Kai'Savs Vayne
Kai'Sa vs Vayne is a very close matchup in LoL patch 26.7. Kai'Sa wins with a 50.0% win rate (+0.0%) over Vayne based on 222 games. Kai'Sa holds the advantage in both the early and late game. Below you'll find the best Kai'Sa build, runes, laning stats, and strategies for the Kai'Sa vs Vayne matchup.
Kai'Sa Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Kai'Sa performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Vayne(50.0%)Who Wins the Kai'Sa vs Vayne Matchup?
Kai'Sa vs Vayne Matchup Summary
The Kai'Sa vs Vayne matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 222 recent matches analyzed, Kai'Sa wins with a 50.0% win rate compared to Vayne's 50.0%, giving Kai'Sa a 0.0 percentage point advantage. Kai'Sa holds a slight edge in both the early and late game, but the margins are thin enough that individual skill and jungle attention will often determine the outcome. Vayne can still find windows through outplays and team coordination. The most significant statistical gap is in crowd control, where Vayne leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Kai'Sa has a statistical edge, but the margin is close enough that respecting Vayne's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Kai'Sa vs Vayne Laning Phase Breakdown
Vayne is favored during the laning phase against Kai'Sa, winning 3 out of 5 key stat categories. Vayne holds advantages in damage, crowd control and sustain, making them the stronger laner in this matchup.
Best Kai'Sa Build Against Vayne
Berserker's Greaves is the optimal boots choice against Vayne, providing the mobility and stats Kai'Sa needs most in this matchup. The top-performing core items for Kai'Sa against Vayne are Kraken Slayer, Guinsoo's Rageblade and Nashor's Tooth. This combination gives Kai'Sa an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Kai'Sa vs Vayne matchup.
Early Game vs Late Game
Kai'Sa50.0%Vayne50.0%Kai'Sa50.0%Vayne50.0%The early game (first 15 minutes) is a toss-up between Kai'Sa and Vayne, with Kai'Sa holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.
Late game (25+ minutes) is equally balanced, with Kai'Sa at 50.0% win rate — only 0.0 points ahead of Vayne. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.
This matchup is remarkably even at every stage of the game. Neither Kai'Sa nor Vayne has a phase-specific advantage, making this a pure skill matchup where individual mechanics, decision-making, and team coordination determine the outcome.
Best Kai'Sa Runes Against Vayne
Precision
Inspiration
The Precision primary with Inspiration secondary combination helps Kai'Sa maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Vayne.
Kai'Sa matchup data for League of Legends patch 26.7. The table below shows Kai'Sa's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Kai'Sa build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 46.74% | 445 | 6.7 | 817 | 13,781 | 41.9% | 51.3% | |
| 45.48% | 420 | 7.0 | 838 | 13,471 | 46.6% | 44.2% | |
| 47.01% | 385 | 6.8 | 829 | 14,004 | 52.8% | 42.0% | |
| 49.56% | 341 | 6.6 | 822 | 13,644 | 53.9% | 45.4% | |
| 47.87% | 328 | 6.7 | 860 | 14,435 | 49.3% | 46.8% | |
| 46.74% | 291 | 6.9 | 918 | 14,194 | 38.0% | 53.7% | |
| 47.27% | 256 | 7.0 | 914 | 14,667 | 45.2% | 48.9% | |
| 50.00% | 222 | 7.0 | 932 | 14,409 | 50.0% | 50.0% | |
| 49.18% | 183 | 7.0 | 855 | 13,686 | 47.2% | 52.0% | |
| 49.10% | 167 | 6.8 | 871 | 14,360 | 54.4% | 44.3% | |
| 48.61% | 144 | 7.0 | 872 | 14,389 | 39.4% | 57.5% | |
| 54.68% | 139 | 6.9 | 838 | 14,064 | 63.0% | 45.5% | |
| 62.50% | 104 | 6.8 | 894 | 14,206 | 59.6% | 65.4% | |
| 49.49% | 99 | 6.8 | 848 | 13,763 | 42.9% | 56.0% | |
| 44.33% | 97 | 7.0 | 820 | 13,850 | 42.0% | 46.8% | |
| 49.47% | 95 | 6.9 | 884 | 14,595 | 54.5% | 45.1% | |
| 42.22% | 90 | 6.8 | 839 | 13,692 | 37.2% | 46.8% | |
| 50.62% | 81 | 6.8 | 883 | 13,624 | 46.5% | 55.3% | |
| 50.67% | 75 | 6.7 | 825 | 14,223 | 41.9% | 56.8% | |
