Syndra - League of Legends Champion
Win Rate
50.2%
Pick Rate
2.2%

Syndravs Vayne

CMage
Patch26.7
Matches508,082
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 12, 2026
MethodologyData Methodology

Syndra vs Vayne is a decisive matchup in LoL patch 26.7. Syndra wins with a 55.6% win rate (+11.1%) over Vayne based on 9 games. Vayne wins the early laning phase while Syndra scales better into the late game. Below you'll find the best Syndra build, runes, laning stats, and strategies for the Syndra vs Vayne matchup.

Syndra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Syndra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 55.6% win rateVayne(55.6%)
Syndra - 55.6% win rate in this matchup
Syndra
55.6% WR
VS
Vayne vs Syndra matchup - 44.4% win rate
Vayne
44.4% WR

Who Wins the Syndra vs Vayne Matchup?

Syndra wins the Syndra vs Vayne matchup
Winner
Syndra
Matches: 9
55.6%
Win Rate
44.4%
6.8
CS / min
6.2
991
DMG / min
1,077
15,787
Gold / game
15,702
73
Heal / min
227
430
DMG Mitigated / min
541
1.3
CC / min
0.4
0.0%
Early Game WR
100.0%
71.4%
Late Game WR
28.6%

Syndra vs Vayne Matchup Summary

The Syndra vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 9 recent matches analyzed, Syndra wins with a 55.6% win rate compared to Vayne's 44.4%, giving Syndra a 11.1 percentage point advantage. Game phase dynamics play a critical role here: Vayne controls the early laning stage, but Syndra outscales as the game goes longer. The matchup shifts dramatically depending on game length — Vayne needs to press advantages before Syndra reaches their power spikes, while Syndra should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Syndra leads by 0.9s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Syndra players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Syndra vs Vayne Laning Phase Breakdown

Syndra wins the laning phase against Vayne in League of Legends

Syndra is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Syndra holds advantages in farming, gold income and crowd control, making them the stronger laner in this matchup.

Farming
6.8Syndra
6.2Vayne
Syndra edges out Vayne by 0.6 CS per minute — a moderate farming advantage that adds up to roughly 9 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Syndra.
Damage
991Syndra
1,077Vayne
Vayne heavily out-damages Syndra by 86 DMG/min, dominating both short trades and all-in fights. Syndra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
15,787Syndra
15,702Vayne
Syndra and Vayne generate nearly equal gold per game, with just a 85 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.3Syndra
0.4Vayne
Syndra brings significantly more crowd control than Vayne, with 0.9 more seconds of CC per minute. This large utility gap makes Syndra far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
502Syndra
768Vayne
Vayne vastly out-sustains Syndra, healing and mitigating 266 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Syndra is forced to recall. Building grievous wounds early is essential for Syndra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Syndra Build Against Vayne

Spellslinger's Shoes is the optimal boots choice against Vayne, providing the mobility and stats Syndra needs most in this matchup. The top-performing core items for Syndra against Vayne are Cosmic Drive, Zhonya's Hourglass and Void Staff. This combination gives Syndra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Syndra vs Vayne matchup.

Early Game vs Late Game

Early Game
Vayne
100.0%
+100.0% advantage
Syndra early game win rateSyndra0.0%
Vayne early game win rateVayne100.0%
Late Game
Syndra
71.4%
+42.9% advantage
Syndra late game win rateSyndra71.4%
Vayne late game win rateVayne28.6%

Vayne dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Syndra. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Syndra is far superior in the late game (25+ minutes), boasting a 71.4% win rate — 42.9 points above Vayne. Extended games heavily favor Syndra, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Vayne must aggressively press their early advantage and close out the game before Syndra reaches their scaling breakpoints. If Syndra survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Syndra Runes Against Vayne

Inspiration rune tree - Syndra primary runes vs VayneInspiration
First Strike - best Syndra rune vs VayneCash Back - best Syndra rune vs VayneTriple Tonic - best Syndra rune vs VayneJack Of All Trades - best Syndra rune vs Vayne
Sorcery rune tree - Syndra secondary runes vs VayneSorcery
Transcendence - best Syndra rune vs VayneManaflow Band - best Syndra rune vs Vayne
100.0% WR

Running Inspiration primary with Sorcery secondary allows Syndra to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.


