Seraphine - League of Legends Champion
Win Rate
50.9%
Pick Rate
4.9%

Seraphinevs Annie

ASupportMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 21, 2026
MethodologyData Methodology

Seraphine vs Annie is a decisive matchup in LoL patch 26.7. Annie wins with a 54.5% win rate (+9.1%) over Seraphine based on 11 games. Seraphine wins the early laning phase while Annie scales better into the late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Annie matchup.

Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Annie - 45.5% win rateAnnie(45.5%)
Seraphine - 45.5% win rate in this matchup
Seraphine
45.5% WR
VS
Annie vs Seraphine matchup - 54.5% win rate
Annie
54.5% WR

Who Wins the Seraphine vs Annie Matchup?

Annie wins the Seraphine vs Annie matchup
Winner
Annie
Matches: 11
45.5%
Win Rate
54.5%
1.8
CS / min
2.1
334
DMG / min
599
8,407
Gold / game
8,845
382
Heal / min
77
340
DMG Mitigated / min
329
0.9
CC / min
1.0
57.1%
Early Game WR
42.9%
25.0%
Late Game WR
75.0%

Seraphine vs Annie Matchup Summary

The Seraphine vs Annie matchup is a decisive matchup in League of Legends ranked play. Based on 11 recent matches analyzed, Annie wins with a 54.5% win rate compared to Seraphine's 45.5%, giving Annie a 9.1 percentage point advantage. Game phase dynamics play a critical role here: Seraphine controls the early laning stage, but Annie outscales as the game goes longer. The matchup shifts dramatically depending on game length — Seraphine needs to press advantages before Annie reaches their power spikes, while Annie should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in damage output, where Annie leads by 265 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Annie has a strong advantage in this matchup. Seraphine players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Annie overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Annie Laning Phase Breakdown

Annie wins the laning phase against Seraphine in League of Legends

Annie is favored during the laning phase against Seraphine, winning 4 out of 5 key stat categories. Annie holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
1.8Seraphine
2.1Annie
Annie edges out Seraphine by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Annie.
Damage
334Seraphine
599Annie
Annie heavily out-damages Seraphine by 265 DMG/min, dominating both short trades and all-in fights. Seraphine should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Annie's sustained damage advantage take over.
Economy
8,407Seraphine
8,845Annie
Annie earns 438 more gold per game than Seraphine, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Annie slightly faster item completions.
Utility
0.9Seraphine
1.0Annie
Both Seraphine and Annie provide similar amounts of crowd control (0.0s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
722Seraphine
407Annie
Seraphine vastly out-sustains Annie, healing and mitigating 315 more damage per minute. This massive durability gap means Seraphine can absorb significant punishment and remain in lane while Annie is forced to recall. Building grievous wounds early is essential for Annie, and focusing on burst trade patterns rather than sustained fights is critical.

Best Seraphine Build Against Annie

Ionian Boots of Lucidity is the optimal boots choice against Annie, providing the mobility and stats Seraphine needs most in this matchup. The top-performing core items for Seraphine against Annie are Echoes of Helia, Moonstone Renewer and Diadem of Songs. This combination gives Seraphine an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Seraphine vs Annie matchup.

Early Game vs Late Game

Early Game
Seraphine
57.1%
+14.3% advantage
Seraphine early game win rateSeraphine57.1%
Annie early game win rateAnnie42.9%
Late Game
Annie
75.0%
+50.0% advantage
Seraphine late game win rateSeraphine25.0%
Annie late game win rateAnnie75.0%

Seraphine dominates the early game (first 15 minutes) with a commanding 57.1% win rate — a 14.3 percentage point lead over Annie. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Annie is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Seraphine. Extended games heavily favor Annie, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Seraphine must aggressively press their early advantage and close out the game before Annie reaches their scaling breakpoints. If Annie survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Seraphine Runes Against Annie

Sorcery rune tree - Seraphine primary runes vs AnnieSorcery
Summon Aery - best Seraphine rune vs AnnieManaflow Band - best Seraphine rune vs AnnieTranscendence - best Seraphine rune vs AnnieGathering Storm - best Seraphine rune vs Annie
Resolve rune tree - Seraphine secondary runes vs AnnieResolve
Font of Life - best Seraphine rune vs AnnieRevitalize - best Seraphine rune vs Annie
100.0% WR

