MalaiseSkill
Enemy loses X Strength. Apply X Weak.
Is Malaise good in Slay the Spire 2?
Malaise is a rare Silent skill in Slay the Spire 2. In combat it resolves as: Enemy loses X Strength. Apply X Weak. It ranks among the strongest cards its class can draft right now, earning a spot at B tier in our Slay the Spire 2 card tier list.
Across 23 recorded runs, decks running it win 38.1% of the time, comfortably clear of the 19.0% average, by 19.1%. It’s a more selective pick, turning up in just 0.6% of decks that could run it. Silent players keep it in 2.1% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.
It performs best next to Adrenaline — together they post a +17.7% swing in win rate. It also has strong chemistry with the relic Miniature Cannon, which moves its win rate by +14.3%. At X energy, it’s upgraded in 25.0% of runs and usually joins the deck around floor 14.
That’s 8 wins, 13 deaths, and 2 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 8.7% of its appearances. Read on for Malaise’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.
Malaise Win Rate & Pick Rate
Malaise’s 38.1% win rate clears the 19.0% all-deck average by 19.1%, the gap charted below.
Run Outcomes with Malaise
Malaise has 8 wins and 15 losses over 23 tracked runs (34.8% won); abandoned runs count as losses.
- Wins 34.8%
- Losses 65.2%
Best Cards to Pair with Malaise
Ranked by win-rate lift, Malaise performs best alongside Adrenaline (+17.7%), Afterimage (+14.0%), and Prepared (+13.7%).
Based on small co-occurring samples — treat these as early signals, not final verdicts.
Best Relics for Malaise
Malaise pairs best with the relics Miniature Cannon (+14.3%), Ice Cream (+14.3%), and Blood Vial (+14.0%), ranked by win-rate lift.
Based on small co-occurring samples — treat these as early signals, not final verdicts.
Malaise Card Details
Malaise is a rare skill costing X energy; it’s upgraded in 25.0% of runs and usually picked up by floor 14.
Enemy loses X Strength. Apply X Weak.
What Ends Runs with Malaise
Malaise’s most common run-enders are Knowledge Demon Boss (8.7%).
- Knowledge Demon Boss8.7% of runs
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Malaise – Frequently Asked Questions
Is Malaise good in Slay the Spire 2?
Across 23 tracked runs, Malaise has a 38.1% win rate — +19.1% above the average deck. Win rate reflects how often runs that include the card end in victory.
What does Malaise do in Slay the Spire 2?
Malaise costs X energy. Enemy loses X Strength. Apply X Weak.
What class is Malaise in Slay the Spire 2?
Malaise is a Rare Silent Skill.
Is Malaise worth upgrading in Slay the Spire 2?
Malaise can be upgraded at a rest site to improve its effect.
What is the best relic for Malaise?
In tracked runs, Malaise has performed best alongside Miniature Cannon, which lifts its win rate by +14.3% over 3 runs together.
See Also
Compare Malaise with the rest of the best Slay the Spire 2 cards, relics, and classes below.