Milio - League of Legends Champion
Win Rate
51.7%
Pick Rate
2.8%

Miliovs Lissandra

ASupportMage
Patch26.14
Matches491,560
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Milio vs Lissandra is a decisive matchup in LoL patch 26.14. Lissandra wins with a 66.7% win rate (+33.3%) over Milio based on 6 games. Lissandra wins the early laning phase while Milio scales better into the late game. Below you'll find the best Milio build, runes, laning stats, and strategies for the Milio vs Lissandra matchup.

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Milio Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Milio performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Milio - 33.3% win rate in this matchup
Milio
33.3% WR
VS
Lissandra vs Milio matchup - 66.7% win rate
Lissandra
66.7% WR

Who Wins the Milio vs Lissandra Matchup?

Lissandra wins the Milio vs Lissandra matchup
Winner
Lissandra
Matches: 6
33.3%
Win Rate
66.7%
1.7
CS / min
2.8
281
DMG / min
607
8,708
Gold / game
9,991
353
Heal / min
140
378
DMG Mitigated / min
348
0.7
CC / min
1.8
0.0%
Early Game WR
100.0%
50.0%
Late Game WR
50.0%

Milio vs Lissandra Matchup Summary

The Milio vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Lissandra wins with a 66.7% win rate compared to Milio's 33.3%, giving Lissandra a 33.3 percentage point advantage. Game phase dynamics play a critical role here: Lissandra controls the early laning stage, but Milio outscales as the game goes longer. The matchup shifts dramatically depending on game length — Lissandra needs to press advantages before Milio reaches their power spikes, while Milio should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Lissandra leads by 1.1s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a strong advantage in this matchup. Milio players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Lissandra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Milio vs Lissandra Laning Phase Breakdown

Lissandra wins the laning phase against Milio in League of Legends

Lissandra is favored during the laning phase against Milio, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
1.7Milio
2.8Lissandra
Lissandra significantly out-farms Milio by 1.1 CS per minute, accumulating an estimated 17 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Milio players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
281Milio
607Lissandra
Lissandra heavily out-damages Milio by 327 DMG/min, dominating both short trades and all-in fights. Milio should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Lissandra's sustained damage advantage take over.
Economy
8,708Milio
9,991Lissandra
Lissandra generates a commanding 1,283 more gold per game than Milio. This substantial economic advantage means Lissandra consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Milio should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.7Milio
1.8Lissandra
Lissandra brings significantly more crowd control than Milio, with 1.1 more seconds of CC per minute. This large utility gap makes Lissandra far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Milio should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
731Milio
488Lissandra
Milio vastly out-sustains Lissandra, healing and mitigating 243 more damage per minute. This massive durability gap means Milio can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Milio Build Against Lissandra

Ionian Boots of Lucidity is the optimal boots choice against Lissandra, providing the mobility and stats Milio needs most in this matchup. The top-performing core items for Milio against Lissandra are Moonstone Renewer, Ardent Censer and Redemption. This combination gives Milio an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Milio vs Lissandra matchup.

Early Game vs Late Game

Early Game
Lissandra
100.0%
+100.0% advantage
Milio early game win rateMilio0.0%
Lissandra early game win rateLissandra100.0%
Late Game
Milio
50.0%
+0.0% advantage
Milio late game win rateMilio50.0%
Lissandra late game win rateLissandra50.0%

Lissandra dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Milio. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Milio at 50.0% win rate — only 0.0 points ahead of Lissandra. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Lissandra has the edge early, but Milio gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Milio Runes Against Lissandra

Sorcery rune tree - Milio primary runes vs LissandraSorcery
Summon Aery - best Milio rune vs LissandraManaflow Band - best Milio rune vs LissandraTranscendence - best Milio rune vs LissandraScorch - best Milio rune vs Lissandra
Resolve rune tree - Milio secondary runes vs LissandraResolve
Bone Plating - best Milio rune vs LissandraRevitalize - best Milio rune vs Lissandra
33.3% WR

The Sorcery and Resolve rune setup gives Milio the best tools to compete against Lissandra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Milio matchup data for League of Legends patch 26.14. The table below shows Milio's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Milio build, runes, laning stats, and early vs late game analysis for that specific matchup.

