Vayne - League of Legends Champion
Win Rate
50.1%
Pick Rate
5.4%

Vaynevs Dr. Mundo

CMarksmanAssassin
Patch26.7
Matches508,082
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 12, 2026
MethodologyData Methodology

Vayne vs Dr. Mundo is a decisive matchup in LoL patch 26.7. Dr. Mundo wins with a 60.0% win rate (+20.0%) over Vayne based on 35 games. Dr. Mundo holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Dr. Mundo matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Dr. Mundo - 40.0% win rateDr. Mundo(40.0%)
Vayne - 40.0% win rate in this matchup
Vayne
40.0% WR
VS
Dr. Mundo vs Vayne matchup - 60.0% win rate
Dr. Mundo
60.0% WR

Who Wins the Vayne vs Dr. Mundo Matchup?

Dr. Mundo wins the Vayne vs Dr. Mundo matchup
Winner
Dr. Mundo
Matches: 35
40.0%
Win Rate
60.0%
5.7
CS / min
5.7
1,141
DMG / min
713
11,808
Gold / game
11,585
301
Heal / min
601
558
DMG Mitigated / min
1,558
0.3
CC / min
0.4
38.9%
Early Game WR
61.1%
41.2%
Late Game WR
58.8%

Vayne vs Dr. Mundo Matchup Summary

The Vayne vs Dr. Mundo matchup is a decisive matchup in League of Legends ranked play. Based on 35 recent matches analyzed, Dr. Mundo wins with a 60.0% win rate compared to Vayne's 40.0%, giving Dr. Mundo a 20.0 percentage point advantage. Dr. Mundo dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Dr. Mundo leads by 1,301 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Dr. Mundo has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Dr. Mundo overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Dr. Mundo Laning Phase Breakdown

Vayne wins the laning phase against Dr. Mundo in League of Legends

Vayne is favored during the laning phase against Dr. Mundo, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
5.7Vayne
5.7Dr. Mundo
Vayne and Dr. Mundo farm at nearly identical rates in this matchup, with only a 0.0 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
1,141Vayne
713Dr. Mundo
Vayne heavily out-damages Dr. Mundo by 428 DMG/min, dominating both short trades and all-in fights. Dr. Mundo should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
11,808Vayne
11,585Dr. Mundo
Vayne and Dr. Mundo generate nearly equal gold per game, with just a 223 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
0.3Vayne
0.4Dr. Mundo
Both Vayne and Dr. Mundo provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
859Vayne
2,160Dr. Mundo
Dr. Mundo vastly out-sustains Vayne, healing and mitigating 1,301 more damage per minute. This massive durability gap means Dr. Mundo can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Dr. Mundo

Berserker's Greaves is the optimal boots choice against Dr. Mundo, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Dr. Mundo are Kraken Slayer, Blade of The Ruined King and Guinsoo's Rageblade. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 80.0% win rate across 5 games — well above average and making it the top item path against Dr. Mundo. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Dr. Mundo matchup.

Early Game vs Late Game

Early Game
Dr. Mundo
61.1%
+22.2% advantage
Vayne early game win rateVayne38.9%
Dr. Mundo early game win rateDr. Mundo61.1%
Late Game
Dr. Mundo
58.8%
+17.6% advantage
Vayne late game win rateVayne41.2%
Dr. Mundo late game win rateDr. Mundo58.8%

Dr. Mundo dominates the early game (first 15 minutes) with a commanding 61.1% win rate — a 22.2 percentage point lead over Vayne. This lopsided early game means Dr. Mundo can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Dr. Mundo is far superior in the late game (25+ minutes), boasting a 58.8% win rate — 17.6 points above Vayne. Extended games heavily favor Dr. Mundo, whose kit and scaling make them a dominant force in team fights and objective control.

