Zyra - League of Legends Champion
Win Rate
51.2%
Pick Rate
2.5%

Zyravs Karthus

AMageSupport
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 7, 2026
MethodologyData Methodology

Zyra vs Karthus is a decisive matchup in LoL patch 26.11. Zyra wins with a 57.1% win rate (+14.3%) over Karthus based on 7 games. Zyra wins the early laning phase while Karthus scales better into the late game. Below you'll find the best Zyra build, runes, laning stats, and strategies for the Zyra vs Karthus matchup.

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Zyra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zyra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Zyra - 57.1% win rate in this matchup
Zyra
57.1% WR
VS
Karthus vs Zyra matchup - 42.9% win rate
Karthus
42.9% WR

Who Wins the Zyra vs Karthus Matchup?

Zyra wins the Zyra vs Karthus matchup
Winner
Zyra
Matches: 7
57.1%
Win Rate
42.9%
1.8
CS / min
2.9
760
DMG / min
1,108
10,268
Gold / game
11,950
171
Heal / min
226
339
DMG Mitigated / min
415
1.4
CC / min
0.6
75.0%
Early Game WR
25.0%
33.3%
Late Game WR
66.7%

Zyra vs Karthus Matchup Summary

The Zyra vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Zyra wins with a 57.1% win rate compared to Karthus's 42.9%, giving Zyra a 14.3 percentage point advantage. Game phase dynamics play a critical role here: Zyra controls the early laning stage, but Karthus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Zyra needs to press advantages before Karthus reaches their power spikes, while Karthus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Zyra leads by 0.8s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Zyra players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zyra vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Zyra in League of Legends

Karthus is favored during the laning phase against Zyra, winning 4 out of 5 key stat categories. Karthus holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
1.8Zyra
2.9Karthus
Karthus significantly out-farms Zyra by 1.1 CS per minute, accumulating an estimated 17 CS lead by mid game. This substantial farming gap gives Karthus a major gold advantage and earlier item completions. Zyra players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
760Zyra
1,108Karthus
Karthus heavily out-damages Zyra by 348 DMG/min, dominating both short trades and all-in fights. Zyra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
10,268Zyra
11,950Karthus
Karthus generates a commanding 1,682 more gold per game than Zyra. This substantial economic advantage means Karthus consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Zyra should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.4Zyra
0.6Karthus
Zyra provides 0.8 seconds more crowd control per minute than Karthus, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Zyra coordinate with their jungler and control the pace of skirmishes.
Sustain
510Zyra
641Karthus
Karthus heals and mitigates 131 more damage per minute than Zyra, providing moderate extra durability. This sustain edge allows Karthus to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Zyra.

Best Zyra Build Against Karthus

Sorcerer's Shoes is the optimal boots choice against Karthus, providing the mobility and stats Zyra needs most in this matchup. The top-performing core items for Zyra against Karthus are Liandry's Torment, Morellonomicon and Blackfire Torch. This combination gives Zyra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zyra vs Karthus matchup.

Early Game vs Late Game

Early Game
Zyra
75.0%
+50.0% advantage
Zyra early game win rateZyra75.0%
Karthus early game win rateKarthus25.0%
Late Game
Karthus
66.7%
+33.3% advantage
Zyra late game win rateZyra33.3%
Karthus late game win rateKarthus66.7%

Zyra dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Karthus. This lopsided early game means Zyra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Karthus is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Zyra. Extended games heavily favor Karthus, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Zyra must aggressively press their early advantage and close out the game before Karthus reaches their scaling breakpoints. If Karthus survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Zyra Runes Against Karthus

Domination rune tree - Zyra primary runes vs KarthusDomination
Electrocute - best Zyra rune vs KarthusCheap Shot - best Zyra rune vs KarthusGrisly Mementos - best Zyra rune vs KarthusUltimate Hunter - best Zyra rune vs Karthus
Sorcery rune tree - Zyra secondary runes vs KarthusSorcery
Manaflow Band - best Zyra rune vs KarthusTranscendence - best Zyra rune vs Karthus
100.0% WR

