Vayne - League of Legends Champion
Win Rate
49.3%
Pick Rate
4.9%

Vaynevs Zeri

CMarksmanAssassin
Patch26.14
Matches104,630
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 17, 2026
MethodologyData Methodology

Vayne vs Zeri is a decisive matchup in LoL patch 26.14. Zeri wins with a 60.0% win rate (+20.0%) over Vayne based on 10 games. Zeri wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Zeri matchup.

Metabot Logo
MetaBot Desktop
Counter picks in champ select
Join Our Discord
Bug reports, feature requests & developer chat
Join Discord

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 40.0% win rate in this matchup
Vayne
40.0% WR
VS
Zeri vs Vayne matchup - 60.0% win rate
Zeri
60.0% WR

Who Wins the Vayne vs Zeri Matchup?

Zeri wins the Vayne vs Zeri matchup
Winner
Zeri
Matches: 10
40.0%
Win Rate
60.0%
7.0
CS / min
7.7
766
DMG / min
927
12,355
Gold / game
13,029
243
Heal / min
144
506
DMG Mitigated / min
414
0.3
CC / min
0.2
20.0%
Early Game WR
80.0%
60.0%
Late Game WR
40.0%

Vayne vs Zeri Matchup Summary

The Vayne vs Zeri matchup is a decisive matchup in League of Legends ranked play. Based on 10 recent matches analyzed, Zeri wins with a 60.0% win rate compared to Vayne's 40.0%, giving Zeri a 20.0 percentage point advantage. Game phase dynamics play a critical role here: Zeri controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Zeri needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Vayne leads by 0.1s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Zeri has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Zeri overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Zeri Laning Phase Breakdown

Zeri wins the laning phase against Vayne in League of Legends

Zeri is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Zeri holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
7.0Vayne
7.7Zeri
Zeri edges out Vayne by 0.7 CS per minute — a moderate farming advantage that adds up to roughly 11 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Zeri.
Damage
766Vayne
927Zeri
Zeri heavily out-damages Vayne by 160 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zeri's sustained damage advantage take over.
Economy
12,355Vayne
13,029Zeri
Zeri earns 674 more gold per game than Vayne, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Zeri slightly faster item completions.
Utility
0.3Vayne
0.2Zeri
Both Vayne and Zeri provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
749Vayne
559Zeri
Vayne vastly out-sustains Zeri, healing and mitigating 190 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Zeri is forced to recall. Building grievous wounds early is essential for Zeri, and focusing on burst trade patterns rather than sustained fights is critical.

Early Game vs Late Game

Early Game
Zeri
80.0%
+60.0% advantage
Vayne early game win rateVayne20.0%
Zeri early game win rateZeri80.0%
Late Game
Vayne
60.0%
+20.0% advantage
Vayne late game win rateVayne60.0%
Zeri late game win rateZeri40.0%

Zeri dominates the early game (first 15 minutes) with a commanding 80.0% win rate — a 60.0 percentage point lead over Vayne. This lopsided early game means Zeri can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Zeri. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Zeri must aggressively press their early advantage and close out the game before Vayne reaches their scaling breakpoints. If Vayne survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Vayne Runes Against Zeri

Precision rune tree - Vayne primary runes vs ZeriPrecision
Lethal Tempo - best Vayne rune vs ZeriTriumph - best Vayne rune vs ZeriLegend: Alacrity - best Vayne rune vs ZeriCoup de Grace - best Vayne rune vs Zeri
Resolve rune tree - Vayne secondary runes vs ZeriResolve
Conditioning - best Vayne rune vs ZeriOvergrowth - best Vayne rune vs Zeri
50.0% WR

