Lethality•Power

Is Lethality good in Slay the Spire 2?

Lethality is an uncommon Necrobinder power in Slay the Spire 2. In combat it resolves as: The first Attack each turn deals 50% additional damage. It currently underperforms most alternatives, sitting at D tier in our Slay the Spire 2 card rankings.

Across 16 recorded runs, decks running it win 6.3% of the time, trailing the 12.6% average by 6.4%. It’s a more selective pick, turning up in just 3.1% of decks that could run it. Necrobinder players keep it in 9.3% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Fetch — together they post a +27.1% swing in win rate. It also has strong chemistry with the relic War Paint, which moves its win rate by +27.1%. At 1 energy, it’s upgraded in 22.2% of runs and usually joins the deck around floor 7.

That’s 1 wins, 15 deaths, and 0 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Phantasmal Gardeners Elite, which closes out 12.5% of its appearances. Read on for Lethality’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Necrobinder run.

Best Cards to Pair with Lethality

Ranked by win-rate lift, Lethality performs best alongside Fetch (+27.1%), Friendship (+27.1%), and Calcify (+27.1%).

Fetch+27.1%3 runsFriendship+27.1%3 runsCalcify+27.1%3 runsAfterlife+27.1%3 runsWisp+13.8%5 runsNecro Mastery+10.4%6 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Lethality Win Rate by Class

Lethality is drafted only by the Necrobinder, where it holds a 6.3% win rate across 16 runs.

The Necrobinderappears in 9.3% of its runs (16 tracked)

Best Relics for Lethality

Lethality pairs best with the relics War Paint (+27.1%), Bound Phylactery (0.0%), and Arcane Scroll (-6.3%), ranked by win-rate lift.

War Paint+27.1%3 runsBound Phylactery0.0%16 runsArcane Scroll-6.3%3 runsJuzu Bracelet-6.3%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Lethality Card Details

Lethality is an uncommon power costing 1 energy; it’s upgraded in 22.2% of runs and usually picked up by floor 7.

The first Attack each turn deals 50% additional damage.

What Ends Runs with Lethality

Lethality’s most common run-enders are Phantasmal Gardeners Elite (12.5%) and Terror Eel Elite (12.5%).

• Phantasmal Gardeners Elite12.5% of runs
• Terror Eel Elite12.5% of runs

See Also

Compare Lethality with the rest of the best Slay the Spire 2 cards, relics, and classes below.