Win Rate
48.7%
Pick Rate
1.9%
Zerivs Vayne
Patch26.17
Matches693,760
LaneAll Lanes
TierAll Tiers
Last UpdatedSep 2, 2026 UTC
MethodologyData Methodology
AuthorDakota Chinnick
Zeri vs Vayne is a moderate matchup in LoL patch 26.17. Vayne wins with a 51.1% win rate (+2.1%) over Zeri based on 47 games. Zeri wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Zeri build, runes, laning stats, and strategies for the Zeri vs Vayne matchup.
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Zeri Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Zeri performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Compare against an opponent
Zeri
48.9% WR
VS
Vayne
51.1% WR
Who Wins the Zeri vs Vayne Matchup?
Winner
Vayne
Matches: 47
48.9%
51.1%
7.6
6.3
1,034
868
14,359
12,638
186
210
471
482
0.2
0.3
60.9%
39.1%
37.5%
62.5%
Zeri vs Vayne Matchup Summary
The Zeri vs Vayne matchup is a very close matchup in League of Legends ranked play. Based on 47 recent matches analyzed, Vayne wins with a 51.1% win rate compared to Zeri's 48.9%, giving Vayne a 2.1 percentage point advantage. Game phase dynamics play a critical role here: Zeri controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Zeri needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Vayne leads by 0.1s CC/min — a difference that heavily influences the outcome of trades and skirmishes. While Vayne is slightly favored, Zeri can absolutely win this lane through smart trading patterns and wave management. Focus on playing around your cooldowns, conceding CS only when necessary, and capitalizing on Vayne's mistakes. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Zeri vs Vayne Laning Phase Breakdown
Zeri is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Zeri holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.
Farming
7.6Zeri
6.3Vayne
Zeri significantly out-farms Vayne by 1.3 CS per minute, accumulating an estimated 19 CS lead by mid game. This substantial farming gap gives Zeri a major gold advantage and earlier item completions. Vayne players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.Damage
1,034Zeri
868Vayne
Zeri heavily out-damages Vayne by 165 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zeri's sustained damage advantage take over.Economy
14,359Zeri
12,638Vayne
Zeri generates a commanding 1,721 more gold per game than Vayne. This substantial economic advantage means Zeri consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.Utility
0.2Zeri
0.3Vayne
Both Zeri and Vayne provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.Sustain
656Zeri
692Vayne
Zeri and Vayne have comparable sustain profiles, with only 35 HP/min separating their healing and damage mitigation. Neither champion can out-attrition the other in lane, so trades will be decided by burst potential and ability usage rather than sustain.Early Game vs Late Game
⚔
Early Game
Zeri
60.9%
+21.7% advantage
Zeri60.9%
Vayne39.1%♕
Late Game
Vayne
62.5%
+25.0% advantage
Zeri37.5%Vayne62.5%Zeri dominates the early game (first 15 minutes) with a commanding 60.9% win rate — a 21.7 percentage point lead over Vayne. This lopsided early game means Zeri can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Vayne is far superior in the late game (25+ minutes), boasting a 62.5% win rate — 25.0 points above Zeri. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.
This matchup features a dramatic power shift: Zeri must aggressively press their early advantage and close out the game before Vayne reaches their scaling breakpoints. If Vayne survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.
Best Zeri Runes Against Vayne
Precision
Inspiration
50.0% WR
The Precision primary with Inspiration secondary combination helps Zeri maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Vayne.
