Zyra - League of Legends Champion
Win Rate
50.5%
Pick Rate
2.7%

Zyravs Lissandra

BMageSupport
Patch26.10
Matches788,689
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 18, 2026
MethodologyData Methodology

Zyra vs Lissandra is a decisive matchup in LoL patch 26.10. Zyra wins with a 60.0% win rate (+20.0%) over Lissandra based on 5 games. Zyra holds the advantage in both the early and late game. Below you'll find the best Zyra build, runes, laning stats, and strategies for the Zyra vs Lissandra matchup.

Zyra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zyra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 60.0% win rateLissandra(60.0%)
Zyra - 60.0% win rate in this matchup
Zyra
60.0% WR
VS
Lissandra vs Zyra matchup - 40.0% win rate
Lissandra
40.0% WR

Who Wins the Zyra vs Lissandra Matchup?

Zyra wins the Zyra vs Lissandra matchup
Winner
Zyra
Matches: 5
60.0%
Win Rate
40.0%
4.0
CS / min
4.3
995
DMG / min
675
10,656
Gold / game
11,128
83
Heal / min
134
302
DMG Mitigated / min
315
2.1
CC / min
1.7
50.0%
Early Game WR
50.0%
66.7%
Late Game WR
33.3%

Zyra vs Lissandra Matchup Summary

The Zyra vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Zyra wins with a 60.0% win rate compared to Lissandra's 40.0%, giving Zyra a 20.0 percentage point advantage. Zyra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in damage output, where Zyra leads by 320 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Zyra players can confidently pick into Lissandra and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Lissandra away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zyra vs Lissandra Laning Phase Breakdown

Lissandra wins the laning phase against Zyra in League of Legends

Lissandra is favored during the laning phase against Zyra, winning 3 out of 5 key stat categories. Lissandra holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.

Farming
4.0Zyra
4.3Lissandra
Zyra and Lissandra farm at nearly identical rates in this matchup, with only a 0.3 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
995Zyra
675Lissandra
Zyra heavily out-damages Lissandra by 320 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zyra's sustained damage advantage take over.
Economy
10,656Zyra
11,128Lissandra
Lissandra earns 472 more gold per game than Zyra, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Lissandra slightly faster item completions.
Utility
2.1Zyra
1.7Lissandra
Zyra provides 0.4 seconds more crowd control per minute than Lissandra, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Zyra coordinate with their jungler and control the pace of skirmishes.
Sustain
385Zyra
449Lissandra
Lissandra heals and mitigates 64 more damage per minute than Zyra, providing moderate extra durability. This sustain edge allows Lissandra to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Zyra.

Best Zyra Build Against Lissandra

Sorcerer's Shoes is the optimal boots choice against Lissandra, providing the mobility and stats Zyra needs most in this matchup. The top-performing core items for Zyra against Lissandra are Malignance, Rylai's Crystal Scepter and Blackfire Torch. This combination gives Zyra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zyra vs Lissandra matchup.

Early Game vs Late Game

Early Game
Zyra
50.0%
+0.0% advantage
Zyra early game win rateZyra50.0%
Lissandra early game win rateLissandra50.0%
Late Game
Zyra
66.7%
+33.3% advantage
Zyra late game win rateZyra66.7%
Lissandra late game win rateLissandra33.3%

The early game (first 15 minutes) is a toss-up between Zyra and Lissandra, with Zyra holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Zyra is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Lissandra. Extended games heavily favor Zyra, whose kit and scaling make them a dominant force in team fights and objective control.

Zyra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Zyra Runes Against Lissandra

Sorcery rune tree - Zyra primary runes vs LissandraSorcery
Arcane Comet - best Zyra rune vs LissandraManaflow Band - best Zyra rune vs LissandraTranscendence - best Zyra rune vs LissandraScorch - best Zyra rune vs Lissandra
Domination rune tree - Zyra secondary runes vs LissandraDomination
Relentless Hunter - best Zyra rune vs LissandraTaste of Blood - best Zyra rune vs Lissandra
100.0% WR

Running Sorcery primary with Domination secondary allows Zyra to press their advantage against Lissandra, amplifying the strengths that make this a favorable matchup.


