Kai'Sa - League of Legends Champion
Win Rate
47.8%
Pick Rate
4.9%

Kai'Savs Cassiopeia

FMarksmanMage
Patch26.7
Matches508,082
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 8, 2026
MethodologyData Methodology

Kai'Sa vs Cassiopeia is a decisive matchup in LoL patch 26.7. Cassiopeia wins with a 83.3% win rate (+66.7%) over Kai'Sa based on 6 games. Kai'Sa wins the early laning phase while Cassiopeia scales better into the late game. Below you'll find the best Kai'Sa build, runes, laning stats, and strategies for the Kai'Sa vs Cassiopeia matchup.

Kai'Sa Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Kai'Sa performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Cassiopeia - 16.7% win rateCassiopeia(16.7%)
Kai'Sa - 16.7% win rate in this matchup
Kai'Sa
16.7% WR
VS
Cassiopeia vs Kai'Sa matchup - 83.3% win rate
Cassiopeia
83.3% WR

Who Wins the Kai'Sa vs Cassiopeia Matchup?

Cassiopeia wins the Kai'Sa vs Cassiopeia matchup
Winner
Cassiopeia
Matches: 6
16.7%
Win Rate
83.3%
7.0
CS / min
6.7
792
DMG / min
840
12,769
Gold / game
13,445
133
Heal / min
297
452
DMG Mitigated / min
654
0.0
CC / min
1.1
50.0%
Early Game WR
50.0%
0.0%
Late Game WR
100.0%

Kai'Sa vs Cassiopeia Matchup Summary

The Kai'Sa vs Cassiopeia matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Cassiopeia wins with a 83.3% win rate compared to Kai'Sa's 16.7%, giving Cassiopeia a 66.7 percentage point advantage. Game phase dynamics play a critical role here: Kai'Sa controls the early laning stage, but Cassiopeia outscales as the game goes longer. The matchup shifts dramatically depending on game length — Kai'Sa needs to press advantages before Cassiopeia reaches their power spikes, while Cassiopeia should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Cassiopeia leads by 1.0s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Cassiopeia has a strong advantage in this matchup. Kai'Sa players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Cassiopeia overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Kai'Sa vs Cassiopeia Laning Phase Breakdown

Cassiopeia wins the laning phase against Kai'Sa in League of Legends

Cassiopeia is favored during the laning phase against Kai'Sa, winning 4 out of 5 key stat categories. Cassiopeia holds advantages in damage, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
7.0Kai'Sa
6.7Cassiopeia
Kai'Sa edges out Cassiopeia by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Kai'Sa.
Damage
792Kai'Sa
840Cassiopeia
Cassiopeia deals 49 more champion damage per minute than Kai'Sa. While noticeable in extended trades, this gap can be offset by Kai'Sa choosing favorable fight windows, such as engaging when Cassiopeia's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
12,769Kai'Sa
13,445Cassiopeia
Cassiopeia earns 676 more gold per game than Kai'Sa, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Cassiopeia slightly faster item completions.
Utility
0.0Kai'Sa
1.1Cassiopeia
Cassiopeia brings significantly more crowd control than Kai'Sa, with 1.0 more seconds of CC per minute. This large utility gap makes Cassiopeia far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Kai'Sa should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
585Kai'Sa
951Cassiopeia
Cassiopeia vastly out-sustains Kai'Sa, healing and mitigating 365 more damage per minute. This massive durability gap means Cassiopeia can absorb significant punishment and remain in lane while Kai'Sa is forced to recall. Building grievous wounds early is essential for Kai'Sa, and focusing on burst trade patterns rather than sustained fights is critical.

Best Kai'Sa Build Against Cassiopeia

Gunmetal Greaves is the optimal boots choice against Cassiopeia, providing the mobility and stats Kai'Sa needs most in this matchup. The top-performing core items for Kai'Sa against Cassiopeia are Kraken Slayer, Guinsoo's Rageblade and Dusk and Dawn. This combination gives Kai'Sa an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Kai'Sa vs Cassiopeia matchup.

Early Game vs Late Game

Early Game
Kai'Sa
50.0%
+0.0% advantage
Kai'Sa early game win rateKai'Sa50.0%
Cassiopeia early game win rateCassiopeia50.0%
Late Game
Cassiopeia
100.0%
+100.0% advantage
Kai'Sa late game win rateKai'Sa0.0%
Cassiopeia late game win rateCassiopeia100.0%

The early game (first 15 minutes) is a toss-up between Kai'Sa and Cassiopeia, with Kai'Sa holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Cassiopeia is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Kai'Sa. Extended games heavily favor Cassiopeia, whose kit and scaling make them a dominant force in team fights and objective control.

The power dynamics shift as the game progresses — Kai'Sa has the edge early, but Cassiopeia gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Kai'Sa Runes Against Cassiopeia

Precision rune tree - Kai'Sa primary runes vs CassiopeiaPrecision
Press the Attack - best Kai'Sa rune vs CassiopeiaPresence of Mind - best Kai'Sa rune vs CassiopeiaLegend: Bloodline - best Kai'Sa rune vs CassiopeiaCoup de Grace - best Kai'Sa rune vs Cassiopeia
Domination rune tree - Kai'Sa secondary runes vs CassiopeiaDomination
Taste of Blood - best Kai'Sa rune vs CassiopeiaTreasure Hunter - best Kai'Sa rune vs Cassiopeia
100.0% WR

The Precision and Domination rune setup gives Kai'Sa the best tools to compete against Cassiopeia in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Kai'Sa matchup data for League of Legends patch 26.7. The table below shows Kai'Sa's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Kai'Sa build, runes, laning stats, and early vs late game analysis for that specific matchup.

