Milio - League of Legends Champion
Win Rate
50.8%
Pick Rate
2.8%

Miliovs Lissandra

BSupportMage
Patch26.10
Matches683,599
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 17, 2026
MethodologyData Methodology

Milio vs Lissandra is a decisive matchup in LoL patch 26.10. Milio wins with a 57.1% win rate (+14.3%) over Lissandra based on 7 games. Lissandra wins the early laning phase while Milio scales better into the late game. Below you'll find the best Milio build, runes, laning stats, and strategies for the Milio vs Lissandra matchup.

Milio Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Milio performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 57.1% win rateLissandra(57.1%)
Milio - 57.1% win rate in this matchup
Milio
57.1% WR
VS
Lissandra vs Milio matchup - 42.9% win rate
Lissandra
42.9% WR

Who Wins the Milio vs Lissandra Matchup?

Milio wins the Milio vs Lissandra matchup
Winner
Milio
Matches: 7
57.1%
Win Rate
42.9%
0.9
CS / min
1.8
202
DMG / min
552
7,402
Gold / game
7,247
571
Heal / min
112
353
DMG Mitigated / min
364
0.7
CC / min
1.6
40.0%
Early Game WR
60.0%
100.0%
Late Game WR
0.0%

Milio vs Lissandra Matchup Summary

The Milio vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Milio wins with a 57.1% win rate compared to Lissandra's 42.9%, giving Milio a 14.3 percentage point advantage. Game phase dynamics play a critical role here: Lissandra controls the early laning stage, but Milio outscales as the game goes longer. The matchup shifts dramatically depending on game length — Lissandra needs to press advantages before Milio reaches their power spikes, while Milio should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in damage output, where Lissandra leads by 350 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Milio players can confidently pick into Lissandra and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Lissandra away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Milio vs Lissandra Laning Phase Breakdown

Lissandra wins the laning phase against Milio in League of Legends

Lissandra is favored during the laning phase against Milio, winning 3 out of 5 key stat categories. Lissandra holds advantages in farming, damage and crowd control, making them the stronger laner in this matchup.

Farming
0.9Milio
1.8Lissandra
Lissandra significantly out-farms Milio by 0.9 CS per minute, accumulating an estimated 14 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Milio players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
202Milio
552Lissandra
Lissandra heavily out-damages Milio by 350 DMG/min, dominating both short trades and all-in fights. Milio should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Lissandra's sustained damage advantage take over.
Economy
7,402Milio
7,247Lissandra
Milio and Lissandra generate nearly equal gold per game, with just a 155 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
0.7Milio
1.6Lissandra
Lissandra brings significantly more crowd control than Milio, with 0.9 more seconds of CC per minute. This large utility gap makes Lissandra far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Milio should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
925Milio
477Lissandra
Milio vastly out-sustains Lissandra, healing and mitigating 448 more damage per minute. This massive durability gap means Milio can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Milio Build Against Lissandra

Ionian Boots of Lucidity is the optimal boots choice against Lissandra, providing the mobility and stats Milio needs most in this matchup. The top-performing core items for Milio against Lissandra are Moonstone Renewer, Mikael's Blessing and Diadem of Songs. This combination gives Milio an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Milio vs Lissandra matchup.

Early Game vs Late Game

Early Game
Lissandra
60.0%
+20.0% advantage
Milio early game win rateMilio40.0%
Lissandra early game win rateLissandra60.0%
Late Game
Milio
100.0%
+100.0% advantage
Milio late game win rateMilio100.0%
Lissandra late game win rateLissandra0.0%

Lissandra dominates the early game (first 15 minutes) with a commanding 60.0% win rate — a 20.0 percentage point lead over Milio. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Milio is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Lissandra. Extended games heavily favor Milio, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Lissandra must aggressively press their early advantage and close out the game before Milio reaches their scaling breakpoints. If Milio survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Milio Runes Against Lissandra

Sorcery rune tree - Milio primary runes vs LissandraSorcery
Summon Aery - best Milio rune vs LissandraAxiom Arcanist - best Milio rune vs LissandraTranscendence - best Milio rune vs LissandraGathering Storm - best Milio rune vs Lissandra
Resolve rune tree - Milio secondary runes vs LissandraResolve
Font of Life - best Milio rune vs LissandraRevitalize - best Milio rune vs Lissandra
100.0% WR

Running Sorcery primary with Resolve secondary allows Milio to press their advantage against Lissandra, amplifying the strengths that make this a favorable matchup.


Milio matchup data for League of Legends patch 26.10. The table below shows Milio's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Milio build, runes, laning stats, and early vs late game analysis for that specific matchup.

