Lissandra - League of Legends Champion
Win Rate
52.3%
Pick Rate
1.9%

Lissandravs Milio

SMage
Patch26.10
Matches683,599
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 17, 2026
MethodologyData Methodology

Lissandra vs Milio is a decisive matchup in LoL patch 26.10. Milio wins with a 57.1% win rate (+14.3%) over Lissandra based on 7 games. Lissandra wins the early laning phase while Milio scales better into the late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Milio matchup.

Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Milio - 42.9% win rateMilio(42.9%)
Lissandra - 42.9% win rate in this matchup
Lissandra
42.9% WR
VS
Milio vs Lissandra matchup - 57.1% win rate
Milio
57.1% WR

Who Wins the Lissandra vs Milio Matchup?

Milio wins the Lissandra vs Milio matchup
Winner
Milio
Matches: 7
42.9%
Win Rate
57.1%
1.8
CS / min
0.9
552
DMG / min
202
7,247
Gold / game
7,402
112
Heal / min
571
364
DMG Mitigated / min
353
1.6
CC / min
0.7
60.0%
Early Game WR
40.0%
0.0%
Late Game WR
100.0%

Lissandra vs Milio Matchup Summary

The Lissandra vs Milio matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Milio wins with a 57.1% win rate compared to Lissandra's 42.9%, giving Milio a 14.3 percentage point advantage. Game phase dynamics play a critical role here: Lissandra controls the early laning stage, but Milio outscales as the game goes longer. The matchup shifts dramatically depending on game length — Lissandra needs to press advantages before Milio reaches their power spikes, while Milio should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in damage output, where Lissandra leads by 350 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Milio has a strong advantage in this matchup. Lissandra players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Milio overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Milio Laning Phase Breakdown

Lissandra wins the laning phase against Milio in League of Legends

Lissandra is favored during the laning phase against Milio, winning 3 out of 5 key stat categories. Lissandra holds advantages in farming, damage and crowd control, making them the stronger laner in this matchup.

Farming
1.8Lissandra
0.9Milio
Lissandra significantly out-farms Milio by 0.9 CS per minute, accumulating an estimated 14 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Milio players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
552Lissandra
202Milio
Lissandra heavily out-damages Milio by 350 DMG/min, dominating both short trades and all-in fights. Milio should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Lissandra's sustained damage advantage take over.
Economy
7,247Lissandra
7,402Milio
Lissandra and Milio generate nearly equal gold per game, with just a 155 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.6Lissandra
0.7Milio
Lissandra brings significantly more crowd control than Milio, with 0.9 more seconds of CC per minute. This large utility gap makes Lissandra far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Milio should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
477Lissandra
925Milio
Milio vastly out-sustains Lissandra, healing and mitigating 448 more damage per minute. This massive durability gap means Milio can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Early Game vs Late Game

Early Game
Lissandra
60.0%
+20.0% advantage
Lissandra early game win rateLissandra60.0%
Milio early game win rateMilio40.0%
Late Game
Milio
100.0%
+100.0% advantage
Lissandra late game win rateLissandra0.0%
Milio late game win rateMilio100.0%

Lissandra dominates the early game (first 15 minutes) with a commanding 60.0% win rate — a 20.0 percentage point lead over Milio. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Milio is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Lissandra. Extended games heavily favor Milio, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Lissandra must aggressively press their early advantage and close out the game before Milio reaches their scaling breakpoints. If Milio survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Lissandra Runes Against Milio

Sorcery rune tree - Lissandra primary runes vs MilioSorcery
Arcane Comet - best Lissandra rune vs MilioManaflow Band - best Lissandra rune vs MilioTranscendence - best Lissandra rune vs MilioScorch - best Lissandra rune vs Milio
Domination rune tree - Lissandra secondary runes vs MilioDomination
Cheap Shot - best Lissandra rune vs MilioUltimate Hunter - best Lissandra rune vs Milio
100.0% WR

