Royal Gamble•Skill

Is Royal Gamble good in Slay the Spire 2?

Royal Gamble is an uncommon Regent skill in Slay the Spire 2. In combat it resolves as: Gain. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 101 recorded runs, decks running it win 29.2% of the time, comfortably clear of the 19.0% average, by 10.3%. It’s a more selective pick, turning up in just 2.7% of decks that could run it. Regent players keep it in 14.8% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.2 times in the decks that take it.

It performs best next to Orbit — together they post a +26.5% swing in win rate. It also has strong chemistry with the relic Potion Belt, which moves its win rate by +27.6%. At 0 energy, it’s upgraded in 27.2% of runs and usually joins the deck around floor 14.

That’s 26 wins, 63 deaths, and 12 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Decimillipede Elite, which closes out 5.0% of its appearances. Read on for Royal Gamble’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Best Cards to Pair with Royal Gamble

Ranked by win-rate lift, Royal Gamble performs best alongside Orbit (+26.5%), Big Bang (+22.8%), and Cosmic Indifference (+22.1%).

Orbit+26.5%16 runsBig Bang+22.8%13 runsCosmic Indifference+22.1%21 runsQuasar+20.4%13 runsPillar of Creation+20.4%10 runsThe Smith+20.4%8 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Royal Gamble Win Rate by Class

Royal Gamble is drafted only by the Regent, where it holds a 29.2% win rate across 101 runs.

The Regentappears in 14.8% of its runs (101 tracked)

Best Relics for Royal Gamble

Royal Gamble pairs best with the relics Potion Belt (+27.6%), Letter Opener (+25.9%), and Fencing Manual (+23.0%), ranked by win-rate lift.

Potion Belt+27.6%12 runsLetter Opener+25.9%8 runsFencing Manual+23.0%9 runsHorn Cleat+22.8%12 runsStrike Dummy+22.5%16 runsAnchor+22.4%17 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Royal Gamble Card Details

Royal Gamble is an uncommon skill costing 0 energy; it’s upgraded in 27.2% of runs and usually picked up by floor 14.

Gain.

What Ends Runs with Royal Gamble

Royal Gamble’s most common run-enders are Decimillipede Elite (5.0%), Infested Prisms Elite (4.0%), and Terror Eel Elite (3.0%).

• Decimillipede Elite5.0% of runs
• Infested Prisms Elite4.0% of runs
• Terror Eel Elite3.0% of runs
• Phrog Parasite Elite3.0% of runs
• Vantom Boss3.0% of runs

See Also

Compare Royal Gamble with the rest of the best Slay the Spire 2 cards, relics, and classes below.