Seraphine - League of Legends Champion
Win Rate
52.4%
Pick Rate
10.2%

Seraphinevs Lissandra

SSupportMage
Patch26.14
Matches491,560
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 25, 2026
MethodologyData Methodology

Seraphine vs Lissandra is a decisive matchup in LoL patch 26.14. Seraphine wins with a 53.9% win rate (+7.7%) over Lissandra based on 13 games. Seraphine holds the advantage in both the early and late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Lissandra matchup.

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Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Seraphine - 53.9% win rate in this matchup
Seraphine
53.9% WR
VS
Lissandra vs Seraphine matchup - 46.1% win rate
Lissandra
46.1% WR

Who Wins the Seraphine vs Lissandra Matchup?

Seraphine wins the Seraphine vs Lissandra matchup
Winner
Seraphine
Matches: 13
53.9%
Win Rate
46.1%
3.3
CS / min
4.1
645
DMG / min
712
9,246
Gold / game
9,629
259
Heal / min
149
377
DMG Mitigated / min
396
1.4
CC / min
1.8
57.1%
Early Game WR
42.9%
50.0%
Late Game WR
50.0%

Seraphine vs Lissandra Matchup Summary

The Seraphine vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 13 recent matches analyzed, Seraphine wins with a 53.9% win rate compared to Lissandra's 46.1%, giving Seraphine a 7.7 percentage point advantage. Seraphine dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in CS, where Lissandra leads by 0.8 CS/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine players can confidently pick into Lissandra and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Lissandra away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Lissandra Laning Phase Breakdown

Lissandra wins the laning phase against Seraphine in League of Legends

Lissandra is favored during the laning phase against Seraphine, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
3.3Seraphine
4.1Lissandra
Lissandra significantly out-farms Seraphine by 0.8 CS per minute, accumulating an estimated 13 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Seraphine players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
645Seraphine
712Lissandra
Lissandra deals 67 more champion damage per minute than Seraphine. While noticeable in extended trades, this gap can be offset by Seraphine choosing favorable fight windows, such as engaging when Lissandra's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
9,246Seraphine
9,629Lissandra
Lissandra earns 383 more gold per game than Seraphine, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Lissandra slightly faster item completions.
Utility
1.4Seraphine
1.8Lissandra
Lissandra provides 0.3 seconds more crowd control per minute than Seraphine, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
636Seraphine
545Lissandra
Seraphine heals and mitigates 91 more damage per minute than Lissandra, providing moderate extra durability. This sustain edge allows Seraphine to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Lissandra.

Best Seraphine Build Against Lissandra

Ionian Boots of Lucidity is the optimal boots choice against Lissandra, providing the mobility and stats Seraphine needs most in this matchup. The top-performing core items for Seraphine against Lissandra are Moonstone Renewer, Imperial Mandate and Diadem of Songs. This combination gives Seraphine an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Seraphine vs Lissandra matchup.

Early Game vs Late Game

Early Game
Seraphine
57.1%
+14.3% advantage
Seraphine early game win rateSeraphine57.1%
Lissandra early game win rateLissandra42.9%
Late Game
Seraphine
50.0%
+0.0% advantage
Seraphine late game win rateSeraphine50.0%
Lissandra late game win rateLissandra50.0%

Seraphine dominates the early game (first 15 minutes) with a commanding 57.1% win rate — a 14.3 percentage point lead over Lissandra. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Seraphine at 50.0% win rate — only 0.0 points ahead of Lissandra. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

Seraphine holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Seraphine Runes Against Lissandra

Sorcery rune tree - Seraphine primary runes vs LissandraSorcery
Arcane Comet - best Seraphine rune vs LissandraManaflow Band - best Seraphine rune vs LissandraTranscendence - best Seraphine rune vs LissandraScorch - best Seraphine rune vs Lissandra
Inspiration rune tree - Seraphine secondary runes vs LissandraInspiration
Biscuit Delivery - best Seraphine rune vs LissandraCosmic Insight - best Seraphine rune vs Lissandra
50.0% WR

Running Sorcery primary with Inspiration secondary allows Seraphine to press their advantage against Lissandra, amplifying the strengths that make this a favorable matchup.