Zyra matchup data for League of Legends patch 26.10. The table below shows Zyra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zyra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zyra matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
48.01%2772.07709,91947.4%48.3%
52.45%2042.174010,18647.8%54.8%
46.67%1651.87519,62955.7%41.4%
45.51%1561.87789,80842.6%47.4%
56.49%1542.077510,02360.3%54.2%
41.61%1492.07809,64948.1%37.9%
50.00%1321.87349,56351.9%48.8%
55.12%1271.977310,08655.6%54.9%
48.00%1252.085510,97940.5%51.1%
49.50%1011.97829,69055.6%46.1%
41.58%1011.97629,72242.5%41.0%
47.47%991.87219,70756.4%41.7%
43.48%921.97268,93038.6%47.9%
50.65%772.372510,00447.8%51.9%
67.12%731.66899,25466.7%67.4%
45.07%711.97089,73454.8%37.5%
64.71%682.286110,02275.0%57.5%
56.72%672.572310,08068.0%50.0%
53.73%671.97929,18264.7%42.4%
53.23%621.67458,56746.9%60.0%
40.98%611.88249,87950.0%34.3%
57.63%591.96408,80261.5%54.5%
50.00%581.979210,35340.9%55.6%
57.89%571.991210,29966.7%53.9%
43.14%511.774211,37856.3%37.1%
55.10%492.274610,04442.1%63.3%
53.19%471.87059,60458.8%50.0%
34.88%431.98079,40837.5%33.3%
59.52%422.17789,23560.0%59.1%
45.95%371.97429,22046.7%45.5%
52.78%361.98369,26150.0%54.5%
50.00%341.77869,64746.1%52.4%
57.58%331.277812,21973.3%44.4%
54.84%313.088111,30733.3%63.6%
46.67%305.792511,91912.5%59.1%
48.28%292.477411,32242.9%50.0%
70.37%271.97559,76261.5%78.6%
37.04%271.494514,46742.9%35.0%
37.04%271.385713,01245.5%31.3%
61.54%263.177910,15288.9%47.1%
50.00%261.981110,77875.0%38.9%
44.00%251.384712,12033.3%47.4%
52.00%251.87358,30857.1%45.5%
54.17%241.283512,49661.5%45.5%
61.90%214.01,11612,49060.0%62.5%
57.14%213.495010,42650.0%66.7%
47.62%213.087512,02050.0%45.5%
57.14%211.485314,14550.0%60.0%
47.62%215.784710,55325.0%61.5%
60.00%201.188912,19450.0%70.0%
70.00%201.796011,822100.0%57.1%
36.84%191.782911,61716.7%46.1%
47.37%191.67919,51345.5%50.0%
42.11%192.685810,38220.0%50.0%
58.82%174.71,05112,70566.7%54.5%
58.82%172.27308,79375.0%53.9%
52.94%171.788312,73550.0%54.5%
41.18%171.679610,92940.0%41.7%
50.00%162.471411,69244.4%57.1%
37.50%161.483611,71444.4%28.6%
50.00%165.688111,06760.0%45.5%
60.00%153.482911,79733.3%66.7%
53.33%156.096010,59033.3%83.3%
60.00%154.981910,73850.0%66.7%
60.00%153.791910,491100.0%53.9%
35.71%143.385111,33950.0%30.0%
42.86%144.285310,88640.0%44.4%
64.29%141.81,04014,76666.7%63.6%
46.15%131.179510,35742.9%50.0%
53.85%131.469610,10637.5%80.0%
75.00%122.37019,52180.0%71.4%
75.00%125.678211,09350.0%100.0%
58.33%121.679311,834100.0%50.0%
54.55%114.888911,51450.0%57.1%
45.45%113.375010,24540.0%50.0%
45.45%111.589813,77666.7%37.5%
50.00%101.292111,65240.0%60.0%
40.00%101.286213,839100.0%33.3%
50.00%104.695011,8320.0%71.4%
40.00%102.887413,172100.0%33.3%
70.00%105.791111,23375.0%66.7%
60.00%105.480611,81550.0%75.0%
60.00%101.58359,00775.0%50.0%
77.78%95.71,00812,739100.0%71.4%
66.67%91.389412,59760.0%75.0%
77.78%91.981911,724100.0%60.0%
44.44%91.87558,52860.0%25.0%
77.78%91.31,02315,390100.0%71.4%
55.56%92.383110,33450.0%66.7%
37.50%86.598012,8460.0%50.0%
50.00%85.29078,76475.0%25.0%
75.00%81.591815,399100.0%66.7%
50.00%85.18388,62520.0%100.0%
42.86%74.91,06911,27966.7%25.0%
42.86%76.18079,80450.0%40.0%
57.14%73.798913,43975.0%33.3%
42.86%74.57387,39340.0%50.0%
28.57%71.787910,7490.0%66.7%
28.57%72.07549,54425.0%33.3%
57.14%76.286712,35750.0%60.0%
28.57%76.21,07311,9630.0%40.0%
66.67%63.97309,645100.0%50.0%
50.00%62.389711,9890.0%100.0%
50.00%61.086413,966100.0%40.0%
50.00%61.982013,0660.0%60.0%
83.33%61.695612,798100.0%75.0%
33.33%62.795913,949100.0%20.0%
83.33%62.46559,91766.7%100.0%
50.00%62.389111,92966.7%33.3%
33.33%61.881410,7760.0%40.0%
16.67%66.11,04812,8750.0%50.0%
66.67%61.388315,373100.0%33.3%
50.00%65.31,12813,99150.0%50.0%
0.00%53.195212,3040.0%0.0%
60.00%54.099510,65650.0%66.7%
60.00%51.174711,81266.7%50.0%
60.00%51.61,03210,28966.7%50.0%
20.00%50.971910,20533.3%0.0%
60.00%51.977811,24150.0%66.7%
80.00%51.485411,247100.0%75.0%

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Zyra vs Lissandra - Frequently Asked Questions

How does Zyra do against Lissandra in League of Legends?

Zyra wins the Zyra vs Lissandra matchup with a 60.0% win rate compared to Lissandra's 40.0%, a 20.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.

How does Zyra do against Lissandra in the early game?

In the early game, Zyra has the advantage against Lissandra with a 50.0% win rate versus 50.0%. Zyra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zyra do against Lissandra in the late game?

In the late game, Zyra takes over the Zyra vs Lissandra matchup with a 66.7% win rate compared to 33.3%. Zyra scales better into team fights and objective contests after 25 minutes.

Who wins the Zyra vs Lissandra matchup?

Zyra wins the matchup against Lissandra with a 60.0% win rate in League of Legends patch 26.10. The 20.0 percentage point advantage means Zyra is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Zyra build against Lissandra?

The best Zyra build against Lissandra includes Malignance, Rylai's Crystal Scepter, Blackfire Torch with Sorcerer's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Zyra runes against Lissandra?

The best Zyra runes against Lissandra use the Sorcery primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Zyra vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Zyra counter Lissandra?

Yes, Zyra has a favorable matchup against Lissandra with a 60.0% win rate. Zyra strongly counters Lissandra in lane based on current patch 26.10 data.

How do I play Zyra against Lissandra?

When playing Zyra against Lissandra, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.