Ultimate Defend•Skill

Is Ultimate Defend good in Slay the Spire 2?

Ultimate Defend is an uncommon Colorless skill in Slay the Spire 2. In combat it resolves as: Gain 11 Block. It ranks among the strongest cards its class can draft right now, earning a spot at B tier in our Slay the Spire 2 card tier list.

Across 14 recorded runs, decks running it win 33.3% of the time, comfortably clear of the 12.6% average, by 20.7%. It’s a more selective pick, turning up in just 2.7% of decks that could run it. Silent players keep it in 4.8% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.

It performs best next to Noxious Fumes — together they post a +66.7% swing in win rate. It also has strong chemistry with the relic Book of Five Rings, which moves its win rate by +66.7%. At 1 energy, it’s upgraded in 14.3% of runs and usually joins the deck around floor 17.

Upgraded, it gains +4 Block, which is why so many decks invest a rest-site upgrade in it. That’s 4 wins, 8 deaths, and 2 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Decimillipede Elite, which closes out 14.3% of its appearances. Read on for Ultimate Defend’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Colorless run.

Best Cards to Pair with Ultimate Defend

Ranked by win-rate lift, Ultimate Defend performs best alongside Noxious Fumes (+66.7%), Snakebite (+66.7%), and Survivor (+33.3%).

Noxious Fumes+66.7%4 runsSnakebite+66.7%3 runsSurvivor+33.3%5 runsDefend+33.3%5 runsSummon Forth+33.3%3 runsNeutralize+16.7%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Ultimate Defend Win Rate by Class

Ultimate Defend is played across 5 classes, led by Silent (66.7%), Regent (40.0%), and Ironclad (0.0%) by win rate.

The Silent66.7%5 runsThe Regent40.0%5 runsThe Ironclad0.0%2 runsThe Defect0.0%1 runsThe Necrobinder0.0%1 runs

Best Relics for Ultimate Defend

Ultimate Defend pairs best with the relics Book of Five Rings (+66.7%), Lantern (+33.3%), and Ring of the Snake (+33.3%), ranked by win-rate lift.

Book of Five Rings+66.7%3 runsLantern+33.3%3 runsRing of the Snake+33.3%5 runsWhite Beast Statue+16.7%3 runsBag of Marbles+16.7%5 runsIce Cream+16.7%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Ultimate Defend Card Details

Ultimate Defend is an uncommon skill costing 1 energy; it’s upgraded in 14.3% of runs and usually picked up by floor 17.

Gain 11 Block.

Upgrade: +4 Block

What Ends Runs with Ultimate Defend

Ultimate Defend’s most common run-enders are Decimillipede Elite (14.3%).

• Decimillipede Elite14.3% of runs

See Also

Compare Ultimate Defend with the rest of the best Slay the Spire 2 cards, relics, and classes below.