Zed - League of Legends Champion
Win Rate
47.6%
Pick Rate
3.3%

Zedvs Karthus

FAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 19, 2026
MethodologyData Methodology

Zed vs Karthus is a decisive matchup in LoL patch 26.7. Zed wins with a 55.6% win rate (+11.1%) over Karthus based on 9 games. Karthus wins the early laning phase while Zed scales better into the late game. Below you'll find the best Zed build, runes, laning stats, and strategies for the Zed vs Karthus matchup.

Zed Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zed performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 55.6% win rateKarthus(55.6%)
Zed - 55.6% win rate in this matchup
Zed
55.6% WR
VS
Karthus vs Zed matchup - 44.4% win rate
Karthus
44.4% WR

Who Wins the Zed vs Karthus Matchup?

Zed wins the Zed vs Karthus matchup
Winner
Zed
Matches: 9
55.6%
Win Rate
44.4%
4.2
CS / min
3.8
986
DMG / min
990
15,918
Gold / game
13,717
259
Heal / min
232
573
DMG Mitigated / min
430
0.3
CC / min
0.4
0.0%
Early Game WR
100.0%
71.4%
Late Game WR
28.6%

Zed vs Karthus Matchup Summary

The Zed vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 9 recent matches analyzed, Zed wins with a 55.6% win rate compared to Karthus's 44.4%, giving Zed a 11.1 percentage point advantage. Game phase dynamics play a critical role here: Karthus controls the early laning stage, but Zed outscales as the game goes longer. The matchup shifts dramatically depending on game length — Karthus needs to press advantages before Zed reaches their power spikes, while Zed should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Karthus leads by 0.2s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Zed players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zed vs Karthus Laning Phase Breakdown

Zed wins the laning phase against Karthus in League of Legends

Zed is favored during the laning phase against Karthus, winning 3 out of 5 key stat categories. Zed holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.

Farming
4.2Zed
3.8Karthus
Zed edges out Karthus by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 6 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Zed.
Damage
986Zed
990Karthus
Damage output is virtually even between Zed and Karthus, with only 4 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
15,918Zed
13,717Karthus
Zed generates a commanding 2,201 more gold per game than Karthus. This substantial economic advantage means Zed consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Karthus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.3Zed
0.4Karthus
Both Zed and Karthus provide similar amounts of crowd control (0.2s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
832Zed
662Karthus
Zed vastly out-sustains Karthus, healing and mitigating 170 more damage per minute. This massive durability gap means Zed can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Zed Build Against Karthus

Plated Steelcaps is the optimal boots choice against Karthus, providing the mobility and stats Zed needs most in this matchup. The top-performing core items for Zed against Karthus are Voltaic Cyclosword, Eclipse and Spear of Shojin. This combination gives Zed an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zed vs Karthus matchup.

Early Game vs Late Game

Early Game
Karthus
100.0%
+100.0% advantage
Zed early game win rateZed0.0%
Karthus early game win rateKarthus100.0%
Late Game
Zed
71.4%
+42.9% advantage
Zed late game win rateZed71.4%
Karthus late game win rateKarthus28.6%

Karthus dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Zed. This lopsided early game means Karthus can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Zed is far superior in the late game (25+ minutes), boasting a 71.4% win rate — 42.9 points above Karthus. Extended games heavily favor Zed, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Karthus must aggressively press their early advantage and close out the game before Zed reaches their scaling breakpoints. If Zed survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Zed Runes Against Karthus

Inspiration rune tree - Zed primary runes vs KarthusInspiration
First Strike - best Zed rune vs KarthusCash Back - best Zed rune vs KarthusTriple Tonic - best Zed rune vs KarthusJack Of All Trades - best Zed rune vs Karthus
Domination rune tree - Zed secondary runes vs KarthusDomination
Sudden Impact - best Zed rune vs KarthusRelentless Hunter - best Zed rune vs Karthus
100.0% WR

