Panache•Power

Is Panache good in Slay the Spire 2?

Panache is an uncommon Colorless power in Slay the Spire 2. In combat it resolves as: Every time you play 5 cards in a single turn, deal damage to ALL enemies. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 166 recorded runs, decks running it win 32.9% of the time, comfortably clear of the 13.9% average, by 19.0%. It’s a more selective pick, turning up in just 1.4% of decks that could run it. Offer data backs the pick — taken 6.8% of the time it is shown, with 28.9% for runs that took it against 24.6% for runs that did not, a +3.4% pick lift across 38 decided runs. Silent players keep it in 2.1% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Mad Science — together they post a +21.7% swing in win rate. It also has strong chemistry with the relic Whetstone, which moves its win rate by +24.2%. At 0 energy, it’s upgraded in 19.3% of runs and usually joins the deck around floor 21.

That’s 54 wins, 110 deaths, and 2 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Aeonglass Boss, which closes out 6.0% of its appearances. Read on for Panache’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Colorless run.

Pick or Skip: Panache

Out of 559 recorded offers Panache is taken 6.8% of the time, and taking it is worth +3.4% in pick lift — 28.9% for runs that picked it against 24.6% for runs that skipped, across 38 decided runs.

Taken 38 times out of 559 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Panache

Panache is strongest when it joins the deck in Act 3, where runs win 59.5% across 44 runs — one of 3 recorded pickup windows.

Win rate of runs by the act Panache entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Panache

Ranked by win-rate lift, Panache performs best alongside Mad Science (+21.7%), Up My Sleeve (+19.8%), and Accuracy (+19.3%).

Mad Science+21.7%18 runsUp My Sleeve+19.8%19 runsAccuracy+19.3%26 runsTactician+18.2%16 runsBlade Dance+17.8%32 runsInfinite Blades+13.2%22 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Panache Win Rate by Class

Panache is played across 5 classes, led by Silent (42.6%), Ironclad (34.5%), and Regent (27.3%) by win rate.

The Silent42.6%62 runsThe Ironclad34.5%29 runsThe Regent27.3%23 runsThe Defect22.9%35 runsThe Necrobinder18.8%16 runs

Best Relics for Panache

Panache pairs best with the relics Whetstone (+24.2%), Permafrost (+21.1%), and Vajra (+20.5%), ranked by win-rate lift.

Whetstone+24.2%31 runsPermafrost+21.1%23 runsVajra+20.5%29 runsPendulum+20.1%34 runsNunchaku+20.0%18 runsAnchor+18.9%34 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Panache Card Details

Panache is an uncommon power costing 0 energy; it’s upgraded in 19.3% of runs and usually picked up by floor 21.

Every time you play 5 cards in a single turn, deal damage to ALL enemies.

What Ends Runs with Panache

Panache’s most common run-enders are Aeonglass Boss (6.0%), Knowledge Demon Boss (6.0%), and Entomancer Elite (4.2%).

• Aeonglass Boss6.0% of runs
• Knowledge Demon Boss6.0% of runs
• Entomancer Elite4.2% of runs
• Mecha Knight Elite4.2% of runs
• The Insatiable Boss4.2% of runs

See Also

Compare Panache with the rest of the best Slay the Spire 2 cards, relics, and classes below.