| 52.24% | 67 | 7.3 | 850 | 14,041 | 51.4% | 53.1% | |
| 37.04% | 54 | 7.3 | 909 | 15,522 | 33.3% | 39.4% | |
| 56.00% | 50 | 6.5 | 1,041 | 13,903 | 44.0% | 68.0% | |
| 59.18% | 49 | 6.8 | 882 | 14,470 | 57.1% | 60.7% | |
| 42.22% | 45 | 7.0 | 919 | 15,698 | 41.2% | 42.9% | |
| 34.88% | 43 | 7.0 | 817 | 14,174 | 41.2% | 30.8% | |
| 32.50% | 40 | 6.9 | 910 | 13,483 | 40.0% | 25.0% | |
| 58.97% | 39 | 7.3 | 988 | 15,479 | 68.8% | 52.2% | |
| 58.97% | 39 | 6.9 | 784 | 13,404 | 63.6% | 52.9% | |
| 39.47% | 38 | 6.6 | 832 | 15,001 | 43.8% | 36.4% | |
| 33.33% | 33 | 6.8 | 932 | 13,843 | 31.3% | 35.3% | |
| 40.74% | 27 | 7.0 | 967 | 15,142 | 44.4% | 38.9% | |
| 63.64% | 22 | 7.1 | 903 | 14,048 | 63.6% | 63.6% | |
| 52.38% | 21 | 7.5 | 874 | 14,137 | 57.1% | 42.9% | |
| 40.00% | 15 | 7.2 | 733 | 13,192 | 25.0% | 57.1% | |
| 50.00% | 14 | 7.0 | 778 | 13,706 | 33.3% | 62.5% | |
| 15.38% | 13 | 7.3 | 874 | 13,541 | 40.0% | 0.0% | |
| 33.33% | 12 | 6.9 | 807 | 14,318 | 33.3% | 33.3% | |
| 45.45% | 11 | 6.4 | 827 | 13,534 | 33.3% | 60.0% | |
| 20.00% | 10 | 7.1 | 841 | 12,042 | 0.0% | 40.0% | |
| 30.00% | 10 | 7.0 | 946 | 14,554 | 25.0% | 33.3% | |
| 75.00% | 8 | 6.7 | 1,072 | 13,448 | 66.7% | 80.0% | |
| 42.86% | 7 | 7.5 | 794 | 14,035 | 50.0% | 33.3% | |
| 85.71% | 7 | 4.8 | 920 | 14,873 | 100.0% | 80.0% | |
| 42.86% | 7 | 7.6 | 931 | 15,817 | 100.0% | 20.0% | |
| 14.29% | 7 | 6.7 | 738 | 12,613 | 33.3% | 0.0% | |
| 71.43% | 7 | 6.7 | 882 | 11,280 | 75.0% | 66.7% | |
| 66.67% | 6 | 6.8 | 839 | 11,750 | 66.7% | 66.7% | |
| 66.67% | 6 | 6.5 | 833 | 12,582 | 50.0% | 100.0% | |
| 16.67% | 6 | 7.0 | 792 | 12,769 | 50.0% | 0.0% | |
| 50.00% | 6 | 8.1 | 943 | 14,638 | 66.7% | 33.3% | |
| 83.33% | 6 | 7.1 | 1,155 | 19,580 | 0.0% | 83.3% | |
| 20.00% | 5 | 5.5 | 1,014 | 14,010 | 0.0% | 33.3% | |
| 80.00% | 5 | 6.5 | 1,139 | 16,068 | 100.0% | 75.0% | |
| 40.00% | 5 | 6.2 | 1,313 | 16,520 | 100.0% | 25.0% | |
| 60.00% | 5 | 6.5 | 1,158 | 11,042 | 66.7% | 50.0% | |
| 20.00% | 5 | 7.0 | 1,158 | 12,547 | 25.0% | 0.0% | |
| 60.00% | 5 | 8.0 | 953 | 13,538 | 33.3% | 100.0% | |
| 40.00% | 5 | 7.2 | 538 | 13,637 | 50.0% | 33.3% | |
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Kai'Sa vs Vayne - Frequently Asked Questions
How does Kai'Sa do against Vayne in League of Legends?
Kai'Sa wins the Kai'Sa vs Vayne matchup with a 50.0% win rate compared to Vayne's 50.0%, a 0.0 percentage point difference. This data is based on 222 recent ranked games in patch 26.7.
How does Kai'Sa do against Vayne in the early game?
In the early game, Kai'Sa has the advantage against Vayne with a 50.0% win rate versus 50.0%. Kai'Sa players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Kai'Sa do against Vayne in the late game?
In the late game, Kai'Sa takes over the Kai'Sa vs Vayne matchup with a 50.0% win rate compared to 50.0%. Kai'Sa scales better into team fights and objective contests after 25 minutes.
Who wins the Kai'Sa vs Vayne matchup?
Kai'Sa wins the matchup against Vayne with a 50.0% win rate in League of Legends patch 26.7. The 0.0 percentage point advantage means Kai'Sa is slightly favored in this lane matchup based on 222 games analyzed.
What is the best Kai'Sa build against Vayne?
The best Kai'Sa build against Vayne includes Kraken Slayer, Guinsoo's Rageblade, Nashor's Tooth with Berserker's Greaves. Check the matchup breakdown above for the full item path and build order.
What are the best Kai'Sa runes against Vayne?
The best Kai'Sa runes against Vayne use the Precision primary tree with Inspiration secondary. This rune setup achieves a 57.9% win rate in the Kai'Sa vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Kai'Sa counter Vayne?
Yes, Kai'Sa has a favorable matchup against Vayne with a 50.0% win rate. Kai'Sa slightly edges out Vayne in lane based on current patch 26.7 data.
How do I play Kai'Sa against Vayne?
When playing Kai'Sa against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.