Vayne - League of Legends Champion
Win Rate
49.1%
Pick Rate
4.7%

Vaynevs Sett

DMarksmanAssassin
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 7, 2026
MethodologyData Methodology

Vayne vs Sett is a decisive matchup in LoL patch 26.11. Vayne wins with a 55.8% win rate (+11.6%) over Sett based on 86 games. Sett wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Sett matchup.

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Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 55.8% win rate in this matchup
Vayne
55.8% WR
VS
Sett vs Vayne matchup - 44.2% win rate
Sett
44.2% WR

Who Wins the Vayne vs Sett Matchup?

Vayne wins the Vayne vs Sett matchup
Winner
Vayne
Matches: 86
55.8%
Win Rate
44.2%
6.1
CS / min
5.5
899
DMG / min
704
10,748
Gold / game
10,438
216
Heal / min
164
496
DMG Mitigated / min
1,280
0.4
CC / min
0.8
43.2%
Early Game WR
56.8%
65.3%
Late Game WR
34.7%

Vayne vs Sett Matchup Summary

The Vayne vs Sett matchup is a decisive matchup in League of Legends ranked play. Based on 86 recent matches analyzed, Vayne wins with a 55.8% win rate compared to Sett's 44.2%, giving Vayne a 11.6 percentage point advantage. Game phase dynamics play a critical role here: Sett controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Sett needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Sett leads by 0.4s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Sett and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Sett away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Sett Laning Phase Breakdown

Vayne wins the laning phase against Sett in League of Legends

Vayne is favored during the laning phase against Sett, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
6.1Vayne
5.5Sett
Vayne edges out Sett by 0.6 CS per minute — a moderate farming advantage that adds up to roughly 9 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Vayne.
Damage
899Vayne
704Sett
Vayne heavily out-damages Sett by 196 DMG/min, dominating both short trades and all-in fights. Sett should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
10,748Vayne
10,438Sett
Vayne earns 310 more gold per game than Sett, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Vayne slightly faster item completions.
Utility
0.4Vayne
0.8Sett
Sett provides 0.4 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Sett coordinate with their jungler and control the pace of skirmishes.
Sustain
712Vayne
1,445Sett
Sett vastly out-sustains Vayne, healing and mitigating 733 more damage per minute. This massive durability gap means Sett can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Sett

Berserker's Greaves is the optimal boots choice against Sett, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Sett are Terminus, Blade of The Ruined King and Guinsoo's Rageblade. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 7 games — well above average and making it the top item path against Sett. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Sett matchup.

Early Game vs Late Game

Early Game
Sett
56.8%
+13.5% advantage
Vayne early game win rateVayne43.2%
Sett early game win rateSett56.8%
Late Game
Vayne
65.3%
+30.6% advantage
Vayne late game win rateVayne65.3%
Sett late game win rateSett34.7%

Sett dominates the early game (first 15 minutes) with a commanding 56.8% win rate — a 13.5 percentage point lead over Vayne. This lopsided early game means Sett can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 65.3% win rate — 30.6 points above Sett. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Sett must aggressively press their early advantage and close out the game before Vayne reaches their scaling breakpoints. If Vayne survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Vayne Runes Against Sett

Precision rune tree - Vayne primary runes vs SettPrecision
Press the Attack - best Vayne rune vs SettTriumph - best Vayne rune vs SettLegend: Alacrity - best Vayne rune vs SettCoup de Grace - best Vayne rune vs Sett
Resolve rune tree - Vayne secondary runes vs SettResolve
Conditioning - best Vayne rune vs SettOvergrowth - best Vayne rune vs Sett
63.6% WR

