Anivia - League of Legends Champion
Win Rate
49.5%
Pick Rate
1.9%

Aniviavs Lissandra

DMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 3, 2026
MethodologyData Methodology

Anivia vs Lissandra is a decisive matchup in LoL patch 26.11. Lissandra wins with a 53.6% win rate (+7.1%) over Anivia based on 28 games. Anivia wins the early laning phase while Lissandra scales better into the late game. Below you'll find the best Anivia build, runes, laning stats, and strategies for the Anivia vs Lissandra matchup.

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Anivia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Anivia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Anivia - 46.4% win rate in this matchup
Anivia
46.4% WR
VS
Lissandra vs Anivia matchup - 53.6% win rate
Lissandra
53.6% WR

Who Wins the Anivia vs Lissandra Matchup?

Lissandra wins the Anivia vs Lissandra matchup
Winner
Lissandra
Matches: 28
46.4%
Win Rate
53.6%
6.6
CS / min
6.7
767
DMG / min
858
12,350
Gold / game
11,891
189
Heal / min
141
633
DMG Mitigated / min
447
1.6
CC / min
1.7
66.7%
Early Game WR
33.3%
36.8%
Late Game WR
63.2%

Anivia vs Lissandra Matchup Summary

The Anivia vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 28 recent matches analyzed, Lissandra wins with a 53.6% win rate compared to Anivia's 46.4%, giving Lissandra a 7.1 percentage point advantage. Game phase dynamics play a critical role here: Anivia controls the early laning stage, but Lissandra outscales as the game goes longer. The matchup shifts dramatically depending on game length — Anivia needs to press advantages before Lissandra reaches their power spikes, while Lissandra should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Anivia leads by 234 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a strong advantage in this matchup. Anivia players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Lissandra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Anivia vs Lissandra Laning Phase Breakdown

Lissandra wins the laning phase against Anivia in League of Legends

Lissandra is favored during the laning phase against Anivia, winning 3 out of 5 key stat categories. Lissandra holds advantages in farming, damage and crowd control, making them the stronger laner in this matchup.

Farming
6.6Anivia
6.7Lissandra
Anivia and Lissandra farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
767Anivia
858Lissandra
Lissandra heavily out-damages Anivia by 91 DMG/min, dominating both short trades and all-in fights. Anivia should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Lissandra's sustained damage advantage take over.
Economy
12,350Anivia
11,891Lissandra
Anivia earns 458 more gold per game than Lissandra, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Anivia slightly faster item completions.
Utility
1.6Anivia
1.7Lissandra
Both Anivia and Lissandra provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
823Anivia
588Lissandra
Anivia vastly out-sustains Lissandra, healing and mitigating 234 more damage per minute. This massive durability gap means Anivia can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Anivia Build Against Lissandra

Swiftmarch is the optimal boots choice against Lissandra, providing the mobility and stats Anivia needs most in this matchup. The top-performing core items for Anivia against Lissandra are Rod of Ages, Liandry's Torment and Seraph's Embrace. This combination gives Anivia an effective balance of damage, survivability, and utility for the matchup. This build has a 33.3% win rate across 3 games. While the overall matchup may be difficult, this item path gives Anivia the best chance to compete against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Anivia vs Lissandra matchup.

Early Game vs Late Game

Early Game
Anivia
66.7%
+33.3% advantage
Anivia early game win rateAnivia66.7%
Lissandra early game win rateLissandra33.3%
Late Game
Lissandra
63.2%
+26.3% advantage
Anivia late game win rateAnivia36.8%
Lissandra late game win rateLissandra63.2%

Anivia dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Lissandra. This lopsided early game means Anivia can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Lissandra is far superior in the late game (25+ minutes), boasting a 63.2% win rate — 26.3 points above Anivia. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Anivia must aggressively press their early advantage and close out the game before Lissandra reaches their scaling breakpoints. If Lissandra survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Anivia Runes Against Lissandra

