Annie - League of Legends Champion
Win Rate
52.0%
Pick Rate
1.3%

Annievs Seraphine

SMageSupport
Patch26.14
Matches226,800
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Annie vs Seraphine is a decisive matchup in LoL patch 26.14. Seraphine wins with a 71.4% win rate (+42.9%) over Annie based on 7 games. Seraphine holds the advantage in both the early and late game. Below you'll find the best Annie build, runes, laning stats, and strategies for the Annie vs Seraphine matchup.

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Annie Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Annie performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Annie - 28.6% win rate in this matchup
Annie
28.6% WR
VS
Seraphine vs Annie matchup - 71.4% win rate
Seraphine
71.4% WR

Who Wins the Annie vs Seraphine Matchup?

Seraphine wins the Annie vs Seraphine matchup
Winner
Seraphine
Matches: 7
28.6%
Win Rate
71.4%
3.2
CS / min
3.0
731
DMG / min
461
10,070
Gold / game
9,277
75
Heal / min
140
368
DMG Mitigated / min
265
1.0
CC / min
1.1
33.3%
Early Game WR
66.7%
25.0%
Late Game WR
75.0%

Annie vs Seraphine Matchup Summary

The Annie vs Seraphine matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Seraphine wins with a 71.4% win rate compared to Annie's 28.6%, giving Seraphine a 42.9 percentage point advantage. Seraphine dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Annie players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in damage output, where Annie leads by 269 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine has a strong advantage in this matchup. Annie players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Seraphine overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Annie vs Seraphine Laning Phase Breakdown

Annie wins the laning phase against Seraphine in League of Legends

Annie is favored during the laning phase against Seraphine, winning 4 out of 5 key stat categories. Annie holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
3.2Annie
3.0Seraphine
Annie and Seraphine farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
731Annie
461Seraphine
Annie heavily out-damages Seraphine by 269 DMG/min, dominating both short trades and all-in fights. Seraphine should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Annie's sustained damage advantage take over.
Economy
10,070Annie
9,277Seraphine
Annie earns 793 more gold per game than Seraphine, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Annie slightly faster item completions.
Utility
1.0Annie
1.1Seraphine
Both Annie and Seraphine provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
443Annie
405Seraphine
Annie and Seraphine have comparable sustain profiles, with only 38 HP/min separating their healing and damage mitigation. Neither champion can out-attrition the other in lane, so trades will be decided by burst potential and ability usage rather than sustain.

Best Annie Build Against Seraphine

Spellslinger's Shoes is the optimal boots choice against Seraphine, providing the mobility and stats Annie needs most in this matchup. The top-performing core items for Annie against Seraphine are Liandry's Torment, Shadowflame and Malignance. This combination gives Annie an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Annie vs Seraphine matchup.

Early Game vs Late Game

Early Game
Seraphine
66.7%
+33.3% advantage
Annie early game win rateAnnie33.3%
Seraphine early game win rateSeraphine66.7%
Late Game
Seraphine
75.0%
+50.0% advantage
Annie late game win rateAnnie25.0%
Seraphine late game win rateSeraphine75.0%

Seraphine dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Annie. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Seraphine is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Annie. Extended games heavily favor Seraphine, whose kit and scaling make them a dominant force in team fights and objective control.

Seraphine holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Annie players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Annie Runes Against Seraphine

Inspiration rune tree - Annie primary runes vs SeraphineInspiration
First Strike - best Annie rune vs SeraphineMagical Footwear - best Annie rune vs SeraphineBiscuit Delivery - best Annie rune vs SeraphineCosmic Insight - best Annie rune vs Seraphine
Sorcery rune tree - Annie secondary runes vs SeraphineSorcery
Transcendence - best Annie rune vs SeraphineGathering Storm - best Annie rune vs Seraphine
100.0% WR

The Inspiration and Sorcery rune setup gives Annie the best tools to compete against Seraphine in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Annie matchup data for League of Legends patch 26.14. The table below shows Annie's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Annie build, runes, laning stats, and early vs late game analysis for that specific matchup.

Annie matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
65.12%435.693911,49761.1%68.0%
35.29%346.08989,96922.2%50.0%
50.00%265.393911,07341.7%57.1%
45.00%206.08309,83330.0%60.0%
80.00%205.498012,11571.4%84.6%
47.37%195.21,03111,71912.5%72.7%
50.00%185.391911,69050.0%50.0%
61.11%185.590411,03760.0%61.5%
43.75%164.87189,86833.3%50.0%
38.46%135.272311,05433.3%40.0%
46.15%135.71,06714,471100.0%41.7%
41.67%125.469210,35928.6%60.0%
50.00%126.290111,8260.0%66.7%
58.33%124.68859,13383.3%33.3%
72.73%116.11,17612,37650.0%85.7%
60.00%105.31,03610,27050.0%66.7%
40.00%105.783311,7210.0%50.0%
44.44%95.492410,01266.7%33.3%
66.67%94.975711,67275.0%60.0%
66.67%95.490110,33966.7%66.7%
50.00%85.180110,91150.0%50.0%
50.00%84.57909,94966.7%40.0%
57.14%75.274610,22666.7%50.0%
28.57%73.273110,07033.3%25.0%
85.71%75.79709,82875.0%100.0%
16.67%64.68139,7860.0%20.0%
66.67%65.71,09014,4810.0%66.7%
50.00%65.698311,4960.0%75.0%
66.67%65.294913,5460.0%66.7%
83.33%64.81,1017,37866.7%100.0%
50.00%65.782411,023100.0%40.0%
40.00%55.795713,21050.0%33.3%
20.00%53.88048,8230.0%25.0%
40.00%55.479913,0040.0%50.0%
75.00%47.11,15312,76850.0%100.0%

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Annie vs Seraphine - Frequently Asked Questions

How does Annie do against Seraphine in League of Legends?

Seraphine wins the Annie vs Seraphine matchup with a 71.4% win rate compared to Annie's 28.6%, a 42.9 percentage point difference. This data is based on 7 recent ranked games in patch 26.14.

How does Annie do against Seraphine in the early game?

In the early game, Seraphine has the advantage against Annie with a 66.7% win rate versus 33.3%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Annie do against Seraphine in the late game?

In the late game, Seraphine takes over the Annie vs Seraphine matchup with a 75.0% win rate compared to 25.0%. Seraphine scales better into team fights and objective contests after 25 minutes.

Who wins the Annie vs Seraphine matchup?

Seraphine wins the matchup against Annie with a 71.4% win rate in League of Legends patch 26.14. The 42.9 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Annie build against Seraphine?

The best Annie build against Seraphine includes Liandry's Torment, Shadowflame, Malignance with Spellslinger's Shoes. Check the matchup breakdown above for the full item path and build order.

What are the best Annie runes against Seraphine?

The best Annie runes against Seraphine use the Inspiration primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Annie vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.

Does Annie counter Seraphine?

No, Annie struggles against Seraphine with only a 28.6% win rate. Seraphine has the advantage in this matchup. Annie players should focus on safe farming and avoiding extended trades to minimize Seraphine's lead.

How do I play Annie against Seraphine?

When playing Annie against Seraphine, play cautiously and avoid Seraphine's power spikes. Look for jungle assistance and team-dependent plays since Seraphine has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.