Anivia - League of Legends Champion
Win Rate
48.8%
Pick Rate
2.3%

Aniviavs Lissandra

FMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 19, 2026
MethodologyData Methodology

Anivia vs Lissandra is a decisive matchup in LoL patch 26.7. Lissandra wins with a 58.6% win rate (+17.2%) over Anivia based on 29 games. Lissandra holds the advantage in both the early and late game. Below you'll find the best Anivia build, runes, laning stats, and strategies for the Anivia vs Lissandra matchup.

Anivia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Anivia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 41.4% win rateLissandra(41.4%)
Anivia - 41.4% win rate in this matchup
Anivia
41.4% WR
VS
Lissandra vs Anivia matchup - 58.6% win rate
Lissandra
58.6% WR

Who Wins the Anivia vs Lissandra Matchup?

Lissandra wins the Anivia vs Lissandra matchup
Winner
Lissandra
Matches: 29
41.4%
Win Rate
58.6%
6.6
CS / min
6.5
828
DMG / min
962
11,876
Gold / game
11,727
181
Heal / min
163
551
DMG Mitigated / min
439
1.7
CC / min
1.6
36.4%
Early Game WR
63.6%
44.4%
Late Game WR
55.6%

Anivia vs Lissandra Matchup Summary

The Anivia vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 29 recent matches analyzed, Lissandra wins with a 58.6% win rate compared to Anivia's 41.4%, giving Lissandra a 17.2 percentage point advantage. Lissandra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Anivia players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Anivia leads by 131 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a strong advantage in this matchup. Anivia players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Lissandra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Anivia vs Lissandra Laning Phase Breakdown

Anivia wins the laning phase against Lissandra in League of Legends

Anivia is favored during the laning phase against Lissandra, winning 4 out of 5 key stat categories. Anivia holds advantages in farming, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.6Anivia
6.5Lissandra
Anivia and Lissandra farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
828Anivia
962Lissandra
Lissandra heavily out-damages Anivia by 134 DMG/min, dominating both short trades and all-in fights. Anivia should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Lissandra's sustained damage advantage take over.
Economy
11,876Anivia
11,727Lissandra
Anivia and Lissandra generate nearly equal gold per game, with just a 149 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.7Anivia
1.6Lissandra
Both Anivia and Lissandra provide similar amounts of crowd control (0.0s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
732Anivia
601Lissandra
Anivia heals and mitigates 131 more damage per minute than Lissandra, providing moderate extra durability. This sustain edge allows Anivia to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Lissandra.

Best Anivia Build Against Lissandra

Mercury's Treads is the optimal boots choice against Lissandra, providing the mobility and stats Anivia needs most in this matchup. The top-performing core items for Anivia against Lissandra are Rod of Ages, Liandry's Torment and Malignance. This combination gives Anivia an effective balance of damage, survivability, and utility for the matchup. This build has a 25.0% win rate across 4 games. While the overall matchup may be difficult, this item path gives Anivia the best chance to compete against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Anivia vs Lissandra matchup.

Early Game vs Late Game

Early Game
Lissandra
63.6%
+27.3% advantage
Anivia early game win rateAnivia36.4%
Lissandra early game win rateLissandra63.6%
Late Game
Lissandra
55.6%
+11.1% advantage
Anivia late game win rateAnivia44.4%
Lissandra late game win rateLissandra55.6%

Lissandra dominates the early game (first 15 minutes) with a commanding 63.6% win rate — a 27.3 percentage point lead over Anivia. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Lissandra is far superior in the late game (25+ minutes), boasting a 55.6% win rate — 11.1 points above Anivia. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.

Lissandra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Anivia players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Anivia Runes Against Lissandra

Domination rune tree - Anivia primary runes vs LissandraDomination
Electrocute - best Anivia rune vs LissandraCheap Shot - best Anivia rune vs LissandraGrisly Mementos - best Anivia rune vs LissandraRelentless Hunter - best Anivia rune vs Lissandra
Sorcery rune tree - Anivia secondary runes vs LissandraSorcery
Gathering Storm - best Anivia rune vs LissandraAxiom Arcanist - best Anivia rune vs Lissandra
100.0% WR

