Red SkullRelic
While your HP is at or below %, you have additional Strength.
Is Red Skull good in Slay the Spire 2?
In Slay the Spire 2, Red Skull is a common relic you can pick up on your climb. Its effect: While your HP is at or below %, you have additional Strength. Performance-wise it’s a steady, unspectacular pick rated C tier overall.
Over 41 tracked runs the win rate of decks holding it sits at 46.0%, 27.0% ahead of the 19.0% all-run baseline. It sees lighter play, carried in only 1.1% of runs. It does its best work in the hands of the Ironclad, who post a 46.0% win rate with it. Within Ironclad runs specifically, it’s carried 5.8% of the time.
Its standout card pairing is Uppercut, which lifts the relic’s win rate by +54.0% when both are in play. It also works nicely with Dismantle, good for a +54.0% win-rate change. It typically enters the deck near floor 19. As a common relic, how often it’s offered depends on its rarity tier.
Of the runs that carried it, 17 ended in victory while 20 fell to a defeat. Its most common run-ender is Kaiser Crab Boss, finishing 7.3% of the runs it appears in. See the best cards, class split, and threats below for the full read on whether Red Skull is worth grabbing.
Red Skull Win Rate & Pick Rate
At a 46.0% win rate, Red Skull runs 27.0% ahead of the 19.0% all-run baseline — the bars below put the two side by side.
Run Outcomes with Red Skull
Across the 41 runs that carried Red Skull, 17 ended in a win and 24 in a loss — a 41.5% win share, counting abandons as losses.
- Wins 41.5%
- Losses 58.5%
Red Skull Win Rate by Class
Red Skull’s class data comes mostly from the Ironclad, at a 46.0% win rate over 41 runs.
The Ironcladappears in 5.8% of its runs (41 tracked)Red Skull Details
Carried in 1.1% of runs, Red Skull is a common relic typically acquired near floor 19.
While your HP is at or below %, you have additional Strength.
What Ends Runs with Red Skull
Runs carrying Red Skull end most often against Kaiser Crab Boss (7.3%), Soul Fysh Boss (4.9%), and Mecha Knight Elite (4.9%) — the share of its runs each accounts for is shown.
- Kaiser Crab Boss7.3% of runs
- Soul Fysh Boss4.9% of runs
- Mecha Knight Elite4.9% of runs
- The Insatiable Boss4.9% of runs
- Queen Boss4.9% of runs
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Red Skull – Frequently Asked Questions
Is Red Skull good in Slay the Spire 2?
Across 41 tracked runs carrying it, Red Skull wins 46.0% of the time — +27.0% above the average run. Win rate reflects how often runs with the relic end in victory.
What does Red Skull do in Slay the Spire 2?
While your HP is at or below %, you have additional Strength.
How rare is Red Skull in Slay the Spire 2?
Red Skull is a Common relic, picked up in 1.1% of tracked runs.
What is the best card to use with Red Skull?
In tracked runs, Red Skull has performed best alongside Uppercut, which lifts its win rate by +54.0% over 3 runs together.
See Also
Keep exploring Slay the Spire 2 tier lists and stats below.