Vaynevs Dr. Mundo
Vayne vs Dr. Mundo is a decisive matchup in LoL patch 26.10. Dr. Mundo wins with a 53.2% win rate (+6.3%) over Vayne based on 79 games. Dr. Mundo wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Dr. Mundo matchup.
Vayne Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who Wins the Vayne vs Dr. Mundo Matchup?
Vayne vs Dr. Mundo Matchup Summary
The Vayne vs Dr. Mundo matchup is a decisive matchup in League of Legends ranked play. Based on 79 recent matches analyzed, Dr. Mundo wins with a 53.2% win rate compared to Vayne's 46.8%, giving Dr. Mundo a 6.3 percentage point advantage. Game phase dynamics play a critical role here: Dr. Mundo controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Dr. Mundo needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Dr. Mundo leads by 1,276 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Dr. Mundo has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Dr. Mundo overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Vayne vs Dr. Mundo Laning Phase Breakdown
Dr. Mundo is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Dr. Mundo holds advantages in farming, crowd control and sustain, making them the stronger laner in this matchup.
Best Vayne Build Against Dr. Mundo
Berserker's Greaves is the optimal boots choice against Dr. Mundo, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Dr. Mundo are Kraken Slayer, Blade of The Ruined King and Experimental Hexplate. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 66.7% win rate across 3 games — well above average and making it the top item path against Dr. Mundo. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Dr. Mundo matchup.
Early Game vs Late Game
Vayne40.6%
Dr. Mundo59.4%Vayne51.1%Dr. Mundo48.9%Dr. Mundo dominates the early game (first 15 minutes) with a commanding 59.4% win rate — a 18.8 percentage point lead over Vayne. This lopsided early game means Dr. Mundo can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
In the late game (25+ minutes), Vayne takes over with a 51.1% win rate, leading Dr. Mundo by 2.1 percentage points. Vayne scales more effectively into team fights and objective contests.
The power dynamics shift as the game progresses — Dr. Mundo has the edge early, but Vayne gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.
Best Vayne Runes Against Dr. Mundo
Precision
Resolve
The Precision and Resolve rune setup gives Vayne the best tools to compete against Dr. Mundo in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Vayne matchup data for League of Legends patch 26.10. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 42.21% | 860 | 6.1 | 872 | 13,380 | 43.6% | 41.3% | |
| 48.35% | 668 | 6.0 | 788 | 12,821 | 46.9% | 49.5% | |
| 46.65% | 641 | 6.1 | 827 | 12,937 | 45.2% | 47.9% | |
| 53.54% | 536 | 6.2 | 841 | 13,288 | 52.5% | 54.4% | |
| 52.47% | 507 | 6.0 | 811 | 12,884 | 47.2% | 56.4% | |
| 48.71% | 505 | 5.7 | 770 | 12,213 | 46.5% | 50.5% | |
