Zyra - League of Legends Champion
Win Rate
51.5%
Pick Rate
2.8%

Zyravs Karthus

SMageSupport
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 20, 2026
MethodologyData Methodology

Zyra vs Karthus is a decisive matchup in LoL patch 26.7. Zyra wins with a 62.5% win rate (+25.0%) over Karthus based on 8 games. Karthus wins the early laning phase while Zyra scales better into the late game. Below you'll find the best Zyra build, runes, laning stats, and strategies for the Zyra vs Karthus matchup.

Zyra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zyra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 62.5% win rateKarthus(62.5%)
Zyra - 62.5% win rate in this matchup
Zyra
62.5% WR
VS
Karthus vs Zyra matchup - 37.5% win rate
Karthus
37.5% WR

Who Wins the Zyra vs Karthus Matchup?

Zyra wins the Zyra vs Karthus matchup
Winner
Zyra
Matches: 8
62.5%
Win Rate
37.5%
1.7
CS / min
1.8
1,025
DMG / min
1,338
15,940
Gold / game
16,668
272
Heal / min
325
407
DMG Mitigated / min
491
1.3
CC / min
0.8
0.0%
Early Game WR
100.0%
71.4%
Late Game WR
28.6%

Zyra vs Karthus Matchup Summary

The Zyra vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 8 recent matches analyzed, Zyra wins with a 62.5% win rate compared to Karthus's 37.5%, giving Zyra a 25.0 percentage point advantage. Game phase dynamics play a critical role here: Karthus controls the early laning stage, but Zyra outscales as the game goes longer. The matchup shifts dramatically depending on game length — Karthus needs to press advantages before Zyra reaches their power spikes, while Zyra should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Zyra leads by 0.5s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Zyra players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zyra vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Zyra in League of Legends

Karthus is favored during the laning phase against Zyra, winning 4 out of 5 key stat categories. Karthus holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
1.7Zyra
1.8Karthus
Zyra and Karthus farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
1,025Zyra
1,338Karthus
Karthus heavily out-damages Zyra by 313 DMG/min, dominating both short trades and all-in fights. Zyra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
15,940Zyra
16,668Karthus
Karthus earns 728 more gold per game than Zyra, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Karthus slightly faster item completions.
Utility
1.3Zyra
0.8Karthus
Zyra provides 0.5 seconds more crowd control per minute than Karthus, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Zyra coordinate with their jungler and control the pace of skirmishes.
Sustain
680Zyra
816Karthus
Karthus heals and mitigates 136 more damage per minute than Zyra, providing moderate extra durability. This sustain edge allows Karthus to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Zyra.

Best Zyra Build Against Karthus

Sorcerer's Shoes is the optimal boots choice against Karthus, providing the mobility and stats Zyra needs most in this matchup. The top-performing core items for Zyra against Karthus are Liandry's Torment, Shadowflame and Zhonya's Hourglass. This combination gives Zyra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 66.7% win rate across 3 games — well above average and making it the top item path against Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zyra vs Karthus matchup.

Early Game vs Late Game

Early Game
Karthus
100.0%
+100.0% advantage
Zyra early game win rateZyra0.0%
Karthus early game win rateKarthus100.0%
Late Game
Zyra
71.4%
+42.9% advantage
Zyra late game win rateZyra71.4%
Karthus late game win rateKarthus28.6%

Karthus dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Zyra. This lopsided early game means Karthus can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Zyra is far superior in the late game (25+ minutes), boasting a 71.4% win rate — 42.9 points above Karthus. Extended games heavily favor Zyra, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Karthus must aggressively press their early advantage and close out the game before Zyra reaches their scaling breakpoints. If Zyra survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Zyra Runes Against Karthus

Domination rune tree - Zyra primary runes vs KarthusDomination
Dark Harvest - best Zyra rune vs KarthusCheap Shot - best Zyra rune vs KarthusDeep Ward - best Zyra rune vs KarthusTreasure Hunter - best Zyra rune vs Karthus
Sorcery rune tree - Zyra secondary runes vs KarthusSorcery
Celerity - best Zyra rune vs KarthusNimbus Cloak - best Zyra rune vs Karthus
100.0% WR