Domination rune tree - Anivia primary runes vs LissandraDomination
Electrocute - best Anivia rune vs LissandraCheap Shot - best Anivia rune vs LissandraGrisly Mementos - best Anivia rune vs LissandraRelentless Hunter - best Anivia rune vs Lissandra
Precision rune tree - Anivia secondary runes vs LissandraPrecision
Coup de Grace - best Anivia rune vs LissandraPresence of Mind - best Anivia rune vs Lissandra
50.0% WR

The Domination and Precision rune setup gives Anivia the best tools to compete against Lissandra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Anivia matchup data for League of Legends patch 26.11. The table below shows Anivia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Anivia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Anivia matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.88%1046.971411,69144.0%61.1%
52.81%896.778510,93155.8%48.6%
42.05%886.774011,12647.4%38.0%
47.67%865.265810,92533.3%58.0%
44.05%846.479911,26241.7%45.8%
52.17%696.869510,94858.1%47.4%
53.62%696.772411,66353.3%53.9%
38.71%626.485011,89147.8%33.3%
43.55%626.068710,82543.8%43.3%
44.26%616.672611,46340.0%47.2%
46.55%586.471910,85942.3%50.0%
49.09%556.267710,15451.4%45.0%
55.10%496.370911,61352.6%56.7%
50.00%486.264510,97842.1%55.2%
60.42%486.770912,00353.9%62.9%
68.18%446.086910,83873.9%61.9%
53.49%436.573111,46243.8%59.3%
39.02%416.874912,14042.9%37.0%
52.50%406.777212,00658.8%47.8%
50.00%402.654610,09847.4%52.4%
48.65%375.977311,31441.7%52.0%
47.22%366.787111,73656.3%40.0%
61.11%364.868711,97158.3%62.5%
38.24%341.95458,83236.4%41.7%
38.24%343.363310,98241.7%36.4%
45.45%335.970910,68550.0%42.9%
51.52%336.275810,94450.0%52.9%
50.00%326.379710,53760.0%41.2%
53.13%326.482810,73550.0%56.3%
41.94%314.081910,78738.5%44.4%
41.94%316.878212,06446.1%38.9%
38.71%316.67619,64735.3%42.9%
46.67%302.16249,30545.5%47.4%
44.83%297.072710,78335.7%53.3%
44.83%295.764010,80036.4%50.0%
46.43%286.676712,35066.7%36.8%
35.71%286.369410,36633.3%38.5%
42.31%262.55789,38636.4%46.7%
46.15%266.67039,61642.9%50.0%
56.00%256.57499,37956.3%55.6%
41.67%242.460510,00537.5%43.8%
58.33%246.771311,38933.3%73.3%
54.17%245.46138,48457.1%50.0%
50.00%246.176811,50263.6%38.5%
62.50%247.36959,81664.3%60.0%
41.67%246.565610,52830.8%54.5%
39.13%236.583912,71425.0%42.1%
50.00%226.269211,49328.6%60.0%
31.82%225.368810,29122.2%38.5%
38.10%212.15637,85328.6%57.1%
61.90%216.386710,86444.4%75.0%
30.00%206.16979,34937.5%25.0%
75.00%207.076210,60790.0%60.0%
55.00%207.170611,28160.0%50.0%
60.00%206.175811,19466.7%54.5%
36.84%196.879610,68328.6%41.7%
57.89%196.877811,67255.6%60.0%
61.11%186.384412,58633.3%75.0%
35.29%174.087811,30650.0%27.3%
23.53%176.972712,39412.5%33.3%
43.75%167.57199,02641.7%50.0%
50.00%166.289310,01260.0%45.5%
62.50%166.874211,72060.0%63.6%
31.25%167.078412,22628.6%33.3%
26.67%152.852410,3090.0%36.4%
60.00%152.246010,33342.9%75.0%
73.33%151.95479,23055.6%100.0%
53.33%156.783311,37850.0%57.1%
66.67%156.595211,02166.7%66.7%
40.00%156.674011,87520.0%50.0%
64.29%147.478011,12555.6%80.0%
35.71%146.374510,28557.1%14.3%
57.14%141.96108,78760.0%55.6%
28.57%147.277911,06028.6%28.6%
38.46%132.04899,70033.3%42.9%
61.54%136.61,06910,68842.9%83.3%
46.15%131.95278,75650.0%42.9%
46.15%136.584611,98580.0%25.0%
38.46%131.74598,57433.3%42.9%
61.54%132.15319,81762.5%60.0%
53.85%136.979812,12650.0%55.6%
58.33%127.085211,01571.4%40.0%
27.27%116.689811,49950.0%22.2%
40.00%106.675212,88266.7%28.6%
50.00%105.672213,026100.0%37.5%
30.00%103.14569,9990.0%60.0%
70.00%101.64557,65366.7%75.0%
60.00%105.582813,202100.0%55.6%
40.00%106.872912,28350.0%37.5%
40.00%105.471310,84833.3%50.0%
55.56%94.071712,35333.3%66.7%
44.44%96.275110,02266.7%33.3%
33.33%95.576713,0980.0%37.5%
55.56%96.079411,629100.0%42.9%
88.89%96.772912,355100.0%75.0%
25.00%86.379611,15425.0%25.0%
50.00%86.274411,58150.0%50.0%
87.50%86.967912,488100.0%83.3%
62.50%82.05498,28880.0%33.3%
62.50%86.465810,97566.7%60.0%
37.50%84.74577,57040.0%33.3%
25.00%81.75539,25020.0%33.3%
37.50%85.258610,29225.0%50.0%
42.86%76.463610,67075.0%0.0%
71.43%76.966510,57850.0%100.0%
14.29%72.65748,96520.0%0.0%
71.43%76.58519,21750.0%100.0%
42.86%76.067310,37633.3%50.0%
28.57%76.674212,5870.0%40.0%
83.33%67.370510,68575.0%100.0%
50.00%62.36308,70450.0%50.0%
33.33%66.77168,39250.0%0.0%
16.67%67.074611,60133.3%0.0%
50.00%65.56898,26640.0%100.0%
80.00%56.364912,607100.0%75.0%
20.00%56.04778,04250.0%0.0%
40.00%53.668110,2360.0%66.7%
80.00%54.16588,54080.0%0.0%
40.00%56.95839,08350.0%33.3%
60.00%56.073814,7160.0%60.0%
80.00%51.858511,8900.0%80.0%
60.00%55.467111,7600.0%75.0%

