Senna - League of Legends Champion
Win Rate
49.7%
Pick Rate
4.6%

Sennavs Seraphine

CSupportMarksman
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 21, 2026
MethodologyData Methodology

Senna vs Seraphine is a moderate matchup in LoL patch 26.7. Seraphine wins with a 51.6% win rate (+3.1%) over Senna based on 159 games. Seraphine wins the early laning phase while Senna scales better into the late game. Below you'll find the best Senna build, runes, laning stats, and strategies for the Senna vs Seraphine matchup.

Senna Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Senna performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Seraphine - 48.4% win rateSeraphine(48.4%)
Senna - 48.4% win rate in this matchup
Senna
48.4% WR
VS
Seraphine vs Senna matchup - 51.6% win rate
Seraphine
51.6% WR

Who Wins the Senna vs Seraphine Matchup?

Seraphine wins the Senna vs Seraphine matchup
Winner
Seraphine
Matches: 159
48.4%
Win Rate
51.6%
1.6
CS / min
1.5
518
DMG / min
487
10,037
Gold / game
9,184
526
Heal / min
330
342
DMG Mitigated / min
360
1.3
CC / min
1.2
45.7%
Early Game WR
54.3%
50.6%
Late Game WR
49.4%

Senna vs Seraphine Matchup Summary

The Senna vs Seraphine matchup is a moderate matchup in League of Legends ranked play. Based on 159 recent matches analyzed, Seraphine wins with a 51.6% win rate compared to Senna's 48.4%, giving Seraphine a 3.1 percentage point advantage. Game phase dynamics play a critical role here: Seraphine controls the early laning stage, but Senna outscales as the game goes longer. The matchup shifts dramatically depending on game length — Seraphine needs to press advantages before Senna reaches their power spikes, while Senna should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Senna leads by 178 HP/min — a difference that heavily influences the outcome of trades and skirmishes. While Seraphine is slightly favored, Senna can absolutely win this lane through smart trading patterns and wave management. Focus on playing around your cooldowns, conceding CS only when necessary, and capitalizing on Seraphine's mistakes. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Senna vs Seraphine Laning Phase Breakdown

Senna wins the laning phase against Seraphine in League of Legends

Senna is favored during the laning phase against Seraphine, winning 5 out of 5 key stat categories. Senna holds advantages in farming, damage, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
1.6Senna
1.5Seraphine
Senna and Seraphine farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
518Senna
487Seraphine
Senna deals 31 more champion damage per minute than Seraphine. While noticeable in extended trades, this gap can be offset by Seraphine choosing favorable fight windows, such as engaging when Senna's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
10,037Senna
9,184Seraphine
Senna generates a commanding 852 more gold per game than Seraphine. This substantial economic advantage means Senna consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Seraphine should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.3Senna
1.2Seraphine
Both Senna and Seraphine provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
868Senna
691Seraphine
Senna vastly out-sustains Seraphine, healing and mitigating 178 more damage per minute. This massive durability gap means Senna can absorb significant punishment and remain in lane while Seraphine is forced to recall. Building grievous wounds early is essential for Seraphine, and focusing on burst trade patterns rather than sustained fights is critical.

Best Senna Build Against Seraphine

Boots of Swiftness is the optimal boots choice against Seraphine, providing the mobility and stats Senna needs most in this matchup. The top-performing core items for Senna against Seraphine are Dawncore, Echoes of Helia and Moonstone Renewer. This combination gives Senna an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 80.0% win rate across 5 games — well above average and making it the top item path against Seraphine. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Senna vs Seraphine matchup.

Early Game vs Late Game

Early Game
Seraphine
54.3%
+8.6% advantage
Senna early game win rateSenna45.7%
Seraphine early game win rateSeraphine54.3%
Late Game
Senna
50.6%
+1.1% advantage
Senna late game win rateSenna50.6%
Seraphine late game win rateSeraphine49.4%

Seraphine dominates the early game (first 15 minutes) with a commanding 54.3% win rate — a 8.6 percentage point lead over Senna. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Senna at 50.6% win rate — only 1.1 points ahead of Seraphine. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Seraphine has the edge early, but Senna gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Senna Runes Against Seraphine

Sorcery rune tree - Senna primary runes vs SeraphineSorcery
Summon Aery - best Senna rune vs SeraphineManaflow Band - best Senna rune vs SeraphineTranscendence - best Senna rune vs SeraphineScorch - best Senna rune vs Seraphine
Resolve rune tree - Senna secondary runes vs SeraphineResolve
Font of Life - best Senna rune vs SeraphineRevitalize - best Senna rune vs Seraphine
60.6% WR

The Sorcery and Resolve rune setup gives Senna the best tools to compete against Seraphine in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Senna matchup data for League of Legends patch 26.7. The table below shows Senna's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Senna build, runes, laning stats, and early vs late game analysis for that specific matchup.