Kai'Sa matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
46.74%4456.781713,78141.9%51.3%
45.48%4207.083813,47146.6%44.2%
47.01%3856.882914,00452.8%42.0%
49.56%3416.682213,64453.9%45.4%
47.87%3286.786014,43549.3%46.8%
46.74%2916.991814,19438.0%53.7%
47.27%2567.091414,66745.2%48.9%
50.00%2227.093214,40950.0%50.0%
49.18%1837.085513,68647.2%52.0%
49.10%1676.887114,36054.4%44.3%
48.61%1447.087214,38939.4%57.5%
54.68%1396.983814,06463.0%45.5%
62.50%1046.889414,20659.6%65.4%
49.49%996.884813,76342.9%56.0%
44.33%977.082013,85042.0%46.8%
49.47%956.988414,59554.5%45.1%
42.22%906.883913,69237.2%46.8%
50.62%816.888313,62446.5%55.3%
50.67%756.782514,22341.9%56.8%
52.24%677.385014,04151.4%53.1%
37.04%547.390915,52233.3%39.4%
56.00%506.51,04113,90344.0%68.0%
59.18%496.888214,47057.1%60.7%
42.22%457.091915,69841.2%42.9%
34.88%437.081714,17441.2%30.8%
32.50%406.991013,48340.0%25.0%
58.97%397.398815,47968.8%52.2%
58.97%396.978413,40463.6%52.9%
39.47%386.683215,00143.8%36.4%
33.33%336.893213,84331.3%35.3%
40.74%277.096715,14244.4%38.9%
63.64%227.190314,04863.6%63.6%
52.38%217.587414,13757.1%42.9%
40.00%157.273313,19225.0%57.1%
50.00%147.077813,70633.3%62.5%
15.38%137.387413,54140.0%0.0%
33.33%126.980714,31833.3%33.3%
45.45%116.482713,53433.3%60.0%
20.00%107.184112,0420.0%40.0%
30.00%107.094614,55425.0%33.3%
75.00%86.71,07213,44866.7%80.0%
42.86%77.579414,03550.0%33.3%
85.71%74.892014,873100.0%80.0%
42.86%77.693115,817100.0%20.0%
14.29%76.773812,61333.3%0.0%
71.43%76.788211,28075.0%66.7%
66.67%66.883911,75066.7%66.7%
66.67%66.583312,58250.0%100.0%
16.67%67.079212,76950.0%0.0%
50.00%68.194314,63866.7%33.3%
83.33%67.11,15519,5800.0%83.3%
20.00%55.51,01414,0100.0%33.3%
80.00%56.51,13916,068100.0%75.0%
40.00%56.21,31316,520100.0%25.0%
60.00%56.51,15811,04266.7%50.0%
20.00%57.01,15812,54725.0%0.0%
60.00%58.095313,53833.3%100.0%
40.00%57.253813,63750.0%33.3%

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Kai'Sa vs Cassiopeia - Frequently Asked Questions

How does Kai'Sa do against Cassiopeia in League of Legends?

Cassiopeia wins the Kai'Sa vs Cassiopeia matchup with a 83.3% win rate compared to Kai'Sa's 16.7%, a 66.7 percentage point difference. This data is based on 6 recent ranked games in patch 26.7.

How does Kai'Sa do against Cassiopeia in the early game?

In the early game, Kai'Sa has the advantage against Cassiopeia with a 50.0% win rate versus 50.0%. Kai'Sa players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Kai'Sa do against Cassiopeia in the late game?

In the late game, Cassiopeia takes over the Kai'Sa vs Cassiopeia matchup with a 100.0% win rate compared to 0.0%. Cassiopeia scales better into team fights and objective contests after 25 minutes.

Who wins the Kai'Sa vs Cassiopeia matchup?

Cassiopeia wins the matchup against Kai'Sa with a 83.3% win rate in League of Legends patch 26.7. The 66.7 percentage point advantage means Cassiopeia is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Kai'Sa build against Cassiopeia?

The best Kai'Sa build against Cassiopeia includes Kraken Slayer, Guinsoo's Rageblade, Dusk and Dawn with Gunmetal Greaves. Check the matchup breakdown above for the full item path and build order.

What are the best Kai'Sa runes against Cassiopeia?

The best Kai'Sa runes against Cassiopeia use the Precision primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Kai'Sa vs Cassiopeia matchup. See the full rune breakdown in the matchup comparison above.

Does Kai'Sa counter Cassiopeia?

No, Kai'Sa struggles against Cassiopeia with only a 16.7% win rate. Cassiopeia has the advantage in this matchup. Kai'Sa players should focus on safe farming and avoiding extended trades to minimize Cassiopeia's lead.

How do I play Kai'Sa against Cassiopeia?

When playing Kai'Sa against Cassiopeia, play cautiously and avoid Cassiopeia's power spikes. Look for jungle assistance and team-dependent plays since Cassiopeia has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.