Running Domination primary with Sorcery secondary allows Zyra to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Zyra matchup data for League of Legends patch 26.7. The table below shows Zyra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zyra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zyra matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
53.03%1321.77389,44957.6%49.3%
57.14%1261.973710,56664.9%53.9%
47.93%1211.87469,67255.1%43.1%
52.43%1031.974710,16363.4%45.2%
55.32%941.976110,11345.7%61.0%
57.78%901.873410,33561.1%55.6%
43.21%811.77529,44950.0%37.2%
48.75%801.878210,02744.1%52.2%
57.75%711.880410,55950.0%62.2%
64.18%672.079511,28661.9%65.2%
43.75%641.97019,66340.0%46.1%
59.68%621.87319,22170.4%51.4%
43.55%621.87629,74836.4%47.5%
39.34%611.86669,11726.7%51.6%
53.33%602.186010,22153.9%52.9%
48.28%582.47049,79962.5%38.2%
50.88%571.87549,99642.9%58.6%
48.08%521.97859,84158.3%39.3%
52.00%502.05969,91752.2%51.9%
46.94%492.677110,65958.8%40.6%
45.83%481.96729,45145.0%46.4%
55.81%431.67849,80366.7%45.5%
35.00%401.77249,65718.8%45.8%
55.26%381.990610,81742.9%62.5%
38.89%362.082811,31658.3%29.2%
48.57%351.68149,48861.5%40.9%
55.88%341.88099,77264.3%50.0%
42.42%331.879712,54023.1%55.0%
43.33%301.274912,27954.5%36.8%
50.00%301.87719,62937.5%64.3%
60.71%282.387210,44060.0%61.1%
28.00%251.77498,94315.4%41.7%
64.00%251.878610,64085.7%55.6%
60.00%251.485113,18655.6%62.5%
58.33%241.97499,09956.3%62.5%
40.91%221.585912,89911.1%61.5%
54.55%222.680311,81383.3%43.8%
50.00%201.381611,74853.9%42.9%
40.00%202.165910,09737.5%41.7%
40.00%201.676611,94736.4%44.4%
63.16%191.879011,21677.8%50.0%
63.16%191.678712,66728.6%83.3%
47.37%192.58209,99844.4%50.0%
55.56%181.686510,88987.5%30.0%
61.11%182.785211,77180.0%53.9%
38.89%181.382112,73833.3%50.0%
52.94%171.577813,34675.0%33.3%
50.00%162.38459,69160.0%45.5%
75.00%161.082411,66190.0%50.0%
60.00%151.487213,764100.0%45.5%
46.67%152.71,12213,61375.0%36.4%
53.33%152.284610,87733.3%83.3%
66.67%152.479210,91050.0%77.8%
85.71%141.31,02312,88375.0%100.0%
57.14%141.395413,46860.0%55.6%
84.62%131.693613,68383.3%85.7%
46.15%134.680611,35160.0%37.5%
38.46%132.51,06513,91025.0%44.4%
41.67%126.38118,96050.0%33.3%
50.00%121.998511,40042.9%60.0%
16.67%123.583711,97820.0%14.3%
66.67%121.71,01512,92133.3%77.8%
72.73%115.998713,86950.0%85.7%
63.64%112.999510,87950.0%71.4%
54.55%115.97709,27850.0%60.0%
50.00%105.896512,23950.0%50.0%
50.00%101.473510,84066.7%25.0%
60.00%103.36267,78233.3%100.0%
50.00%101.292612,73333.3%57.1%
44.44%91.38719,74333.3%66.7%
55.56%91.392012,10750.0%57.1%
44.44%92.777611,02650.0%42.9%
25.00%85.599112,38850.0%16.7%
50.00%85.587410,51633.3%60.0%
62.50%85.57429,33875.0%50.0%
25.00%85.685610,82825.0%25.0%
75.00%81.584915,037100.0%71.4%
62.50%81.489514,02050.0%66.7%
25.00%81.791314,67250.0%16.7%
62.50%81.71,02515,9400.0%71.4%
75.00%86.797711,582100.0%33.3%
57.14%71.61,01414,3470.0%66.7%
71.43%75.879011,29750.0%80.0%
57.14%71.97939,60466.7%50.0%
71.43%72.181713,08850.0%100.0%
57.14%70.972112,17366.7%50.0%
57.14%73.372710,40150.0%66.7%
57.14%73.578112,070100.0%40.0%
71.43%71.21,08612,924100.0%60.0%
71.43%73.09569,873100.0%60.0%
57.14%71.884714,16450.0%60.0%
42.86%73.579910,4820.0%60.0%
57.14%71.887812,15550.0%60.0%
28.57%73.674510,13066.7%0.0%
14.29%75.087211,33150.0%0.0%
57.14%71.474512,29433.3%75.0%
42.86%71.77618,45250.0%33.3%
83.33%64.11,09415,5240.0%83.3%
50.00%61.11,02314,197100.0%25.0%
50.00%61.590914,5550.0%50.0%
33.33%61.81,01512,33533.3%33.3%
50.00%65.171710,3930.0%75.0%
50.00%61.071310,48666.7%33.3%
33.33%65.97768,08425.0%50.0%
33.33%62.41,12612,69850.0%25.0%
80.00%55.578310,43950.0%100.0%
20.00%53.184713,3640.0%25.0%
80.00%51.581411,641100.0%66.7%
20.00%52.35989,1770.0%33.3%
60.00%54.77619,06833.3%100.0%
20.00%55.583110,3030.0%33.3%

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Zyra vs Karthus - Frequently Asked Questions

How does Zyra do against Karthus in League of Legends?

Zyra wins the Zyra vs Karthus matchup with a 62.5% win rate compared to Karthus's 37.5%, a 25.0 percentage point difference. This data is based on 8 recent ranked games in patch 26.7.

How does Zyra do against Karthus in the early game?

In the early game, Karthus has the advantage against Zyra with a 100.0% win rate versus 0.0%. Karthus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zyra do against Karthus in the late game?

In the late game, Zyra takes over the Zyra vs Karthus matchup with a 71.4% win rate compared to 28.6%. Zyra scales better into team fights and objective contests after 25 minutes.

Who wins the Zyra vs Karthus matchup?

Zyra wins the matchup against Karthus with a 62.5% win rate in League of Legends patch 26.7. The 25.0 percentage point advantage means Zyra is significantly favored in this lane matchup based on 8 games analyzed.

What is the best Zyra build against Karthus?

The best Zyra build against Karthus includes Liandry's Torment, Shadowflame, Zhonya's Hourglass with Sorcerer's Shoes. This build achieves a 66.7% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Zyra runes against Karthus?

The best Zyra runes against Karthus use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Zyra vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Zyra counter Karthus?

Yes, Zyra has a favorable matchup against Karthus with a 62.5% win rate. Zyra strongly counters Karthus in lane based on current patch 26.7 data.

How do I play Zyra against Karthus?

When playing Zyra against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Karthus. Build the recommended items and runes for this specific matchup for the best results.