Lissandra - League of Legends Champion
Win Rate
51.3%
Pick Rate
2.2%

Lissandravs Seraphine

AMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 24, 2026
MethodologyData Methodology

Lissandra vs Seraphine is a decisive matchup in LoL patch 26.7. Seraphine wins with a 80.0% win rate (+60.0%) over Lissandra based on 5 games. Seraphine holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Seraphine matchup.

Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Seraphine - 20.0% win rateSeraphine(20.0%)
Lissandra - 20.0% win rate in this matchup
Lissandra
20.0% WR
VS
Seraphine vs Lissandra matchup - 80.0% win rate
Seraphine
80.0% WR

Who Wins the Lissandra vs Seraphine Matchup?

Seraphine wins the Lissandra vs Seraphine matchup
Winner
Seraphine
Matches: 5
20.0%
Win Rate
80.0%
5.0
CS / min
4.6
597
DMG / min
779
8,214
Gold / game
10,157
65
Heal / min
202
356
DMG Mitigated / min
277
1.4
CC / min
1.1
25.0%
Early Game WR
75.0%
0.0%
Late Game WR
100.0%

Lissandra vs Seraphine Matchup Summary

The Lissandra vs Seraphine matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Seraphine wins with a 80.0% win rate compared to Lissandra's 20.0%, giving Seraphine a 60.0 percentage point advantage. Seraphine dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in damage output, where Seraphine leads by 183 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine has a strong advantage in this matchup. Lissandra players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Seraphine overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Seraphine Laning Phase Breakdown

Seraphine wins the laning phase against Lissandra in League of Legends

Seraphine is favored during the laning phase against Lissandra, winning 3 out of 5 key stat categories. Seraphine holds advantages in damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
5.0Lissandra
4.6Seraphine
Lissandra edges out Seraphine by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 6 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
597Lissandra
779Seraphine
Seraphine heavily out-damages Lissandra by 183 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Seraphine's sustained damage advantage take over.
Economy
8,214Lissandra
10,157Seraphine
Seraphine generates a commanding 1,943 more gold per game than Lissandra. This substantial economic advantage means Seraphine consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Lissandra should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.4Lissandra
1.1Seraphine
Both Lissandra and Seraphine provide similar amounts of crowd control (0.3s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
421Lissandra
478Seraphine
Seraphine heals and mitigates 57 more damage per minute than Lissandra, providing moderate extra durability. This sustain edge allows Seraphine to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Lissandra.

Best Lissandra Build Against Seraphine

Spellslinger's Shoes is the optimal boots choice against Seraphine, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Seraphine are Zhonya's Hourglass, Malignance and Rabadon's Deathcap. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Seraphine matchup.

Early Game vs Late Game

Early Game
Seraphine
75.0%
+50.0% advantage
Lissandra early game win rateLissandra25.0%
Seraphine early game win rateSeraphine75.0%
Late Game
Seraphine
100.0%
+100.0% advantage
Lissandra late game win rateLissandra0.0%
Seraphine late game win rateSeraphine100.0%

Seraphine dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Lissandra. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Seraphine is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Lissandra. Extended games heavily favor Seraphine, whose kit and scaling make them a dominant force in team fights and objective control.

Seraphine holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Lissandra Runes Against Seraphine

Sorcery rune tree - Lissandra primary runes vs SeraphineSorcery
Arcane Comet - best Lissandra rune vs SeraphineManaflow Band - best Lissandra rune vs SeraphineTranscendence - best Lissandra rune vs SeraphineScorch - best Lissandra rune vs Seraphine
Domination rune tree - Lissandra secondary runes vs SeraphineDomination
Cheap Shot - best Lissandra rune vs SeraphineUltimate Hunter - best Lissandra rune vs Seraphine
100.0% WR