Syndra matchup data for League of Legends patch 26.7. The table below shows Syndra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Syndra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Syndra matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
55.04%1297.393112,75149.2%60.3%
46.07%897.091912,96650.0%43.6%
50.00%846.885111,63640.0%59.1%
51.85%817.290913,13051.3%52.4%
52.56%787.384812,64655.6%50.0%
45.83%727.080813,01541.9%48.8%
44.78%676.479211,52944.8%44.7%
62.07%586.799613,99473.9%54.3%
50.00%546.992112,08943.3%58.3%
39.22%517.088613,35433.3%43.3%
40.82%496.674711,69523.8%53.6%
54.35%467.291112,93255.0%53.9%
48.84%436.780412,39344.4%52.0%
42.86%426.983511,61942.1%43.5%
59.52%427.086612,85426.7%77.8%
64.29%426.978811,43565.2%63.2%
52.38%427.095212,82152.6%52.2%
43.90%416.587011,26045.0%42.9%
47.50%406.999613,60450.0%45.8%
52.50%407.095113,76650.0%53.9%
55.56%367.080112,03360.0%45.5%
52.78%367.01,02013,39542.9%59.1%
47.22%366.882410,06640.9%57.1%
37.14%357.081310,77134.8%41.7%
54.55%337.291513,64766.7%47.6%
65.63%327.01,07214,11163.6%66.7%
58.06%317.41,02513,88564.7%50.0%
51.61%317.01,01113,79260.0%43.8%
37.93%296.980212,04841.7%35.3%
55.17%297.089312,26573.3%35.7%
60.00%257.187712,74645.5%71.4%
39.13%237.284011,86833.3%50.0%
61.90%217.31,01812,21066.7%58.3%
25.00%207.090211,53822.2%27.3%
40.00%207.692513,00642.9%38.5%
52.63%197.01,02813,4750.0%71.4%
55.56%186.998712,65533.3%66.7%
55.56%186.585012,49842.9%63.6%
70.59%177.81,20513,80077.8%62.5%
47.06%177.297513,92437.5%55.6%
56.25%167.796215,264100.0%36.4%
43.75%166.687113,10120.0%54.5%
62.50%167.296914,00777.8%42.9%
60.00%157.687813,43662.5%57.1%
60.00%156.986613,97880.0%50.0%
64.29%147.394113,07666.7%62.5%
50.00%146.889613,06783.3%25.0%
38.46%137.21,02312,79842.9%33.3%
53.85%137.187610,64962.5%40.0%
61.54%137.088414,04166.7%57.1%
50.00%127.194611,92566.7%33.3%
66.67%127.183612,79262.5%75.0%
55.56%96.899115,7870.0%71.4%
33.33%97.399211,99928.6%50.0%
37.50%86.81,03812,80040.0%33.3%
57.14%77.689013,21050.0%66.7%
42.86%75.881910,10640.0%50.0%
42.86%76.71,01311,89233.3%50.0%
66.67%67.08819,08450.0%100.0%
50.00%67.91,08615,078100.0%40.0%
83.33%65.790914,734100.0%80.0%
50.00%66.694412,37333.3%66.7%
50.00%67.082911,19750.0%50.0%
83.33%66.51,08015,590100.0%75.0%
66.67%67.71,03716,00250.0%75.0%
0.00%57.690213,6370.0%0.0%
80.00%56.484513,566100.0%66.7%
60.00%57.51,03214,08233.3%100.0%
60.00%57.395612,89766.7%50.0%
60.00%52.485211,91450.0%66.7%
40.00%57.069511,8570.0%66.7%

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Syndra vs Vayne - Frequently Asked Questions

How does Syndra do against Vayne in League of Legends?

Syndra wins the Syndra vs Vayne matchup with a 55.6% win rate compared to Vayne's 44.4%, a 11.1 percentage point difference. This data is based on 9 recent ranked games in patch 26.7.

How does Syndra do against Vayne in the early game?

In the early game, Vayne has the advantage against Syndra with a 100.0% win rate versus 0.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Syndra do against Vayne in the late game?

In the late game, Syndra takes over the Syndra vs Vayne matchup with a 71.4% win rate compared to 28.6%. Syndra scales better into team fights and objective contests after 25 minutes.

Who wins the Syndra vs Vayne matchup?

Syndra wins the matchup against Vayne with a 55.6% win rate in League of Legends patch 26.7. The 11.1 percentage point advantage means Syndra is significantly favored in this lane matchup based on 9 games analyzed.

What is the best Syndra build against Vayne?

The best Syndra build against Vayne includes Cosmic Drive, Zhonya's Hourglass, Void Staff with Spellslinger's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Syndra runes against Vayne?

The best Syndra runes against Vayne use the Inspiration primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Syndra vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Syndra counter Vayne?

Yes, Syndra has a favorable matchup against Vayne with a 55.6% win rate. Syndra strongly counters Vayne in lane based on current patch 26.7 data.

How do I play Syndra against Vayne?

When playing Syndra against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Vayne. Build the recommended items and runes for this specific matchup for the best results.