Karthus - League of Legends Champion
Win Rate
49.1%
Pick Rate
1.0%

Karthusvs Annie

CMage
Patch26.13
Matches177,854
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 27, 2026
MethodologyData Methodology

Karthus vs Annie is a decisive matchup in LoL patch 26.13. Annie wins with a 100.0% win rate (+100.0%) over Karthus based on 1 games. Annie wins the early laning phase while Karthus scales better into the late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Annie matchup.

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Karthus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 0.0% win rate in this matchup
Karthus
0.0% WR
VS
Annie vs Karthus matchup - 100.0% win rate
Annie
100.0% WR

Who Wins the Karthus vs Annie Matchup?

Annie wins the Karthus vs Annie matchup
Winner
Annie
Matches: 1
0.0%
Win Rate
100.0%
8.8
CS / min
8.3
1,136
DMG / min
745
12,253
Gold / game
11,429
38
Heal / min
87
269
DMG Mitigated / min
357
0.5
CC / min
0.7
0.0%
Early Game WR
100.0%
0.0%
Late Game WR
0.0%

Karthus vs Annie Matchup Summary

The Karthus vs Annie matchup is a decisive matchup in League of Legends ranked play. Based on 1 recent matches analyzed, Annie wins with a 100.0% win rate compared to Karthus's 0.0%, giving Annie a 100.0 percentage point advantage. Game phase dynamics play a critical role here: Annie controls the early laning stage, but Karthus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Annie needs to press advantages before Karthus reaches their power spikes, while Karthus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in damage output, where Karthus leads by 391 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Annie has a strong advantage in this matchup. Karthus players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Annie overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Karthus vs Annie Laning Phase Breakdown

Karthus wins the laning phase against Annie in League of Legends

Karthus is favored during the laning phase against Annie, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
8.8Karthus
8.3Annie
Karthus edges out Annie by 0.6 CS per minute — a moderate farming advantage that adds up to roughly 9 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Karthus.
Damage
1,136Karthus
745Annie
Karthus heavily out-damages Annie by 391 DMG/min, dominating both short trades and all-in fights. Annie should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
12,253Karthus
11,429Annie
Karthus generates a commanding 824 more gold per game than Annie. This substantial economic advantage means Karthus consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Annie should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.5Karthus
0.7Annie
Both Karthus and Annie provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
307Karthus
445Annie
Annie heals and mitigates 138 more damage per minute than Karthus, providing moderate extra durability. This sustain edge allows Annie to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Karthus.

Best Karthus Build Against Annie

Spellslinger's Shoes is the optimal boots choice against Annie, providing the mobility and stats Karthus needs most in this matchup. The top-performing core items for Karthus against Annie are Shadowflame, Malignance and Blackfire Torch. This combination gives Karthus an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Karthus vs Annie matchup.

Early Game vs Late Game

Early Game
Annie
100.0%
+100.0% advantage
Karthus early game win rateKarthus0.0%
Annie early game win rateAnnie100.0%
Late Game
Karthus
0.0%
+0.0% advantage
Karthus late game win rateKarthus0.0%
Annie late game win rateAnnie0.0%

Annie dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Karthus. This lopsided early game means Annie can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Karthus at 0.0% win rate — only 0.0 points ahead of Annie. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Annie has the edge early, but Karthus gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Karthus Runes Against Annie

Inspiration rune tree - Karthus primary runes vs AnnieInspiration
First Strike - best Karthus rune vs AnnieCash Back - best Karthus rune vs AnnieTriple Tonic - best Karthus rune vs AnnieCosmic Insight - best Karthus rune vs Annie
Sorcery rune tree - Karthus secondary runes vs AnnieSorcery
Axiom Arcanist - best Karthus rune vs AnnieGathering Storm - best Karthus rune vs Annie
0.0% WR

The Inspiration and Sorcery rune setup gives Karthus the best tools to compete against Annie in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Karthus matchup data for League of Legends patch 26.13. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Karthus matchup win rates and stats in League of Legends patch 26.13
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
42.86%140.91,28613,91150.0%40.0%
54.55%111.270610,23437.5%100.0%
30.00%101.81,19514,40040.0%20.0%
40.00%101.11,13413,1780.0%50.0%
55.56%91.71,04413,09760.0%50.0%
44.44%96.81,16614,84750.0%40.0%
22.22%92.21,49415,9120.0%28.6%
37.50%81.61,09915,15325.0%50.0%
50.00%83.51,37515,627100.0%33.3%
50.00%81.41,18314,05733.3%60.0%
37.50%86.11,0708,60860.0%0.0%
57.14%71.61,21113,49266.7%50.0%
33.33%66.21,29715,64750.0%25.0%
66.67%67.01,68417,65250.0%75.0%
80.00%56.11,74419,3670.0%80.0%
60.00%54.81,78214,97950.0%66.7%
20.00%51.91,26115,7240.0%33.3%
40.00%51.31,17412,275100.0%25.0%
0.00%56.71,24513,5310.0%0.0%
20.00%56.61,66113,95050.0%0.0%
40.00%56.31,55416,23150.0%33.3%
60.00%52.11,2029,57533.3%100.0%
80.00%55.81,35314,285100.0%66.7%
20.00%51.899211,70250.0%0.0%
60.00%51.21,33714,83366.7%50.0%
40.00%51.299211,93433.3%50.0%
60.00%52.599412,62975.0%0.0%
25.00%41.273310,6730.0%50.0%
66.67%31.196513,3330.0%66.7%
0.00%11.25876,0680.0%0.0%
0.00%18.81,13612,2530.0%0.0%

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Karthus vs Annie - Frequently Asked Questions

How does Karthus do against Annie in League of Legends?

Annie wins the Karthus vs Annie matchup with a 100.0% win rate compared to Karthus's 0.0%, a 100.0 percentage point difference. This data is based on 1 recent ranked games in patch 26.13.

How does Karthus do against Annie in the early game?

In the early game, Annie has the advantage against Karthus with a 100.0% win rate versus 0.0%. Annie players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Karthus do against Annie in the late game?

In the late game, Karthus takes over the Karthus vs Annie matchup with a 0.0% win rate compared to 0.0%. Karthus scales better into team fights and objective contests after 25 minutes.

Who wins the Karthus vs Annie matchup?

Annie wins the matchup against Karthus with a 100.0% win rate in League of Legends patch 26.13. The 100.0 percentage point advantage means Annie is significantly favored in this lane matchup based on 1 games analyzed.

What is the best Karthus build against Annie?

The best Karthus build against Annie includes Shadowflame, Malignance, Blackfire Torch with Spellslinger's Shoes. Check the matchup breakdown above for the full item path and build order.

What are the best Karthus runes against Annie?

The best Karthus runes against Annie use the Inspiration primary tree with Sorcery secondary. This rune setup achieves a 0.0% win rate in the Karthus vs Annie matchup. See the full rune breakdown in the matchup comparison above.

Does Karthus counter Annie?

No, Karthus struggles against Annie with only a 0.0% win rate. Annie has the advantage in this matchup. Karthus players should focus on safe farming and avoiding extended trades to minimize Annie's lead.

How do I play Karthus against Annie?

When playing Karthus against Annie, play cautiously and avoid Annie's power spikes. Focus on safe farming — you outscale Annie in the late game. Use the matchup-specific build and runes above to optimize your chances.