| 53.60% | 376 | 6.2 | 852 | 12,805 | 50.3% | 56.5% | |
| 50.98% | 306 | 6.3 | 892 | 13,184 | 46.1% | 55.2% | |
| 54.39% | 239 | 6.1 | 896 | 13,103 | 50.0% | 58.4% | |
| 52.75% | 218 | 6.0 | 826 | 12,717 | 49.5% | 55.3% | |
| 45.19% | 208 | 5.9 | 798 | 13,223 | 44.3% | 45.8% | |
| 49.50% | 200 | 6.1 | 827 | 13,582 | 46.8% | 51.2% | |
| 44.38% | 169 | 5.8 | 793 | 12,546 | 49.4% | 40.2% | |
| 46.71% | 167 | 6.4 | 951 | 12,236 | 47.8% | 46.0% | |
| 46.01% | 163 | 6.1 | 783 | 12,737 | 47.2% | 45.0% | |
| 47.50% | 160 | 6.0 | 817 | 12,747 | 46.1% | 48.8% | |
| 51.57% | 159 | 6.5 | 865 | 13,511 | 49.3% | 53.3% | |
| 43.67% | 158 | 5.8 | 656 | 11,114 | 37.7% | 48.3% | |
| 56.25% | 144 | 6.3 | 866 | 11,228 | 48.5% | 63.2% | |
| 58.96% | 134 | 5.9 | 931 | 11,611 | 60.0% | 58.2% | |
| 34.35% | 131 | 5.7 | 601 | 10,574 | 26.3% | 40.5% | |
| 48.03% | 127 | 5.9 | 810 | 12,758 | 32.8% | 60.9% | |
| 43.80% | 121 | 5.9 | 861 | 13,047 | 41.7% | 45.2% | |
| 46.61% | 118 | 6.2 | 803 | 12,418 | 44.6% | 49.1% | |
| 44.95% | 109 | 6.4 | 834 | 13,387 | 48.8% | 42.6% | |
| 56.07% | 107 | 5.9 | 933 | 11,833 | 63.3% | 50.0% | |
| 47.06% | 102 | 6.3 | 870 | 12,650 | 47.9% | 46.3% | |
| 56.18% | 89 | 6.2 | 725 | 10,514 | 51.1% | 61.4% | |
| 56.82% | 88 | 6.1 | 803 | 12,053 | 59.6% | 53.7% | |
| 45.68% | 81 | 5.7 | 903 | 11,091 | 48.7% | 42.9% | |
| 53.09% | 81 | 6.5 | 1,099 | 12,990 | 41.7% | 62.2% | |
| 46.84% | 79 | 6.2 | 1,298 | 12,010 | 40.6% | 51.1% | |
| 53.42% | 73 | 5.7 | 1,120 | 12,612 | 51.9% | 54.4% | |
| 52.94% | 68 | 5.9 | 807 | 11,301 | 56.3% | 50.0% | |
| 42.65% | 68 | 5.9 | 947 | 12,250 | 26.1% | 51.1% | |
| 55.88% | 68 | 6.8 | 874 | 11,940 | 55.9% | 55.9% | |
| 50.00% | 68 | 6.6 | 851 | 11,661 | 48.5% | 51.4% | |
| 41.18% | 68 | 6.4 | 953 | 12,133 | 57.1% | 30.0% | |
| 58.06% | 62 | 6.3 | 977 | 12,030 | 59.3% | 57.1% | |
| 47.46% | 59 | 6.2 | 989 | 11,887 | 48.0% | 47.1% | |
| 52.83% | 53 | 6.0 | 733 | 13,262 | 45.0% | 57.6% | |
| 56.60% | 53 | 5.8 | 801 | 12,189 | 54.5% | 58.1% | |
| 52.83% | 53 | 5.8 | 821 | 12,721 | 54.5% | 51.6% | |
| 58.49% | 53 | 6.2 | 936 | 12,238 | 57.1% | 59.4% | |
| 58.49% | 53 | 6.3 | 1,030 | 13,721 | 50.0% | 65.5% | |
| 49.02% | 51 | 5.9 | 874 | 10,987 | 44.0% | 53.9% | |
| 50.00% | 50 | 6.2 | 867 | 12,630 | 40.0% | 60.0% | |
| 63.27% | 49 | 6.4 | 804 | 12,522 | 80.0% | 51.7% | |
| 58.33% | 48 | 6.2 | 884 | 11,914 | 56.5% | 60.0% | |
| 42.55% | 47 | 6.4 | 850 | 12,414 | 50.0% | 36.0% | |
| 53.33% | 45 | 5.6 | 800 | 11,861 | 45.0% | 60.0% | |
| 54.55% | 44 | 6.0 | 909 | 13,606 | 57.1% | 53.3% | |
| 55.81% | 43 | 6.4 | 922 | 13,202 | 63.2% | 50.0% | |
| 37.21% | 43 | 5.9 | 783 | 12,220 | 50.0% | 29.6% | |
| 47.62% | 42 | 6.1 | 904 | 13,379 | 35.0% | 59.1% | |
| 51.22% | 41 | 6.3 | 1,025 | 12,349 | 41.2% | 58.3% | |
| 45.00% | 40 | 5.3 | 848 | 12,889 | 50.0% | 42.3% | |
| 50.00% | 40 | 6.5 | 842 | 12,057 | 52.6% | 47.6% | |
| 51.28% | 39 | 6.0 | 908 | 11,110 | 60.9% | 37.5% | |
