Noxious Fumes•Power

Is Noxious Fumes good in Slay the Spire 2?

Noxious Fumes is an uncommon Silent power in Slay the Spire 2. In combat it resolves as: At the start of your turn, apply Poison to ALL enemies. It ranks among the strongest cards its class can draft right now, earning a spot at B tier in our Slay the Spire 2 card tier list.

Across 16 recorded runs, decks running it win 27.3% of the time, comfortably clear of the 12.6% average, by 14.7%. It’s a more selective pick, turning up in just 3.1% of decks that could run it. Silent players keep it in 15.4% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Ultimate Defend — together they post a +72.7% swing in win rate. It also has strong chemistry with the relic Ice Cream, which moves its win rate by +72.7%. At 1 energy, it’s upgraded in 33.3% of runs and usually joins the deck around floor 15.

That’s 3 wins, 8 deaths, and 5 abandoned runs with it in the deck. Read on for Noxious Fumes’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Best Cards to Pair with Noxious Fumes

Ranked by win-rate lift, Noxious Fumes performs best alongside Ultimate Defend (+72.7%), Flechettes (+72.7%), and Piercing Wail (+72.7%).

Ultimate Defend+72.7%4 runsFlechettes+72.7%3 runsPiercing Wail+72.7%3 runsFlick-Flack+39.4%3 runsAdrenaline+32.7%5 runsAccelerant+22.7%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Noxious Fumes Win Rate by Class

Noxious Fumes is drafted only by the Silent, where it holds a 27.3% win rate across 16 runs.

The Silentappears in 15.4% of its runs (16 tracked)

Best Relics for Noxious Fumes

Noxious Fumes pairs best with the relics Ice Cream (+72.7%), Oddly Smooth Stone (+72.7%), and Bag of Marbles (+47.7%), ranked by win-rate lift.

Ice Cream+72.7%3 runsOddly Smooth Stone+72.7%3 runsBag of Marbles+47.7%6 runsBlood Vial+39.4%3 runsBronze Scales+39.4%4 runsThe Chosen Cheese+22.7%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Noxious Fumes Card Details

Noxious Fumes is an uncommon power costing 1 energy; it’s upgraded in 33.3% of runs and usually picked up by floor 15.

At the start of your turn, apply Poison to ALL enemies.

See Also

Compare Noxious Fumes with the rest of the best Slay the Spire 2 cards, relics, and classes below.