Cassiopeia - League of Legends Champion
Win Rate
48.3%
Pick Rate
0.9%

Cassiopeiavs Kai'Sa

FMage
Patch26.14
Matches491,560
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Cassiopeia vs Kai'Sa is a decisive matchup in LoL patch 26.14. Kai'Sa wins with a 66.7% win rate (+33.3%) over Cassiopeia based on 6 games. Kai'Sa wins the early laning phase while Cassiopeia scales better into the late game. Below you'll find the best Cassiopeia build, runes, laning stats, and strategies for the Cassiopeia vs Kai'Sa matchup.

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Cassiopeia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Cassiopeia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Cassiopeia - 33.3% win rate in this matchup
Cassiopeia
33.3% WR
VS
Kai'Sa vs Cassiopeia matchup - 66.7% win rate
Kai'Sa
66.7% WR

Who Wins the Cassiopeia vs Kai'Sa Matchup?

Kai'Sa wins the Cassiopeia vs Kai'Sa matchup
Winner
Kai'Sa
Matches: 6
33.3%
Win Rate
66.7%
6.3
CS / min
6.3
598
DMG / min
594
8,920
Gold / game
10,135
137
Heal / min
157
367
DMG Mitigated / min
391
1.1
CC / min
0.1
25.0%
Early Game WR
75.0%
50.0%
Late Game WR
50.0%

Cassiopeia vs Kai'Sa Matchup Summary

The Cassiopeia vs Kai'Sa matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Kai'Sa wins with a 66.7% win rate compared to Cassiopeia's 33.3%, giving Kai'Sa a 33.3 percentage point advantage. Game phase dynamics play a critical role here: Kai'Sa controls the early laning stage, but Cassiopeia outscales as the game goes longer. The matchup shifts dramatically depending on game length — Kai'Sa needs to press advantages before Cassiopeia reaches their power spikes, while Cassiopeia should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Cassiopeia leads by 1.0s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Kai'Sa has a strong advantage in this matchup. Cassiopeia players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Kai'Sa overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Cassiopeia vs Kai'Sa Laning Phase Breakdown

Kai'Sa wins the laning phase against Cassiopeia in League of Legends

Kai'Sa is favored during the laning phase against Cassiopeia, winning 3 out of 5 key stat categories. Kai'Sa holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.

Farming
6.3Cassiopeia
6.3Kai'Sa
Cassiopeia and Kai'Sa farm at nearly identical rates in this matchup, with only a 0.0 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
598Cassiopeia
594Kai'Sa
Damage output is virtually even between Cassiopeia and Kai'Sa, with only 4 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
8,920Cassiopeia
10,135Kai'Sa
Kai'Sa generates a commanding 1,215 more gold per game than Cassiopeia. This substantial economic advantage means Kai'Sa consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Cassiopeia should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.1Cassiopeia
0.1Kai'Sa
Cassiopeia brings significantly more crowd control than Kai'Sa, with 1.0 more seconds of CC per minute. This large utility gap makes Cassiopeia far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Kai'Sa should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
504Cassiopeia
547Kai'Sa
Cassiopeia and Kai'Sa have comparable sustain profiles, with only 43 HP/min separating their healing and damage mitigation. Neither champion can out-attrition the other in lane, so trades will be decided by burst potential and ability usage rather than sustain.

Best Cassiopeia Build Against Kai'Sa

The top-performing core items for Cassiopeia against Kai'Sa are Rod of Ages, Liandry's Torment and Rylai's Crystal Scepter. This combination gives Cassiopeia an effective balance of damage, survivability, and utility for the matchup. This streamlined build focuses on the essentials for the Cassiopeia vs Kai'Sa matchup, with room for situational adjustments based on team compositions and game state.

Early Game vs Late Game

Early Game
Kai'Sa
75.0%
+50.0% advantage
Cassiopeia early game win rateCassiopeia25.0%
Kai'Sa early game win rateKai'Sa75.0%
Late Game
Cassiopeia
50.0%
+0.0% advantage
Cassiopeia late game win rateCassiopeia50.0%
Kai'Sa late game win rateKai'Sa50.0%

Kai'Sa dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Cassiopeia. This lopsided early game means Kai'Sa can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Cassiopeia at 50.0% win rate — only 0.0 points ahead of Kai'Sa. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Kai'Sa has the edge early, but Cassiopeia gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Cassiopeia Runes Against Kai'Sa

Sorcery rune tree - Cassiopeia primary runes vs Kai'SaSorcery
Deathfire Touch - best Cassiopeia rune vs Kai'SaManaflow Band - best Cassiopeia rune vs Kai'SaTranscendence - best Cassiopeia rune vs Kai'SaScorch - best Cassiopeia rune vs Kai'Sa
Precision rune tree - Cassiopeia secondary runes vs Kai'SaPrecision
Coup de Grace - best Cassiopeia rune vs Kai'SaPresence of Mind - best Cassiopeia rune vs Kai'Sa
33.3% WR

