Noxious Fumes•Power

Is Noxious Fumes good in Slay the Spire 2?

Noxious Fumes is an uncommon Silent power in Slay the Spire 2. In combat it resolves as: At the start of your turn, apply Poison to ALL enemies. It currently underperforms most alternatives, sitting at D tier in our Slay the Spire 2 card rankings.

Across 130 recorded runs, decks running it win 26.9% of the time, comfortably clear of the 19.0% average, by 7.9%. It’s a more selective pick, turning up in just 3.4% of decks that could run it. Defect players keep it in 0.2% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.3 times in the decks that take it.

It performs best next to Tactician — together they post a +29.2% swing in win rate. It also has strong chemistry with the relic Bronze Scales, which moves its win rate by +25.2%. At 1 energy, it’s upgraded in 42.2% of runs and usually joins the deck around floor 14.

That’s 29 wins, 79 deaths, and 22 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Entomancer Elite, which closes out 6.2% of its appearances. Read on for Noxious Fumes’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Best Cards to Pair with Noxious Fumes

Ranked by win-rate lift, Noxious Fumes performs best alongside Tactician (+29.2%), Reflex (+26.6%), and Shadowmeld (+18.4%).

Tactician+29.2%21 runsReflex+26.6%13 runsShadowmeld+18.4%8 runsMaster of Strategy+17.7%5 runsRicochet+15.9%25 runsAfterimage+15.9%15 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Noxious Fumes Win Rate by Class

Noxious Fumes is played across 3 classes, led by Defect (100.0%), Silent (26.4%), and Regent (0.0%) by win rate.

The Defect100.0%1 runsThe Silent26.4%128 runsThe Regent0.0%1 runs

Best Relics for Noxious Fumes

Noxious Fumes pairs best with the relics Bronze Scales (+25.2%), Gorget (+23.9%), and Centennial Puzzle (+22.1%), ranked by win-rate lift.

Bronze Scales+25.2%26 runsGorget+23.9%18 runsCentennial Puzzle+22.1%22 runsLasting Candy+21.6%11 runsReptile Trinket+21.2%8 runsMango???+20.9%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Noxious Fumes Card Details

Noxious Fumes is an uncommon power costing 1 energy; it’s upgraded in 42.2% of runs and usually picked up by floor 14.

At the start of your turn, apply Poison to ALL enemies.

What Ends Runs with Noxious Fumes

Noxious Fumes’s most common run-enders are Entomancer Elite (6.2%), Knowledge Demon Boss (5.4%), and Queen Boss (5.4%).

• Entomancer Elite6.2% of runs
• Knowledge Demon Boss5.4% of runs
• Queen Boss5.4% of runs
• Test Subject Boss3.8% of runs
• The Insatiable Boss3.8% of runs

See Also

Compare Noxious Fumes with the rest of the best Slay the Spire 2 cards, relics, and classes below.