Red Skull Relic

Is Red Skull good in Slay the Spire 2?

In Slay the Spire 2, Red Skull is a common relic you can pick up on your climb. Its effect: While your HP is at or below %, you have additional Strength. The data marks it as a weaker relic, settling at D tier — rarely a run-defining grab.

Over 324 tracked runs the win rate of decks holding it sits at 33.0%, 19.2% ahead of the 13.8% all-run baseline. It sees lighter play, carried in only 1.6% of runs. It does its best work in the hands of the Ironclad, who post a 33.0% win rate with it. Within Ironclad runs specifically, it’s carried 7.0% of the time.

Its standout card pairing is Dark Embrace, which lifts the relic’s win rate by +27.0% when both are in play. It also works nicely with Primal Force, good for a +25.8% win-rate change. It typically enters the deck near floor 21. As a common relic, how often it’s offered depends on its rarity tier.

Of the runs that carried it, 106 ended in victory while 215 fell to a defeat. Its most common run-ender is Test Subject Boss, finishing 8.6% of the runs it appears in. See the best cards, class split, and threats below for the full read on whether Red Skull is worth grabbing.

Pick or Skip: Red Skull

Players take Red Skull in 57.3% of the 571 offers it appears in; those runs win 32.7% against 35.0% for runs that passed, a pick lift of -2.3% over 324 decided runs.

Taken 327 times out of 571 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

Best Cards with Red Skull

The cards that gain the most from carrying Red Skull are Dark Embrace (+27.0%), Primal Force (+25.8%), and Barricade (+24.1%), each shown with its win-rate swing.

Dark Embrace+27.0%15 runsPrimal Force+25.8%17 runsBarricade+24.1%35 runsHowl from Beyond+22.5%36 runsOffering+19.5%59 runsPillage+19.0%25 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Red Skull Win Rate by Class

Red Skull’s class data comes mostly from the Ironclad, at a 33.0% win rate over 324 runs.

The Ironcladappears in 7.0% of its runs (324 tracked)

Red Skull Details

Carried in 1.6% of runs, Red Skull is a common relic typically acquired near floor 21.

While your HP is at or below %, you have additional Strength.

What Ends Runs with Red Skull

Runs carrying Red Skull end most often against Test Subject Boss (8.6%), Queen Boss (7.4%), and Kaiser Crab Boss (6.8%) — the share of its runs each accounts for is shown.

• Test Subject Boss8.6% of runs
• Queen Boss7.4% of runs
• Kaiser Crab Boss6.8% of runs
• Knowledge Demon Boss5.9% of runs
• Aeonglass Boss5.2% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.