Running Inspiration primary with Domination secondary allows Zed to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Zed matchup data for League of Legends patch 26.7. The table below shows Zed's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zed build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zed matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.53%1586.493812,91352.0%53.0%
55.65%1246.791113,15651.7%59.1%
44.92%1186.686512,85848.0%42.6%
53.49%866.21,02013,51154.5%52.8%
47.67%865.492311,89048.0%47.2%
51.81%836.582512,42645.0%58.1%
51.81%836.596012,61150.0%53.9%
39.76%836.394912,89246.1%34.1%
38.75%806.189713,43331.0%43.1%
51.32%766.394812,90453.3%50.0%
54.05%746.696913,64462.5%47.6%
52.11%716.392813,49253.6%51.2%
53.73%676.495313,18348.3%57.9%
53.73%676.392913,58752.0%54.8%
38.81%676.484412,49935.7%41.0%
45.45%666.097412,89142.9%47.4%
42.86%635.484712,44444.0%42.1%
47.46%596.278711,65641.9%53.6%
51.02%496.181112,45941.7%60.0%
55.32%476.41,05912,92752.0%59.1%
53.19%475.290513,35447.6%57.7%
51.16%436.179812,46655.6%48.0%
55.81%436.31,00512,88370.0%43.5%
45.24%426.093212,73055.0%36.4%
50.00%386.087812,99443.8%54.5%
55.26%386.41,01312,14450.0%62.5%
57.89%385.394213,18557.1%58.8%
62.16%376.81,02712,63365.0%58.8%
45.71%356.389713,36642.9%47.6%
51.43%356.082612,55235.3%66.7%
64.71%345.294013,85662.5%65.4%
55.88%346.71,03112,66862.5%50.0%
64.52%316.71,02012,82850.0%73.7%
51.61%316.193912,12041.2%64.3%
28.57%286.174212,01333.3%23.1%
51.85%276.71,12614,66644.4%55.6%
60.00%256.383012,22862.5%58.8%
52.00%251.475713,07853.3%50.0%
45.83%241.986015,14066.7%33.3%
25.00%245.51,09611,93023.1%27.3%
56.52%232.694414,33558.3%54.5%
26.09%236.588712,96025.0%26.7%
40.91%226.583911,97837.5%42.9%
36.36%221.577914,14237.5%35.7%
57.14%216.496514,26280.0%50.0%
38.10%213.584112,76236.4%40.0%
45.00%206.21,07114,07944.4%45.5%
55.00%202.184414,31475.0%41.7%
50.00%205.181511,35740.0%60.0%
36.84%191.978813,42554.5%12.5%
52.63%197.11,16414,33575.0%36.4%
61.11%186.31,05214,60383.3%50.0%
41.18%172.099118,0220.0%50.0%
56.25%162.21,12712,97054.5%60.0%
62.50%166.81,08814,22766.7%60.0%
60.00%153.398514,34457.1%62.5%
53.33%156.289313,02971.4%37.5%
60.00%155.588711,64050.0%71.4%
40.00%155.086613,68442.9%37.5%
57.14%146.490311,75457.1%57.1%
64.29%142.581914,26675.0%60.0%
30.77%136.576811,77142.9%16.7%
76.92%135.81,00713,169100.0%62.5%
58.33%121.293115,24466.7%55.6%
45.45%111.592313,35525.0%57.1%
36.36%116.21,01114,35940.0%33.3%
27.27%116.31,06213,15760.0%0.0%
72.73%117.196015,222100.0%57.1%
0.00%112.583515,2560.0%0.0%
54.55%112.276313,943100.0%28.6%
45.45%116.31,04312,17950.0%42.9%
36.36%111.685715,62033.3%37.5%
40.00%106.080210,86550.0%25.0%
50.00%103.073213,45950.0%50.0%
60.00%101.477613,17550.0%66.7%
40.00%102.981012,81550.0%33.3%
33.33%91.199915,66325.0%40.0%
88.89%94.379214,51175.0%100.0%
33.33%95.579214,5410.0%37.5%
44.44%97.494510,26750.0%33.3%
44.44%96.797411,52060.0%25.0%
55.56%94.298615,9180.0%71.4%
55.56%91.196014,344100.0%20.0%
50.00%81.31,23616,25433.3%60.0%
50.00%87.187713,24175.0%25.0%
75.00%82.11,12116,031100.0%60.0%
37.50%81.481516,4860.0%37.5%
50.00%86.51,11814,86866.7%40.0%
42.86%75.965811,13320.0%100.0%
42.86%73.51,04014,12540.0%50.0%
71.43%75.295713,3730.0%83.3%
57.14%75.01,13615,60150.0%66.7%
85.71%71.580114,24175.0%100.0%
57.14%70.981914,31350.0%60.0%
16.67%63.997917,0120.0%16.7%
83.33%65.974711,255100.0%66.7%
66.67%61.880912,48080.0%0.0%
66.67%65.586311,57175.0%50.0%
50.00%67.21,09112,97433.3%66.7%
33.33%64.967011,33033.3%33.3%
66.67%61.379119,114100.0%60.0%
80.00%56.41,71219,228100.0%75.0%
40.00%52.170515,1850.0%50.0%
60.00%56.195213,48550.0%66.7%
20.00%51.061611,1410.0%33.3%
60.00%54.585912,09433.3%100.0%
80.00%52.698813,047100.0%66.7%
20.00%51.095913,8650.0%33.3%
60.00%56.078713,8250.0%100.0%
40.00%55.993013,3000.0%50.0%
40.00%56.59519,98333.3%50.0%
80.00%57.41,25316,097100.0%66.7%
40.00%57.31,34517,6690.0%40.0%

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Zed vs Karthus - Frequently Asked Questions

How does Zed do against Karthus in League of Legends?

Zed wins the Zed vs Karthus matchup with a 55.6% win rate compared to Karthus's 44.4%, a 11.1 percentage point difference. This data is based on 9 recent ranked games in patch 26.7.

How does Zed do against Karthus in the early game?

In the early game, Karthus has the advantage against Zed with a 100.0% win rate versus 0.0%. Karthus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zed do against Karthus in the late game?

In the late game, Zed takes over the Zed vs Karthus matchup with a 71.4% win rate compared to 28.6%. Zed scales better into team fights and objective contests after 25 minutes.

Who wins the Zed vs Karthus matchup?

Zed wins the matchup against Karthus with a 55.6% win rate in League of Legends patch 26.7. The 11.1 percentage point advantage means Zed is significantly favored in this lane matchup based on 9 games analyzed.

What is the best Zed build against Karthus?

The best Zed build against Karthus includes Voltaic Cyclosword, Eclipse, Spear of Shojin with Plated Steelcaps. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Zed runes against Karthus?

The best Zed runes against Karthus use the Inspiration primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Zed vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Zed counter Karthus?

Yes, Zed has a favorable matchup against Karthus with a 55.6% win rate. Zed strongly counters Karthus in lane based on current patch 26.7 data.

How do I play Zed against Karthus?

When playing Zed against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Karthus. Build the recommended items and runes for this specific matchup for the best results.