The Sorcery and Precision rune setup gives Cassiopeia the best tools to compete against Kai'Sa in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Cassiopeia matchup data for League of Legends patch 26.14. The table below shows Cassiopeia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Cassiopeia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Cassiopeia matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
43.24%376.687710,50526.7%54.5%
50.00%305.986510,45845.5%52.6%
46.67%306.576610,53142.9%50.0%
48.28%296.596411,07356.3%38.5%
29.63%276.584211,42727.3%31.3%
56.52%235.565010,05440.0%69.2%
54.55%226.371710,75233.3%69.2%
66.67%216.37939,59277.8%58.3%
77.78%186.483212,09887.5%70.0%
41.18%176.285910,9870.0%63.6%
47.06%176.891610,67333.3%62.5%
58.82%176.888311,90250.0%66.7%
58.82%176.586211,85957.1%60.0%
41.18%176.169610,42414.3%60.0%
68.75%166.672512,820100.0%61.5%
25.00%166.664410,61922.2%28.6%
60.00%156.786412,06180.0%50.0%
28.57%145.294711,21520.0%33.3%
64.29%146.393715,587100.0%58.3%
30.77%137.266010,23833.3%28.6%
46.15%136.388711,89860.0%37.5%
38.46%136.074911,49325.0%44.4%
58.33%126.079110,35466.7%50.0%
18.18%116.481613,1240.0%20.0%
36.36%116.579511,10620.0%50.0%
45.45%116.469811,23660.0%33.3%
20.00%106.471010,02220.0%20.0%
77.78%96.196912,63266.7%83.3%
22.22%96.095414,9540.0%28.6%
77.78%97.08358,42185.7%50.0%
44.44%96.593012,24866.7%33.3%
66.67%96.81,03312,45566.7%66.7%
77.78%96.086413,088100.0%71.4%
37.50%86.696514,89433.3%40.0%
37.50%86.473911,89950.0%33.3%
57.14%77.41,13111,888100.0%40.0%
71.43%76.891011,39175.0%66.7%
42.86%76.791011,03033.3%50.0%
42.86%75.26188,80525.0%66.7%
42.86%77.297413,0710.0%75.0%
85.71%76.492914,88250.0%100.0%
0.00%75.96439,8530.0%0.0%
42.86%76.385110,5390.0%75.0%
85.71%76.81,02112,042100.0%66.7%
42.86%76.483311,76233.3%50.0%
57.14%76.39008,83866.7%50.0%
42.86%77.773510,61850.0%33.3%
57.14%75.68649,854100.0%0.0%
42.86%76.270312,07250.0%40.0%
57.14%76.77769,86875.0%33.3%
33.33%66.17299,1760.0%50.0%
16.67%64.871711,9290.0%20.0%
33.33%66.26488,58266.7%0.0%
33.33%66.35988,92025.0%50.0%
50.00%66.694713,80550.0%50.0%
16.67%66.07129,87933.3%0.0%
50.00%66.083412,8820.0%75.0%
33.33%66.495213,2040.0%40.0%
50.00%67.21,0929,78425.0%100.0%
20.00%56.072010,7890.0%33.3%
60.00%57.21,06212,03050.0%66.7%
40.00%56.569212,20150.0%33.3%
80.00%58.293011,461100.0%50.0%

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Cassiopeia vs Kai'Sa - Frequently Asked Questions

How does Cassiopeia do against Kai'Sa in League of Legends?

Kai'Sa wins the Cassiopeia vs Kai'Sa matchup with a 66.7% win rate compared to Cassiopeia's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.14.

How does Cassiopeia do against Kai'Sa in the early game?

In the early game, Kai'Sa has the advantage against Cassiopeia with a 75.0% win rate versus 25.0%. Kai'Sa players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Cassiopeia do against Kai'Sa in the late game?

In the late game, Cassiopeia takes over the Cassiopeia vs Kai'Sa matchup with a 50.0% win rate compared to 50.0%. Cassiopeia scales better into team fights and objective contests after 25 minutes.

Who wins the Cassiopeia vs Kai'Sa matchup?

Kai'Sa wins the matchup against Cassiopeia with a 66.7% win rate in League of Legends patch 26.14. The 33.3 percentage point advantage means Kai'Sa is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Cassiopeia build against Kai'Sa?

The best Cassiopeia build against Kai'Sa includes Rod of Ages, Liandry's Torment, Rylai's Crystal Scepter. Check the matchup breakdown above for the full item path and build order.

What are the best Cassiopeia runes against Kai'Sa?

The best Cassiopeia runes against Kai'Sa use the Sorcery primary tree with Precision secondary. This rune setup achieves a 33.3% win rate in the Cassiopeia vs Kai'Sa matchup. See the full rune breakdown in the matchup comparison above.

Does Cassiopeia counter Kai'Sa?

No, Cassiopeia struggles against Kai'Sa with only a 33.3% win rate. Kai'Sa has the advantage in this matchup. Cassiopeia players should focus on safe farming and avoiding extended trades to minimize Kai'Sa's lead.

How do I play Cassiopeia against Kai'Sa?

When playing Cassiopeia against Kai'Sa, play cautiously and avoid Kai'Sa's power spikes. Focus on safe farming — you outscale Kai'Sa in the late game. Use the matchup-specific build and runes above to optimize your chances.