Seraphine - League of Legends Champion
Win Rate
50.9%
Pick Rate
4.9%

Seraphinevs Lissandra

ASupportMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 20, 2026
MethodologyData Methodology

Seraphine vs Lissandra is a decisive matchup in LoL patch 26.7. Seraphine wins with a 80.0% win rate (+60.0%) over Lissandra based on 5 games. Seraphine holds the advantage in both the early and late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Lissandra matchup.

Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 80.0% win rateLissandra(80.0%)
Seraphine - 80.0% win rate in this matchup
Seraphine
80.0% WR
VS
Lissandra vs Seraphine matchup - 20.0% win rate
Lissandra
20.0% WR

Who Wins the Seraphine vs Lissandra Matchup?

Seraphine wins the Seraphine vs Lissandra matchup
Winner
Seraphine
Matches: 5
80.0%
Win Rate
20.0%
4.6
CS / min
5.0
779
DMG / min
597
10,157
Gold / game
8,214
202
Heal / min
65
277
DMG Mitigated / min
356
1.1
CC / min
1.4
75.0%
Early Game WR
25.0%
100.0%
Late Game WR
0.0%

Seraphine vs Lissandra Matchup Summary

The Seraphine vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Seraphine wins with a 80.0% win rate compared to Lissandra's 20.0%, giving Seraphine a 60.0 percentage point advantage. Seraphine dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in damage output, where Seraphine leads by 183 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine players can confidently pick into Lissandra and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Lissandra away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Lissandra Laning Phase Breakdown

Seraphine wins the laning phase against Lissandra in League of Legends

Seraphine is favored during the laning phase against Lissandra, winning 3 out of 5 key stat categories. Seraphine holds advantages in damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
4.6Seraphine
5.0Lissandra
Lissandra edges out Seraphine by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 6 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
779Seraphine
597Lissandra
Seraphine heavily out-damages Lissandra by 183 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Seraphine's sustained damage advantage take over.
Economy
10,157Seraphine
8,214Lissandra
Seraphine generates a commanding 1,943 more gold per game than Lissandra. This substantial economic advantage means Seraphine consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Lissandra should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.1Seraphine
1.4Lissandra
Both Seraphine and Lissandra provide similar amounts of crowd control (0.3s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
478Seraphine
421Lissandra
Seraphine heals and mitigates 57 more damage per minute than Lissandra, providing moderate extra durability. This sustain edge allows Seraphine to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Lissandra.

Best Seraphine Build Against Lissandra

Spellslinger's Shoes is the optimal boots choice against Lissandra, providing the mobility and stats Seraphine needs most in this matchup. The top-performing core items for Seraphine against Lissandra are Luden's Echo, Shadowflame and Malignance. This combination gives Seraphine an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Seraphine vs Lissandra matchup.

Early Game vs Late Game

Early Game
Seraphine
75.0%
+50.0% advantage
Seraphine early game win rateSeraphine75.0%
Lissandra early game win rateLissandra25.0%
Late Game
Seraphine
100.0%
+100.0% advantage
Seraphine late game win rateSeraphine100.0%
Lissandra late game win rateLissandra0.0%

Seraphine dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Lissandra. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Seraphine is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Lissandra. Extended games heavily favor Seraphine, whose kit and scaling make them a dominant force in team fights and objective control.

Seraphine holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Seraphine Runes Against Lissandra

Domination rune tree - Seraphine primary runes vs LissandraDomination
Electrocute - best Seraphine rune vs LissandraCheap Shot - best Seraphine rune vs LissandraGrisly Mementos - best Seraphine rune vs LissandraUltimate Hunter - best Seraphine rune vs Lissandra
Precision rune tree - Seraphine secondary runes vs LissandraPrecision
Presence of Mind - best Seraphine rune vs LissandraCoup de Grace - best Seraphine rune vs Lissandra
100.0% WR

Running Domination primary with Precision secondary allows Seraphine to press their advantage against Lissandra, amplifying the strengths that make this a favorable matchup.