Milio matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
48.94%2840.91828,25443.6%52.3%
47.41%2700.91977,88645.7%49.0%
48.82%2110.92027,81647.6%50.0%
56.78%1991.11978,39550.6%60.7%
54.07%1720.92118,12051.3%56.3%
54.97%1710.92028,10247.1%62.8%
52.07%1690.92048,27746.1%57.1%
49.30%1421.02018,06855.2%45.2%
55.73%1310.91838,14551.7%58.9%
48.80%1250.91948,53936.7%56.6%
56.07%1070.91748,41758.1%54.7%
50.48%1051.01937,90444.0%56.4%
43.00%1000.92078,40535.9%47.5%
46.46%990.92117,86344.0%49.0%
46.46%991.02107,77246.9%46.0%
43.48%920.92088,00643.5%43.5%
56.10%821.01778,26944.1%64.6%
53.66%820.91868,66747.1%58.3%
38.36%730.91667,48645.0%30.3%
50.00%700.91937,91857.7%45.5%
55.38%651.02087,99150.0%62.1%
52.38%630.92398,03350.0%54.0%
41.94%620.92527,62733.3%53.9%
42.62%610.92278,89140.9%43.6%
43.64%550.91978,27121.7%59.4%
61.11%540.91858,15160.7%61.5%
41.51%530.91927,44233.3%50.0%
47.92%480.91998,28552.6%44.8%
54.17%481.02038,35243.5%64.0%
60.00%350.92108,38680.0%45.0%
43.75%321.01827,77321.1%76.9%
64.52%310.91998,62773.3%56.3%
53.85%260.92288,83954.5%53.3%
48.00%250.92177,94436.4%57.1%
68.18%220.91908,42266.7%70.0%
47.62%210.81928,85257.1%42.9%
57.89%191.02199,14757.1%58.3%
63.16%190.82057,72850.0%72.7%
61.11%180.71948,48557.1%63.6%
62.50%160.91908,35966.7%60.0%
66.67%150.91748,62650.0%85.7%
66.67%121.52298,90750.0%75.0%
54.55%111.11956,19762.5%33.3%
63.64%111.72239,15175.0%57.1%
54.55%110.91799,38750.0%55.6%
44.44%90.91968,3610.0%57.1%
66.67%91.42059,63266.7%66.7%
55.56%91.01997,992100.0%42.9%
25.00%80.91968,9650.0%40.0%
62.50%81.02448,294100.0%25.0%
62.50%80.91618,07950.0%75.0%
37.50%81.01975,97933.3%50.0%
25.00%81.01647,8510.0%40.0%
12.50%81.01657,5480.0%33.3%
42.86%70.81819,96950.0%40.0%
28.57%71.01717,0170.0%50.0%
57.14%70.92027,40240.0%100.0%
33.33%60.72159,2950.0%50.0%
83.33%61.81796,95066.7%100.0%
83.33%60.81448,62866.7%100.0%
83.33%61.62888,99466.7%100.0%
60.00%50.824910,557100.0%50.0%
80.00%50.82279,63666.7%100.0%
20.00%51.02859,2880.0%25.0%
80.00%51.11737,63780.0%0.0%

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Milio vs Lissandra - Frequently Asked Questions

How does Milio do against Lissandra in League of Legends?

Milio wins the Milio vs Lissandra matchup with a 57.1% win rate compared to Lissandra's 42.9%, a 14.3 percentage point difference. This data is based on 7 recent ranked games in patch 26.10.

How does Milio do against Lissandra in the early game?

In the early game, Lissandra has the advantage against Milio with a 60.0% win rate versus 40.0%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Milio do against Lissandra in the late game?

In the late game, Milio takes over the Milio vs Lissandra matchup with a 100.0% win rate compared to 0.0%. Milio scales better into team fights and objective contests after 25 minutes.

Who wins the Milio vs Lissandra matchup?

Milio wins the matchup against Lissandra with a 57.1% win rate in League of Legends patch 26.10. The 14.3 percentage point advantage means Milio is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Milio build against Lissandra?

The best Milio build against Lissandra includes Moonstone Renewer, Mikael's Blessing, Diadem of Songs with Ionian Boots of Lucidity. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Milio runes against Lissandra?

The best Milio runes against Lissandra use the Sorcery primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Milio vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Milio counter Lissandra?

Yes, Milio has a favorable matchup against Lissandra with a 57.1% win rate. Milio strongly counters Lissandra in lane based on current patch 26.10 data.

How do I play Milio against Lissandra?

When playing Milio against Lissandra, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Lissandra. Build the recommended items and runes for this specific matchup for the best results.