Senna matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
47.56%2251.455810,21750.0%45.5%
51.38%1811.557710,53146.8%54.8%
50.89%1695.577513,46844.9%55.0%
53.85%1691.655010,89748.6%57.9%
48.43%1591.651810,03745.7%50.6%
46.48%1425.977213,18240.9%51.3%
53.96%1391.556610,21550.8%56.9%
46.46%1271.558510,35650.0%43.8%
59.68%1241.557610,15460.0%59.4%
58.47%1181.45839,95557.1%59.7%
49.57%1156.587813,88151.9%47.5%
50.88%1145.981612,83553.6%48.3%
49.12%1146.178212,78941.5%55.7%
48.62%1092.367910,70336.6%55.9%
52.34%1076.288313,40056.1%48.0%
43.40%1066.184713,35437.5%48.3%
44.44%991.452910,19151.2%39.7%
50.51%991.657710,15046.9%54.0%
42.55%941.452910,51535.1%47.4%
48.84%861.45719,95844.2%53.5%
54.12%851.555710,24150.0%57.8%
49.38%816.078412,43353.5%44.7%
57.69%781.44659,34560.9%53.1%
48.68%762.355811,16840.0%54.4%
52.05%731.46059,89852.5%51.5%
44.44%726.288013,61254.8%36.6%
56.94%722.758511,20638.7%70.7%
42.86%701.45219,61243.6%41.9%
59.70%671.45689,46151.4%68.8%
56.45%621.755910,86863.6%52.5%
50.00%626.178013,00832.1%64.7%
42.11%571.950310,77833.3%47.2%
56.36%552.153811,59855.6%56.8%
47.06%511.46859,61034.6%60.0%
54.90%511.366410,89141.7%66.7%
48.00%501.665310,52550.0%46.1%
45.83%485.679114,32253.3%42.4%
51.06%475.784912,93544.0%59.1%
53.33%456.175013,70643.8%58.6%
58.14%436.384512,97069.2%41.2%
39.02%411.559310,86537.5%40.0%
43.59%391.569712,29841.7%44.4%
48.72%391.56049,81963.6%29.4%
60.00%356.589014,81666.7%56.5%
40.00%351.464010,05850.0%31.6%
55.88%341.35429,23359.1%50.0%
51.61%316.187513,86036.8%75.0%
50.00%281.754410,52950.0%50.0%
60.71%286.490314,33153.9%66.7%
50.00%263.374512,44637.5%55.6%
41.67%246.184613,02233.3%50.0%
50.00%242.157311,24850.0%50.0%
45.45%221.462710,22355.6%38.5%
63.64%226.277813,82480.0%50.0%
42.86%215.574611,73750.0%33.3%
55.00%206.295213,00370.0%40.0%
50.00%206.988813,62854.5%44.4%
50.00%185.272912,60662.5%40.0%
66.67%181.259210,65971.4%63.6%
64.71%171.871211,27677.8%50.0%
26.67%151.85137,91340.0%0.0%
46.15%133.059410,69233.3%57.1%
38.46%136.282613,43142.9%33.3%
50.00%122.062411,59980.0%28.6%
58.33%125.754212,02366.7%33.3%
58.33%121.46798,55860.0%57.1%
36.36%111.44259,59016.7%60.0%
72.73%114.51,01110,58860.0%83.3%
45.45%111.84269,88240.0%50.0%
63.64%112.961811,07460.0%66.7%
40.00%106.083613,30460.0%20.0%
60.00%102.356210,70160.0%60.0%
50.00%103.678010,68960.0%40.0%
77.78%96.677114,58380.0%75.0%
66.67%92.276511,77650.0%71.4%
25.00%83.669611,5340.0%40.0%
75.00%81.353712,18466.7%80.0%
37.50%81.169011,5090.0%50.0%
14.29%73.665310,92850.0%0.0%
71.43%71.25269,68875.0%66.7%
50.00%64.866012,36766.7%33.3%
40.00%54.373311,81033.3%50.0%
0.00%52.95609,6090.0%0.0%
60.00%56.470814,61333.3%100.0%
60.00%52.975613,365100.0%50.0%
60.00%56.276314,10050.0%66.7%
40.00%51.745511,50350.0%33.3%
60.00%52.379614,391100.0%50.0%

Get the MetaBot Desktop App

Level up your gameplay with real-time overlays, automatic game detection, and instant stats — all on your desktop.

In-game overlaysAuto game detectionMulti-game supportPersonal dashboard
Download NowFree download
🔍

Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.

Report an Issue

Senna vs Seraphine - Frequently Asked Questions

How does Senna do against Seraphine in League of Legends?

Seraphine wins the Senna vs Seraphine matchup with a 51.6% win rate compared to Senna's 48.4%, a 3.1 percentage point difference. This data is based on 159 recent ranked games in patch 26.7.

How does Senna do against Seraphine in the early game?

In the early game, Seraphine has the advantage against Senna with a 54.3% win rate versus 45.7%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Senna do against Seraphine in the late game?

In the late game, Senna takes over the Senna vs Seraphine matchup with a 50.6% win rate compared to 49.4%. Senna scales better into team fights and objective contests after 25 minutes.

Who wins the Senna vs Seraphine matchup?

Seraphine wins the matchup against Senna with a 51.6% win rate in League of Legends patch 26.7. The 3.1 percentage point advantage means Seraphine is moderately favored in this lane matchup based on 159 games analyzed.

What is the best Senna build against Seraphine?

The best Senna build against Seraphine includes Dawncore, Echoes of Helia, Moonstone Renewer with Boots of Swiftness. This build achieves a 80.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Senna runes against Seraphine?

The best Senna runes against Seraphine use the Sorcery primary tree with Resolve secondary. This rune setup achieves a 60.6% win rate in the Senna vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.

Does Senna counter Seraphine?

No, Senna struggles against Seraphine with only a 48.4% win rate. Seraphine has the advantage in this matchup. Senna players should focus on safe farming and avoiding extended trades to minimize Seraphine's lead.

How do I play Senna against Seraphine?

When playing Senna against Seraphine, play cautiously and avoid Seraphine's power spikes. Focus on safe farming — you outscale Seraphine in the late game. Use the matchup-specific build and runes above to optimize your chances.