- Win Rate
- 48.8%
- Pick Rate
- 2.5%
- Ban Rate
- 3.7%
Vayne vs Sett
- Patch
- 26.22
- Games
- 4,820
- Lane
- All Lanes
- Tier
- All Tiers
- Last Updated
- Nov 14, 2026 UTC
- Author
- Dakota Chinnick
- Methodology
- Data Methodology
Vayne vs Sett (Top): Vayne wins 57.8% of 116 ranked games over the last 2 patches (gold diff at 15: +206). Patch 26.22 build & runes.
Vayne57.8%
Current data slightly favors Vayne, but the sample is too limited for a strong conclusion: Vayne wins 57.8% of 116 games (95% range 48.7–66.4%).
Vayne Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who wins Vayne vs Sett?
Vayne wins 57.8% of these games. With this many games the true rate is most likely between 48.7% and 66.4% (95% range).
- Expected
- 49.6% From both champions' overall Top win rates
- Matchup effect
- +8.2 pts Observed minus expected
- Sample
- 116 games Lane: Top · Patch 26.21–26.22
- vs patch 26.21
- — Not enough games on both patches
Lane: Top · Ranked Solo/Duo & Flex · North America server · All ranks · Patch 26.21–26.22 · Oct 27 – Nov 14
The headline win rate covers patches 26.21–26.22 (116 games). The lane, game-length, build and rune sections below use patch 26.22 only (47 games).
Key takeaways
- Current data slightly favors Vayne, but the sample is too limited for a strong conclusion: Vayne wins 57.8% of 116 games (95% range 48.7–66.4%).
- Both champions' overall Top win rates predict 49.6% for Vayne; the result is within the margin of error of that, so this matchup mostly reflects the two champions' general strength.
- Neither side reliably wins the lane: the average gold difference at 15 minutes is 206, within the margin of error (47 games).
- Vayne players pick Doran's Bow + Health Potion + Health Potion far more often against Sett: 34.8% of their other Top games, 53.2% here.
How we calculate this
Games: ranked Solo/Duo and Flex games on the North America server from the patch shown. Remakes (games under 5 minutes) are excluded.
A game only counts when Vayne and Sett played the same position on opposite teams, so roaming, lane swaps within a team or a champion merely being in the same game never count as this matchup.
The 95% range is a Wilson score interval. Confidence comes from how wide that range is: within ±3 points is very high, ±5 high, ±8 moderate, anything wider low. Below 20 games a matchup is not classified at all.
Expected win rate combines both champions’ win rates in this lane (same games and filters) with the log5 formula: E = A(1−B) / (A(1−B) + B(1−A)). Matchup effect = observed − expected.
"What changes" compares Vayne's choices in this matchup with the same champion's other games in the same lane, and lists a change only when it is at least 3 points and statistically significant (two-proportion z-test, |z| ≥ 2, 20+ games).
Results are not split by rank: the sample per rank is too small for honest per-rank matchup numbers.
Vayne vs Sett Laning Stats
At 15 minutes
Whole-game averages
Vayne vs Sett Win Rate by Game Length
Vayne's win rate against Sett by game length. The dot is the win rate, the bar its 95% range and the dashed line the champion's usual win rate at that length. Lengths with fewer than 25 games are left blank.
No game length stands out: Vayne's results against Sett in short and long games are within the margin of error of each other.
Vayne vs Sett Power Spikes
Who is ahead at each stage, measured from these games. A stage reads "Even" when the difference is inside the margin of error, and "Insufficient data" when there are too few games to tell.
- Lane (15 min)EvenVayne gold at 15: +206
- First itemVayneVayne: 13.9 min · Sett: 14.9 min
- Games under 20 minInsufficient data
- 20–30 min gamesInsufficient data
- 30+ min gamesInsufficient data
What Vayne Changes Against Sett
Choices Vayne players make noticeably more or less often in this matchup than in their other Top games.
Doran's Bow + Health Potion + Health PotionStarting itemsUsually34.8%vs Sett53.2%+18.4 pts68.0% WR here
Exhaust + FlashSummoner spellsUsually30.0%vs Sett14.9%−15.1 pts
Kraken SlayerItemUsually12.6%vs Sett23.4%+10.8 pts
Best Vayne Build vs Sett
Usual Vayne build (Top)
78.9% win rate · 19 games
Against Sett
Not enough matchup-specific build data: only 5 of 27 Vayne games against Sett carried a complete build, which is too few to recommend an item path from. Use Vayne's standard build instead.
- Vayne usually completes Blade of The Ruined King first, at 13.9 min (median of 28 games).
- Sett usually completes Stridebreaker first, at 14.9 min (median of 41 games).
- Skill priority: Q > W > E — the same as usual.
Builds are ranked by the lower edge of their win rate range, not the raw win rate, so a build seen in a handful of wins never outranks a proven one.
Best Vayne Runes vs Sett
Usual Vayne runes (Top)
Lethal Tempo
62.5% win rate · 24 games
Against Sett
Lethal Tempo68.2% win rate · 22 games
Plan your Vayne draft in Draft Lab
Draft Lab lays out both teams lane by lane with live matchup win rates, damage profiles and game-phase lean, and suggests picks and bans from current meta data.
- Full 5v5 draft board
- Lane matchup win rates
- Pick and ban suggestions
Vayne matchup data for League of Legends patch 26.22. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.
Other Vayne Matchups
Hardest for Vayne
Easiest for Vayne
Win rate and games for each matchup. Lists are ranked by the edge of the 95% range so small samples cannot top them; matchups with at least 50 games only.
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Vayne vs Sett FAQ - Patch 26.21–26.22
Who wins Vayne vs Sett?
Current data slightly favors Vayne, but the sample is too limited for a strong conclusion: Vayne wins 57.8% of 116 games (95% range 48.7–66.4%).
What is Vayne's win rate against Sett?
Vayne wins 57.8% of 116 Top games against Sett on patch 26.21–26.22 (95% range 48.7–66.4%). Based on both champions' overall Top win rates, 49.6% would be expected.
Does Vayne counter Sett?
Not clearly. Vayne wins 57.8% of 116 games against Sett, and the 95% range (48.7–66.4%) includes 50%, so neither champion reliably counters the other on current data.
Who wins lane, Vayne or Sett?
Neither side reliably wins the lane: the average gold difference at 15 minutes is 206, within the margin of error (47 games).
Does Vayne outscale Sett?
There are too few games of each length to tell yet.
When is Sett strongest against Vayne?
On current data there is no stage of the game where Sett is ahead of Vayne beyond the margin of error.
What should Vayne build against Sett?
There are not enough games for a matchup-specific core, so use Vayne's usual Top core: Kraken Slayer, Terminus, Blade of The Ruined King. The biggest change against Sett: Doran's Bow + Health Potion + Health Potion (34.8% usually, 53.2% here).
What runes should Vayne use against Sett?
Lethal Tempo with Precision and Resolve — 68.2% over 22 games against Sett. The biggest change against Sett: Exhaust + Flash (30.0% usually, 14.9% here).