The Domination and Sorcery rune setup gives Anivia the best tools to compete against Lissandra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Anivia matchup data for League of Legends patch 26.7. The table below shows Anivia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Anivia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Anivia matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
43.37%836.674612,01848.6%39.1%
38.36%736.775011,25838.7%38.1%
41.94%626.668811,23941.9%41.9%
37.74%536.380811,34037.0%38.5%
50.00%524.365710,28650.0%50.0%
44.23%526.679810,75548.1%40.0%
55.77%525.975612,17466.7%48.4%
47.83%466.684411,23252.2%43.5%
48.89%456.575211,20645.0%52.0%
54.55%446.267111,13960.9%47.6%
59.52%426.873410,49773.1%37.5%
50.00%406.869410,26242.9%57.9%
44.74%386.570410,53950.0%37.5%
31.43%356.878212,63433.3%30.4%
35.48%316.383112,71142.9%29.4%
48.39%316.870312,66940.0%56.3%
38.71%311.853810,15545.5%35.0%
54.84%314.883311,99650.0%57.1%
60.00%306.271311,45945.5%68.4%
53.33%306.975311,39762.5%42.9%
41.38%296.682811,87636.4%44.4%
50.00%286.773111,81358.3%43.8%
44.44%276.665810,34743.8%45.5%
44.44%274.867810,34038.5%50.0%
53.85%266.780310,96530.8%76.9%
62.50%246.884611,82076.9%45.5%
54.17%245.274412,21557.1%52.9%
45.83%246.471311,90144.4%46.7%
47.83%231.95409,03750.0%45.5%
56.52%236.375412,08170.0%46.1%
69.57%236.875711,04371.4%66.7%
50.00%226.067311,80525.0%64.3%
59.09%226.873611,46853.9%66.7%
47.62%211.95419,21633.3%58.3%
60.00%206.978312,31860.0%60.0%
45.00%201.94849,49440.0%50.0%
45.00%206.280010,89833.3%54.5%
36.84%191.95597,75246.1%16.7%
52.63%193.664510,67575.0%36.4%
31.58%192.85448,37428.6%40.0%
21.05%191.85629,76025.0%18.2%
57.89%196.787411,13055.6%60.0%
68.42%196.678812,01471.4%66.7%
33.33%187.183912,36150.0%25.0%
55.56%183.664611,34933.3%66.7%
35.29%172.463310,03922.2%50.0%
41.18%177.069611,07140.0%42.9%
35.29%176.571411,48428.6%40.0%
31.25%163.185610,56933.3%30.0%
50.00%162.75339,91240.0%54.5%
50.00%163.55749,07512.5%87.5%
60.00%151.960210,52733.3%77.8%
46.67%155.367213,05360.0%40.0%
42.86%141.75328,24640.0%50.0%
57.14%141.74578,91950.0%62.5%
64.29%141.75269,39766.7%62.5%
38.46%136.583212,10816.7%57.1%
61.54%136.879213,00366.7%57.1%
61.54%136.371710,46862.5%60.0%
69.23%136.885612,70283.3%57.1%
76.92%137.279812,363100.0%50.0%
41.67%125.792412,47950.0%37.5%
41.67%121.94858,55237.5%50.0%
83.33%127.31,15912,87880.0%85.7%
58.33%125.568212,22440.0%71.4%
63.64%116.890710,27380.0%50.0%
63.64%116.01,06210,87680.0%50.0%
27.27%111.55528,62725.0%33.3%
36.36%114.991914,95825.0%42.9%
45.45%116.492711,56450.0%40.0%
27.27%111.760810,16950.0%22.2%
40.00%106.490812,21640.0%40.0%
60.00%107.677212,32275.0%50.0%
70.00%106.385311,39360.0%80.0%
77.78%96.81,03913,830100.0%75.0%
22.22%92.84618,7840.0%40.0%
44.44%96.978211,81150.0%42.9%
44.44%92.957312,3380.0%50.0%
22.22%96.366911,0900.0%33.3%
44.44%96.387812,55350.0%40.0%
55.56%91.661111,01066.7%50.0%
62.50%86.764912,597100.0%57.1%
50.00%82.566810,737100.0%42.9%
62.50%86.778511,94633.3%80.0%
37.50%87.477111,91666.7%20.0%
87.50%87.61,01513,365100.0%75.0%
57.14%77.06549,67540.0%100.0%
71.43%77.997312,83380.0%50.0%
71.43%76.469410,66375.0%66.7%
42.86%77.06589,61460.0%0.0%
14.29%77.185411,6170.0%25.0%
50.00%66.08157,92350.0%50.0%
66.67%67.079214,190100.0%60.0%
83.33%66.295112,293100.0%75.0%
50.00%66.25959,45050.0%50.0%
50.00%63.575212,7410.0%50.0%
66.67%66.152511,39850.0%75.0%
16.67%61.94419,1820.0%25.0%
40.00%57.277811,38733.3%50.0%
80.00%57.266811,841100.0%66.7%
20.00%51.66978,61820.0%0.0%
60.00%56.998513,7750.0%75.0%
20.00%53.15079,3830.0%33.3%

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Anivia vs Lissandra - Frequently Asked Questions

How does Anivia do against Lissandra in League of Legends?

Lissandra wins the Anivia vs Lissandra matchup with a 58.6% win rate compared to Anivia's 41.4%, a 17.2 percentage point difference. This data is based on 29 recent ranked games in patch 26.7.

How does Anivia do against Lissandra in the early game?

In the early game, Lissandra has the advantage against Anivia with a 63.6% win rate versus 36.4%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Anivia do against Lissandra in the late game?

In the late game, Lissandra takes over the Anivia vs Lissandra matchup with a 55.6% win rate compared to 44.4%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Anivia vs Lissandra matchup?

Lissandra wins the matchup against Anivia with a 58.6% win rate in League of Legends patch 26.7. The 17.2 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 29 games analyzed.

What is the best Anivia build against Lissandra?

The best Anivia build against Lissandra includes Rod of Ages, Liandry's Torment, Malignance with Mercury's Treads. This build achieves a 25.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Anivia runes against Lissandra?

The best Anivia runes against Lissandra use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Anivia vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Anivia counter Lissandra?

No, Anivia struggles against Lissandra with only a 41.4% win rate. Lissandra has the advantage in this matchup. Anivia players should focus on safe farming and avoiding extended trades to minimize Lissandra's lead.

How do I play Anivia against Lissandra?

When playing Anivia against Lissandra, play cautiously and avoid Lissandra's power spikes. Look for jungle assistance and team-dependent plays since Lissandra has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.