Lissandra - League of Legends Champion
Win Rate
51.6%
Pick Rate
1.7%

Lissandravs Zoe

SMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 7, 2026
MethodologyData Methodology

Lissandra vs Zoe is a decisive matchup in LoL patch 26.11. Zoe wins with a 62.5% win rate (+25.0%) over Lissandra based on 24 games. Zoe holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Zoe matchup.

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Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 37.5% win rate in this matchup
Lissandra
37.5% WR
VS
Zoe vs Lissandra matchup - 62.5% win rate
Zoe
62.5% WR

Who Wins the Lissandra vs Zoe Matchup?

Zoe wins the Lissandra vs Zoe matchup
Winner
Zoe
Matches: 24
37.5%
Win Rate
62.5%
6.4
CS / min
6.0
701
DMG / min
1,013
11,947
Gold / game
13,003
154
Heal / min
95
439
DMG Mitigated / min
308
1.4
CC / min
1.3
44.4%
Early Game WR
55.6%
33.3%
Late Game WR
66.7%

Lissandra vs Zoe Matchup Summary

The Lissandra vs Zoe matchup is a decisive matchup in League of Legends ranked play. Based on 24 recent matches analyzed, Zoe wins with a 62.5% win rate compared to Lissandra's 37.5%, giving Zoe a 25.0 percentage point advantage. Zoe dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Lissandra leads by 190 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Zoe has a strong advantage in this matchup. Lissandra players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Zoe overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Zoe Laning Phase Breakdown

Lissandra wins the laning phase against Zoe in League of Legends

Lissandra is favored during the laning phase against Zoe, winning 3 out of 5 key stat categories. Lissandra holds advantages in farming, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.4Lissandra
6.0Zoe
Lissandra edges out Zoe by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
701Lissandra
1,013Zoe
Zoe heavily out-damages Lissandra by 312 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zoe's sustained damage advantage take over.
Economy
11,947Lissandra
13,003Zoe
Zoe generates a commanding 1,056 more gold per game than Lissandra. This substantial economic advantage means Zoe consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Lissandra should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.4Lissandra
1.3Zoe
Both Lissandra and Zoe provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
593Lissandra
403Zoe
Lissandra vastly out-sustains Zoe, healing and mitigating 190 more damage per minute. This massive durability gap means Lissandra can absorb significant punishment and remain in lane while Zoe is forced to recall. Building grievous wounds early is essential for Zoe, and focusing on burst trade patterns rather than sustained fights is critical.

Best Lissandra Build Against Zoe

Spellslinger's Shoes is the optimal boots choice against Zoe, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Zoe are Shadowflame, Zhonya's Hourglass and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build has a 33.3% win rate across 3 games. While the overall matchup may be difficult, this item path gives Lissandra the best chance to compete against Zoe. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Zoe matchup.

Early Game vs Late Game

Early Game
Zoe
55.6%
+11.1% advantage
Lissandra early game win rateLissandra44.4%
Zoe early game win rateZoe55.6%
Late Game
Zoe
66.7%
+33.3% advantage
Lissandra late game win rateLissandra33.3%
Zoe late game win rateZoe66.7%

Zoe dominates the early game (first 15 minutes) with a commanding 55.6% win rate — a 11.1 percentage point lead over Lissandra. This lopsided early game means Zoe can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Zoe is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Lissandra. Extended games heavily favor Zoe, whose kit and scaling make them a dominant force in team fights and objective control.

Zoe holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Lissandra Runes Against Zoe

Sorcery rune tree - Lissandra primary runes vs ZoeSorcery
Arcane Comet - best Lissandra rune vs ZoeManaflow Band - best Lissandra rune vs ZoeTranscendence - best Lissandra rune vs ZoeScorch - best Lissandra rune vs Zoe
Domination rune tree - Lissandra secondary runes vs ZoeDomination
Cheap Shot - best Lissandra rune vs ZoeUltimate Hunter - best Lissandra rune vs Zoe
33.3% WR

