Seraphine - League of Legends Champion
Win Rate
52.3%
Pick Rate
7.8%

Seraphinevs Annie

SSupportMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 5, 2026
MethodologyData Methodology

Seraphine vs Annie is a decisive matchup in LoL patch 26.11. Seraphine wins with a 63.6% win rate (+27.3%) over Annie based on 22 games. Seraphine holds the advantage in both the early and late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Annie matchup.

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Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Seraphine - 63.6% win rate in this matchup
Seraphine
63.6% WR
VS
Annie vs Seraphine matchup - 36.4% win rate
Annie
36.4% WR

Who Wins the Seraphine vs Annie Matchup?

Seraphine wins the Seraphine vs Annie matchup
Winner
Seraphine
Matches: 22
63.6%
Win Rate
36.4%
2.2
CS / min
2.3
508
DMG / min
770
11,567
Gold / game
11,963
252
Heal / min
70
443
DMG Mitigated / min
421
1.2
CC / min
1.1
60.0%
Early Game WR
40.0%
64.7%
Late Game WR
35.3%

Seraphine vs Annie Matchup Summary

The Seraphine vs Annie matchup is a decisive matchup in League of Legends ranked play. Based on 22 recent matches analyzed, Seraphine wins with a 63.6% win rate compared to Annie's 36.4%, giving Seraphine a 27.3 percentage point advantage. Seraphine dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Annie players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in damage output, where Annie leads by 262 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine players can confidently pick into Annie and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Annie away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Annie Laning Phase Breakdown

Annie wins the laning phase against Seraphine in League of Legends

Annie is favored during the laning phase against Seraphine, winning 3 out of 5 key stat categories. Annie holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
2.2Seraphine
2.3Annie
Seraphine and Annie farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
508Seraphine
770Annie
Annie heavily out-damages Seraphine by 262 DMG/min, dominating both short trades and all-in fights. Seraphine should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Annie's sustained damage advantage take over.
Economy
11,567Seraphine
11,963Annie
Annie earns 396 more gold per game than Seraphine, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Annie slightly faster item completions.
Utility
1.2Seraphine
1.1Annie
Both Seraphine and Annie provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
695Seraphine
491Annie
Seraphine vastly out-sustains Annie, healing and mitigating 204 more damage per minute. This massive durability gap means Seraphine can absorb significant punishment and remain in lane while Annie is forced to recall. Building grievous wounds early is essential for Annie, and focusing on burst trade patterns rather than sustained fights is critical.

Best Seraphine Build Against Annie

Ionian Boots of Lucidity is the optimal boots choice against Annie, providing the mobility and stats Seraphine needs most in this matchup. The top-performing core items for Seraphine against Annie are Cryptbloom, Malignance and Seraph's Embrace. This combination gives Seraphine an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Annie. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Seraphine vs Annie matchup.

Early Game vs Late Game

Early Game
Seraphine
60.0%
+20.0% advantage
Seraphine early game win rateSeraphine60.0%
Annie early game win rateAnnie40.0%
Late Game
Seraphine
64.7%
+29.4% advantage
Seraphine late game win rateSeraphine64.7%
Annie late game win rateAnnie35.3%

Seraphine dominates the early game (first 15 minutes) with a commanding 60.0% win rate — a 20.0 percentage point lead over Annie. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Seraphine is far superior in the late game (25+ minutes), boasting a 64.7% win rate — 29.4 points above Annie. Extended games heavily favor Seraphine, whose kit and scaling make them a dominant force in team fights and objective control.

Seraphine holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Annie players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Seraphine Runes Against Annie

Sorcery rune tree - Seraphine primary runes vs AnnieSorcery
Arcane Comet - best Seraphine rune vs AnnieAxiom Arcanist - best Seraphine rune vs AnnieTranscendence - best Seraphine rune vs AnnieWaterwalking - best Seraphine rune vs Annie
Resolve rune tree - Seraphine secondary runes vs AnnieResolve
Overgrowth - best Seraphine rune vs AnnieConditioning - best Seraphine rune vs Annie
100.0% WR

Running Sorcery primary with Resolve secondary allows Seraphine to press their advantage against Annie, amplifying the strengths that make this a favorable matchup.


