Lissandra - League of Legends Champion
Win Rate
51.3%
Pick Rate
2.2%

Lissandravs Zoe

AMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 22, 2026
MethodologyData Methodology

Lissandra vs Zoe is a decisive matchup in LoL patch 26.7. Lissandra wins with a 64.0% win rate (+28.0%) over Zoe based on 25 games. Lissandra holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Zoe matchup.

Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Zoe - 64.0% win rateZoe(64.0%)
Lissandra - 64.0% win rate in this matchup
Lissandra
64.0% WR
VS
Zoe vs Lissandra matchup - 36.0% win rate
Zoe
36.0% WR

Who Wins the Lissandra vs Zoe Matchup?

Lissandra wins the Lissandra vs Zoe matchup
Winner
Lissandra
Matches: 25
64.0%
Win Rate
36.0%
6.6
CS / min
6.2
805
DMG / min
956
11,124
Gold / game
10,910
167
Heal / min
98
394
DMG Mitigated / min
311
1.5
CC / min
1.2
50.0%
Early Game WR
50.0%
73.3%
Late Game WR
26.7%

Lissandra vs Zoe Matchup Summary

The Lissandra vs Zoe matchup is a decisive matchup in League of Legends ranked play. Based on 25 recent matches analyzed, Lissandra wins with a 64.0% win rate compared to Zoe's 36.0%, giving Lissandra a 28.0 percentage point advantage. Lissandra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Zoe players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Lissandra leads by 153 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra players can confidently pick into Zoe and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Zoe away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Zoe Laning Phase Breakdown

Lissandra wins the laning phase against Zoe in League of Legends

Lissandra is favored during the laning phase against Zoe, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.6Lissandra
6.2Zoe
Lissandra edges out Zoe by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 6 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
805Lissandra
956Zoe
Zoe heavily out-damages Lissandra by 152 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zoe's sustained damage advantage take over.
Economy
11,124Lissandra
10,910Zoe
Lissandra and Zoe generate nearly equal gold per game, with just a 213 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.5Lissandra
1.2Zoe
Lissandra provides 0.3 seconds more crowd control per minute than Zoe, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
561Lissandra
408Zoe
Lissandra vastly out-sustains Zoe, healing and mitigating 153 more damage per minute. This massive durability gap means Lissandra can absorb significant punishment and remain in lane while Zoe is forced to recall. Building grievous wounds early is essential for Zoe, and focusing on burst trade patterns rather than sustained fights is critical.

Best Lissandra Build Against Zoe

Spellslinger's Shoes is the optimal boots choice against Zoe, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Zoe are Luden's Echo, Shadowflame and Zhonya's Hourglass. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 2 games — well above average and making it the top item path against Zoe. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Zoe matchup.

Early Game vs Late Game

Early Game
Lissandra
50.0%
+0.0% advantage
Lissandra early game win rateLissandra50.0%
Zoe early game win rateZoe50.0%
Late Game
Lissandra
73.3%
+46.7% advantage
Lissandra late game win rateLissandra73.3%
Zoe late game win rateZoe26.7%

The early game (first 15 minutes) is a toss-up between Lissandra and Zoe, with Lissandra holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Lissandra is far superior in the late game (25+ minutes), boasting a 73.3% win rate — 46.7 points above Zoe. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.

Lissandra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Zoe players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Lissandra Runes Against Zoe

Domination rune tree - Lissandra primary runes vs ZoeDomination
Electrocute - best Lissandra rune vs ZoeCheap Shot - best Lissandra rune vs ZoeGrisly Mementos - best Lissandra rune vs ZoeUltimate Hunter - best Lissandra rune vs Zoe
Sorcery rune tree - Lissandra secondary runes vs ZoeSorcery
Manaflow Band - best Lissandra rune vs ZoeTranscendence - best Lissandra rune vs Zoe
83.3% WR

Running Domination primary with Sorcery secondary allows Lissandra to press their advantage against Zoe, amplifying the strengths that make this a favorable matchup.


