Decay•Curse

Is Decay good in Slay the Spire 2?

Decay is a curse Curse curse in Slay the Spire 2. In combat it resolves as: At the end of your turn, if this is in your Hand, take 2 damage. It ranks among the strongest cards its class can draft right now, earning a spot at S tier in our Slay the Spire 2 card tier list.

Across 69 recorded runs, decks running it win 43.1% of the time, comfortably clear of the 19.0% average, by 24.1%. It’s a more selective pick, turning up in just 1.8% of decks that could run it. Necrobinder players keep it in 1.0% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.

It performs best next to Leap — together they post a +16.3% swing in win rate. It also has strong chemistry with the relic Horn Cleat, which moves its win rate by +23.4%. At - energy, it’s upgraded in 0.0% of runs and usually joins the deck around floor 26.

That’s 25 wins, 33 deaths, and 11 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 7.2% of its appearances. Read on for Decay’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Curse run.

Best Cards to Pair with Decay

Ranked by win-rate lift, Decay performs best alongside Leap (+16.3%), Scrape (+16.3%), and Grave Warden (+15.1%).

Leap+16.3%4 runsScrape+16.3%4 runsGrave Warden+15.1%6 runsDirge+13.1%3 runsFeral+13.1%3 runsStoke+13.1%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Decay Win Rate by Class

Decay is played across 5 classes, led by Necrobinder (62.5%), Defect (50.0%), and Silent (37.5%) by win rate.

The Necrobinder62.5%8 runsThe Defect50.0%14 runsThe Silent37.5%17 runsThe Regent37.5%9 runsThe Ironclad35.7%21 runs

Best Relics for Decay

Decay pairs best with the relics Horn Cleat (+23.4%), Lizard Tail (+21.3%), and Oddly Smooth Stone (+19.1%), ranked by win-rate lift.

Horn Cleat+23.4%7 runsLizard Tail+21.3%6 runsOddly Smooth Stone+19.1%13 runsSturdy Clamp+19.0%5 runsMercury Hourglass+17.6%7 runsPotion Belt+17.3%17 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Decay Card Details

Decay is a curse curse costing - energy; it’s upgraded in 0.0% of runs and usually picked up by floor 26.

At the end of your turn, if this is in your Hand, take 2 damage.

What Ends Runs with Decay

Decay’s most common run-enders are Knowledge Demon Boss (7.2%), Kaiser Crab Boss (4.3%), and Test Subject Boss (4.3%).

• Knowledge Demon Boss7.2% of runs
• Kaiser Crab Boss4.3% of runs
• Test Subject Boss4.3% of runs
• Knights Elite4.3% of runs
• The Obscura Normal2.9% of runs

See Also

Compare Decay with the rest of the best Slay the Spire 2 cards, relics, and classes below.