Dr. Mundo holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Dr. Mundo

Precision rune tree - Vayne primary runes vs Dr. MundoPrecision
Lethal Tempo - best Vayne rune vs Dr. MundoPresence of Mind - best Vayne rune vs Dr. MundoLegend: Alacrity - best Vayne rune vs Dr. MundoCut Down - best Vayne rune vs Dr. Mundo
Sorcery rune tree - Vayne secondary runes vs Dr. MundoSorcery
Manaflow Band - best Vayne rune vs Dr. MundoCelerity - best Vayne rune vs Dr. Mundo
100.0% WR

The Precision and Sorcery rune setup gives Vayne the best tools to compete against Dr. Mundo in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Vayne matchup data for League of Legends patch 26.7. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.02%3576.081713,23145.3%52.0%
52.47%3246.289813,59649.3%55.2%
48.09%3146.283212,81944.0%52.7%
49.01%3025.982512,93747.5%50.3%
52.94%2726.083913,07152.8%53.1%
45.37%2276.496014,25446.9%44.2%
50.00%2226.493713,71750.0%50.0%
52.71%2036.585613,74148.9%56.0%
52.32%1516.582813,28755.4%49.4%
58.39%1496.695312,70051.6%63.5%
51.30%1155.881313,71761.5%42.9%
47.71%1096.088213,23938.2%57.4%
55.67%976.488012,62559.6%51.1%
51.55%976.380612,73552.5%50.0%
50.00%945.983213,59546.7%53.1%
36.36%886.279012,98330.0%41.7%
47.44%786.692813,28446.3%48.6%
61.33%756.692412,10266.7%55.6%
55.56%726.185813,24745.2%63.4%
57.35%686.085313,57456.0%58.1%
36.76%686.288112,39436.7%36.8%
52.54%596.383712,51848.5%57.7%
42.37%596.287012,82834.4%51.9%
38.60%575.760511,22540.0%37.0%
37.50%565.560110,77030.4%42.4%
43.40%536.21,04512,46744.4%42.3%
44.00%506.188613,06147.8%40.7%
53.06%496.11,21413,80450.0%55.2%
65.91%446.186913,29266.7%65.4%
56.82%445.692114,04761.1%53.9%
43.18%445.799611,54831.3%50.0%
50.00%406.384813,58435.3%60.9%
55.00%405.989314,58823.1%70.4%
57.50%406.395114,24860.0%56.7%
48.72%396.595213,49157.9%40.0%
57.89%386.01,02912,41355.0%61.1%
42.11%386.192313,74144.4%40.0%
54.05%377.092811,69252.4%56.3%
40.54%375.880412,22541.2%40.0%
40.00%355.71,14111,80838.9%41.2%
55.88%346.585611,12557.9%53.3%
50.00%326.098613,59966.7%43.5%
66.67%306.289612,54050.0%81.3%
56.67%306.298113,89653.9%58.8%
48.28%296.785812,18028.6%66.7%
55.17%296.31,02413,69462.5%46.1%
51.85%275.798412,39145.5%56.3%
61.54%266.185111,71961.5%61.5%
64.00%256.080811,77055.6%68.8%
44.00%256.892712,26342.9%45.5%
33.33%246.483511,60541.7%25.0%
56.52%235.592112,42462.5%53.3%
43.48%236.383712,92160.0%30.8%
40.91%226.678811,10141.7%40.0%
52.38%215.992313,47740.0%63.6%
60.00%205.290914,35220.0%73.3%
47.37%196.91,00811,89263.6%25.0%
50.00%186.273213,04560.0%37.5%
50.00%186.21,05312,78455.6%44.4%
44.44%186.483711,79542.9%45.5%
50.00%185.875412,37328.6%63.6%
76.47%176.91,02114,29680.0%75.0%
29.41%176.982911,89737.5%22.2%
41.18%176.086215,19160.0%33.3%
43.75%166.083811,77362.5%25.0%
56.25%166.690711,52757.1%55.6%
37.50%165.465913,20816.7%50.0%
68.75%166.793713,92583.3%60.0%
53.33%155.968611,41937.5%71.4%
73.33%156.485112,62177.8%66.7%
50.00%145.785111,11416.7%75.0%
42.86%144.364512,05114.3%71.4%
53.85%133.388514,16275.0%44.4%
53.85%135.71,05513,76250.0%55.6%
58.33%125.656210,02757.1%60.0%
25.00%124.586213,08325.0%25.0%
50.00%126.378413,32833.3%66.7%
27.27%116.277113,46233.3%25.0%
63.64%116.387415,82666.7%62.5%
36.36%116.665110,70650.0%20.0%
45.45%115.591912,62950.0%40.0%
72.73%116.474510,85071.4%75.0%
45.45%116.01,06414,50840.0%50.0%
70.00%106.699613,49075.0%66.7%
40.00%106.887613,21633.3%50.0%
55.56%96.393712,28633.3%100.0%
44.44%96.21,07715,702100.0%28.6%
33.33%96.877411,06920.0%50.0%
25.00%85.569310,37825.0%25.0%
50.00%85.99738,78533.3%100.0%
37.50%81.983414,72733.3%40.0%
42.86%75.690112,809100.0%20.0%
0.00%76.655810,7000.0%0.0%
42.86%74.665114,53850.0%40.0%
71.43%76.168213,12675.0%66.7%
57.14%75.588812,31625.0%100.0%
57.14%75.489512,10050.0%66.7%
42.86%74.077311,64333.3%50.0%
57.14%72.51,31315,57625.0%100.0%
33.33%64.65709,10525.0%50.0%
66.67%65.91,08915,49350.0%75.0%
50.00%65.776213,18250.0%50.0%
50.00%61.989114,832100.0%40.0%
16.67%65.384410,4420.0%33.3%
0.00%65.979510,7240.0%0.0%
83.33%66.196311,361100.0%50.0%
50.00%66.380413,574100.0%40.0%
40.00%54.793914,778100.0%0.0%
60.00%51.71,19517,6480.0%75.0%
20.00%51.56919,37833.3%0.0%
60.00%55.31,10015,380100.0%50.0%
20.00%56.891512,5530.0%33.3%
40.00%56.51,02117,6030.0%40.0%

