vayne
Usual Sett build (Top)
87.5% win rate · 16 games
Against Vayne
Not enough matchup-specific build data: only 5 of 36 Sett games against Vayne carried a complete build, which is too few to recommend an item path from. Use Sett's standard build instead.
- Sett usually completes Stridebreaker first, at 15.5 min (median of 61 games).
- Vayne usually completes Blade of The Ruined King first, at 14.6 min (median of 51 games).
- Skill priority: Q > W > E — the same as usual.
Builds are ranked by the lower edge of their win rate range, not the raw win rate, so a build seen in a handful of wins never outranks a proven one.
Best Sett Runes vs Vayne
Plan your Sett draft in Draft Lab
Draft Lab lays out both teams lane by lane with live matchup win rates, damage profiles and game-phase lean, and suggests picks and bans from current meta data.
- Full 5v5 draft board
- Lane matchup win rates
- Pick and ban suggestions

Sett matchup data for League of Legends patch 26.19. The table below shows Sett's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Sett build, runes, laning stats, and early vs late game analysis for that specific matchup.
Other Sett Matchups
Hardest for Sett
Easiest for Sett
Win rate and games for each matchup. Lists are ranked by the edge of the 95% range so small samples cannot top them; matchups with at least 50 games only.
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Sett vs Vayne FAQ - Patch 26.19
Who wins Sett vs Vayne?
Current data slightly favors Vayne, but the sample is too limited for a strong conclusion: Sett wins 45.5% of 77 games (95% range 34.8–56.5%).
What is Sett's win rate against Vayne?
Sett wins 45.5% of 77 Top games against Vayne on patch 26.19 (95% range 34.8–56.5%). Based on both champions' overall Top win rates, 52.9% would be expected.
Does Sett counter Vayne?
Not clearly. Sett wins 45.5% of 77 games against Vayne, and the 95% range (34.8–56.5%) includes 50%, so neither champion reliably counters the other on current data.
Who wins lane, Sett or Vayne?
Neither side reliably wins the lane: the average gold difference at 15 minutes is 209, within the margin of error (77 games).
Does Sett outscale Vayne?
There are too few games of each length to tell yet.
When is Vayne strongest against Sett?
Vayne is measurably ahead in: First item.
What should Sett build against Vayne?
There are not enough games for a matchup-specific core, so use Sett's usual Top core: Blade of The Ruined King, Heartsteel, Overlord's Bloodmail. The biggest change against Vayne: Doran's Blade + Health Potion (41.5% usually, 19.5% here).
What runes should Sett use against Vayne?
Conqueror with Precision and Resolve — 50.0% over 28 games against Vayne. The biggest change against Vayne: Flash + Ignite (86.0% usually, 71.4% here).