Zeri matchup data for League of Legends patch 26.17. The table below shows Zeri's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zeri build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 39.78% | 186 | 7.6 | 868 | 13,950 | 37.2% | 42.4% | |
| 45.07% | 142 | 7.4 | 861 | 13,864 | 47.3% | 42.6% | |
| 61.36% | 132 | 7.8 | 1,026 | 15,222 | 57.6% | 65.2% | |
| 55.73% | 131 | 7.4 | 924 | 14,841 | 57.4% | 54.5% | |
| 44.44% | 99 | 6.9 | 856 | 13,931 | 45.2% | 43.9% | |
| 50.52% | 97 | 7.4 | 907 | 14,139 | 49.0% | 52.1% | |
| 41.77% | 79 | 7.8 | 901 | 14,151 | 46.5% | 36.1% | |
| 52.00% | 75 | 7.2 | 881 | 13,703 | 56.1% | 47.1% | |
| 45.95% | 74 | 7.4 | 856 | 13,789 | 50.0% | 42.1% | |
| 45.45% | 66 | 7.4 | 888 | 14,030 | 51.5% | 39.4% | |
| 55.74% | 61 | 7.3 | 787 | 14,278 | 57.1% | 54.5% | |
| 42.31% | 52 | 7.6 | 872 | 15,353 | 35.0% | 46.9% | |
| 48.94% | 47 | 7.6 | 1,034 | 14,359 | 60.9% | 37.5% | |
| 59.52% | 42 | 7.6 | 1,002 | 16,379 | 54.5% | 61.3% | |
| 52.50% | 40 | 7.4 | 838 | 13,731 | 42.9% | 63.2% | |
| 55.00% | 40 | 7.6 | 825 | 14,804 | 61.1% | 50.0% | |
| 35.90% | 39 | 7.7 | 775 | 14,298 | 28.6% | 44.4% | |
| 26.32% | 38 | 7.5 | 815 | 13,936 | 15.0% | 38.9% | |
| 60.61% | 33 | 7.6 | 807 | 13,742 | 53.3% | 66.7% | |
| 68.00% | 25 | 7.6 | 1,023 | 15,951 | 92.3% | 41.7% | |
| 54.17% | 24 | 7.3 | 912 | 14,471 | 36.4% | 69.2% | |
| 77.27% | 22 | 7.6 | 886 | 17,463 | 80.0% | 76.5% | |
| 50.00% | 20 | 7.9 | 832 | 14,343 | 44.4% | 54.5% | |
| 36.84% | 19 | 7.9 | 998 | 14,405 | 50.0% | 22.2% | |
| 55.56% | 18 | 7.2 | 849 | 15,293 | 62.5% | 50.0% | |
| 41.18% | 17 | 8.0 | 927 | 13,961 | 62.5% | 22.2% | |
| 26.67% | 15 | 7.2 | 868 | 14,411 | 20.0% | 30.0% | |
| 50.00% | 14 | 7.5 | 993 | 14,590 | 50.0% | 50.0% | |
| 76.92% | 13 | 8.5 | 1,213 | 17,632 | 60.0% | 87.5% | |
| 66.67% | 12 | 7.0 | 847 | 15,696 | 100.0% | 50.0% | |
| 50.00% | 10 | 8.1 | 784 | 13,433 | 42.9% | 66.7% | |
| 50.00% | 10 | 7.7 | 848 | 14,300 | 66.7% | 25.0% | |
| 33.33% | 9 | 7.4 | 950 | 13,851 | 40.0% | 25.0% | |
| 33.33% | 9 | 6.8 | 964 | 12,820 | 0.0% | 60.0% | |
| 55.56% | 9 | 8.0 | 852 | 15,245 | 50.0% | 60.0% | |
| 50.00% | 8 | 7.5 | 646 | 12,372 | 25.0% | 75.0% | |
| 42.86% | 7 | 8.0 | 832 | 16,213 | 50.0% | 40.0% | |
| 28.57% | 7 | 7.4 | 816 | 13,586 | 40.0% | 0.0% | |
| 66.67% | 6 | 7.3 | 969 | 15,272 | 50.0% | 75.0% | |
| 40.00% | 5 | 1.1 | 625 | 11,267 | 66.7% | 0.0% | |
| 60.00% | 5 | 7.9 | 1,024 | 14,957 | 75.0% | 0.0% | |
| 40.00% | 5 | 7.0 | 1,126 | 14,343 | 50.0% | 33.3% | |
| 60.00% | 5 | 6.9 | 1,034 | 16,076 | 100.0% | 50.0% | |
| 40.00% | 5 | 4.2 | 464 | 7,901 | 50.0% | 0.0% |
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Zeri vs Vayne - Frequently Asked Questions
How does Zeri do against Vayne in League of Legends?
Vayne wins the Zeri vs Vayne matchup with a 51.1% win rate compared to Zeri's 48.9%, a 2.1 percentage point difference. This data is based on 47 recent ranked games in patch 26.17.
How does Zeri do against Vayne in the early game?
In the early game, Zeri has the advantage against Vayne with a 60.9% win rate versus 39.1%. Zeri players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Zeri do against Vayne in the late game?
In the late game, Vayne takes over the Zeri vs Vayne matchup with a 62.5% win rate compared to 37.5%. Vayne scales better into team fights and objective contests after 25 minutes.
Who wins the Zeri vs Vayne matchup?
Vayne wins the matchup against Zeri with a 51.1% win rate in League of Legends patch 26.17. The 2.1 percentage point advantage means Vayne is moderately favored in this lane matchup based on 47 games analyzed.
What is the best Zeri build against Vayne?
The best Zeri build against Vayne includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Zeri runes against Vayne?
The best Zeri runes against Vayne use the Precision primary tree with Inspiration secondary. This rune setup achieves a 50.0% win rate in the Zeri vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Zeri counter Vayne?
No, Zeri struggles against Vayne with only a 48.9% win rate. Vayne has the advantage in this matchup. Zeri players should focus on safe farming and avoiding extended trades to minimize Vayne's lead.
How do I play Zeri against Vayne?
When playing Zeri against Vayne, play cautiously and avoid Vayne's power spikes. Look for jungle assistance and team-dependent plays since Vayne has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.
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