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Anivia vs Lissandra - Frequently Asked Questions

How does Anivia do against Lissandra in League of Legends?

Lissandra wins the Anivia vs Lissandra matchup with a 53.6% win rate compared to Anivia's 46.4%, a 7.1 percentage point difference. This data is based on 28 recent ranked games in patch 26.11.

How does Anivia do against Lissandra in the early game?

In the early game, Anivia has the advantage against Lissandra with a 66.7% win rate versus 33.3%. Anivia players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Anivia do against Lissandra in the late game?

In the late game, Lissandra takes over the Anivia vs Lissandra matchup with a 63.2% win rate compared to 36.8%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Anivia vs Lissandra matchup?

Lissandra wins the matchup against Anivia with a 53.6% win rate in League of Legends patch 26.11. The 7.1 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 28 games analyzed.

What is the best Anivia build against Lissandra?

The best Anivia build against Lissandra includes Rod of Ages, Liandry's Torment, Seraph's Embrace with Swiftmarch. This build achieves a 33.3% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Anivia runes against Lissandra?

The best Anivia runes against Lissandra use the Domination primary tree with Precision secondary. This rune setup achieves a 50.0% win rate in the Anivia vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Anivia counter Lissandra?

No, Anivia struggles against Lissandra with only a 46.4% win rate. Lissandra has the advantage in this matchup. Anivia players should focus on safe farming and avoiding extended trades to minimize Lissandra's lead.

How do I play Anivia against Lissandra?

When playing Anivia against Lissandra, play cautiously and avoid Lissandra's power spikes. Look for jungle assistance and team-dependent plays since Lissandra has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.