| 50.00% | 38 | 6.3 | 888 | 13,077 | 40.0% | 53.6% | |
| 63.16% | 38 | 4.1 | 867 | 11,739 | 59.1% | 68.8% | |
| 37.84% | 37 | 5.4 | 745 | 10,304 | 21.1% | 55.6% | |
| 58.33% | 36 | 6.5 | 956 | 11,031 | 47.6% | 73.3% | |
| 51.43% | 35 | 6.5 | 919 | 11,948 | 61.5% | 45.5% | |
| 45.45% | 33 | 5.5 | 823 | 12,066 | 25.0% | 57.1% | |
| 75.76% | 33 | 5.7 | 742 | 11,321 | 82.3% | 68.8% | |
| 50.00% | 30 | 6.1 | 1,027 | 12,921 | 58.3% | 44.4% | |
| 50.00% | 28 | 6.0 | 806 | 12,719 | 33.3% | 57.9% | |
| 60.71% | 28 | 6.1 | 765 | 11,907 | 64.3% | 57.1% | |
| 51.85% | 27 | 5.2 | 812 | 11,409 | 28.6% | 76.9% | |
| 40.74% | 27 | 6.2 | 683 | 9,797 | 46.7% | 33.3% | |
| 48.15% | 27 | 6.3 | 774 | 11,833 | 50.0% | 46.7% | |
| 46.15% | 26 | 5.9 | 727 | 11,522 | 50.0% | 42.9% | |
| 53.85% | 26 | 6.4 | 896 | 13,089 | 41.7% | 64.3% | |
| 65.38% | 26 | 6.4 | 888 | 12,576 | 60.0% | 68.8% | |
| 46.15% | 26 | 6.1 | 811 | 12,732 | 33.3% | 57.1% | |
| 52.00% | 25 | 5.5 | 819 | 13,406 | 57.1% | 50.0% | |
| 20.00% | 25 | 5.9 | 677 | 11,114 | 7.1% | 36.4% | |
| 58.33% | 24 | 6.2 | 854 | 13,429 | 54.5% | 61.5% | |
| 37.50% | 24 | 5.0 | 626 | 8,646 | 25.0% | 62.5% | |
| 47.83% | 23 | 6.2 | 875 | 13,728 | 50.0% | 46.1% | |
| 43.48% | 23 | 6.5 | 927 | 11,037 | 40.0% | 46.1% | |
| 63.64% | 22 | 3.5 | 952 | 12,743 | 69.2% | 55.6% | |
| 42.86% | 21 | 5.0 | 672 | 11,616 | 45.5% | 40.0% | |
| 38.10% | 21 | 6.3 | 999 | 10,857 | 36.4% | 40.0% | |
| 33.33% | 21 | 6.0 | 947 | 11,415 | 40.0% | 27.3% | |
| 35.00% | 20 | 6.2 | 726 | 12,173 | 44.4% | 27.3% | |
| 30.00% | 20 | 6.0 | 748 | 12,018 | 28.6% | 30.8% | |
| 63.16% | 19 | 4.6 | 1,064 | 12,921 | 54.5% | 75.0% | |
| 50.00% | 18 | 6.7 | 924 | 11,793 | 55.6% | 44.4% | |
| 44.44% | 18 | 6.5 | 1,011 | 12,353 | 33.3% | 50.0% | |
| 37.50% | 16 | 5.3 | 670 | 9,773 | 18.2% | 80.0% | |
| 50.00% | 16 | 6.7 | 993 | 14,038 | 71.4% | 33.3% | |
| 50.00% | 16 | 6.3 | 924 | 12,955 | 80.0% | 36.4% | |
| 50.00% | 16 | 5.7 | 1,008 | 13,676 | 50.0% | 50.0% | |
| 60.00% | 15 | 5.8 | 984 | 13,362 | 50.0% | 63.6% | |
| 60.00% | 15 | 6.0 | 953 | 14,670 | 33.3% | 66.7% | |
| 64.29% | 14 | 5.1 | 1,014 | 13,683 | 50.0% | 70.0% | |
| 38.46% | 13 | 3.6 | 779 | 11,679 | 33.3% | 42.9% | |
| 46.15% | 13 | 2.9 | 721 | 13,246 | 20.0% | 62.5% | |
| 50.00% | 12 | 6.3 | 721 | 11,962 | 50.0% | 50.0% | |
| 66.67% | 12 | 5.9 | 1,033 | 11,796 | 71.4% | 60.0% | |
| 72.73% | 11 | 5.6 | 900 | 12,586 | 60.0% | 83.3% | |
| 54.55% | 11 | 5.1 | 991 | 14,168 | 66.7% | 50.0% | |
| 27.27% | 11 | 3.3 | 618 | 11,941 | 50.0% | 14.3% | |
| 36.36% | 11 | 6.4 | 775 | 9,363 | 37.5% | 33.3% | |
| 60.00% | 10 | 3.5 | 950 | 11,451 | 50.0% | 75.0% | |
| 70.00% | 10 | 3.5 | 984 | 14,774 | 50.0% | 75.0% | |
| 70.00% | 10 | 2.2 | 881 | 12,712 | 50.0% | 83.3% | |
| 30.00% | 10 | 3.0 | 751 | 12,482 | 20.0% | 40.0% | |
| 50.00% | 10 | 4.9 | 749 | 14,596 | 0.0% | 55.6% | |
| 40.00% | 10 | 3.2 | 887 | 13,613 | 66.7% | 28.6% | |
| 33.33% | 9 | 6.8 | 813 | 13,438 | 25.0% | 40.0% | |