The Sorcery and Domination rune setup gives Lissandra the best tools to compete against Milio in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Lissandra matchup data for League of Legends patch 26.10. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.35%1496.677111,28049.3%54.9%
54.35%1386.883812,17660.4%50.6%
55.56%1356.779712,02060.8%52.4%
58.82%1196.585711,81445.3%69.7%
53.85%1046.691412,01655.6%52.9%
50.98%1026.672711,35753.5%49.1%
50.00%806.886711,96240.0%56.0%
47.37%765.974811,29345.5%48.8%
45.21%736.568110,57627.3%60.0%
52.17%696.996112,15155.2%50.0%
53.13%646.588712,25569.2%42.1%
42.37%596.378711,75545.0%41.0%
41.38%586.680412,36452.2%34.3%
43.14%516.991310,43742.3%44.0%
42.86%427.390910,24141.7%44.4%
47.62%426.876010,09547.8%47.4%
43.59%396.492411,96047.1%40.9%
47.37%386.773912,00953.3%43.5%
60.53%386.682310,50361.9%58.8%
54.29%356.582911,10157.9%50.0%
55.88%346.288711,52147.1%64.7%
50.00%346.793312,04433.3%59.1%
43.33%306.375411,37862.5%36.4%
43.33%306.181910,81153.9%35.3%
50.00%306.783811,58266.7%38.9%
53.33%306.476812,25175.0%45.5%
65.52%297.089411,64469.2%62.5%
57.14%286.683111,94141.7%68.8%
50.00%286.680410,04369.2%33.3%
48.15%276.790212,52950.0%47.4%
40.74%277.088912,17457.1%35.0%
46.15%266.980410,29062.5%20.0%
30.77%266.793811,90144.4%23.5%
46.15%266.978211,53466.7%35.3%
29.17%245.895512,91442.9%23.5%
63.64%226.780410,92969.2%55.6%
61.90%216.279511,32762.5%61.5%
52.38%216.884811,51866.7%41.7%
45.00%207.185310,18254.5%33.3%
57.89%196.189310,29954.5%62.5%
33.33%186.465611,45037.5%30.0%
55.56%185.679210,17166.7%44.4%
17.65%175.868812,21714.3%20.0%
43.75%163.559310,75350.0%41.7%
68.75%166.588012,43080.0%63.6%
64.29%147.090011,20040.0%77.8%
42.86%147.176211,12255.6%20.0%
57.14%146.887914,155100.0%45.5%
46.15%136.683211,21450.0%40.0%
41.67%126.385814,250100.0%36.4%
75.00%125.977512,474100.0%66.7%
36.36%116.788512,71725.0%42.9%
72.73%116.678011,31550.0%85.7%
81.82%117.892313,197100.0%66.7%
70.00%106.681311,36880.0%60.0%
33.33%97.577010,76266.7%16.7%
33.33%96.773911,320100.0%14.3%
44.44%96.975912,01160.0%25.0%
50.00%83.780812,85866.7%40.0%
37.50%87.391710,19520.0%66.7%
62.50%87.589112,23766.7%60.0%
50.00%87.31,05311,45750.0%50.0%
25.00%81.54948,3330.0%40.0%
50.00%82.75139,630100.0%33.3%
50.00%87.01,06011,42833.3%60.0%
62.50%86.091112,81766.7%60.0%
25.00%87.080111,32920.0%33.3%
50.00%86.11,00311,85340.0%66.7%
12.50%85.575810,4670.0%14.3%
57.14%72.462312,2880.0%57.1%
42.86%71.85527,24760.0%0.0%
28.57%76.783812,06833.3%25.0%
57.14%76.57077,45375.0%33.3%
28.57%77.01,20012,84850.0%20.0%
71.43%77.094211,67033.3%100.0%
50.00%67.596513,326100.0%25.0%
83.33%67.61,02412,158100.0%66.7%
33.33%65.176510,856100.0%20.0%
33.33%66.278310,96850.0%25.0%
66.67%64.367711,77250.0%75.0%
83.33%66.51,01112,025100.0%75.0%
60.00%56.28127,81460.0%0.0%
80.00%56.994810,95466.7%100.0%
0.00%56.675011,4390.0%0.0%
40.00%56.880213,193100.0%25.0%
20.00%56.692910,16050.0%0.0%
40.00%56.992711,982100.0%25.0%

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Lissandra vs Milio - Frequently Asked Questions

How does Lissandra do against Milio in League of Legends?

Milio wins the Lissandra vs Milio matchup with a 57.1% win rate compared to Lissandra's 42.9%, a 14.3 percentage point difference. This data is based on 7 recent ranked games in patch 26.10.

How does Lissandra do against Milio in the early game?

In the early game, Lissandra has the advantage against Milio with a 60.0% win rate versus 40.0%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Milio in the late game?

In the late game, Milio takes over the Lissandra vs Milio matchup with a 100.0% win rate compared to 0.0%. Milio scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Milio matchup?

Milio wins the matchup against Lissandra with a 57.1% win rate in League of Legends patch 26.10. The 14.3 percentage point advantage means Milio is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Lissandra build against Milio?

The best Lissandra build against Milio includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Milio?

The best Lissandra runes against Milio use the Sorcery primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Milio matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Milio?

No, Lissandra struggles against Milio with only a 42.9% win rate. Milio has the advantage in this matchup. Lissandra players should focus on safe farming and avoiding extended trades to minimize Milio's lead.

How do I play Lissandra against Milio?

When playing Lissandra against Milio, play cautiously and avoid Milio's power spikes. Look for jungle assistance and team-dependent plays since Milio has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.