Senna - League of Legends Champion
Win Rate
50.0%
Pick Rate
6.3%

Sennavs Lissandra

BSupportMarksman
Patch26.10
Matches683,599
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 18, 2026
MethodologyData Methodology

Senna vs Lissandra is a very close matchup in LoL patch 26.10. Senna wins with a 50.0% win rate (+0.0%) over Lissandra based on 8 games. Lissandra wins the early laning phase while Senna scales better into the late game. Below you'll find the best Senna build, runes, laning stats, and strategies for the Senna vs Lissandra matchup.

Senna Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Senna performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 50.0% win rateLissandra(50.0%)
Senna - 50.0% win rate in this matchup
Senna
50.0% WR
VS
Lissandra vs Senna matchup - 50.0% win rate
Lissandra
50.0% WR

Who Wins the Senna vs Lissandra Matchup?

Senna wins the Senna vs Lissandra matchup
Winner
Senna
Matches: 8
50.0%
Win Rate
50.0%
3.6
CS / min
3.7
885
DMG / min
808
14,314
Gold / game
12,858
475
Heal / min
173
490
DMG Mitigated / min
513
1.4
CC / min
1.8
33.3%
Early Game WR
66.7%
60.0%
Late Game WR
40.0%

Senna vs Lissandra Matchup Summary

The Senna vs Lissandra matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 8 recent matches analyzed, Senna wins with a 50.0% win rate compared to Lissandra's 50.0%, giving Senna a 0.0 percentage point advantage. Game phase dynamics play a critical role here: Lissandra controls the early laning stage, but Senna outscales as the game goes longer. The matchup shifts dramatically depending on game length — Lissandra needs to press advantages before Senna reaches their power spikes, while Senna should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Senna leads by 279 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Senna has a statistical edge, but the margin is close enough that respecting Lissandra's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Senna vs Lissandra Laning Phase Breakdown

Senna wins the laning phase against Lissandra in League of Legends

Senna is favored during the laning phase against Lissandra, winning 3 out of 5 key stat categories. Senna holds advantages in damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
3.6Senna
3.7Lissandra
Senna and Lissandra farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
885Senna
808Lissandra
Senna deals 77 more champion damage per minute than Lissandra. While noticeable in extended trades, this gap can be offset by Lissandra choosing favorable fight windows, such as engaging when Senna's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
14,314Senna
12,858Lissandra
Senna generates a commanding 1,456 more gold per game than Lissandra. This substantial economic advantage means Senna consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Lissandra should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.4Senna
1.8Lissandra
Lissandra provides 0.5 seconds more crowd control per minute than Senna, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
965Senna
686Lissandra
Senna vastly out-sustains Lissandra, healing and mitigating 279 more damage per minute. This massive durability gap means Senna can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Senna Build Against Lissandra

Boots of Swiftness is the optimal boots choice against Lissandra, providing the mobility and stats Senna needs most in this matchup. The top-performing core items for Senna against Lissandra are Rapid Firecannon, Statikk Shiv and Black Cleaver. This combination gives Senna an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Senna vs Lissandra matchup.

Early Game vs Late Game

Early Game
Lissandra
66.7%
+33.3% advantage
Senna early game win rateSenna33.3%
Lissandra early game win rateLissandra66.7%
Late Game
Senna
60.0%
+20.0% advantage
Senna late game win rateSenna60.0%
Lissandra late game win rateLissandra40.0%

Lissandra dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Senna. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Senna is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Lissandra. Extended games heavily favor Senna, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Lissandra must aggressively press their early advantage and close out the game before Senna reaches their scaling breakpoints. If Senna survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Senna Runes Against Lissandra

Sorcery rune tree - Senna primary runes vs LissandraSorcery
Deathfire Touch - best Senna rune vs LissandraManaflow Band - best Senna rune vs LissandraTranscendence - best Senna rune vs LissandraGathering Storm - best Senna rune vs Lissandra
Precision rune tree - Senna secondary runes vs LissandraPrecision
Legend: Haste - best Senna rune vs LissandraPresence of Mind - best Senna rune vs Lissandra
100.0% WR

The Sorcery primary with Precision secondary combination helps Senna maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Lissandra.


