Lethality Power

Is Lethality good in Slay the Spire 2?

Lethality is an uncommon Necrobinder power in Slay the Spire 2. In combat it resolves as: The first Attack each turn deals 50% additional damage. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 684 recorded runs, decks running it win 28.2% of the time, comfortably clear of the 13.8% average, by 14.4%. It’s a more selective pick, turning up in just 3.3% of decks that could run it. Offer data backs the pick — taken 33.6% of the time it is shown, with 30.7% for runs that took it against 26.9% for runs that did not, a +3.8% pick lift across 528 decided runs. Necrobinder players keep it in 18.2% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.2 times in the decks that take it.

It performs best next to Legion of Bone — together they post a +27.4% swing in win rate. It also has strong chemistry with the relic Sword of Jade, which moves its win rate by +36.5%. At 1 energy, it’s upgraded in 45.4% of runs and usually joins the deck around floor 16.

That’s 192 wins, 488 deaths, and 4 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Decimillipede Elite, which closes out 6.4% of its appearances. Read on for Lethality’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Necrobinder run.

Pick or Skip: Lethality

Out of 1735 recorded offers Lethality is taken 33.6% of the time, and taking it is worth +3.8% in pick lift — 30.7% for runs that picked it against 26.9% for runs that skipped, across 528 decided runs.

Taken 583 times out of 1735 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Lethality

Lethality is strongest when it joins the deck in Act 3, where runs win 55.8% across 86 runs — one of 3 recorded pickup windows.

Win rate of runs by the act Lethality entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Lethality

Ranked by win-rate lift, Lethality performs best alongside Legion of Bone (+27.4%), Mad Science (+24.5%), and Hidden Gem (+22.9%).

Legion of Bone+27.4%31 runsMad Science+24.5%39 runsHidden Gem+22.9%19 runsEradicate+22.2%65 runsUltimate Defend+21.3%26 runsPagestorm+21.0%77 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Lethality Win Rate by Class

Lethality is drafted only by the Necrobinder, where it holds a 28.0% win rate across 661 runs.

The Necrobinderappears in 18.2% of its runs (661 tracked)

Best Relics for Lethality

Lethality pairs best with the relics Sword of Jade (+36.5%), Molten Egg (+35.4%), and Mummified Hand (+30.7%), ranked by win-rate lift.

Sword of Jade+36.5%16 runsMolten Egg+35.4%19 runsMummified Hand+30.7%27 runsCaptain's Wheel+28.3%18 runsCloak Clasp+27.7%29 runsHorn Cleat+27.7%63 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Lethality Card Details

Lethality is an uncommon power costing 1 energy; it’s upgraded in 45.4% of runs and usually picked up by floor 16.

The first Attack each turn deals 50% additional damage.

What Ends Runs with Lethality

Lethality’s most common run-enders are Decimillipede Elite (6.4%), Aeonglass Boss (5.6%), and Test Subject Boss (5.0%).

• Decimillipede Elite6.4% of runs
• Aeonglass Boss5.6% of runs
• Test Subject Boss5.0% of runs
• Knowledge Demon Boss4.7% of runs
• Infested Prisms Elite3.7% of runs

See Also

Compare Lethality with the rest of the best Slay the Spire 2 cards, relics, and classes below.