Lissandra - League of Legends Champion
Win Rate
51.6%
Pick Rate
1.7%

Lissandravs Seraphine

SMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 8, 2026
MethodologyData Methodology

Lissandra vs Seraphine is a very close matchup in LoL patch 26.11. Lissandra wins with a 50.0% win rate (+0.0%) over Seraphine based on 14 games. Lissandra holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Seraphine matchup.

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Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 50.0% win rate in this matchup
Lissandra
50.0% WR
VS
Seraphine vs Lissandra matchup - 50.0% win rate
Seraphine
50.0% WR

Who Wins the Lissandra vs Seraphine Matchup?

Lissandra wins the Lissandra vs Seraphine matchup
Winner
Lissandra
Matches: 14
50.0%
Win Rate
50.0%
4.2
CS / min
2.6
549
DMG / min
551
10,943
Gold / game
9,742
128
Heal / min
226
426
DMG Mitigated / min
402
1.4
CC / min
1.1
50.0%
Early Game WR
50.0%
50.0%
Late Game WR
50.0%

Lissandra vs Seraphine Matchup Summary

The Lissandra vs Seraphine matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 14 recent matches analyzed, Lissandra wins with a 50.0% win rate compared to Seraphine's 50.0%, giving Lissandra a 0.0 percentage point advantage. Lissandra holds a slight edge in both the early and late game, but the margins are thin enough that individual skill and jungle attention will often determine the outcome. Seraphine can still find windows through outplays and team coordination. The most significant statistical gap is in CS, where Lissandra leads by 1.6 CS/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a statistical edge, but the margin is close enough that respecting Seraphine's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Seraphine Laning Phase Breakdown

Lissandra wins the laning phase against Seraphine in League of Legends

Lissandra is favored during the laning phase against Seraphine, winning 3 out of 5 key stat categories. Lissandra holds advantages in farming, gold income and crowd control, making them the stronger laner in this matchup.

Farming
4.2Lissandra
2.6Seraphine
Lissandra significantly out-farms Seraphine by 1.6 CS per minute, accumulating an estimated 23 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Seraphine players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
549Lissandra
551Seraphine
Damage output is virtually even between Lissandra and Seraphine, with only 2 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
10,943Lissandra
9,742Seraphine
Lissandra generates a commanding 1,201 more gold per game than Seraphine. This substantial economic advantage means Lissandra consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Seraphine should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.4Lissandra
1.1Seraphine
Lissandra provides 0.3 seconds more crowd control per minute than Seraphine, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
554Lissandra
628Seraphine
Seraphine heals and mitigates 74 more damage per minute than Lissandra, providing moderate extra durability. This sustain edge allows Seraphine to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Lissandra.

Best Lissandra Build Against Seraphine

Sorcerer's Shoes is the optimal boots choice against Seraphine, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Seraphine are Luden's Echo, Liandry's Torment and Zhonya's Hourglass. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Seraphine. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Seraphine matchup.

Early Game vs Late Game

Early Game
Lissandra
50.0%
+0.0% advantage
Lissandra early game win rateLissandra50.0%
Seraphine early game win rateSeraphine50.0%
Late Game
Lissandra
50.0%
+0.0% advantage
Lissandra late game win rateLissandra50.0%
Seraphine late game win rateSeraphine50.0%

The early game (first 15 minutes) is a toss-up between Lissandra and Seraphine, with Lissandra holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Late game (25+ minutes) is equally balanced, with Lissandra at 50.0% win rate — only 0.0 points ahead of Seraphine. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

This matchup is remarkably even at every stage of the game. Neither Lissandra nor Seraphine has a phase-specific advantage, making this a pure skill matchup where individual mechanics, decision-making, and team coordination determine the outcome.

Best Lissandra Runes Against Seraphine

Sorcery rune tree - Lissandra primary runes vs SeraphineSorcery
Arcane Comet - best Lissandra rune vs SeraphineManaflow Band - best Lissandra rune vs SeraphineTranscendence - best Lissandra rune vs SeraphineScorch - best Lissandra rune vs Seraphine
Domination rune tree - Lissandra secondary runes vs SeraphineDomination
Cheap Shot - best Lissandra rune vs SeraphineUltimate Hunter - best Lissandra rune vs Seraphine
100.0% WR

The Sorcery primary with Domination secondary combination helps Lissandra maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Seraphine.


