Annie - League of Legends Champion
Win Rate
50.0%
Pick Rate
1.4%

Annievs Seraphine

CMageSupport
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 21, 2026
MethodologyData Methodology

Annie vs Seraphine is a decisive matchup in LoL patch 26.7. Annie wins with a 54.5% win rate (+9.1%) over Seraphine based on 11 games. Seraphine wins the early laning phase while Annie scales better into the late game. Below you'll find the best Annie build, runes, laning stats, and strategies for the Annie vs Seraphine matchup.

Annie Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Annie performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Seraphine - 54.5% win rateSeraphine(54.5%)
Annie - 54.5% win rate in this matchup
Annie
54.5% WR
VS
Seraphine vs Annie matchup - 45.5% win rate
Seraphine
45.5% WR

Who Wins the Annie vs Seraphine Matchup?

Annie wins the Annie vs Seraphine matchup
Winner
Annie
Matches: 11
54.5%
Win Rate
45.5%
2.1
CS / min
1.8
599
DMG / min
334
8,845
Gold / game
8,407
77
Heal / min
382
329
DMG Mitigated / min
340
1.0
CC / min
0.9
42.9%
Early Game WR
57.1%
75.0%
Late Game WR
25.0%

Annie vs Seraphine Matchup Summary

The Annie vs Seraphine matchup is a decisive matchup in League of Legends ranked play. Based on 11 recent matches analyzed, Annie wins with a 54.5% win rate compared to Seraphine's 45.5%, giving Annie a 9.1 percentage point advantage. Game phase dynamics play a critical role here: Seraphine controls the early laning stage, but Annie outscales as the game goes longer. The matchup shifts dramatically depending on game length — Seraphine needs to press advantages before Annie reaches their power spikes, while Annie should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in damage output, where Annie leads by 265 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Annie players can confidently pick into Seraphine and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Seraphine away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Annie vs Seraphine Laning Phase Breakdown

Annie wins the laning phase against Seraphine in League of Legends

Annie is favored during the laning phase against Seraphine, winning 4 out of 5 key stat categories. Annie holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
2.1Annie
1.8Seraphine
Annie edges out Seraphine by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Annie.
Damage
599Annie
334Seraphine
Annie heavily out-damages Seraphine by 265 DMG/min, dominating both short trades and all-in fights. Seraphine should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Annie's sustained damage advantage take over.
Economy
8,845Annie
8,407Seraphine
Annie earns 438 more gold per game than Seraphine, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Annie slightly faster item completions.
Utility
1.0Annie
0.9Seraphine
Both Annie and Seraphine provide similar amounts of crowd control (0.0s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
407Annie
722Seraphine
Seraphine vastly out-sustains Annie, healing and mitigating 315 more damage per minute. This massive durability gap means Seraphine can absorb significant punishment and remain in lane while Annie is forced to recall. Building grievous wounds early is essential for Annie, and focusing on burst trade patterns rather than sustained fights is critical.

Best Annie Build Against Seraphine

Sorcerer's Shoes is the optimal boots choice against Seraphine, providing the mobility and stats Annie needs most in this matchup. The top-performing core items for Annie against Seraphine are Liandry's Torment, Malignance and Rabadon's Deathcap. This combination gives Annie an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Annie vs Seraphine matchup.

Early Game vs Late Game

Early Game
Seraphine
57.1%
+14.3% advantage
Annie early game win rateAnnie42.9%
Seraphine early game win rateSeraphine57.1%
Late Game
Annie
75.0%
+50.0% advantage
Annie late game win rateAnnie75.0%
Seraphine late game win rateSeraphine25.0%

Seraphine dominates the early game (first 15 minutes) with a commanding 57.1% win rate — a 14.3 percentage point lead over Annie. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Annie is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Seraphine. Extended games heavily favor Annie, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Seraphine must aggressively press their early advantage and close out the game before Annie reaches their scaling breakpoints. If Annie survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Annie Runes Against Seraphine

Domination rune tree - Annie primary runes vs SeraphineDomination
Electrocute - best Annie rune vs SeraphineCheap Shot - best Annie rune vs SeraphineDeep Ward - best Annie rune vs SeraphineTreasure Hunter - best Annie rune vs Seraphine
Sorcery rune tree - Annie secondary runes vs SeraphineSorcery
Gathering Storm - best Annie rune vs SeraphineTranscendence - best Annie rune vs Seraphine
100.0% WR

Running Domination primary with Sorcery secondary allows Annie to press their advantage against Seraphine, amplifying the strengths that make this a favorable matchup.


Annie matchup data for League of Legends patch 26.7. The table below shows Annie's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Annie build, runes, laning stats, and early vs late game analysis for that specific matchup.