| 55.56% | 9 | 6.5 | 1,081 | 14,802 | 100.0% | 33.3% | |
| 55.56% | 9 | 1.2 | 710 | 11,670 | 60.0% | 50.0% | |
| 44.44% | 9 | 6.9 | 996 | 10,362 | 50.0% | 40.0% | |
| 44.44% | 9 | 5.6 | 891 | 10,790 | 20.0% | 75.0% | |
| 37.50% | 8 | 5.8 | 644 | 11,385 | 66.7% | 20.0% | |
| 62.50% | 8 | 4.0 | 1,293 | 13,786 | 60.0% | 66.7% | |
| 75.00% | 8 | 3.1 | 889 | 12,617 | 75.0% | 75.0% | |
| 71.43% | 7 | 3.0 | 532 | 7,751 | 50.0% | 100.0% | |
| 57.14% | 7 | 5.3 | 911 | 12,799 | 33.3% | 75.0% | |
| 28.57% | 7 | 6.5 | 816 | 9,928 | 25.0% | 33.3% | |
| 71.43% | 7 | 5.9 | 678 | 11,941 | 100.0% | 50.0% | |
| 50.00% | 6 | 4.3 | 996 | 14,686 | 50.0% | 50.0% | |
| 66.67% | 6 | 6.5 | 1,069 | 14,100 | 66.7% | 66.7% | |
| 60.00% | 5 | 6.3 | 1,000 | 16,366 | 100.0% | 50.0% | |
| 0.00% | 5 | 6.7 | 547 | 8,027 | 0.0% | 0.0% | |
| 80.00% | 5 | 2.4 | 1,036 | 14,100 | 100.0% | 75.0% | |
| 40.00% | 5 | 2.4 | 924 | 16,141 | 0.0% | 40.0% | |
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Vayne vs Dr. Mundo - Frequently Asked Questions
How does Vayne do against Dr. Mundo in League of Legends?
Dr. Mundo wins the Vayne vs Dr. Mundo matchup with a 53.2% win rate compared to Vayne's 46.8%, a 6.3 percentage point difference. This data is based on 79 recent ranked games in patch 26.10.
How does Vayne do against Dr. Mundo in the early game?
In the early game, Dr. Mundo has the advantage against Vayne with a 59.4% win rate versus 40.6%. Dr. Mundo players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Vayne do against Dr. Mundo in the late game?
In the late game, Vayne takes over the Vayne vs Dr. Mundo matchup with a 51.1% win rate compared to 48.9%. Vayne scales better into team fights and objective contests after 25 minutes.
Who wins the Vayne vs Dr. Mundo matchup?
Dr. Mundo wins the matchup against Vayne with a 53.2% win rate in League of Legends patch 26.10. The 6.3 percentage point advantage means Dr. Mundo is significantly favored in this lane matchup based on 79 games analyzed.
What is the best Vayne build against Dr. Mundo?
The best Vayne build against Dr. Mundo includes Kraken Slayer, Blade of The Ruined King, Experimental Hexplate with Berserker's Greaves. This build achieves a 66.7% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.
What are the best Vayne runes against Dr. Mundo?
The best Vayne runes against Dr. Mundo use the Precision primary tree with Resolve secondary. This rune setup achieves a 60.0% win rate in the Vayne vs Dr. Mundo matchup. See the full rune breakdown in the matchup comparison above.
Does Vayne counter Dr. Mundo?
No, Vayne struggles against Dr. Mundo with only a 46.8% win rate. Dr. Mundo has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Dr. Mundo's lead.
How do I play Vayne against Dr. Mundo?
When playing Vayne against Dr. Mundo, play cautiously and avoid Dr. Mundo's power spikes. Focus on safe farming — you outscale Dr. Mundo in the late game. Use the matchup-specific build and runes above to optimize your chances.