The Sorcery and Domination rune setup gives Lissandra the best tools to compete against Seraphine in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Lissandra matchup data for League of Legends patch 26.7. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
60.00%1306.883712,37853.6%64.9%
57.52%1136.882011,83565.2%52.2%
50.00%766.890711,85747.2%52.5%
45.95%746.778211,93537.5%52.4%
47.95%736.982512,39648.3%47.7%
52.11%717.081212,61135.7%62.8%
53.62%696.788911,32658.1%50.0%
54.55%666.798912,99555.2%54.0%
50.00%626.990112,04736.7%62.5%
54.10%616.687711,06545.5%64.3%
57.38%616.276711,40053.6%60.6%
34.48%586.766810,83031.4%39.1%
40.00%556.372811,33333.3%45.2%
46.94%496.975711,65340.0%51.7%
50.00%486.776511,97850.0%50.0%
50.00%406.476411,31941.2%56.5%
65.00%407.283311,56863.6%66.7%
56.41%397.084511,79244.4%66.7%
60.00%356.876110,99150.0%70.6%
48.57%356.881511,55440.0%55.0%
36.36%336.784111,39846.7%27.8%
21.21%336.478711,43923.1%20.0%
63.33%307.380811,58476.5%46.1%
62.07%297.188313,06883.3%47.1%
58.62%296.596211,72763.6%55.6%
53.57%286.983410,91262.5%41.7%
46.43%286.68679,78147.1%45.5%
53.57%286.881411,53950.0%56.3%
59.26%277.079712,15157.1%61.5%
69.23%266.586913,22971.4%68.4%
57.69%266.679612,06775.0%42.9%
40.00%257.276711,82854.5%28.6%
64.00%256.680511,12450.0%73.3%
41.67%246.992712,63340.0%42.9%
66.67%247.178811,24454.5%76.9%
73.68%197.196712,77550.0%90.9%
44.44%187.31,06512,47460.0%25.0%
64.71%177.290311,48980.0%42.9%
33.33%156.473710,70622.2%50.0%
57.14%146.289412,26342.9%71.4%
42.86%147.375110,43150.0%25.0%
76.92%136.783113,11175.0%77.8%
38.46%136.082212,47860.0%25.0%
30.77%136.896711,40720.0%37.5%
15.38%136.584811,09216.7%14.3%
45.45%116.480812,11440.0%50.0%
27.27%116.792811,21620.0%33.3%
54.55%116.888611,95450.0%57.1%
40.00%106.882512,83166.7%28.6%
50.00%106.452910,44128.6%100.0%
55.56%96.295114,28150.0%57.1%
88.89%97.280612,70675.0%100.0%
55.56%97.288211,46775.0%40.0%
55.56%95.672312,03950.0%60.0%
55.56%97.786112,78766.7%50.0%
75.00%87.487510,71080.0%66.7%
57.14%77.387510,78575.0%33.3%
42.86%75.873510,32566.7%25.0%
85.71%77.087111,26283.3%100.0%
71.43%76.173511,33280.0%50.0%
50.00%61.761410,6240.0%60.0%
83.33%67.91,14313,99850.0%100.0%
33.33%67.796512,2420.0%66.7%
33.33%66.686711,32825.0%50.0%
50.00%62.45439,94466.7%33.3%
83.33%67.183312,020100.0%80.0%
16.67%67.26078,27816.7%0.0%
60.00%56.01,16411,19766.7%50.0%
40.00%53.07276,78640.0%0.0%
20.00%57.793410,62525.0%0.0%
20.00%55.05978,21425.0%0.0%
40.00%53.45178,76125.0%100.0%
80.00%55.064712,91850.0%100.0%
40.00%56.783411,7270.0%66.7%
60.00%56.077611,837100.0%33.3%
40.00%56.374111,1560.0%50.0%
60.00%56.897912,10050.0%66.7%
80.00%56.51,08510,600100.0%66.7%

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Lissandra vs Seraphine - Frequently Asked Questions

How does Lissandra do against Seraphine in League of Legends?

Seraphine wins the Lissandra vs Seraphine matchup with a 80.0% win rate compared to Lissandra's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.7.

How does Lissandra do against Seraphine in the early game?

In the early game, Seraphine has the advantage against Lissandra with a 75.0% win rate versus 25.0%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Seraphine in the late game?

In the late game, Seraphine takes over the Lissandra vs Seraphine matchup with a 100.0% win rate compared to 0.0%. Seraphine scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Seraphine matchup?

Seraphine wins the matchup against Lissandra with a 80.0% win rate in League of Legends patch 26.7. The 60.0 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Lissandra build against Seraphine?

The best Lissandra build against Seraphine includes Zhonya's Hourglass, Malignance, Rabadon's Deathcap with Spellslinger's Shoes. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Seraphine?

The best Lissandra runes against Seraphine use the Sorcery primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Seraphine?

No, Lissandra struggles against Seraphine with only a 20.0% win rate. Seraphine has the advantage in this matchup. Lissandra players should focus on safe farming and avoiding extended trades to minimize Seraphine's lead.

How do I play Lissandra against Seraphine?

When playing Lissandra against Seraphine, play cautiously and avoid Seraphine's power spikes. Look for jungle assistance and team-dependent plays since Seraphine has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.