Running Precision primary with Resolve secondary allows Vayne to press their advantage against Sett, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.11. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
46.01%4766.078912,87544.3%47.4%
47.20%4476.079112,72545.4%48.6%
46.26%4285.779612,71544.9%47.3%
53.92%3956.085712,96853.2%54.6%
47.85%3726.289413,18946.8%48.6%
52.99%3516.284313,14252.5%53.4%
52.98%2856.390413,45646.2%58.8%
53.90%2696.387713,73748.2%58.0%
52.38%1895.988612,46846.1%58.2%
51.92%1566.591311,98950.0%53.4%
54.30%1516.185913,22758.5%51.2%
50.33%1516.180413,00743.8%55.2%
45.95%1485.978013,60345.3%46.3%
45.38%1306.177613,08138.2%50.7%
47.83%1156.481213,76538.5%52.6%
42.61%1156.178112,08234.0%49.2%
50.88%1145.886612,98941.2%58.7%
45.19%1046.489913,17548.7%43.1%
59.80%1026.585413,18963.5%56.0%
31.00%1005.563510,36011.1%47.3%
45.83%965.885713,16444.4%46.7%
50.53%956.31,12012,73751.6%50.0%
58.06%936.379613,00854.8%60.8%
44.09%935.862511,33042.4%45.0%
45.56%905.883011,35543.6%47.1%
45.98%876.385113,57237.9%50.0%
55.81%866.189910,74843.2%65.3%
55.95%846.21,29211,54651.4%59.2%
56.41%786.388313,43557.1%55.8%
54.84%625.981412,06158.3%52.6%
45.76%596.287712,77548.0%44.1%
51.92%526.091311,59248.1%56.0%
45.10%516.592112,14440.9%48.3%
52.00%506.087513,62147.8%55.6%
35.42%486.272110,98228.0%43.5%
58.33%486.198911,81064.0%52.2%
45.83%486.21,00510,83851.9%38.1%
50.00%466.297013,36447.4%51.9%
58.70%466.291413,67162.5%54.5%
54.55%446.287414,06357.1%53.3%
44.19%436.683913,74455.0%34.8%
26.19%425.987411,67823.5%28.0%
48.78%415.983611,64443.5%55.6%
52.50%405.683813,60737.5%56.3%
38.46%396.785410,96150.0%28.6%
41.03%396.07439,57128.6%55.6%
67.57%376.589811,52662.5%76.9%
45.95%375.683211,99840.0%50.0%
52.94%346.475912,24550.0%54.5%
52.94%346.41,05111,47452.6%53.3%
66.67%336.393813,52461.5%70.0%
48.48%336.478411,26950.0%46.1%
48.48%336.597913,30562.5%44.0%
40.63%325.382011,34442.1%38.5%
62.50%325.779613,16341.7%75.0%
40.63%326.267610,36931.6%53.9%
58.06%316.484912,13864.3%52.9%
53.33%305.685512,15255.6%52.4%
60.00%306.095312,30876.9%47.1%
43.33%306.664611,44137.5%50.0%
55.56%275.379211,00650.0%60.0%
48.15%276.283411,46543.8%54.5%
50.00%265.969311,80141.7%57.1%
50.00%266.171011,42146.1%53.9%
30.77%265.370011,00127.3%33.3%
50.00%265.883412,30154.5%46.7%
48.00%256.081612,91020.0%66.7%
44.00%256.475811,84450.0%38.5%
54.17%246.399112,32564.3%40.0%
45.83%246.085011,12557.1%30.0%
56.52%235.761010,29945.5%66.7%
45.45%226.573412,18438.5%55.6%
40.91%226.080612,81544.4%38.5%
42.11%196.292010,37245.5%37.5%
63.16%196.387012,58950.0%72.7%
42.11%195.881712,14257.1%33.3%
61.11%185.61,00813,43366.7%58.3%
62.50%166.188511,54762.5%62.5%
80.00%152.288517,36850.0%84.6%
53.33%156.498513,30150.0%54.5%
60.00%156.583311,24437.5%85.7%
46.67%156.687611,53050.0%42.9%
46.67%155.491613,99225.0%54.5%
42.86%146.482413,96675.0%30.0%
42.86%146.084113,4470.0%66.7%
53.85%136.584913,506100.0%33.3%
46.15%135.275011,57950.0%42.9%
66.67%125.61,02512,92880.0%57.1%
33.33%126.092711,90033.3%33.3%
54.55%115.61,00213,29850.0%57.1%
63.64%116.164210,20450.0%80.0%
54.55%112.982014,06866.7%40.0%
81.82%116.277512,783100.0%71.4%
54.55%113.484613,74333.3%62.5%
54.55%115.576111,64971.4%25.0%
45.45%115.69159,80875.0%28.6%
40.00%104.670811,73250.0%25.0%
60.00%105.782012,59750.0%62.5%
50.00%103.877113,23733.3%57.1%
40.00%105.592611,89340.0%40.0%
66.67%93.81,03913,79866.7%66.7%
33.33%96.11,07613,2730.0%50.0%
55.56%96.793013,145100.0%20.0%
33.33%96.085513,01833.3%33.3%
55.56%93.986012,86033.3%66.7%
50.00%85.887014,56550.0%50.0%
62.50%87.368411,84766.7%50.0%
50.00%83.288313,47975.0%25.0%
25.00%85.26909,10216.7%50.0%
37.50%85.85269,89450.0%25.0%
57.14%74.076010,75033.3%75.0%
71.43%73.674311,42580.0%50.0%
42.86%74.572311,69733.3%50.0%
28.57%74.567612,0460.0%40.0%
50.00%63.578115,0220.0%60.0%
33.33%66.882313,7790.0%50.0%
33.33%62.998912,89833.3%33.3%
66.67%65.91,00614,14350.0%75.0%
20.00%54.75778,99933.3%0.0%
40.00%52.161112,29050.0%0.0%
40.00%56.41,17614,5940.0%50.0%
80.00%56.21,02413,762100.0%66.7%
40.00%55.996213,2480.0%50.0%
40.00%56.06739,21850.0%0.0%
40.00%56.47269,89240.0%0.0%

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Vayne vs Sett - Frequently Asked Questions

How does Vayne do against Sett in League of Legends?

Vayne wins the Vayne vs Sett matchup with a 55.8% win rate compared to Sett's 44.2%, a 11.6 percentage point difference. This data is based on 86 recent ranked games in patch 26.11.

How does Vayne do against Sett in the early game?

In the early game, Sett has the advantage against Vayne with a 56.8% win rate versus 43.2%. Sett players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Sett in the late game?

In the late game, Vayne takes over the Vayne vs Sett matchup with a 65.3% win rate compared to 34.7%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Sett matchup?

Vayne wins the matchup against Sett with a 55.8% win rate in League of Legends patch 26.11. The 11.6 percentage point advantage means Vayne is significantly favored in this lane matchup based on 86 games analyzed.

What is the best Vayne build against Sett?

The best Vayne build against Sett includes Terminus, Blade of The Ruined King, Guinsoo's Rageblade with Berserker's Greaves. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Sett?

The best Vayne runes against Sett use the Precision primary tree with Resolve secondary. This rune setup achieves a 63.6% win rate in the Vayne vs Sett matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Sett?

Yes, Vayne has a favorable matchup against Sett with a 55.8% win rate. Vayne strongly counters Sett in lane based on current patch 26.11 data.

How do I play Vayne against Sett?

When playing Vayne against Sett, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Sett. Build the recommended items and runes for this specific matchup for the best results.