Royal Gamble Skill

Is Royal Gamble good in Slay the Spire 2?

Royal Gamble is an uncommon Regent skill in Slay the Spire 2. In combat it resolves as: Gain. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 449 recorded runs, decks running it win 33.2% of the time, comfortably clear of the 13.8% average, by 19.3%. It’s a more selective pick, turning up in just 2.1% of decks that could run it. Offer data backs the pick — taken 31.9% of the time it is shown, with 32.6% for runs that took it against 29.8% for runs that did not, a +2.7% pick lift across 356 decided runs. Regent players keep it in 13.7% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.2 times in the decks that take it.

It performs best next to Mad Science — together they post a +27.5% swing in win rate. It also has strong chemistry with the relic Tuning Fork, which moves its win rate by +32.0%. At 0 energy, it’s upgraded in 33.5% of runs and usually joins the deck around floor 17.

That’s 146 wins, 294 deaths, and 9 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Queen Boss, which closes out 5.1% of its appearances. Read on for Royal Gamble’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Pick or Skip: Royal Gamble

Out of 1232 recorded offers Royal Gamble is taken 31.9% of the time, and taking it is worth +2.7% in pick lift — 32.6% for runs that picked it against 29.8% for runs that skipped, across 356 decided runs.

Taken 393 times out of 1232 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Royal Gamble

Royal Gamble is strongest when it joins the deck in Act 3, where runs win 72.5% across 70 runs — one of 3 recorded pickup windows.

Win rate of runs by the act Royal Gamble entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Royal Gamble

Ranked by win-rate lift, Royal Gamble performs best alongside Mad Science (+27.5%), Arsenal (+24.1%), and Pale Blue Dot (+21.7%).

Mad Science+27.5%35 runsArsenal+24.1%29 runsPale Blue Dot+21.7%28 runsBig Bang+21.3%76 runsThe Smith+20.2%60 runsDying Star+20.1%76 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Royal Gamble Win Rate by Class

Royal Gamble is drafted only by the Regent, where it holds a 33.2% win rate across 449 runs.

The Regentappears in 13.7% of its runs (449 tracked)

Best Relics for Royal Gamble

Royal Gamble pairs best with the relics Tuning Fork (+32.0%), Pendulum (+26.9%), and Fencing Manual (+25.3%), ranked by win-rate lift.

Tuning Fork+32.0%36 runsPendulum+26.9%84 runsFencing Manual+25.3%37 runsEternal Feather+24.9%38 runsCandelabra+24.4%35 runsCaptain's Wheel+24.1%16 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Royal Gamble Card Details

Royal Gamble is an uncommon skill costing 0 energy; it’s upgraded in 33.5% of runs and usually picked up by floor 17.

Gain.

What Ends Runs with Royal Gamble

Royal Gamble’s most common run-enders are Queen Boss (5.1%), Knowledge Demon Boss (4.5%), and Kaiser Crab Boss (3.8%).

• Queen Boss5.1% of runs
• Knowledge Demon Boss4.5% of runs
• Kaiser Crab Boss3.8% of runs
• Test Subject Boss3.6% of runs
• Infested Prisms Elite3.3% of runs

See Also

Compare Royal Gamble with the rest of the best Slay the Spire 2 cards, relics, and classes below.