The Sorcery and Domination rune setup gives Lissandra the best tools to compete against Zoe in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Lissandra matchup data for League of Legends patch 26.11. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
58.02%1316.885811,86355.0%60.6%
61.60%1256.791812,36268.6%56.8%
54.47%1236.988112,08353.1%55.4%
54.95%1116.874811,41055.8%54.2%
51.52%996.684011,78453.5%50.0%
50.00%986.985712,17845.0%53.5%
55.56%816.992811,72160.5%51.2%
44.74%766.878111,74844.1%45.2%
57.53%736.785911,06161.5%52.9%
52.86%706.487411,10854.3%51.4%
48.53%687.090811,10755.0%39.3%
53.73%676.178010,94653.1%54.3%
48.28%586.778112,35453.9%43.8%
41.07%566.774210,62436.7%46.1%
58.93%566.573210,32060.6%56.5%
53.70%546.488811,71551.9%55.6%
52.08%486.888112,08468.2%38.5%
55.32%476.384311,46055.6%55.2%
51.16%436.883412,58750.0%51.9%
43.59%396.482510,76435.0%52.6%
46.15%396.577310,88341.2%50.0%
39.47%386.680212,13937.5%40.9%
56.76%376.374210,61842.1%72.2%
56.76%376.878712,41658.8%55.0%
56.76%376.880811,53576.9%45.8%
32.43%377.080410,61129.4%35.0%
48.65%377.083812,68066.7%40.0%
33.33%336.992311,15131.3%35.3%
66.67%306.784412,08075.0%61.1%
65.52%296.986511,46770.6%58.3%
53.57%286.785811,89133.3%63.2%
61.54%267.193811,18175.0%40.0%
37.50%246.470111,94744.4%33.3%
58.33%247.382212,59060.0%57.1%
50.00%227.076411,84454.5%45.5%
54.55%226.61,01413,02066.7%50.0%
31.82%226.768410,84522.2%38.5%
33.33%216.874611,90044.4%25.0%
57.14%215.782310,46554.5%60.0%
73.68%196.980510,70775.0%72.7%
57.89%196.985412,58375.0%45.5%
61.11%187.488713,06550.0%70.0%
38.89%187.294812,87866.7%25.0%
58.82%176.51,06612,41342.9%70.0%
62.50%166.268611,07572.7%40.0%
56.25%166.892312,01450.0%57.1%
66.67%156.984213,080100.0%54.5%
64.29%146.190813,43275.0%60.0%
50.00%144.254910,94350.0%50.0%
64.29%146.779211,67883.3%50.0%
57.14%147.01,08911,13070.0%25.0%
53.85%136.693411,37550.0%57.1%
58.33%127.51,05412,44966.7%50.0%
63.64%116.090612,08133.3%100.0%
45.45%115.590412,09425.0%57.1%
63.64%112.682511,48750.0%71.4%
30.00%105.47418,70242.9%0.0%
70.00%107.194411,75183.3%50.0%
70.00%106.21,13613,233100.0%50.0%
50.00%106.889914,6330.0%62.5%
70.00%106.481112,0790.0%87.5%
55.56%96.281411,09650.0%66.7%
33.33%96.885511,75450.0%20.0%
66.67%96.578212,16033.3%83.3%
22.22%92.55189,7830.0%40.0%
85.71%77.71,15311,498100.0%66.7%
71.43%76.482813,449100.0%66.7%
57.14%77.384211,22350.0%66.7%
100.00%78.28329,161100.0%100.0%
57.14%72.986810,35560.0%50.0%
42.86%77.48559,99550.0%33.3%
57.14%77.080513,44150.0%66.7%
50.00%66.469210,47333.3%66.7%
33.33%66.78659,25050.0%0.0%
50.00%65.784212,7490.0%50.0%
80.00%56.88199,894100.0%66.7%
60.00%57.671711,88250.0%66.7%
60.00%57.593814,8270.0%75.0%
40.00%52.155411,1230.0%40.0%
60.00%56.576611,909100.0%50.0%
40.00%56.95498,21433.3%50.0%
80.00%53.669512,683100.0%50.0%
60.00%52.24318,35366.7%50.0%
60.00%57.51,17014,036100.0%33.3%
40.00%55.596514,4230.0%40.0%
80.00%57.31,24116,644100.0%75.0%
80.00%56.388712,12650.0%100.0%
60.00%56.074710,44750.0%100.0%
20.00%56.67479,3500.0%33.3%

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Lissandra vs Zoe - Frequently Asked Questions

How does Lissandra do against Zoe in League of Legends?

Zoe wins the Lissandra vs Zoe matchup with a 62.5% win rate compared to Lissandra's 37.5%, a 25.0 percentage point difference. This data is based on 24 recent ranked games in patch 26.11.

How does Lissandra do against Zoe in the early game?

In the early game, Zoe has the advantage against Lissandra with a 55.6% win rate versus 44.4%. Zoe players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Zoe in the late game?

In the late game, Zoe takes over the Lissandra vs Zoe matchup with a 66.7% win rate compared to 33.3%. Zoe scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Zoe matchup?

Zoe wins the matchup against Lissandra with a 62.5% win rate in League of Legends patch 26.11. The 25.0 percentage point advantage means Zoe is significantly favored in this lane matchup based on 24 games analyzed.

What is the best Lissandra build against Zoe?

The best Lissandra build against Zoe includes Shadowflame, Zhonya's Hourglass, Malignance with Spellslinger's Shoes. This build achieves a 33.3% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Zoe?

The best Lissandra runes against Zoe use the Sorcery primary tree with Domination secondary. This rune setup achieves a 33.3% win rate in the Lissandra vs Zoe matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Zoe?

No, Lissandra struggles against Zoe with only a 37.5% win rate. Zoe has the advantage in this matchup. Lissandra players should focus on safe farming and avoiding extended trades to minimize Zoe's lead.

How do I play Lissandra against Zoe?

When playing Lissandra against Zoe, play cautiously and avoid Zoe's power spikes. Look for jungle assistance and team-dependent plays since Zoe has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.