Lissandra matchup data for League of Legends patch 26.11. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
58.02%1316.885811,86355.0%60.6%
61.60%1256.791812,36268.6%56.8%
54.47%1236.988112,08353.1%55.4%
54.95%1116.874811,41055.8%54.2%
51.52%996.684011,78453.5%50.0%
50.00%986.985712,17845.0%53.5%
55.56%816.992811,72160.5%51.2%
44.74%766.878111,74844.1%45.2%
57.53%736.785911,06161.5%52.9%
52.86%706.487411,10854.3%51.4%
48.53%687.090811,10755.0%39.3%
53.73%676.178010,94653.1%54.3%
48.28%586.778112,35453.9%43.8%
41.07%566.774210,62436.7%46.1%
58.93%566.573210,32060.6%56.5%
53.70%546.488811,71551.9%55.6%
52.08%486.888112,08468.2%38.5%
55.32%476.384311,46055.6%55.2%
51.16%436.883412,58750.0%51.9%
43.59%396.482510,76435.0%52.6%
46.15%396.577310,88341.2%50.0%
39.47%386.680212,13937.5%40.9%
56.76%376.374210,61842.1%72.2%
56.76%376.878712,41658.8%55.0%
56.76%376.880811,53576.9%45.8%
32.43%377.080410,61129.4%35.0%
48.65%377.083812,68066.7%40.0%
33.33%336.992311,15131.3%35.3%
66.67%306.784412,08075.0%61.1%
65.52%296.986511,46770.6%58.3%
53.57%286.785811,89133.3%63.2%
61.54%267.193811,18175.0%40.0%
37.50%246.470111,94744.4%33.3%
58.33%247.382212,59060.0%57.1%
50.00%227.076411,84454.5%45.5%
54.55%226.61,01413,02066.7%50.0%
31.82%226.768410,84522.2%38.5%
33.33%216.874611,90044.4%25.0%
57.14%215.782310,46554.5%60.0%
73.68%196.980510,70775.0%72.7%
57.89%196.985412,58375.0%45.5%
61.11%187.488713,06550.0%70.0%
38.89%187.294812,87866.7%25.0%
58.82%176.51,06612,41342.9%70.0%
62.50%166.268611,07572.7%40.0%
56.25%166.892312,01450.0%57.1%
66.67%156.984213,080100.0%54.5%
64.29%146.190813,43275.0%60.0%
50.00%144.254910,94350.0%50.0%
64.29%146.779211,67883.3%50.0%
57.14%147.01,08911,13070.0%25.0%
53.85%136.693411,37550.0%57.1%
58.33%127.51,05412,44966.7%50.0%
63.64%116.090612,08133.3%100.0%
45.45%115.590412,09425.0%57.1%
63.64%112.682511,48750.0%71.4%
30.00%105.47418,70242.9%0.0%
70.00%107.194411,75183.3%50.0%
70.00%106.21,13613,233100.0%50.0%
50.00%106.889914,6330.0%62.5%
70.00%106.481112,0790.0%87.5%
55.56%96.281411,09650.0%66.7%
33.33%96.885511,75450.0%20.0%
66.67%96.578212,16033.3%83.3%
22.22%92.55189,7830.0%40.0%
85.71%77.71,15311,498100.0%66.7%
71.43%76.482813,449100.0%66.7%
57.14%77.384211,22350.0%66.7%
100.00%78.28329,161100.0%100.0%
57.14%72.986810,35560.0%50.0%
42.86%77.48559,99550.0%33.3%
57.14%77.080513,44150.0%66.7%
50.00%66.469210,47333.3%66.7%
33.33%66.78659,25050.0%0.0%
50.00%65.784212,7490.0%50.0%
80.00%56.88199,894100.0%66.7%
60.00%57.671711,88250.0%66.7%
60.00%57.593814,8270.0%75.0%
40.00%52.155411,1230.0%40.0%
60.00%56.576611,909100.0%50.0%
40.00%56.95498,21433.3%50.0%
80.00%53.669512,683100.0%50.0%
60.00%52.24318,35366.7%50.0%
60.00%57.51,17014,036100.0%33.3%
40.00%55.596514,4230.0%40.0%
80.00%57.31,24116,644100.0%75.0%
80.00%56.388712,12650.0%100.0%
60.00%56.074710,44750.0%100.0%
20.00%56.67479,3500.0%33.3%

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Lissandra vs Seraphine - Frequently Asked Questions

How does Lissandra do against Seraphine in League of Legends?

Lissandra wins the Lissandra vs Seraphine matchup with a 50.0% win rate compared to Seraphine's 50.0%, a 0.0 percentage point difference. This data is based on 14 recent ranked games in patch 26.11.

How does Lissandra do against Seraphine in the early game?

In the early game, Lissandra has the advantage against Seraphine with a 50.0% win rate versus 50.0%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Seraphine in the late game?

In the late game, Lissandra takes over the Lissandra vs Seraphine matchup with a 50.0% win rate compared to 50.0%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Seraphine matchup?

Lissandra wins the matchup against Seraphine with a 50.0% win rate in League of Legends patch 26.11. The 0.0 percentage point advantage means Lissandra is slightly favored in this lane matchup based on 14 games analyzed.

What is the best Lissandra build against Seraphine?

The best Lissandra build against Seraphine includes Luden's Echo, Liandry's Torment, Zhonya's Hourglass with Sorcerer's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Seraphine?

The best Lissandra runes against Seraphine use the Sorcery primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Seraphine?

Yes, Lissandra has a favorable matchup against Seraphine with a 50.0% win rate. Lissandra slightly edges out Seraphine in lane based on current patch 26.11 data.

How do I play Lissandra against Seraphine?

When playing Lissandra against Seraphine, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.