Running Domination primary with Sorcery secondary allows Zyra to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Zyra matchup data for League of Legends patch 26.11. The table below shows Zyra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zyra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zyra matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.03%2461.97399,69355.3%49.6%
50.47%2122.373910,23653.8%48.5%
53.13%1601.97699,62852.9%53.3%
54.90%1531.87649,71658.7%52.2%
52.00%1501.97739,68957.4%48.3%
54.23%1421.97419,76250.8%56.8%
56.30%1351.979110,11661.9%53.8%
49.15%1182.073510,06540.9%54.0%
41.38%1162.279610,92333.3%44.6%
51.14%881.97228,79156.8%45.5%
51.90%792.073810,23053.9%50.9%
52.63%762.375810,89252.4%52.7%
50.00%741.87119,70153.6%47.8%
44.44%722.075210,37328.6%51.0%
40.91%661.87199,85959.1%31.8%
57.38%611.76858,93655.6%58.8%
52.63%572.288910,44647.4%55.3%
54.39%572.095610,13361.1%51.3%
47.37%571.96109,43952.2%44.1%
59.65%571.97719,58363.2%57.9%
58.93%562.376310,48364.3%57.1%
55.36%562.17989,89157.7%53.3%
46.30%541.87859,91660.0%38.2%
51.02%492.27719,81247.6%53.6%
53.06%491.87889,90456.5%50.0%
50.00%421.98119,76262.5%42.3%
60.98%411.977110,09441.2%75.0%
55.00%402.07059,58347.4%61.9%
38.46%391.87578,55243.8%34.8%
48.57%351.96539,08961.5%40.9%
61.29%311.477713,02969.2%55.6%
33.33%271.877912,11450.0%26.3%
37.04%274.595510,86712.5%47.4%
50.00%261.98669,32940.0%56.3%
48.00%251.783712,26244.4%50.0%
66.67%242.285911,02875.0%62.5%
56.52%231.976310,71233.3%64.7%
50.00%223.681411,54722.2%69.2%
50.00%221.688012,35454.5%45.5%
52.38%213.076711,13866.7%46.7%
57.14%211.692613,06157.1%57.1%
23.81%215.668410,18633.3%11.1%
42.86%212.66967,83436.4%50.0%
50.00%206.096910,98055.6%45.5%
60.00%201.979010,60040.0%66.7%
55.00%201.268312,01233.3%72.7%
52.63%191.67819,64333.3%61.5%
55.56%182.579411,59460.0%53.9%
61.11%184.279112,37260.0%61.5%
38.89%182.065910,04733.3%44.4%
56.25%161.292912,97075.0%37.5%
62.50%162.078810,664100.0%50.0%
37.50%166.01,02611,57350.0%25.0%
33.33%152.26148,16442.9%25.0%
53.33%152.596510,67150.0%54.5%
57.14%141.075711,29371.4%42.9%
50.00%141.878710,94142.9%57.1%
57.14%141.780511,02857.1%57.1%
42.86%140.975510,46960.0%33.3%
76.92%131.984412,069100.0%66.7%
58.33%122.697013,18866.7%55.6%
45.45%112.21,00713,28333.3%50.0%
45.45%111.97049,90850.0%42.9%
27.27%116.097012,5380.0%42.9%
54.55%115.99569,65450.0%60.0%
50.00%101.480112,13266.7%42.9%
70.00%103.187711,167100.0%40.0%
40.00%102.985411,62240.0%40.0%
70.00%101.51,07613,077100.0%62.5%
22.22%92.31,04712,5760.0%25.0%
77.78%91.589310,94280.0%75.0%
33.33%91.71,08211,1770.0%60.0%
66.67%92.673911,041100.0%50.0%
44.44%92.88199,81533.3%50.0%
25.00%85.786912,8360.0%25.0%
12.50%86.11,07811,8620.0%16.7%
50.00%86.41,15912,71350.0%50.0%
62.50%82.371411,33050.0%66.7%
62.50%85.41,13410,09866.7%60.0%
87.50%81.591910,39583.3%100.0%
87.50%82.888712,618100.0%85.7%
57.14%71.876010,26875.0%33.3%
71.43%73.085112,967100.0%60.0%
42.86%71.690413,8970.0%50.0%
71.43%74.77709,75866.7%75.0%
85.71%76.885510,92680.0%100.0%
71.43%76.699710,39050.0%100.0%
57.14%71.587212,27050.0%66.7%
42.86%75.498812,06950.0%40.0%
28.57%74.78509,7010.0%40.0%
50.00%65.789111,675100.0%40.0%
16.67%62.05887,85125.0%0.0%
66.67%61.381010,27666.7%66.7%
50.00%63.581611,00333.3%66.7%
83.33%61.972110,876100.0%75.0%
66.67%61.37409,56760.0%100.0%
50.00%61.590514,080100.0%40.0%
50.00%64.61,03014,4280.0%75.0%
50.00%65.297310,4070.0%75.0%
20.00%51.27579,950100.0%0.0%
100.00%50.971212,315100.0%100.0%
40.00%55.48719,3000.0%66.7%
60.00%54.268111,7160.0%60.0%
20.00%55.586910,11333.3%0.0%
20.00%51.464911,0460.0%50.0%
60.00%55.489910,8390.0%75.0%
60.00%52.977312,0100.0%75.0%
80.00%55.21,0109,81066.7%100.0%
80.00%57.11,1668,75175.0%100.0%
60.00%51.069511,3950.0%75.0%

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Zyra vs Karthus - Frequently Asked Questions

How does Zyra do against Karthus in League of Legends?

Zyra wins the Zyra vs Karthus matchup with a 57.1% win rate compared to Karthus's 42.9%, a 14.3 percentage point difference. This data is based on 7 recent ranked games in patch 26.11.

How does Zyra do against Karthus in the early game?

In the early game, Zyra has the advantage against Karthus with a 75.0% win rate versus 25.0%. Zyra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zyra do against Karthus in the late game?

In the late game, Karthus takes over the Zyra vs Karthus matchup with a 66.7% win rate compared to 33.3%. Karthus scales better into team fights and objective contests after 25 minutes.

Who wins the Zyra vs Karthus matchup?

Zyra wins the matchup against Karthus with a 57.1% win rate in League of Legends patch 26.11. The 14.3 percentage point advantage means Zyra is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Zyra build against Karthus?

The best Zyra build against Karthus includes Liandry's Torment, Morellonomicon, Blackfire Torch with Sorcerer's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Zyra runes against Karthus?

The best Zyra runes against Karthus use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Zyra vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Zyra counter Karthus?

Yes, Zyra has a favorable matchup against Karthus with a 57.1% win rate. Zyra strongly counters Karthus in lane based on current patch 26.11 data.

How do I play Zyra against Karthus?

When playing Zyra against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.