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Vayne vs Dr. Mundo - Frequently Asked Questions

How does Vayne do against Dr. Mundo in League of Legends?

Dr. Mundo wins the Vayne vs Dr. Mundo matchup with a 60.0% win rate compared to Vayne's 40.0%, a 20.0 percentage point difference. This data is based on 35 recent ranked games in patch 26.7.

How does Vayne do against Dr. Mundo in the early game?

In the early game, Dr. Mundo has the advantage against Vayne with a 61.1% win rate versus 38.9%. Dr. Mundo players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Dr. Mundo in the late game?

In the late game, Dr. Mundo takes over the Vayne vs Dr. Mundo matchup with a 58.8% win rate compared to 41.2%. Dr. Mundo scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Dr. Mundo matchup?

Dr. Mundo wins the matchup against Vayne with a 60.0% win rate in League of Legends patch 26.7. The 20.0 percentage point advantage means Dr. Mundo is significantly favored in this lane matchup based on 35 games analyzed.

What is the best Vayne build against Dr. Mundo?

The best Vayne build against Dr. Mundo includes Kraken Slayer, Blade of The Ruined King, Guinsoo's Rageblade with Berserker's Greaves. This build achieves a 80.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Dr. Mundo?

The best Vayne runes against Dr. Mundo use the Precision primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Dr. Mundo matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Dr. Mundo?

No, Vayne struggles against Dr. Mundo with only a 40.0% win rate. Dr. Mundo has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Dr. Mundo's lead.

How do I play Vayne against Dr. Mundo?

When playing Vayne against Dr. Mundo, play cautiously and avoid Dr. Mundo's power spikes. Look for jungle assistance and team-dependent plays since Dr. Mundo has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.