Annie matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
45.98%876.094612,03938.5%52.1%
42.86%845.986911,27542.5%43.2%
46.00%505.580410,85652.2%40.7%
60.00%505.596211,12952.2%66.7%
55.00%406.093311,39656.5%52.9%
43.59%395.791511,94221.4%56.0%
45.95%375.886912,18741.7%48.0%
55.56%365.384211,00158.8%52.6%
54.29%355.087211,89464.3%47.6%
47.06%345.889510,88735.0%64.3%
37.50%325.796611,72316.7%50.0%
43.33%305.978810,94758.3%33.3%
46.67%305.484012,03137.5%50.0%
44.83%295.871310,38826.7%64.3%
71.43%285.999912,33466.7%76.9%
46.43%285.286310,62838.5%53.3%
48.15%274.282911,46650.0%47.4%
46.15%266.093111,78455.6%41.2%
52.00%256.076910,39233.3%69.2%
33.33%246.387510,52545.5%23.1%
43.48%235.894212,20030.0%53.9%
50.00%225.596811,66666.7%38.5%
30.00%205.582410,34033.3%25.0%
45.00%206.390710,00846.1%42.9%
47.37%195.483011,54312.5%72.7%
33.33%185.21,02611,54730.0%37.5%
70.59%175.875611,05275.0%66.7%
37.50%163.68529,59312.5%62.5%
43.75%166.488710,48150.0%33.3%
37.50%165.782811,50060.0%27.3%
53.33%151.46229,27950.0%55.6%
66.67%156.397811,67170.0%60.0%
61.54%135.372811,40175.0%55.6%
33.33%121.75498,22333.3%33.3%
50.00%121.66919,77057.1%40.0%
41.67%125.194712,03860.0%28.6%
54.55%112.15998,84542.9%75.0%
90.91%114.08319,13785.7%100.0%
45.45%115.51,06912,73325.0%57.1%
70.00%106.588311,780100.0%25.0%
40.00%102.27229,90140.0%40.0%
60.00%105.61,09311,46860.0%60.0%
50.00%106.11,01511,96260.0%40.0%
44.44%96.889112,01120.0%75.0%
33.33%95.29477,19850.0%0.0%
66.67%94.775710,24450.0%80.0%
75.00%81.87039,69180.0%66.7%
62.50%82.977911,22366.7%60.0%
37.50%82.66579,5510.0%50.0%
62.50%81.771711,07660.0%66.7%
85.71%75.694313,370100.0%80.0%
0.00%74.85678,1960.0%0.0%
57.14%75.684711,61166.7%50.0%
71.43%73.56829,60533.3%100.0%
42.86%76.38668,90325.0%66.7%
42.86%75.994313,302100.0%33.3%
85.71%75.195912,52950.0%100.0%
50.00%65.697412,5110.0%60.0%
50.00%64.57117,57525.0%100.0%
66.67%61.251210,7010.0%80.0%
33.33%65.492913,7750.0%40.0%
50.00%65.41,19514,59350.0%50.0%
60.00%54.690112,9020.0%75.0%
60.00%55.01,01012,9840.0%60.0%
20.00%52.35038,22725.0%0.0%

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Annie vs Seraphine - Frequently Asked Questions

How does Annie do against Seraphine in League of Legends?

Annie wins the Annie vs Seraphine matchup with a 54.5% win rate compared to Seraphine's 45.5%, a 9.1 percentage point difference. This data is based on 11 recent ranked games in patch 26.7.

How does Annie do against Seraphine in the early game?

In the early game, Seraphine has the advantage against Annie with a 57.1% win rate versus 42.9%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Annie do against Seraphine in the late game?

In the late game, Annie takes over the Annie vs Seraphine matchup with a 75.0% win rate compared to 25.0%. Annie scales better into team fights and objective contests after 25 minutes.

Who wins the Annie vs Seraphine matchup?

Annie wins the matchup against Seraphine with a 54.5% win rate in League of Legends patch 26.7. The 9.1 percentage point advantage means Annie is significantly favored in this lane matchup based on 11 games analyzed.

What is the best Annie build against Seraphine?

The best Annie build against Seraphine includes Liandry's Torment, Malignance, Rabadon's Deathcap with Sorcerer's Shoes. Check the matchup breakdown above for the full item path and build order.

What are the best Annie runes against Seraphine?

The best Annie runes against Seraphine use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Annie vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.

Does Annie counter Seraphine?

Yes, Annie has a favorable matchup against Seraphine with a 54.5% win rate. Annie strongly counters Seraphine in lane based on current patch 26.7 data.

How do I play Annie against Seraphine?

When playing Annie against Seraphine, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Seraphine. Build the recommended items and runes for this specific matchup for the best results.