- Win Rate
- 0%
- Pick Rate
- 0%
- Ban Rate
- 5.4%
Vayne Mid Runes: Keystone & Shards
- Patch
- 26.20
- Matches
- 654,440
- Lane
- Mid
- Tier
- All Tiers
- Last Updated
- Oct 12, 2026 UTC
- Methodology
- Data Methodology
- Author
- Dakota Chinnick
Best Mid Vayne runes for LoL Patch 26.20 - Keystone from the Primary tree with Secondary secondary (0% WR, 0% pick rate). Vayne's optimal primary runes are {primaryRunes}. Secondary tree: {secondaryRunes}.
Primary Tree
Secondary Tree
Primary Tree
Secondary Tree
Every Vayne Mid Keystone and Secondary Tree (Patch 26.20)
73 gamesVayne Mid runs Lethal Tempo in 62% of games, with a 46.7% win rate. Standard stat shards: Attack Speed (offense), Adaptive Force (flex), Health Scaling (defense).
Keystones
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Lethal TempoMost played | 61.6% | 46.7% | 45 |
Pick rate is the share of Vayne games in this lane that used the rune; options under 40 games are left out. A higher win rate on a rarely picked rune is usually a matchup-specific choice, not a general upgrade.
Vayne Minor Runes by Tree
Every minor rune Vayne players take, grouped by rune tree, with how often it is picked and how often it wins.
Precision
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Legend: AlacrityMost played | 83.6% | 42.6% | 61 |
 Triumph | 79.5% | 43.1% | 58 |
 Coup de Grace | 75.3% | 40.0% | 55 |
Vayne Stat Shards
Which stat shards Vayne players choose in each of the three shard rows, and the win rate of each.
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Adaptive Force (flex)Most played | 95.9% | 42.9% | 70 |
 Attack Speed (offense) | 91.8% | 43.3% | 67 |
 Health Scaling (defense) | 79.5% | 41.4% | 58 |
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Vayne Runes FAQ - Patch 26.20
What is the best keystone for Vayne Mid?
Lethal Tempo: Vayne Mid takes it in 62% of ranked games and wins 46.7% of 45 games.
What stat shards should Vayne take?
Most Vayne players take Attack Speed (offense), Adaptive Force (flex), Health Scaling (defense) — one from each shard row.
What are the best Vayne runes in patch 26.20?
The best Vayne runes in patch 26.20 use the Primary tree with , and the Secondary tree with . This rune setup achieves a 0% win rate with a 0% pick rate.
What is the win rate for Vayne's best rune page?
Vayne's best rune page has a 0% win rate in patch 26.20, which is NaN% compared to Vayne's average win rate. This rune setup has a 0% pick rate among Vayne players.
What keystone should I use on Vayne?
your chosen keystone from the Primary tree is the best keystone rune for Vayne in patch 26.20. This keystone synergizes well with Vayne's kit and provides a 0% win rate.
What is Vayne's primary rune tree?
Vayne's primary rune tree is Primary. The optimal Primary runes for Vayne are , with your chosen keystone being the keystone of choice.
What is Vayne's secondary rune tree?
Vayne's best secondary rune tree is Secondary. The recommended Secondary runes are , which complement Vayne's Primary primary tree.
What are alternative rune setups for Vayne?
An alternative Vayne rune setup uses alternative keystone from the Primary tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.
How popular are Vayne's runes?
Vayne's top rune page has a 0% pick rate in patch 26.20. This indicates that 0% of Vayne players use the your chosen keystone setup with Primary and Secondary trees.