Seraphine - League of Legends Champion
Win Rate
52.1%
Pick Rate
7.6%

Seraphinevs Lissandra

SSupportMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 10, 2026
MethodologyData Methodology

Seraphine vs Lissandra is a very close matchup in LoL patch 26.11. Seraphine wins with a 50.0% win rate (+0.0%) over Lissandra based on 14 games. Seraphine holds the advantage in both the early and late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Lissandra matchup.

MetaBot Desktop
Live In-Game Overlays
Join Our Discord
Bug reports, feature requests & developer chat
Join Discord

Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Seraphine - 50.0% win rate in this matchup
Seraphine
50.0% WR
VS
Lissandra vs Seraphine matchup - 50.0% win rate
Lissandra
50.0% WR

Who Wins the Seraphine vs Lissandra Matchup?

Seraphine wins the Seraphine vs Lissandra matchup
Winner
Seraphine
Matches: 14
50.0%
Win Rate
50.0%
2.6
CS / min
4.2
551
DMG / min
549
9,742
Gold / game
10,943
226
Heal / min
128
402
DMG Mitigated / min
426
1.1
CC / min
1.4
50.0%
Early Game WR
50.0%
50.0%
Late Game WR
50.0%

Seraphine vs Lissandra Matchup Summary

The Seraphine vs Lissandra matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 14 recent matches analyzed, Seraphine wins with a 50.0% win rate compared to Lissandra's 50.0%, giving Seraphine a 0.0 percentage point advantage. Seraphine holds a slight edge in both the early and late game, but the margins are thin enough that individual skill and jungle attention will often determine the outcome. Lissandra can still find windows through outplays and team coordination. The most significant statistical gap is in CS, where Lissandra leads by 1.6 CS/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine has a statistical edge, but the margin is close enough that respecting Lissandra's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Lissandra Laning Phase Breakdown

Lissandra wins the laning phase against Seraphine in League of Legends

Lissandra is favored during the laning phase against Seraphine, winning 3 out of 5 key stat categories. Lissandra holds advantages in farming, gold income and crowd control, making them the stronger laner in this matchup.

Farming
2.6Seraphine
4.2Lissandra
Lissandra significantly out-farms Seraphine by 1.6 CS per minute, accumulating an estimated 23 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Seraphine players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
551Seraphine
549Lissandra
Damage output is virtually even between Seraphine and Lissandra, with only 2 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
9,742Seraphine
10,943Lissandra
Lissandra generates a commanding 1,201 more gold per game than Seraphine. This substantial economic advantage means Lissandra consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Seraphine should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.1Seraphine
1.4Lissandra
Lissandra provides 0.3 seconds more crowd control per minute than Seraphine, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
628Seraphine
554Lissandra
Seraphine heals and mitigates 74 more damage per minute than Lissandra, providing moderate extra durability. This sustain edge allows Seraphine to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Lissandra.

Best Seraphine Build Against Lissandra

Ionian Boots of Lucidity is the optimal boots choice against Lissandra, providing the mobility and stats Seraphine needs most in this matchup. The top-performing core items for Seraphine against Lissandra are Malignance, Rylai's Crystal Scepter and Diadem of Songs. This combination gives Seraphine an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Seraphine vs Lissandra matchup.

Early Game vs Late Game

Early Game
Seraphine
50.0%
+0.0% advantage
Seraphine early game win rateSeraphine50.0%
Lissandra early game win rateLissandra50.0%
Late Game
Seraphine
50.0%
+0.0% advantage
Seraphine late game win rateSeraphine50.0%
Lissandra late game win rateLissandra50.0%

The early game (first 15 minutes) is a toss-up between Seraphine and Lissandra, with Seraphine holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Late game (25+ minutes) is equally balanced, with Seraphine at 50.0% win rate — only 0.0 points ahead of Lissandra. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

This matchup is remarkably even at every stage of the game. Neither Seraphine nor Lissandra has a phase-specific advantage, making this a pure skill matchup where individual mechanics, decision-making, and team coordination determine the outcome.