The Sorcery and Resolve rune setup gives Seraphine the best tools to compete against Annie in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Seraphine matchup data for League of Legends patch 26.7. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
54.18%2991.64439,72745.0%59.6%
44.49%2631.34388,73041.4%48.0%
53.94%2411.34619,24352.6%55.2%
53.01%1831.44589,30748.8%56.4%
53.59%1811.44469,09849.4%57.5%
53.66%1641.44779,15159.3%48.2%
51.57%1591.54879,18454.3%49.4%
56.96%1581.44609,12365.1%51.6%
51.45%1381.44108,92450.8%52.1%
57.58%1321.44559,01657.4%57.8%
44.44%1261.34078,50942.9%46.0%
48.72%1171.655210,13343.2%51.3%
55.17%1161.54939,75339.1%65.7%
48.28%1161.754110,06752.2%45.7%
54.29%1051.34268,52558.2%50.0%
47.57%1031.54449,60136.6%54.8%
53.92%1021.44648,93753.9%54.0%
50.50%1011.43578,58654.9%46.0%
65.31%982.04699,74265.0%65.5%
51.11%901.45449,00546.1%54.9%
60.67%891.45258,87651.2%69.6%
48.05%771.64329,06447.1%48.8%
48.48%661.64499,83052.0%46.3%
56.06%661.446210,05756.0%56.1%
59.09%661.34709,19553.3%63.9%
51.52%661.45339,38642.9%57.9%
50.00%561.34318,78350.0%50.0%
50.91%555.059410,15445.7%60.0%
61.11%541.45039,73561.1%61.1%
45.10%511.45549,19748.0%42.3%
56.00%501.64589,66571.4%44.8%
68.09%471.34338,79683.3%52.2%
41.30%461.44408,44340.7%42.1%
55.26%386.575312,73061.1%50.0%
41.67%361.55229,34566.7%23.8%
45.71%351.45389,51041.2%50.0%
51.43%356.577612,68062.5%42.1%
41.18%341.95239,70342.9%40.0%
62.50%324.466312,14861.5%63.2%
61.54%261.45069,89770.0%56.3%
57.69%265.866912,09666.7%50.0%
72.00%253.654911,21477.8%68.8%
47.83%231.34387,54662.5%14.3%
39.13%231.34279,80042.9%37.5%
45.45%225.768813,31257.1%40.0%
42.86%212.04569,77930.0%54.5%
60.00%206.873212,63062.5%58.3%
68.42%192.25288,37271.4%60.0%
52.63%194.566310,72362.5%45.5%
77.78%185.262111,90780.0%75.0%
50.00%182.23929,53214.3%72.7%
17.65%171.95419,5550.0%30.0%
68.75%166.175711,132100.0%44.4%
56.25%165.061711,17950.0%58.3%
37.50%161.44408,74328.6%44.4%
40.00%155.879112,89180.0%20.0%
53.33%152.65158,83558.3%33.3%
60.00%156.969012,35375.0%42.9%
57.14%141.65038,97662.5%50.0%
50.00%126.066912,17266.7%33.3%
58.33%121.95109,80057.1%60.0%
41.67%124.362911,9680.0%50.0%
50.00%125.572511,57837.5%75.0%
45.45%111.83348,40757.1%25.0%
45.45%111.448611,0260.0%50.0%
20.00%101.94449,6570.0%40.0%
30.00%106.083411,91850.0%16.7%
66.67%95.04869,88271.4%50.0%
66.67%96.791812,31350.0%100.0%
44.44%91.652310,69633.3%50.0%
66.67%95.06849,58460.0%75.0%
55.56%95.878611,74075.0%40.0%
62.50%86.375213,234100.0%50.0%
62.50%84.164710,851100.0%0.0%
62.50%86.072611,59850.0%75.0%
50.00%81.63948,88825.0%75.0%
50.00%82.659011,57450.0%50.0%
37.50%84.34689,60866.7%20.0%
50.00%86.075212,12750.0%50.0%
75.00%81.84619,71750.0%100.0%
50.00%84.75939,70720.0%100.0%
28.57%71.54699,3480.0%50.0%
57.14%72.24578,64566.7%50.0%
85.71%71.55068,91275.0%100.0%
42.86%71.44499,4630.0%60.0%
50.00%63.866510,38850.0%50.0%
50.00%61.253910,07150.0%50.0%
50.00%62.45769,27866.7%33.3%
50.00%65.060611,31766.7%33.3%
40.00%56.077711,01533.3%50.0%
20.00%55.151210,8920.0%25.0%
60.00%55.872310,033100.0%50.0%
20.00%51.43949,2580.0%33.3%
80.00%54.677910,15775.0%100.0%
40.00%52.76589,47233.3%50.0%

Get the MetaBot Desktop App

Level up your gameplay with real-time overlays, automatic game detection, and instant stats — all on your desktop.

In-game overlaysAuto game detectionMulti-game supportPersonal dashboard
Download NowFree download
🔍

Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.

Report an Issue

Seraphine vs Annie - Frequently Asked Questions

How does Seraphine do against Annie in League of Legends?

Annie wins the Seraphine vs Annie matchup with a 54.5% win rate compared to Seraphine's 45.5%, a 9.1 percentage point difference. This data is based on 11 recent ranked games in patch 26.7.

How does Seraphine do against Annie in the early game?

In the early game, Seraphine has the advantage against Annie with a 57.1% win rate versus 42.9%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Annie in the late game?

In the late game, Annie takes over the Seraphine vs Annie matchup with a 75.0% win rate compared to 25.0%. Annie scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Annie matchup?

Annie wins the matchup against Seraphine with a 54.5% win rate in League of Legends patch 26.7. The 9.1 percentage point advantage means Annie is significantly favored in this lane matchup based on 11 games analyzed.

What is the best Seraphine build against Annie?

The best Seraphine build against Annie includes Echoes of Helia, Moonstone Renewer, Diadem of Songs with Ionian Boots of Lucidity. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Annie?

The best Seraphine runes against Annie use the Sorcery primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Seraphine vs Annie matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Annie?

No, Seraphine struggles against Annie with only a 45.5% win rate. Annie has the advantage in this matchup. Seraphine players should focus on safe farming and avoiding extended trades to minimize Annie's lead.

How do I play Seraphine against Annie?

When playing Seraphine against Annie, play cautiously and avoid Annie's power spikes. Look for jungle assistance and team-dependent plays since Annie has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.