The Precision and Resolve rune setup gives Vayne the best tools to compete against Zeri in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Vayne matchup data for League of Legends patch 26.14. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
46.38%695.784712,66650.0%44.4%
55.22%675.886913,28856.0%54.8%
48.44%646.284912,29851.7%45.7%
47.46%596.288813,98021.4%55.6%
48.94%476.584611,42746.1%52.4%
36.17%476.173912,4980.0%51.5%
51.35%376.395512,65426.7%68.2%
39.39%336.480513,36933.3%41.7%
40.74%276.391213,43050.0%36.8%
40.00%256.080510,88530.8%50.0%
44.00%256.184813,51520.0%50.0%
65.00%206.384211,31685.7%53.9%
40.00%205.973011,00430.0%50.0%
47.06%175.686512,15550.0%45.5%
56.25%166.489612,69850.0%60.0%
43.75%166.21,04014,05533.3%50.0%
25.00%165.57789,95011.1%42.9%
42.86%146.089314,23140.0%44.4%
57.14%146.084113,070100.0%40.0%
50.00%145.981111,94925.0%60.0%
53.85%136.01,02412,38950.0%57.1%
41.67%126.579613,05520.0%57.1%
50.00%126.41,09412,67640.0%57.1%
58.33%126.875711,52337.5%100.0%
66.67%126.679115,12433.3%77.8%
83.33%126.67898,66781.8%100.0%
72.73%115.290112,22675.0%71.4%
72.73%115.969612,05150.0%85.7%
40.00%107.076612,35520.0%60.0%
50.00%105.87309,02928.6%100.0%
40.00%105.375111,0470.0%66.7%
90.00%106.91,37814,629100.0%85.7%
33.33%95.91,09811,46025.0%40.0%
77.78%97.079010,74683.3%66.7%
44.44%96.990616,7150.0%50.0%
37.50%86.174213,4940.0%42.9%
42.86%76.695214,5050.0%60.0%
71.43%77.21,35616,04850.0%80.0%
71.43%76.11,00314,896100.0%66.7%
71.43%76.01,24813,755100.0%60.0%
42.86%76.483911,6500.0%60.0%
66.67%66.07727,10660.0%100.0%
33.33%66.290313,02450.0%25.0%
40.00%55.399213,924100.0%25.0%
40.00%56.01,05714,8920.0%50.0%
40.00%57.777012,413100.0%25.0%
80.00%56.999112,634100.0%75.0%
60.00%56.158411,67650.0%66.7%
60.00%52.79919,890100.0%0.0%

Get the MetaBot Desktop App

Level up your gameplay with real-time overlays, automatic game detection, and instant stats — all on your desktop.

In-game overlaysAuto game detectionMulti-game supportPersonal dashboard
Download NowFree download
🔍

Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.

Report an Issue

Vayne vs Zeri - Frequently Asked Questions

How does Vayne do against Zeri in League of Legends?

Zeri wins the Vayne vs Zeri matchup with a 60.0% win rate compared to Vayne's 40.0%, a 20.0 percentage point difference. This data is based on 10 recent ranked games in patch 26.14.

How does Vayne do against Zeri in the early game?

In the early game, Zeri has the advantage against Vayne with a 80.0% win rate versus 20.0%. Zeri players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Zeri in the late game?

In the late game, Vayne takes over the Vayne vs Zeri matchup with a 60.0% win rate compared to 40.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Zeri matchup?

Zeri wins the matchup against Vayne with a 60.0% win rate in League of Legends patch 26.14. The 20.0 percentage point advantage means Zeri is significantly favored in this lane matchup based on 10 games analyzed.

What is the best Vayne build against Zeri?

The best Vayne build against Zeri includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Zeri?

The best Vayne runes against Zeri use the Precision primary tree with Resolve secondary. This rune setup achieves a 50.0% win rate in the Vayne vs Zeri matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Zeri?

No, Vayne struggles against Zeri with only a 40.0% win rate. Zeri has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Zeri's lead.

How do I play Vayne against Zeri?

When playing Vayne against Zeri, play cautiously and avoid Zeri's power spikes. Focus on safe farming — you outscale Zeri in the late game. Use the matchup-specific build and runes above to optimize your chances.