Best Seraphine Runes Against Lissandra

Sorcery rune tree - Seraphine primary runes vs LissandraSorcery
Stormraider's Surge - best Seraphine rune vs LissandraManaflow Band - best Seraphine rune vs LissandraTranscendence - best Seraphine rune vs LissandraScorch - best Seraphine rune vs Lissandra
Precision rune tree - Seraphine secondary runes vs LissandraPrecision
Presence of Mind - best Seraphine rune vs LissandraLegend: Haste - best Seraphine rune vs Lissandra
100.0% WR

The Sorcery primary with Precision secondary combination helps Seraphine maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Lissandra.


Seraphine matchup data for League of Legends patch 26.11. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
47.75%7791.74669,35944.9%49.5%
50.91%5501.44939,17358.0%45.0%
49.45%5481.44879,00751.2%48.0%
50.83%5431.44879,19746.8%53.9%
52.69%5011.54979,35248.8%55.5%
50.21%4781.85269,25551.6%49.0%
48.69%4211.54709,01249.2%48.3%
50.00%3341.44539,01050.4%49.7%
50.91%3301.95249,71553.4%49.2%
51.72%3191.44699,56046.7%55.4%
52.44%3071.44938,93052.7%52.2%
53.17%2841.74839,53147.7%56.6%
52.84%2821.44878,90149.2%55.8%
50.78%2581.54449,24750.5%51.0%
47.97%2461.54669,32744.7%50.4%
54.85%2371.85849,76454.8%54.9%
54.85%2371.44528,96551.9%57.4%
53.07%2281.53918,66358.8%46.8%
54.63%2271.84989,66455.6%54.0%
43.13%2111.35028,90135.6%48.8%
52.22%2031.45229,03758.4%47.4%
43.22%1991.54988,96147.1%40.4%
48.44%1921.44979,41851.2%46.3%
53.45%1741.84629,23249.4%56.7%
49.70%1691.66149,70344.4%52.2%
52.26%1551.44799,11856.9%48.2%
57.53%1461.45699,69067.9%51.1%
54.48%1454.566211,52162.3%50.0%
52.52%1391.44899,05164.1%42.7%
61.29%1241.64819,07567.7%54.8%
50.00%1221.44628,51250.8%49.1%
50.00%1201.45089,23252.8%47.8%
51.30%1151.44638,90542.2%57.1%
59.13%1156.281412,23054.7%62.9%
53.49%861.54809,03567.5%41.3%
54.88%825.867711,89860.0%51.9%
61.25%804.878912,00275.9%52.9%
56.76%746.880712,47863.9%50.0%
53.42%732.05109,99152.0%54.2%
56.16%731.55149,44956.8%55.6%
46.88%641.54679,51052.0%43.6%
43.33%601.65579,12160.7%28.1%
48.33%602.14408,59548.3%48.4%
54.24%596.283112,84042.1%60.0%
54.24%593.359210,05860.9%50.0%
60.34%585.375111,90651.9%67.7%
63.16%572.056710,73279.0%55.3%
44.23%521.75759,42052.0%37.0%
51.06%472.04629,10847.6%53.9%
50.00%402.260810,02652.6%47.6%
56.76%376.389112,39562.5%52.4%
44.44%362.55159,08730.8%52.2%
60.61%334.259811,53455.6%62.5%
51.52%335.366611,60061.5%45.0%
42.42%336.281310,73542.1%42.9%
51.52%336.878711,42658.8%43.8%
65.63%321.64749,16373.3%58.8%
65.63%324.168110,15666.7%64.7%
58.06%311.64859,79966.7%52.6%
56.67%306.673310,93362.5%50.0%
41.38%291.45019,36630.8%50.0%
44.44%275.167710,72263.6%31.3%
62.96%271.649810,32862.5%63.2%
54.17%244.26249,65645.5%61.5%
50.00%222.45679,74940.0%58.3%
45.45%223.04909,41825.0%57.1%
63.64%222.250811,56760.0%64.7%
40.00%206.580113,55633.3%41.2%
55.00%206.779212,47966.7%45.5%
55.00%202.04629,45857.1%53.9%
45.00%205.871411,07240.0%50.0%
70.00%201.464510,69887.5%58.3%
63.16%191.443410,16060.0%64.3%
61.11%185.67038,05964.3%50.0%
58.82%176.286512,02650.0%63.6%
35.29%171.244610,23775.0%23.1%
75.00%166.791813,62771.4%77.8%
37.50%161.54798,92840.0%36.4%
60.00%156.776112,98866.7%55.6%
40.00%155.359710,54633.3%44.4%
60.00%151.646310,50775.0%54.5%
50.00%143.264710,32850.0%50.0%
50.00%142.65519,74250.0%50.0%
42.86%144.85849,77450.0%37.5%
53.85%136.392112,20066.7%42.9%
30.77%134.16039,87733.3%28.6%
61.54%133.15949,46842.9%83.3%
58.33%126.78259,19670.0%0.0%
50.00%124.36669,42433.3%66.7%
58.33%126.076411,19160.0%57.1%
72.73%116.175811,907100.0%66.7%
27.27%114.55499,3630.0%50.0%
54.55%116.266011,06050.0%60.0%
60.00%105.680311,24250.0%75.0%
80.00%101.44777,16187.5%50.0%
66.67%94.552110,244100.0%62.5%
44.44%91.84238,69366.7%33.3%
37.50%86.293011,95740.0%33.3%
62.50%81.66239,74233.3%80.0%
37.50%81.53958,01025.0%50.0%
37.50%81.34679,59625.0%50.0%
25.00%85.367010,06850.0%16.7%
25.00%83.45779,67325.0%25.0%
62.50%81.457011,7740.0%71.4%
75.00%85.470711,28850.0%83.3%
50.00%81.14638,69050.0%50.0%
50.00%86.298713,25366.7%40.0%
75.00%81.648710,73550.0%83.3%
85.71%71.45378,417100.0%0.0%
42.86%71.949210,03133.3%50.0%
71.43%73.163510,657100.0%60.0%
57.14%73.473912,184100.0%50.0%
100.00%73.15957,466100.0%100.0%
71.43%73.05208,01175.0%66.7%
33.33%67.382210,97625.0%50.0%
100.00%62.35489,903100.0%100.0%
83.33%62.247410,918100.0%80.0%
50.00%61.63829,86350.0%50.0%
100.00%55.957011,5490.0%100.0%
40.00%51.649610,44750.0%33.3%
60.00%51.256510,3000.0%75.0%
40.00%56.06469,77425.0%100.0%
40.00%53.864610,54966.7%0.0%
80.00%51.549910,15550.0%100.0%