Lissandra matchup data for League of Legends patch 26.7. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
60.00%1306.883712,37853.6%64.9%
57.52%1136.882011,83565.2%52.2%
50.00%766.890711,85747.2%52.5%
45.95%746.778211,93537.5%52.4%
47.95%736.982512,39648.3%47.7%
52.11%717.081212,61135.7%62.8%
53.62%696.788911,32658.1%50.0%
54.55%666.798912,99555.2%54.0%
50.00%626.990112,04736.7%62.5%
54.10%616.687711,06545.5%64.3%
57.38%616.276711,40053.6%60.6%
34.48%586.766810,83031.4%39.1%
40.00%556.372811,33333.3%45.2%
46.94%496.975711,65340.0%51.7%
50.00%486.776511,97850.0%50.0%
50.00%406.476411,31941.2%56.5%
65.00%407.283311,56863.6%66.7%
56.41%397.084511,79244.4%66.7%
60.00%356.876110,99150.0%70.6%
48.57%356.881511,55440.0%55.0%
36.36%336.784111,39846.7%27.8%
21.21%336.478711,43923.1%20.0%
63.33%307.380811,58476.5%46.1%
62.07%297.188313,06883.3%47.1%
58.62%296.596211,72763.6%55.6%
53.57%286.983410,91262.5%41.7%
46.43%286.68679,78147.1%45.5%
53.57%286.881411,53950.0%56.3%
59.26%277.079712,15157.1%61.5%
69.23%266.586913,22971.4%68.4%
57.69%266.679612,06775.0%42.9%
40.00%257.276711,82854.5%28.6%
64.00%256.680511,12450.0%73.3%
41.67%246.992712,63340.0%42.9%
66.67%247.178811,24454.5%76.9%
73.68%197.196712,77550.0%90.9%
44.44%187.31,06512,47460.0%25.0%
64.71%177.290311,48980.0%42.9%
33.33%156.473710,70622.2%50.0%
57.14%146.289412,26342.9%71.4%
42.86%147.375110,43150.0%25.0%
76.92%136.783113,11175.0%77.8%
38.46%136.082212,47860.0%25.0%
30.77%136.896711,40720.0%37.5%
15.38%136.584811,09216.7%14.3%
45.45%116.480812,11440.0%50.0%
27.27%116.792811,21620.0%33.3%
54.55%116.888611,95450.0%57.1%
40.00%106.882512,83166.7%28.6%
50.00%106.452910,44128.6%100.0%
55.56%96.295114,28150.0%57.1%
88.89%97.280612,70675.0%100.0%
55.56%97.288211,46775.0%40.0%
55.56%95.672312,03950.0%60.0%
55.56%97.786112,78766.7%50.0%
75.00%87.487510,71080.0%66.7%
57.14%77.387510,78575.0%33.3%
42.86%75.873510,32566.7%25.0%
85.71%77.087111,26283.3%100.0%
71.43%76.173511,33280.0%50.0%
50.00%61.761410,6240.0%60.0%
83.33%67.91,14313,99850.0%100.0%
33.33%67.796512,2420.0%66.7%
33.33%66.686711,32825.0%50.0%
50.00%62.45439,94466.7%33.3%
83.33%67.183312,020100.0%80.0%
16.67%67.26078,27816.7%0.0%
60.00%56.01,16411,19766.7%50.0%
40.00%53.07276,78640.0%0.0%
20.00%57.793410,62525.0%0.0%
20.00%55.05978,21425.0%0.0%
40.00%53.45178,76125.0%100.0%
80.00%55.064712,91850.0%100.0%
40.00%56.783411,7270.0%66.7%
60.00%56.077611,837100.0%33.3%
40.00%56.374111,1560.0%50.0%
60.00%56.897912,10050.0%66.7%
80.00%56.51,08510,600100.0%66.7%

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Lissandra vs Zoe - Frequently Asked Questions

How does Lissandra do against Zoe in League of Legends?

Lissandra wins the Lissandra vs Zoe matchup with a 64.0% win rate compared to Zoe's 36.0%, a 28.0 percentage point difference. This data is based on 25 recent ranked games in patch 26.7.

How does Lissandra do against Zoe in the early game?

In the early game, Lissandra has the advantage against Zoe with a 50.0% win rate versus 50.0%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Zoe in the late game?

In the late game, Lissandra takes over the Lissandra vs Zoe matchup with a 73.3% win rate compared to 26.7%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Zoe matchup?

Lissandra wins the matchup against Zoe with a 64.0% win rate in League of Legends patch 26.7. The 28.0 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 25 games analyzed.

What is the best Lissandra build against Zoe?

The best Lissandra build against Zoe includes Luden's Echo, Shadowflame, Zhonya's Hourglass with Spellslinger's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Zoe?

The best Lissandra runes against Zoe use the Domination primary tree with Sorcery secondary. This rune setup achieves a 83.3% win rate in the Lissandra vs Zoe matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Zoe?

Yes, Lissandra has a favorable matchup against Zoe with a 64.0% win rate. Lissandra strongly counters Zoe in lane based on current patch 26.7 data.

How do I play Lissandra against Zoe?

When playing Lissandra against Zoe, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.