Eradicate•Attack

Is Eradicate good in Slay the Spire 2?

Eradicate is a rare Necrobinder attack in Slay the Spire 2. In combat it resolves as: Deal 11 damage X times. It currently underperforms most alternatives, sitting at D tier in our Slay the Spire 2 card rankings.

Across 43 recorded runs, decks running it win 25.0% of the time, comfortably clear of the 18.9% average, by 6.0%. It’s a more selective pick, turning up in just 1.1% of decks that could run it. Silent players keep it in 0.1% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Shared Fate — together they post a +14.3% swing in win rate. It also has strong chemistry with the relic Strike Dummy, which moves its win rate by +18.3%. At X energy, it’s upgraded in 25.5% of runs and usually joins the deck around floor 16.

Upgraded, it gains +3 Damage, which is why so many decks invest a rest-site upgrade in it. That’s 10 wins, 30 deaths, and 3 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is The Insatiable Boss, which closes out 7.0% of its appearances. Read on for Eradicate’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Necrobinder run.

Best Cards to Pair with Eradicate

Ranked by win-rate lift, Eradicate performs best alongside Shared Fate (+14.3%), Lethality (+13.6%), and Afterlife (+13.2%).

Shared Fate+14.3%4 runsLethality+13.6%12 runsAfterlife+13.2%7 runsDirge+10.7%13 runsGrave Warden+10.7%11 runsDelay+9.6%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Eradicate Win Rate by Class

Eradicate is played across 3 classes, led by Silent (100.0%), Necrobinder (23.7%), and Regent (0.0%) by win rate.

The Silent100.0%1 runsThe Necrobinder23.7%41 runsThe Regent0.0%1 runs

Best Relics for Eradicate

Eradicate pairs best with the relics Strike Dummy (+18.3%), Large Capsule (+17.3%), and Happy Flower (+16.7%), ranked by win-rate lift.

Strike Dummy+18.3%5 runsLarge Capsule+17.3%3 runsHappy Flower+16.7%8 runsPear+15.6%6 runsTiny Mailbox+14.3%4 runsJoss Paper+14.3%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Eradicate Card Details

Eradicate is a rare attack costing X energy; it’s upgraded in 25.5% of runs and usually picked up by floor 16.

Deal 11 damage X times.

Upgrade: +3 Damage

What Ends Runs with Eradicate

Eradicate’s most common run-enders are The Insatiable Boss (7.0%), Hunter Killer Normal (4.7%), and Kaiser Crab Boss (4.7%).

• The Insatiable Boss7.0% of runs
• Hunter Killer Normal4.7% of runs
• Kaiser Crab Boss4.7% of runs
• Lagavulin Matriarch Boss4.7% of runs
• Louse Progenitor Normal4.7% of runs

See Also

Compare Eradicate with the rest of the best Slay the Spire 2 cards, relics, and classes below.