Annie - League of Legends Champion
Win Rate
47.4%
Pick Rate
1.3%

Annievs Karthus

FMageSupport
Patch26.13
Matches177,854
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 27, 2026
MethodologyData Methodology

Annie vs Karthus is a decisive matchup in LoL patch 26.13. Annie wins with a 100.0% win rate (+100.0%) over Karthus based on 1 games. Annie holds the advantage in both the early and late game. Below you'll find the best Annie build, runes, laning stats, and strategies for the Annie vs Karthus matchup.

Metabot Logo
MetaBot Desktop
Live In-Game Overlays
Join Our Discord
Bug reports, feature requests & developer chat
Join Discord

Annie Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Annie performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Annie - 100.0% win rate in this matchup
Annie
100.0% WR
VS
Karthus vs Annie matchup - 0.0% win rate
Karthus
0.0% WR

Who Wins the Annie vs Karthus Matchup?

Annie wins the Annie vs Karthus matchup
Winner
Annie
Matches: 1
100.0%
Win Rate
0.0%
8.3
CS / min
8.8
745
DMG / min
1,136
11,429
Gold / game
12,253
87
Heal / min
38
357
DMG Mitigated / min
269
0.7
CC / min
0.5
100.0%
Early Game WR
0.0%
0.0%
Late Game WR
0.0%

Annie vs Karthus Matchup Summary

The Annie vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 1 recent matches analyzed, Annie wins with a 100.0% win rate compared to Karthus's 0.0%, giving Annie a 100.0 percentage point advantage. Annie dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in damage output, where Karthus leads by 391 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Annie players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Annie vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Annie in League of Legends

Karthus is favored during the laning phase against Annie, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
8.3Annie
8.8Karthus
Karthus edges out Annie by 0.6 CS per minute — a moderate farming advantage that adds up to roughly 9 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Karthus.
Damage
745Annie
1,136Karthus
Karthus heavily out-damages Annie by 391 DMG/min, dominating both short trades and all-in fights. Annie should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
11,429Annie
12,253Karthus
Karthus generates a commanding 824 more gold per game than Annie. This substantial economic advantage means Karthus consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Annie should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.7Annie
0.5Karthus
Both Annie and Karthus provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
445Annie
307Karthus
Annie heals and mitigates 138 more damage per minute than Karthus, providing moderate extra durability. This sustain edge allows Annie to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Karthus.

Early Game vs Late Game

Early Game
Annie
100.0%
+100.0% advantage
Annie early game win rateAnnie100.0%
Karthus early game win rateKarthus0.0%
Late Game
Annie
0.0%
+0.0% advantage
Annie late game win rateAnnie0.0%
Karthus late game win rateKarthus0.0%

Annie dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Karthus. This lopsided early game means Annie can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Annie at 0.0% win rate — only 0.0 points ahead of Karthus. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

Annie holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Annie Runes Against Karthus

Domination rune tree - Annie primary runes vs KarthusDomination
Electrocute - best Annie rune vs KarthusCheap Shot - best Annie rune vs KarthusGrisly Mementos - best Annie rune vs KarthusTreasure Hunter - best Annie rune vs Karthus
Inspiration rune tree - Annie secondary runes vs KarthusInspiration
Biscuit Delivery - best Annie rune vs KarthusCosmic Insight - best Annie rune vs Karthus
100.0% WR

Running Domination primary with Inspiration secondary allows Annie to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Annie matchup data for League of Legends patch 26.13. The table below shows Annie's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Annie build, runes, laning stats, and early vs late game analysis for that specific matchup.

Annie matchup win rates and stats in League of Legends patch 26.13
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
46.34%415.11,03911,62247.6%45.0%
57.89%195.58109,25354.5%62.5%
47.06%176.390812,21640.0%50.0%
37.50%164.25549,06855.6%14.3%
50.00%166.392212,43340.0%54.5%
46.67%156.11,06111,84171.4%25.0%
50.00%145.875010,67557.1%42.9%
54.55%115.791210,27560.0%50.0%
50.00%105.675412,6840.0%55.6%
60.00%106.31,01014,38766.7%57.1%
50.00%105.27367,54437.5%100.0%
44.44%96.495510,62125.0%60.0%
55.56%96.882810,51866.7%33.3%
55.56%96.871310,88280.0%25.0%
44.44%95.88279,47920.0%75.0%
44.44%95.380112,6930.0%44.4%
37.50%84.674411,0120.0%50.0%
57.14%76.077711,10350.0%60.0%
42.86%75.379711,12475.0%0.0%
42.86%75.267510,16333.3%50.0%
42.86%72.16949,3710.0%100.0%
57.14%76.094611,55533.3%75.0%
50.00%65.387311,6480.0%75.0%
33.33%64.31,02614,732100.0%20.0%
50.00%65.292411,0860.0%60.0%
40.00%55.784811,37366.7%0.0%
66.67%36.51,05211,39266.7%0.0%
100.00%18.374511,429100.0%0.0%

Get the MetaBot Desktop App

Level up your gameplay with real-time overlays, automatic game detection, and instant stats — all on your desktop.

In-game overlaysAuto game detectionMulti-game supportPersonal dashboard
Download NowFree download
🔍

Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.

Report an Issue

Annie vs Karthus - Frequently Asked Questions

How does Annie do against Karthus in League of Legends?

Annie wins the Annie vs Karthus matchup with a 100.0% win rate compared to Karthus's 0.0%, a 100.0 percentage point difference. This data is based on 1 recent ranked games in patch 26.13.

How does Annie do against Karthus in the early game?

In the early game, Annie has the advantage against Karthus with a 100.0% win rate versus 0.0%. Annie players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Annie do against Karthus in the late game?

In the late game, Annie takes over the Annie vs Karthus matchup with a 0.0% win rate compared to 0.0%. Annie scales better into team fights and objective contests after 25 minutes.

Who wins the Annie vs Karthus matchup?

Annie wins the matchup against Karthus with a 100.0% win rate in League of Legends patch 26.13. The 100.0 percentage point advantage means Annie is significantly favored in this lane matchup based on 1 games analyzed.

What is the best Annie build against Karthus?

The best Annie build against Karthus includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Annie runes against Karthus?

The best Annie runes against Karthus use the Domination primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Annie vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Annie counter Karthus?

Yes, Annie has a favorable matchup against Karthus with a 100.0% win rate. Annie strongly counters Karthus in lane based on current patch 26.13 data.

How do I play Annie against Karthus?

When playing Annie against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.