Senna matchup data for League of Legends patch 26.10. The table below shows Senna's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Senna build, runes, laning stats, and early vs late game analysis for that specific matchup.

Senna matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.43%4351.757410,09442.3%54.2%
49.32%3656.291113,47046.3%51.4%
53.30%3641.66409,98552.4%54.2%
51.08%3231.855110,31239.7%58.9%
53.48%3161.561010,11751.4%55.1%
53.09%3075.372611,65650.0%55.5%
49.81%2651.559510,30048.0%51.4%
50.19%2636.074812,84354.0%47.4%
47.30%2412.363811,30843.7%49.4%
47.37%2091.662010,10646.0%48.4%
45.26%1901.764511,00550.7%42.1%
48.31%1781.56089,48149.0%47.6%
47.67%1721.661610,63847.8%47.6%
45.03%1711.55859,80352.9%37.2%
48.48%1651.56329,43949.4%47.4%
44.24%1656.179612,87043.6%44.8%
46.67%1655.977312,76652.3%43.0%
51.88%1601.55769,90446.5%56.2%
55.70%1585.681413,04347.5%60.8%
51.68%1495.377212,58149.3%53.8%
52.11%1421.552610,13858.1%47.5%
50.71%1402.267211,01360.0%46.3%
55.07%1381.661110,16353.1%56.8%
50.00%1341.858611,22054.4%47.7%
53.79%1321.661910,09656.7%51.4%
57.69%1301.760410,65052.1%61.0%
55.91%1271.568910,24048.5%63.9%
60.00%1251.56379,94463.1%56.7%
50.81%1241.67379,39556.9%44.1%
55.26%1141.860910,60947.7%60.0%
52.63%1141.45909,61455.2%50.0%
53.33%906.084113,14848.8%57.5%
54.32%815.984813,22265.8%44.2%
58.02%812.668811,23456.7%58.8%
50.65%771.56149,84057.5%43.2%
44.74%761.569510,96650.0%41.7%
49.30%716.184012,67953.3%46.3%
50.70%711.55709,81059.4%43.6%
41.18%686.079713,29950.0%34.2%
56.06%666.586213,53266.7%47.2%
44.44%631.765610,20357.6%30.0%
54.84%621.565110,42061.5%50.0%
49.15%595.055711,06253.6%45.2%
62.71%591.667610,87953.9%69.7%
47.27%552.461310,63236.8%52.8%
48.15%545.763411,13937.0%59.3%
43.40%535.882911,68048.1%38.5%
58.00%501.960710,94442.1%67.7%
46.94%491.863611,54337.5%51.5%
60.87%466.788312,91559.1%62.5%
67.44%431.666411,21580.0%60.7%
62.50%403.467111,16156.3%66.7%
50.00%406.386012,66736.8%61.9%
44.74%382.467410,65253.3%39.1%
55.26%385.785113,48333.3%65.4%
45.95%375.476611,80840.0%50.0%
38.89%366.582011,87640.0%37.5%
35.29%342.666311,41930.0%37.5%
63.64%331.473310,01178.6%52.6%
53.13%322.364310,53054.5%52.4%
54.84%315.169611,82730.8%72.2%
51.61%311.56129,67062.5%40.0%
42.86%285.275612,84854.5%35.3%
46.43%286.289513,80650.0%43.8%
42.31%265.675012,72820.0%56.3%
32.00%256.283011,04925.0%44.4%
60.00%255.276211,90871.4%45.5%
38.10%212.866211,76942.9%35.7%
57.89%192.556211,26750.0%61.5%
57.89%192.782111,33644.4%70.0%
47.06%173.182310,59228.6%60.0%
47.06%171.95739,96944.4%50.0%
37.50%161.955810,40742.9%33.3%
56.25%161.659710,16071.4%44.4%
56.25%161.86059,17422.2%100.0%
60.00%151.855910,63342.9%75.0%
64.29%145.682010,51470.0%50.0%
50.00%145.786112,53833.3%62.5%
42.86%143.076012,798100.0%33.3%
35.71%141.967311,02260.0%22.2%
53.85%133.163412,16166.7%50.0%
58.33%122.467412,63975.0%50.0%
33.33%121.55529,41540.0%28.6%
45.45%116.385711,16633.3%50.0%
36.36%115.091111,06740.0%33.3%
50.00%104.06858,77257.1%33.3%
70.00%104.374911,44775.0%66.7%
77.78%92.17359,69975.0%80.0%
33.33%96.366113,78333.3%33.3%
44.44%92.171413,0550.0%44.4%
50.00%84.774112,0060.0%66.7%
37.50%84.978810,16160.0%0.0%
37.50%82.582311,07133.3%40.0%
75.00%81.678912,774100.0%66.7%
62.50%85.076014,570100.0%50.0%
75.00%81.25948,52480.0%66.7%
62.50%84.473713,100100.0%50.0%
50.00%81.47689,20040.0%66.7%
50.00%83.688514,31433.3%60.0%
28.57%74.471711,8360.0%28.6%
57.14%72.767410,48360.0%50.0%
42.86%71.66059,54050.0%33.3%
28.57%74.05868,77825.0%33.3%
42.86%73.162612,48950.0%40.0%
57.14%75.383012,923100.0%50.0%
28.57%74.067011,13066.7%0.0%
57.14%72.491113,47950.0%60.0%
50.00%64.987812,0670.0%60.0%
33.33%65.36549,85933.3%33.3%
40.00%55.276911,05250.0%33.3%
40.00%54.896214,8880.0%50.0%
60.00%53.783013,253100.0%50.0%
60.00%54.762811,4450.0%75.0%
80.00%52.890913,037100.0%75.0%
20.00%56.51,0818,4340.0%50.0%
40.00%54.876211,9830.0%66.7%
20.00%51.45177,98433.3%0.0%
20.00%51.74248,39633.3%0.0%
40.00%56.08499,67133.3%50.0%