Seraphine matchup data for League of Legends patch 26.14. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
53.16%7111.74819,36751.5%54.1%
51.75%4291.55108,83357.1%48.3%
54.52%3981.55039,13350.3%57.6%
48.02%3791.44838,49549.1%47.1%
51.34%3721.64948,76049.7%52.5%
45.48%3541.55209,36553.0%40.9%
51.52%3301.95329,62049.6%52.7%
50.55%2731.54919,35246.5%52.9%
47.43%2531.44388,72453.5%43.5%
51.25%2401.55148,99259.8%44.9%
51.27%2361.44739,16655.6%48.6%
52.99%2341.85839,26944.9%58.8%
46.78%2331.55058,55244.9%48.4%
56.71%2312.35169,48657.0%56.6%
52.38%2101.44748,93357.8%48.8%
51.91%1831.44858,32454.5%50.0%
55.87%1791.53958,91064.0%50.0%
53.07%1795.374111,32450.0%54.8%
50.85%1771.85199,28153.6%49.1%
56.02%1661.55099,26754.0%57.6%
52.47%1625.976711,10365.7%43.2%
51.59%1571.64759,65261.7%47.3%
46.45%1551.66288,48848.0%45.1%
48.37%1531.64749,70351.2%47.3%
50.66%1521.55259,12259.6%45.3%
54.86%1441.44909,33253.6%55.7%
49.28%1381.94979,05744.2%52.3%
55.38%1301.44948,78550.0%58.8%
58.97%1171.44908,67664.0%55.2%
55.65%1151.45379,04852.2%58.0%
59.29%1131.45038,43250.0%66.2%
52.43%1031.45099,35760.0%47.6%
53.92%1024.166410,30653.9%54.0%
54.55%995.977610,62646.1%63.8%
58.06%931.64999,18554.3%60.3%
57.30%891.44918,64361.4%53.3%
63.86%836.084311,78848.6%75.0%
53.25%775.773910,90155.9%51.2%
45.21%731.94539,31152.2%42.0%
36.11%721.54988,98133.3%38.1%
57.14%701.45179,16655.6%58.1%
61.54%656.078011,06369.0%55.6%
50.00%643.86639,74768.2%40.5%
61.90%634.868910,47463.0%61.1%
47.54%612.761610,42127.3%59.0%
48.21%566.078511,47145.8%50.0%
59.62%526.181612,18757.1%61.3%
54.00%501.45608,84660.9%48.1%
48.94%471.84949,58942.9%53.9%
43.48%461.54339,57246.1%42.4%
57.78%455.372012,60925.0%64.9%
54.55%446.367711,99735.3%66.7%
61.36%441.55258,98750.0%67.9%
57.14%422.54878,58155.6%58.3%
60.98%412.15749,53475.0%52.0%
53.66%416.483312,18466.7%43.5%
55.00%401.54869,06552.9%56.5%
50.00%365.976411,05156.3%45.0%
50.00%346.183611,75042.9%55.0%
36.36%331.53968,95946.1%30.0%
66.67%335.364811,49190.9%54.5%
54.84%316.183810,19170.6%35.7%
53.57%286.580512,36836.4%64.7%
42.86%286.280112,68940.0%44.4%
40.00%255.362911,18522.2%50.0%
64.00%252.36789,31844.4%75.0%
66.67%241.34418,16983.3%50.0%
30.43%234.16229,77136.4%25.0%
54.55%225.576911,54555.6%53.9%
65.00%205.462410,76455.6%72.7%
42.11%191.75298,46820.0%66.7%
73.68%193.95989,82285.7%66.7%
58.82%171.655210,13840.0%66.7%
35.29%173.258910,24028.6%40.0%
37.50%163.75519,69033.3%40.0%
68.75%165.873111,38350.0%80.0%
31.25%164.771510,51042.9%22.2%
43.75%166.477210,43645.5%40.0%
40.00%154.44959,89250.0%36.4%
66.67%155.878113,250100.0%50.0%
66.67%152.74889,77166.7%66.7%
42.86%142.26418,95728.6%57.1%
69.23%134.356610,34966.7%71.4%
53.85%133.57288,31450.0%57.1%
46.15%133.15299,02050.0%44.4%
53.85%133.36459,24657.1%50.0%
66.67%122.057810,201100.0%55.6%
58.33%127.083213,37480.0%42.9%
66.67%122.153210,54566.7%66.7%
58.33%121.13417,53971.4%40.0%
45.45%114.96859,29462.5%0.0%
54.55%111.64597,06766.7%40.0%
54.55%113.460410,17460.0%50.0%
45.45%114.96329,44228.6%75.0%
72.73%116.378413,52975.0%71.4%
50.00%105.182912,07833.3%57.1%
70.00%104.26128,41357.1%100.0%
80.00%105.395111,600100.0%71.4%
60.00%101.55159,32450.0%62.5%
33.33%95.666611,01725.0%40.0%
44.44%93.167310,88450.0%40.0%
22.22%95.374911,2480.0%28.6%
37.50%83.170511,06950.0%33.3%
62.50%82.047510,68250.0%75.0%
50.00%81.95667,68550.0%50.0%
75.00%85.895811,97766.7%80.0%
57.14%73.050210,97250.0%60.0%
100.00%71.958610,112100.0%100.0%
100.00%72.56609,161100.0%100.0%
83.33%61.54667,90050.0%100.0%
66.67%62.069710,723100.0%33.3%
66.67%62.855510,27950.0%75.0%
33.33%65.071411,4970.0%40.0%
50.00%65.962611,0990.0%75.0%
50.00%61.36056,62633.3%66.7%
33.33%63.263711,14750.0%25.0%
40.00%51.95389,8290.0%50.0%
40.00%54.372312,2080.0%50.0%
40.00%51.132610,5150.0%40.0%
40.00%54.15138,25733.3%50.0%
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Seraphine vs Lissandra - Frequently Asked Questions

How does Seraphine do against Lissandra in League of Legends?

Seraphine wins the Seraphine vs Lissandra matchup with a 53.9% win rate compared to Lissandra's 46.1%, a 7.7 percentage point difference. This data is based on 13 recent ranked games in patch 26.14.

How does Seraphine do against Lissandra in the early game?

In the early game, Seraphine has the advantage against Lissandra with a 57.1% win rate versus 42.9%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Lissandra in the late game?

In the late game, Seraphine takes over the Seraphine vs Lissandra matchup with a 50.0% win rate compared to 50.0%. Seraphine scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Lissandra matchup?

Seraphine wins the matchup against Lissandra with a 53.9% win rate in League of Legends patch 26.14. The 7.7 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 13 games analyzed.

What is the best Seraphine build against Lissandra?

The best Seraphine build against Lissandra includes Moonstone Renewer, Imperial Mandate, Diadem of Songs with Ionian Boots of Lucidity. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Lissandra?

The best Seraphine runes against Lissandra use the Sorcery primary tree with Inspiration secondary. This rune setup achieves a 50.0% win rate in the Seraphine vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Lissandra?

Yes, Seraphine has a favorable matchup against Lissandra with a 53.9% win rate. Seraphine strongly counters Lissandra in lane based on current patch 26.14 data.

How do I play Seraphine against Lissandra?

When playing Seraphine against Lissandra, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.