Milio matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.57%2531.02038,20746.5%56.5%
53.59%1531.11947,93644.6%60.2%
47.33%1500.92088,26847.9%47.1%
50.00%1440.91957,93841.3%56.8%
59.54%1311.01928,30652.9%63.8%
51.56%1280.92148,16849.0%53.3%
48.70%1151.01778,01249.1%48.3%
49.06%1061.02157,82154.0%44.6%
45.54%1011.01977,69447.9%43.4%
46.84%790.92268,82245.5%47.4%
54.43%790.92008,10053.9%55.0%
53.73%670.92018,43756.5%52.3%
46.77%621.02147,61950.0%43.8%
38.18%551.02157,94124.0%50.0%
50.00%540.91928,79743.8%52.6%
61.54%521.02638,25552.4%67.7%
45.10%511.01847,98333.3%53.3%
60.42%480.91938,49452.9%64.5%
60.87%461.01937,79541.2%72.4%
60.00%450.91617,19470.8%47.6%
57.78%451.02288,04156.0%60.0%
39.53%430.92107,70035.3%42.3%
51.16%431.02288,60546.7%53.6%
58.14%431.02778,64853.3%60.7%
71.43%420.92088,84986.7%63.0%
48.78%411.02328,18570.6%33.3%
54.05%371.02067,78864.7%45.0%
51.43%351.11957,44162.5%42.1%
60.00%350.92257,30870.6%50.0%
57.58%331.02077,32450.0%69.2%
56.00%250.91707,65945.5%64.3%
45.83%240.92328,30442.9%47.1%
52.17%230.91818,65655.6%50.0%
71.43%211.11959,12180.0%68.8%
33.33%210.92237,53025.0%38.5%
45.00%201.01958,42457.1%38.5%
47.37%190.92026,65970.0%22.2%
58.82%170.91929,15775.0%53.9%
42.86%141.12627,65057.1%28.6%
50.00%141.23176,92755.6%40.0%
35.71%141.12007,56428.6%42.9%
61.54%131.72979,03150.0%80.0%
58.33%121.01838,42775.0%50.0%
40.00%101.01748,21525.0%50.0%
77.78%90.81659,21975.0%80.0%
22.22%90.81496,3760.0%33.3%
71.43%70.92228,63575.0%66.7%
57.14%70.81977,82225.0%100.0%
66.67%60.82138,492100.0%50.0%
33.33%60.91949,1770.0%40.0%
66.67%60.92008,124100.0%50.0%
50.00%61.11859,0440.0%50.0%
66.67%60.71917,07366.7%66.7%
33.33%61.72818,7080.0%50.0%
33.33%61.02067,41825.0%50.0%
20.00%50.91757,4660.0%50.0%

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Milio vs Lissandra - Frequently Asked Questions

How does Milio do against Lissandra in League of Legends?

Lissandra wins the Milio vs Lissandra matchup with a 66.7% win rate compared to Milio's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.14.

How does Milio do against Lissandra in the early game?

In the early game, Lissandra has the advantage against Milio with a 100.0% win rate versus 0.0%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Milio do against Lissandra in the late game?

In the late game, Milio takes over the Milio vs Lissandra matchup with a 50.0% win rate compared to 50.0%. Milio scales better into team fights and objective contests after 25 minutes.

Who wins the Milio vs Lissandra matchup?

Lissandra wins the matchup against Milio with a 66.7% win rate in League of Legends patch 26.14. The 33.3 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Milio build against Lissandra?

The best Milio build against Lissandra includes Moonstone Renewer, Ardent Censer, Redemption with Ionian Boots of Lucidity. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Milio runes against Lissandra?

The best Milio runes against Lissandra use the Sorcery primary tree with Resolve secondary. This rune setup achieves a 33.3% win rate in the Milio vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Milio counter Lissandra?

No, Milio struggles against Lissandra with only a 33.3% win rate. Lissandra has the advantage in this matchup. Milio players should focus on safe farming and avoiding extended trades to minimize Lissandra's lead.

How do I play Milio against Lissandra?

When playing Milio against Lissandra, play cautiously and avoid Lissandra's power spikes. Focus on safe farming — you outscale Lissandra in the late game. Use the matchup-specific build and runes above to optimize your chances.