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Senna vs Lissandra - Frequently Asked Questions

How does Senna do against Lissandra in League of Legends?

Senna wins the Senna vs Lissandra matchup with a 50.0% win rate compared to Lissandra's 50.0%, a 0.0 percentage point difference. This data is based on 8 recent ranked games in patch 26.10.

How does Senna do against Lissandra in the early game?

In the early game, Lissandra has the advantage against Senna with a 66.7% win rate versus 33.3%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Senna do against Lissandra in the late game?

In the late game, Senna takes over the Senna vs Lissandra matchup with a 60.0% win rate compared to 40.0%. Senna scales better into team fights and objective contests after 25 minutes.

Who wins the Senna vs Lissandra matchup?

Senna wins the matchup against Lissandra with a 50.0% win rate in League of Legends patch 26.10. The 0.0 percentage point advantage means Senna is slightly favored in this lane matchup based on 8 games analyzed.

What is the best Senna build against Lissandra?

The best Senna build against Lissandra includes Rapid Firecannon, Statikk Shiv, Black Cleaver with Boots of Swiftness. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Senna runes against Lissandra?

The best Senna runes against Lissandra use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Senna vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Senna counter Lissandra?

Yes, Senna has a favorable matchup against Lissandra with a 50.0% win rate. Senna slightly edges out Lissandra in lane based on current patch 26.10 data.

How do I play Senna against Lissandra?

When playing Senna against Lissandra, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Lissandra. Build the recommended items and runes for this specific matchup for the best results.