Lethality•Power

Is Lethality good in Slay the Spire 2?

Lethality is an uncommon Necrobinder power in Slay the Spire 2. In combat it resolves as: The first Attack each turn deals 50% additional damage. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 109 recorded runs, decks running it win 29.3% of the time, comfortably clear of the 18.9% average, by 10.3%. It’s a more selective pick, turning up in just 2.9% of decks that could run it. Regent players keep it in 0.1% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Mad Science — together they post a +23.6% swing in win rate. It also has strong chemistry with the relic Happy Flower, which moves its win rate by +24.9%. At 1 energy, it’s upgraded in 43.2% of runs and usually joins the deck around floor 14.

That’s 31 wins, 75 deaths, and 3 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 5.5% of its appearances. Read on for Lethality’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Necrobinder run.

Best Cards to Pair with Lethality

Ranked by win-rate lift, Lethality performs best alongside Mad Science (+23.6%), Invoke (+18.5%), and Melancholy (+16.9%).

Mad Science+23.6%5 runsInvoke+18.5%39 runsMelancholy+16.9%5 runsPiercing Wail+16.3%3 runsCleanse+14.8%8 runsHaunt+14.4%16 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Lethality Win Rate by Class

Lethality is played across 4 classes, led by Regent (100.0%), Silent (50.0%), and Necrobinder (28.4%) by win rate.

The Regent100.0%1 runsThe Silent50.0%2 runsThe Necrobinder28.4%105 runsThe Defect0.0%1 runs

Best Relics for Lethality

Lethality pairs best with the relics Happy Flower (+24.9%), War Paint (+22.4%), and Potion Belt (+18.9%), ranked by win-rate lift.

Happy Flower+24.9%12 runsWar Paint+22.4%15 runsPotion Belt+18.9%22 runsGorget+18.8%20 runsFestive Popper+18.4%15 runsBronze Scales+18.0%11 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Lethality Card Details

Lethality is an uncommon power costing 1 energy; it’s upgraded in 43.2% of runs and usually picked up by floor 14.

The first Attack each turn deals 50% additional damage.

What Ends Runs with Lethality

Lethality’s most common run-enders are Knowledge Demon Boss (5.5%), Test Subject Boss (5.5%), and Decimillipede Elite (5.5%).

• Knowledge Demon Boss5.5% of runs
• Test Subject Boss5.5% of runs
• Decimillipede Elite5.5% of runs
• Soul Fysh Boss3.7% of runs
• Kaiser Crab Boss3.7% of runs

See Also

Compare Lethality with the rest of the best Slay the Spire 2 cards, relics, and classes below.