Eradicate Attack

Is Eradicate good in Slay the Spire 2?

Eradicate is a rare Necrobinder attack in Slay the Spire 2. In combat it resolves as: Deal 11 damage X times. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 214 recorded runs, decks running it win 36.2% of the time, comfortably clear of the 13.8% average, by 22.4%. It’s a more selective pick, turning up in just 1.0% of decks that could run it. Offer data backs the pick — taken 22.1% of the time it is shown, with 38.9% for runs that took it against 32.9% for runs that did not, a +5.7% pick lift across 162 decided runs. Necrobinder players keep it in 5.7% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Squeeze — together they post a +21.7% swing in win rate. It also has strong chemistry with the relic Ice Cream, which moves its win rate by +28.0%. At X energy, it’s upgraded in 40.2% of runs and usually joins the deck around floor 16.

Upgraded, it gains +3 Damage, which is why so many decks invest a rest-site upgrade in it. That’s 76 wins, 134 deaths, and 4 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Decimillipede Elite, which closes out 6.5% of its appearances. Read on for Eradicate’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Necrobinder run.

Pick or Skip: Eradicate

Out of 784 recorded offers Eradicate is taken 22.1% of the time, and taking it is worth +5.7% in pick lift — 38.9% for runs that picked it against 32.9% for runs that skipped, across 162 decided runs.

Taken 173 times out of 784 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Eradicate

Eradicate is strongest when it joins the deck in Act 2, where runs win 56.1% across 57 runs — one of 3 recorded pickup windows.

Win rate of runs by the act Eradicate entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Eradicate

Ranked by win-rate lift, Eradicate performs best alongside Squeeze (+21.7%), Neurosurge (+19.1%), and Spirit of Ash (+17.7%).

Squeeze+21.7%17 runsNeurosurge+19.1%40 runsSpirit of Ash+17.7%19 runsTransfigure+17.2%24 runsDebilitate+16.9%43 runsDemesne+16.4%33 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Eradicate Win Rate by Class

Eradicate is drafted only by the Necrobinder, where it holds a 36.6% win rate across 206 runs.

The Necrobinderappears in 5.7% of its runs (206 tracked)

Best Relics for Eradicate

Eradicate pairs best with the relics Ice Cream (+28.0%), Ripple Basin (+26.3%), and Tiny Mailbox (+24.6%), ranked by win-rate lift.

Ice Cream+28.0%19 runsRipple Basin+26.3%15 runsTiny Mailbox+24.6%19 runsHappy Flower+23.8%46 runsHorn Cleat+23.3%23 runsLetter Opener+23.3%23 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Eradicate Card Details

Eradicate is a rare attack costing X energy; it’s upgraded in 40.2% of runs and usually picked up by floor 16.

Deal 11 damage X times.

Upgrade: +3 Damage

What Ends Runs with Eradicate

Eradicate’s most common run-enders are Decimillipede Elite (6.5%), Queen Boss (5.6%), and Kaiser Crab Boss (5.6%).

• Decimillipede Elite6.5% of runs
• Queen Boss5.6% of runs
• Kaiser Crab Boss5.6% of runs
• Aeonglass Boss4.7% of runs
• Test Subject Boss3.7% of runs

See Also

Compare Eradicate with the rest of the best Slay the Spire 2 cards, relics, and classes below.