Vayne - League of Legends Champion
Win Rate
48.6%
Pick Rate
4.9%

Vaynevs Zeri

DMarksmanAssassin
Patch26.14
Matches81,210
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 17, 2026
MethodologyData Methodology

Vayne vs Zeri is a decisive matchup in LoL patch 26.14. Vayne wins with a 57.1% win rate (+14.3%) over Zeri based on 7 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Zeri matchup.

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Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 57.1% win rate in this matchup
Vayne
57.1% WR
VS
Zeri vs Vayne matchup - 42.9% win rate
Zeri
42.9% WR

Who Wins the Vayne vs Zeri Matchup?

Vayne wins the Vayne vs Zeri matchup
Winner
Vayne
Matches: 7
57.1%
Win Rate
42.9%
7.0
CS / min
7.5
832
DMG / min
913
15,611
Gold / game
15,473
264
Heal / min
148
541
DMG Mitigated / min
425
0.4
CC / min
0.2
50.0%
Early Game WR
50.0%
60.0%
Late Game WR
40.0%

Vayne vs Zeri Matchup Summary

The Vayne vs Zeri matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Vayne wins with a 57.1% win rate compared to Zeri's 42.9%, giving Vayne a 14.3 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Zeri players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Vayne leads by 0.2s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Zeri and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Zeri away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Zeri Laning Phase Breakdown

Vayne wins the laning phase against Zeri in League of Legends

Vayne is favored during the laning phase against Zeri, winning 3 out of 5 key stat categories. Vayne holds advantages in gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
7.0Vayne
7.5Zeri
Zeri edges out Vayne by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 8 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Zeri.
Damage
832Vayne
913Zeri
Zeri heavily out-damages Vayne by 81 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zeri's sustained damage advantage take over.
Economy
15,611Vayne
15,473Zeri
Vayne and Zeri generate nearly equal gold per game, with just a 137 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
0.4Vayne
0.2Zeri
Both Vayne and Zeri provide similar amounts of crowd control (0.2s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
805Vayne
573Zeri
Vayne vastly out-sustains Zeri, healing and mitigating 232 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Zeri is forced to recall. Building grievous wounds early is essential for Zeri, and focusing on burst trade patterns rather than sustained fights is critical.

Early Game vs Late Game

Early Game
Vayne
50.0%
+0.0% advantage
Vayne early game win rateVayne50.0%
Zeri early game win rateZeri50.0%
Late Game
Vayne
60.0%
+20.0% advantage
Vayne late game win rateVayne60.0%
Zeri late game win rateZeri40.0%

The early game (first 15 minutes) is a toss-up between Vayne and Zeri, with Vayne holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Vayne is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Zeri. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Zeri players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Zeri

Precision rune tree - Vayne primary runes vs ZeriPrecision
Press the Attack - best Vayne rune vs ZeriTriumph - best Vayne rune vs ZeriLegend: Alacrity - best Vayne rune vs ZeriCoup de Grace - best Vayne rune vs Zeri
Resolve rune tree - Vayne secondary runes vs ZeriResolve
Conditioning - best Vayne rune vs ZeriOvergrowth - best Vayne rune vs Zeri
100.0% WR

Running Precision primary with Resolve secondary allows Vayne to press their advantage against Zeri, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.14. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
45.00%605.885712,58450.0%42.1%
54.90%515.784912,77055.0%54.8%
50.00%506.174711,64550.0%50.0%
43.48%466.483913,65116.7%52.9%
50.00%386.586211,28350.0%50.0%
37.14%356.168411,9310.0%54.2%
38.46%266.593312,65616.7%57.1%
54.17%246.587314,05360.0%52.6%
27.78%185.878812,61820.0%30.8%
38.89%186.079710,57233.3%44.4%
38.89%186.291613,17466.7%25.0%
68.75%166.390311,41285.7%55.6%
38.46%135.578910,64350.0%28.6%
61.54%136.385212,653100.0%44.4%
53.85%136.184212,40850.0%54.5%
38.46%136.170010,03128.6%50.0%
30.77%135.787310,62616.7%42.9%
50.00%126.475610,63250.0%50.0%
36.36%115.679913,37625.0%42.9%
50.00%106.576212,43725.0%66.7%
80.00%105.496612,07075.0%83.3%
80.00%106.575814,88433.3%100.0%
44.44%96.692413,41925.0%60.0%
33.33%96.51,04813,5130.0%50.0%
44.44%95.478210,7100.0%80.0%
55.56%95.87349,97633.3%100.0%
37.50%85.81,12411,98633.3%40.0%
87.50%86.91,29513,924100.0%80.0%
87.50%86.88328,94985.7%100.0%
50.00%86.96569,95033.3%100.0%
62.50%85.667011,43733.3%80.0%
37.50%86.21,07213,2960.0%50.0%
57.14%77.083215,61150.0%60.0%
71.43%77.21,35616,04850.0%80.0%
50.00%66.71,02515,8320.0%60.0%
66.67%66.07727,10660.0%100.0%
66.67%67.07609,88580.0%0.0%
66.67%66.71,32314,358100.0%50.0%
33.33%66.689211,8550.0%50.0%
50.00%65.766312,7980.0%50.0%
60.00%52.79919,890100.0%0.0%
60.00%56.158411,67650.0%66.7%
60.00%55.899215,4090.0%60.0%
40.00%57.075911,68750.0%33.3%
60.00%56.987616,5260.0%75.0%
100.00%12.2111665100.0%0.0%

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Vayne vs Zeri - Frequently Asked Questions

How does Vayne do against Zeri in League of Legends?

Vayne wins the Vayne vs Zeri matchup with a 57.1% win rate compared to Zeri's 42.9%, a 14.3 percentage point difference. This data is based on 7 recent ranked games in patch 26.14.

How does Vayne do against Zeri in the early game?

In the early game, Vayne has the advantage against Zeri with a 50.0% win rate versus 50.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Zeri in the late game?

In the late game, Vayne takes over the Vayne vs Zeri matchup with a 60.0% win rate compared to 40.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Zeri matchup?

Vayne wins the matchup against Zeri with a 57.1% win rate in League of Legends patch 26.14. The 14.3 percentage point advantage means Vayne is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Vayne build against Zeri?

The best Vayne build against Zeri includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Zeri?

The best Vayne runes against Zeri use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Zeri matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Zeri?

Yes, Vayne has a favorable matchup against Zeri with a 57.1% win rate. Vayne strongly counters Zeri in lane based on current patch 26.14 data.

How do I play Vayne against Zeri?

When playing Vayne against Zeri, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.