Seraphine matchup data for League of Legends patch 26.7. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
54.18%2991.64439,72745.0%59.6%
44.49%2631.34388,73041.4%48.0%
53.94%2411.34619,24352.6%55.2%
53.01%1831.44589,30748.8%56.4%
53.59%1811.44469,09849.4%57.5%
53.66%1641.44779,15159.3%48.2%
51.57%1591.54879,18454.3%49.4%
56.96%1581.44609,12365.1%51.6%
51.45%1381.44108,92450.8%52.1%
57.58%1321.44559,01657.4%57.8%
44.44%1261.34078,50942.9%46.0%
48.72%1171.655210,13343.2%51.3%
55.17%1161.54939,75339.1%65.7%
48.28%1161.754110,06752.2%45.7%
54.29%1051.34268,52558.2%50.0%
47.57%1031.54449,60136.6%54.8%
53.92%1021.44648,93753.9%54.0%
50.50%1011.43578,58654.9%46.0%
65.31%982.04699,74265.0%65.5%
51.11%901.45449,00546.1%54.9%
60.67%891.45258,87651.2%69.6%
48.05%771.64329,06447.1%48.8%
48.48%661.64499,83052.0%46.3%
56.06%661.446210,05756.0%56.1%
59.09%661.34709,19553.3%63.9%
51.52%661.45339,38642.9%57.9%
50.00%561.34318,78350.0%50.0%
50.91%555.059410,15445.7%60.0%
61.11%541.45039,73561.1%61.1%
45.10%511.45549,19748.0%42.3%
56.00%501.64589,66571.4%44.8%
68.09%471.34338,79683.3%52.2%
41.30%461.44408,44340.7%42.1%
55.26%386.575312,73061.1%50.0%
41.67%361.55229,34566.7%23.8%
45.71%351.45389,51041.2%50.0%
51.43%356.577612,68062.5%42.1%
41.18%341.95239,70342.9%40.0%
62.50%324.466312,14861.5%63.2%
61.54%261.45069,89770.0%56.3%
57.69%265.866912,09666.7%50.0%
72.00%253.654911,21477.8%68.8%
47.83%231.34387,54662.5%14.3%
39.13%231.34279,80042.9%37.5%
45.45%225.768813,31257.1%40.0%
42.86%212.04569,77930.0%54.5%
60.00%206.873212,63062.5%58.3%
68.42%192.25288,37271.4%60.0%
52.63%194.566310,72362.5%45.5%
77.78%185.262111,90780.0%75.0%
50.00%182.23929,53214.3%72.7%
17.65%171.95419,5550.0%30.0%
68.75%166.175711,132100.0%44.4%
56.25%165.061711,17950.0%58.3%
37.50%161.44408,74328.6%44.4%
40.00%155.879112,89180.0%20.0%
53.33%152.65158,83558.3%33.3%
60.00%156.969012,35375.0%42.9%
57.14%141.65038,97662.5%50.0%
50.00%126.066912,17266.7%33.3%
58.33%121.95109,80057.1%60.0%
41.67%124.362911,9680.0%50.0%
50.00%125.572511,57837.5%75.0%
45.45%111.83348,40757.1%25.0%
45.45%111.448611,0260.0%50.0%
20.00%101.94449,6570.0%40.0%
30.00%106.083411,91850.0%16.7%
66.67%95.04869,88271.4%50.0%
66.67%96.791812,31350.0%100.0%
44.44%91.652310,69633.3%50.0%
66.67%95.06849,58460.0%75.0%
55.56%95.878611,74075.0%40.0%
62.50%86.375213,234100.0%50.0%
62.50%84.164710,851100.0%0.0%
62.50%86.072611,59850.0%75.0%
50.00%81.63948,88825.0%75.0%
50.00%82.659011,57450.0%50.0%
37.50%84.34689,60866.7%20.0%
50.00%86.075212,12750.0%50.0%
75.00%81.84619,71750.0%100.0%
50.00%84.75939,70720.0%100.0%
28.57%71.54699,3480.0%50.0%
57.14%72.24578,64566.7%50.0%
85.71%71.55068,91275.0%100.0%
42.86%71.44499,4630.0%60.0%
50.00%63.866510,38850.0%50.0%
50.00%61.253910,07150.0%50.0%
50.00%62.45769,27866.7%33.3%
50.00%65.060611,31766.7%33.3%
40.00%56.077711,01533.3%50.0%
20.00%55.151210,8920.0%25.0%
60.00%55.872310,033100.0%50.0%
20.00%51.43949,2580.0%33.3%
80.00%54.677910,15775.0%100.0%
40.00%52.76589,47233.3%50.0%

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Seraphine vs Lissandra - Frequently Asked Questions

How does Seraphine do against Lissandra in League of Legends?

Seraphine wins the Seraphine vs Lissandra matchup with a 80.0% win rate compared to Lissandra's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.7.

How does Seraphine do against Lissandra in the early game?

In the early game, Seraphine has the advantage against Lissandra with a 75.0% win rate versus 25.0%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Lissandra in the late game?

In the late game, Seraphine takes over the Seraphine vs Lissandra matchup with a 100.0% win rate compared to 0.0%. Seraphine scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Lissandra matchup?

Seraphine wins the matchup against Lissandra with a 80.0% win rate in League of Legends patch 26.7. The 60.0 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Seraphine build against Lissandra?

The best Seraphine build against Lissandra includes Luden's Echo, Shadowflame, Malignance with Spellslinger's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Lissandra?

The best Seraphine runes against Lissandra use the Domination primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Seraphine vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Lissandra?

Yes, Seraphine has a favorable matchup against Lissandra with a 80.0% win rate. Seraphine strongly counters Lissandra in lane based on current patch 26.7 data.

How do I play Seraphine against Lissandra?

When playing Seraphine against Lissandra, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.