Seraphine matchup data for League of Legends patch 26.11. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
47.75%7791.74669,35944.9%49.5%
50.91%5501.44939,17358.0%45.0%
49.45%5481.44879,00751.2%48.0%
50.83%5431.44879,19746.8%53.9%
52.69%5011.54979,35248.8%55.5%
50.21%4781.85269,25551.6%49.0%
48.69%4211.54709,01249.2%48.3%
50.00%3341.44539,01050.4%49.7%
50.91%3301.95249,71553.4%49.2%
51.72%3191.44699,56046.7%55.4%
52.44%3071.44938,93052.7%52.2%
53.17%2841.74839,53147.7%56.6%
52.84%2821.44878,90149.2%55.8%
50.78%2581.54449,24750.5%51.0%
47.97%2461.54669,32744.7%50.4%
54.85%2371.85849,76454.8%54.9%
54.85%2371.44528,96551.9%57.4%
53.07%2281.53918,66358.8%46.8%
54.63%2271.84989,66455.6%54.0%
43.13%2111.35028,90135.6%48.8%
52.22%2031.45229,03758.4%47.4%
43.22%1991.54988,96147.1%40.4%
48.44%1921.44979,41851.2%46.3%
53.45%1741.84629,23249.4%56.7%
49.70%1691.66149,70344.4%52.2%
52.26%1551.44799,11856.9%48.2%
57.53%1461.45699,69067.9%51.1%
54.48%1454.566211,52162.3%50.0%
52.52%1391.44899,05164.1%42.7%
61.29%1241.64819,07567.7%54.8%
50.00%1221.44628,51250.8%49.1%
50.00%1201.45089,23252.8%47.8%
51.30%1151.44638,90542.2%57.1%
59.13%1156.281412,23054.7%62.9%
53.49%861.54809,03567.5%41.3%
54.88%825.867711,89860.0%51.9%
61.25%804.878912,00275.9%52.9%
56.76%746.880712,47863.9%50.0%
53.42%732.05109,99152.0%54.2%
56.16%731.55149,44956.8%55.6%
46.88%641.54679,51052.0%43.6%
43.33%601.65579,12160.7%28.1%
48.33%602.14408,59548.3%48.4%
54.24%596.283112,84042.1%60.0%
54.24%593.359210,05860.9%50.0%
60.34%585.375111,90651.9%67.7%
63.16%572.056710,73279.0%55.3%
44.23%521.75759,42052.0%37.0%
51.06%472.04629,10847.6%53.9%
50.00%402.260810,02652.6%47.6%
56.76%376.389112,39562.5%52.4%
44.44%362.55159,08730.8%52.2%
60.61%334.259811,53455.6%62.5%
51.52%335.366611,60061.5%45.0%
42.42%336.281310,73542.1%42.9%
51.52%336.878711,42658.8%43.8%
65.63%321.64749,16373.3%58.8%
65.63%324.168110,15666.7%64.7%
58.06%311.64859,79966.7%52.6%
56.67%306.673310,93362.5%50.0%
41.38%291.45019,36630.8%50.0%
44.44%275.167710,72263.6%31.3%
62.96%271.649810,32862.5%63.2%
54.17%244.26249,65645.5%61.5%
50.00%222.45679,74940.0%58.3%
45.45%223.04909,41825.0%57.1%
63.64%222.250811,56760.0%64.7%
40.00%206.580113,55633.3%41.2%
55.00%206.779212,47966.7%45.5%
55.00%202.04629,45857.1%53.9%
45.00%205.871411,07240.0%50.0%
70.00%201.464510,69887.5%58.3%
63.16%191.443410,16060.0%64.3%
61.11%185.67038,05964.3%50.0%
58.82%176.286512,02650.0%63.6%
35.29%171.244610,23775.0%23.1%
75.00%166.791813,62771.4%77.8%
37.50%161.54798,92840.0%36.4%
60.00%156.776112,98866.7%55.6%
40.00%155.359710,54633.3%44.4%
60.00%151.646310,50775.0%54.5%
50.00%143.264710,32850.0%50.0%
50.00%142.65519,74250.0%50.0%
42.86%144.85849,77450.0%37.5%
53.85%136.392112,20066.7%42.9%
30.77%134.16039,87733.3%28.6%
61.54%133.15949,46842.9%83.3%
58.33%126.78259,19670.0%0.0%
50.00%124.36669,42433.3%66.7%
58.33%126.076411,19160.0%57.1%
72.73%116.175811,907100.0%66.7%
27.27%114.55499,3630.0%50.0%
54.55%116.266011,06050.0%60.0%
60.00%105.680311,24250.0%75.0%
80.00%101.44777,16187.5%50.0%
66.67%94.552110,244100.0%62.5%
44.44%91.84238,69366.7%33.3%
37.50%86.293011,95740.0%33.3%
62.50%81.66239,74233.3%80.0%
37.50%81.53958,01025.0%50.0%
37.50%81.34679,59625.0%50.0%
25.00%85.367010,06850.0%16.7%
25.00%83.45779,67325.0%25.0%
62.50%81.457011,7740.0%71.4%
75.00%85.470711,28850.0%83.3%
50.00%81.14638,69050.0%50.0%
50.00%86.298713,25366.7%40.0%
75.00%81.648710,73550.0%83.3%
85.71%71.45378,417100.0%0.0%
42.86%71.949210,03133.3%50.0%
71.43%73.163510,657100.0%60.0%
57.14%73.473912,184100.0%50.0%
100.00%73.15957,466100.0%100.0%
71.43%73.05208,01175.0%66.7%
33.33%67.382210,97625.0%50.0%
100.00%62.35489,903100.0%100.0%
83.33%62.247410,918100.0%80.0%
50.00%61.63829,86350.0%50.0%
100.00%55.957011,5490.0%100.0%
40.00%51.649610,44750.0%33.3%
60.00%51.256510,3000.0%75.0%
40.00%56.06469,77425.0%100.0%
40.00%53.864610,54966.7%0.0%
80.00%51.549910,15550.0%100.0%

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Seraphine vs Annie - Frequently Asked Questions

How does Seraphine do against Annie in League of Legends?

Seraphine wins the Seraphine vs Annie matchup with a 63.6% win rate compared to Annie's 36.4%, a 27.3 percentage point difference. This data is based on 22 recent ranked games in patch 26.11.

How does Seraphine do against Annie in the early game?

In the early game, Seraphine has the advantage against Annie with a 60.0% win rate versus 40.0%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Annie in the late game?

In the late game, Seraphine takes over the Seraphine vs Annie matchup with a 64.7% win rate compared to 35.3%. Seraphine scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Annie matchup?

Seraphine wins the matchup against Annie with a 63.6% win rate in League of Legends patch 26.11. The 27.3 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 22 games analyzed.

What is the best Seraphine build against Annie?

The best Seraphine build against Annie includes Cryptbloom, Malignance, Seraph's Embrace with Ionian Boots of Lucidity. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Annie?

The best Seraphine runes against Annie use the Sorcery primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Seraphine vs Annie matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Annie?

Yes, Seraphine has a favorable matchup against Annie with a 63.6% win rate. Seraphine strongly counters Annie in lane based on current patch 26.11 data.

How do I play Seraphine against Annie?

When playing Seraphine against Annie, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.