Hand of Greed•Attack

Is Hand of Greed good in Slay the Spire 2?

In Slay the Spire 2, Hand of Greed is a rare attack from the Colorless card pool. Its effect: Deal 20 damage. If Fatal, gain Gold. The data flags it as a weaker pick, settling at D tier — usually one to pass on unless your deck specifically wants it.

Over 9 tracked runs its win rate sits at 11.1%, 1.5% short of the 12.6% all-deck baseline. It sees niche play, included in only 1.7% of eligible runs. Within Regent runs it’s drafted 3.0% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.0 copies on average.

Its standout pairing so far is Ultimate Strike, which lifts its win rate by +22.2% when the two share a deck. On the relic side, Divine Right is its standout companion, worth a +13.9% win-rate swing alongside it. It costs 2 energy, gets upgraded 33.3% of the time, and tends to be picked up near floor 11.

Upgrading the card adds +5 Damage to its stat line. Of the runs that drafted it, 1 ended in victory against 8 deaths and 0 abandons. Its most common run-ender is The Insatiable Boss, finishing 22.2% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Hand of Greed fits a Colorless deck.

Best Cards to Pair with Hand of Greed

Hand of Greed’s strongest card pairings so far are Ultimate Strike (+22.2%), Greed (+22.2%), and Reflect (+22.2%), each shown with the win-rate lift it adds.

Ultimate Strike+22.2%3 runsGreed+22.2%3 runsReflect+22.2%3 runsRoyal Gamble+22.2%3 runsChild of the Stars+13.9%4 runsDefend+8.9%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Hand of Greed Win Rate by Class

Of the 3 classes that draft Hand of Greed, it performs best with Regent (20.0%), Necrobinder (0.0%), and Ironclad (0.0%).

The Regent20.0%5 runsThe Necrobinder0.0%3 runsThe Ironclad0.0%1 runs

Best Relics for Hand of Greed

The relics that swing Hand of Greed’s win rate the most are Divine Right (+13.9%) and Potion Belt (-11.1%), with each lift shown.

Divine Right+13.9%4 runsPotion Belt-11.1%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Hand of Greed Card Details

A 2-energy rare attack, Hand of Greed is upgraded 33.3% of the time and tends to enter the deck around floor 11.

Deal 20 damage. If Fatal, gain Gold.

Upgrade: +5 Damage

What Ends Runs with Hand of Greed

Runs holding Hand of Greed end most often against The Insatiable Boss (22.2%) — the share of its runs each accounts for is shown.

• The Insatiable Boss22.2% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.