
Annievs Karthus
Annie vs Karthus is a decisive matchup in LoL patch 26.13. Annie wins with a 100.0% win rate (+100.0%) over Karthus based on 1 games. Annie holds the advantage in both the early and late game. Below you'll find the best Annie build, runes, laning stats, and strategies for the Annie vs Karthus matchup.
Annie Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Annie performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who Wins the Annie vs Karthus Matchup?

Annie vs Karthus Matchup Summary
The Annie vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 1 recent matches analyzed, Annie wins with a 100.0% win rate compared to Karthus's 0.0%, giving Annie a 100.0 percentage point advantage. Annie dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in damage output, where Karthus leads by 391 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Annie players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Annie vs Karthus Laning Phase Breakdown
Karthus is favored during the laning phase against Annie, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.
Early Game vs Late Game
Annie dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Karthus. This lopsided early game means Annie can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Late game (25+ minutes) is equally balanced, with Annie at 0.0% win rate — only 0.0 points ahead of Karthus. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.
Annie holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Annie Runes Against Karthus
Running Domination primary with Inspiration secondary allows Annie to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.
Annie matchup data for League of Legends patch 26.13. The table below shows Annie's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Annie build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 46.34% | 41 | 5.1 | 1,039 | 11,622 | 47.6% | 45.0% | |
| 57.89% | 19 | 5.5 | 810 | 9,253 | 54.5% | 62.5% | |
| 47.06% | 17 | 6.3 | 908 | 12,216 | 40.0% | 50.0% | |
| 37.50% | 16 | 4.2 | 554 | 9,068 | 55.6% | 14.3% | |
| 50.00% | 16 | 6.3 | 922 | 12,433 | 40.0% | 54.5% | |
| 46.67% | 15 | 6.1 | 1,061 | 11,841 | 71.4% | 25.0% | |
| 50.00% | 14 | 5.8 | 750 | 10,675 | 57.1% | 42.9% | |
| 54.55% | 11 | 5.7 | 912 | 10,275 | 60.0% | 50.0% | |
| 50.00% | 10 | 5.6 | 754 | 12,684 | 0.0% | 55.6% | |
| 60.00% | 10 | 6.3 | 1,010 | 14,387 | 66.7% | 57.1% | |
| 50.00% | 10 | 5.2 | 736 | 7,544 | 37.5% | 100.0% | |
| 44.44% | 9 | 6.4 | 955 | 10,621 | 25.0% | 60.0% | |
| 55.56% | 9 | 6.8 | 828 | 10,518 | 66.7% | 33.3% | |
| 55.56% | 9 | 6.8 | 713 | 10,882 | 80.0% | 25.0% | |
| 44.44% | 9 | 5.8 | 827 | 9,479 | 20.0% | 75.0% | |
| 44.44% | 9 | 5.3 | 801 | 12,693 | 0.0% | 44.4% | |
| 37.50% | 8 | 4.6 | 744 | 11,012 | 0.0% | 50.0% | |
| 57.14% | 7 | 6.0 | 777 | 11,103 | 50.0% | 60.0% | |
| 42.86% | 7 | 5.3 | 797 | 11,124 | 75.0% | 0.0% | |
| 42.86% | 7 | 5.2 | 675 | 10,163 | 33.3% | 50.0% | |
| 42.86% | 7 | 2.1 | 694 | 9,371 | 0.0% | 100.0% | |
| 57.14% | 7 | 6.0 | 946 | 11,555 | 33.3% | 75.0% | |
| 50.00% | 6 | 5.3 | 873 | 11,648 | 0.0% | 75.0% | |
| 33.33% | 6 | 4.3 | 1,026 | 14,732 | 100.0% | 20.0% | |
| 50.00% | 6 | 5.2 | 924 | 11,086 | 0.0% | 60.0% | |
| 40.00% | 5 | 5.7 | 848 | 11,373 | 66.7% | 0.0% | |
| 66.67% | 3 | 6.5 | 1,052 | 11,392 | 66.7% | 0.0% | |
| 100.00% | 1 | 8.3 | 745 | 11,429 | 100.0% | 0.0% |
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Annie vs Karthus - Frequently Asked Questions
How does Annie do against Karthus in League of Legends?
Annie wins the Annie vs Karthus matchup with a 100.0% win rate compared to Karthus's 0.0%, a 100.0 percentage point difference. This data is based on 1 recent ranked games in patch 26.13.
How does Annie do against Karthus in the early game?
In the early game, Annie has the advantage against Karthus with a 100.0% win rate versus 0.0%. Annie players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Annie do against Karthus in the late game?
In the late game, Annie takes over the Annie vs Karthus matchup with a 0.0% win rate compared to 0.0%. Annie scales better into team fights and objective contests after 25 minutes.
Who wins the Annie vs Karthus matchup?
Annie wins the matchup against Karthus with a 100.0% win rate in League of Legends patch 26.13. The 100.0 percentage point advantage means Annie is significantly favored in this lane matchup based on 1 games analyzed.
What is the best Annie build against Karthus?
The best Annie build against Karthus includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Annie runes against Karthus?
The best Annie runes against Karthus use the Domination primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Annie vs Karthus matchup. See the full rune breakdown in the matchup comparison above.
Does Annie counter Karthus?
Yes, Annie has a favorable matchup against Karthus with a 100.0% win rate. Annie strongly counters Karthus in lane based on current patch 26.13 data.
How do I play Annie against Karthus?
When playing Annie against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.