Get the MetaBot Desktop App

Level up your gameplay with real-time overlays, automatic game detection, and instant stats — all on your desktop.

In-game overlaysAuto game detectionMulti-game supportPersonal dashboard
Download NowFree download
🔍

Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.

Report an Issue

Seraphine vs Lissandra - Frequently Asked Questions

How does Seraphine do against Lissandra in League of Legends?

Seraphine wins the Seraphine vs Lissandra matchup with a 50.0% win rate compared to Lissandra's 50.0%, a 0.0 percentage point difference. This data is based on 14 recent ranked games in patch 26.11.

How does Seraphine do against Lissandra in the early game?

In the early game, Seraphine has the advantage against Lissandra with a 50.0% win rate versus 50.0%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Lissandra in the late game?

In the late game, Seraphine takes over the Seraphine vs Lissandra matchup with a 50.0% win rate compared to 50.0%. Seraphine scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Lissandra matchup?

Seraphine wins the matchup against Lissandra with a 50.0% win rate in League of Legends patch 26.11. The 0.0 percentage point advantage means Seraphine is slightly favored in this lane matchup based on 14 games analyzed.

What is the best Seraphine build against Lissandra?

The best Seraphine build against Lissandra includes Malignance, Rylai's Crystal Scepter, Diadem of Songs with Ionian Boots of Lucidity. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Lissandra?

The best Seraphine runes against Lissandra use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Seraphine vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Lissandra?

Yes, Seraphine has a favorable matchup against Lissandra with a 50.0% win rate. Seraphine slightly edges out Lissandra in lane based on current patch 26.11 data.

How do I play Seraphine against Lissandra?

When playing Seraphine against Lissandra, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.