Cassiopeia - League of Legends Champion
Win Rate
51.2%
Pick Rate
0.8%

Cassiopeiavs Kai'Sa

AMage
Patch26.10
Matches2,379,056
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 25, 2026
MethodologyData Methodology

Cassiopeia vs Kai'Sa is a very close matchup in LoL patch 26.10. Cassiopeia wins with a 50.0% win rate (+0.0%) over Kai'Sa based on 8 games. Cassiopeia holds the advantage in both the early and late game. Below you'll find the best Cassiopeia build, runes, laning stats, and strategies for the Cassiopeia vs Kai'Sa matchup.

Cassiopeia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Cassiopeia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Kai'Sa - 50.0% win rateKai'Sa(50.0%)
Cassiopeia - 50.0% win rate in this matchup
Cassiopeia
50.0% WR
VS
Kai'Sa vs Cassiopeia matchup - 50.0% win rate
Kai'Sa
50.0% WR

Who Wins the Cassiopeia vs Kai'Sa Matchup?

Cassiopeia wins the Cassiopeia vs Kai'Sa matchup
Winner
Cassiopeia
Matches: 8
50.0%
Win Rate
50.0%
7.6
CS / min
6.9
936
DMG / min
744
13,631
Gold / game
13,834
313
Heal / min
124
550
DMG Mitigated / min
413
1.1
CC / min
0.0
50.0%
Early Game WR
50.0%
50.0%
Late Game WR
50.0%

Cassiopeia vs Kai'Sa Matchup Summary

The Cassiopeia vs Kai'Sa matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 8 recent matches analyzed, Cassiopeia wins with a 50.0% win rate compared to Kai'Sa's 50.0%, giving Cassiopeia a 0.0 percentage point advantage. Cassiopeia holds a slight edge in both the early and late game, but the margins are thin enough that individual skill and jungle attention will often determine the outcome. Kai'Sa can still find windows through outplays and team coordination. The most significant statistical gap is in crowd control, where Cassiopeia leads by 1.1s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Cassiopeia has a statistical edge, but the margin is close enough that respecting Kai'Sa's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Cassiopeia vs Kai'Sa Laning Phase Breakdown

Cassiopeia wins the laning phase against Kai'Sa in League of Legends

Cassiopeia is favored during the laning phase against Kai'Sa, winning 4 out of 5 key stat categories. Cassiopeia holds advantages in farming, damage, crowd control and sustain, making them the stronger laner in this matchup.

Farming
7.6Cassiopeia
6.9Kai'Sa
Cassiopeia edges out Kai'Sa by 0.7 CS per minute — a moderate farming advantage that adds up to roughly 10 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Cassiopeia.
Damage
936Cassiopeia
744Kai'Sa
Cassiopeia heavily out-damages Kai'Sa by 192 DMG/min, dominating both short trades and all-in fights. Kai'Sa should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Cassiopeia's sustained damage advantage take over.
Economy
13,631Cassiopeia
13,834Kai'Sa
Cassiopeia and Kai'Sa generate nearly equal gold per game, with just a 203 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.1Cassiopeia
0.0Kai'Sa
Cassiopeia brings significantly more crowd control than Kai'Sa, with 1.1 more seconds of CC per minute. This large utility gap makes Cassiopeia far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Kai'Sa should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
863Cassiopeia
538Kai'Sa
Cassiopeia vastly out-sustains Kai'Sa, healing and mitigating 325 more damage per minute. This massive durability gap means Cassiopeia can absorb significant punishment and remain in lane while Kai'Sa is forced to recall. Building grievous wounds early is essential for Kai'Sa, and focusing on burst trade patterns rather than sustained fights is critical.

Best Cassiopeia Build Against Kai'Sa

The top-performing core items for Cassiopeia against Kai'Sa are Rod of Ages, Liandry's Torment and Rylai's Crystal Scepter. This combination gives Cassiopeia an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 2 games — well above average and making it the top item path against Kai'Sa. This streamlined build focuses on the essentials for the Cassiopeia vs Kai'Sa matchup, with room for situational adjustments based on team compositions and game state.

Early Game vs Late Game

Early Game
Cassiopeia
50.0%
+0.0% advantage
Cassiopeia early game win rateCassiopeia50.0%
Kai'Sa early game win rateKai'Sa50.0%
Late Game
Cassiopeia
50.0%
+0.0% advantage
Cassiopeia late game win rateCassiopeia50.0%
Kai'Sa late game win rateKai'Sa50.0%

The early game (first 15 minutes) is a toss-up between Cassiopeia and Kai'Sa, with Cassiopeia holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Late game (25+ minutes) is equally balanced, with Cassiopeia at 50.0% win rate — only 0.0 points ahead of Kai'Sa. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

This matchup is remarkably even at every stage of the game. Neither Cassiopeia nor Kai'Sa has a phase-specific advantage, making this a pure skill matchup where individual mechanics, decision-making, and team coordination determine the outcome.

Best Cassiopeia Runes Against Kai'Sa

Precision rune tree - Cassiopeia primary runes vs Kai'SaPrecision
Conqueror - best Cassiopeia rune vs Kai'SaPresence of Mind - best Cassiopeia rune vs Kai'SaLegend: Haste - best Cassiopeia rune vs Kai'SaLast Stand - best Cassiopeia rune vs Kai'Sa
Sorcery rune tree - Cassiopeia secondary runes vs Kai'SaSorcery
Manaflow Band - best Cassiopeia rune vs Kai'SaTranscendence - best Cassiopeia rune vs Kai'Sa
100.0% WR

The Precision primary with Sorcery secondary combination helps Cassiopeia maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Kai'Sa.


Cassiopeia matchup data for League of Legends patch 26.10. The table below shows Cassiopeia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Cassiopeia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Cassiopeia matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
46.55%586.482311,86463.6%36.1%
46.81%476.891811,96044.4%48.3%
51.06%476.574611,16357.1%46.1%
37.78%456.986911,13340.9%34.8%
53.49%436.680510,95856.5%50.0%
51.43%356.876712,32077.8%42.3%
26.47%346.276711,33415.4%33.3%
53.13%326.891611,16038.5%63.2%
70.97%316.890213,39363.6%75.0%
54.84%316.176810,21735.7%70.6%
40.00%306.270011,38044.4%38.1%
50.00%306.085711,74435.7%62.5%
55.56%276.577611,55236.4%68.8%
61.54%266.397411,51845.5%73.3%
61.54%266.283510,70972.7%53.3%
42.31%266.385111,68440.0%43.8%
37.50%246.582611,34425.0%43.8%
54.17%246.691611,23538.5%72.7%
45.83%246.869811,75340.0%50.0%
52.17%236.688212,79472.7%33.3%
43.48%236.668310,32050.0%36.4%
42.86%216.383711,13940.0%45.5%
28.57%216.494412,06410.0%45.5%
57.89%197.188111,38866.7%50.0%
52.63%197.380111,76270.0%33.3%
66.67%186.885111,46366.7%66.7%
50.00%186.769311,02533.3%66.7%
61.11%186.51,01113,86980.0%53.9%
68.75%166.891512,42466.7%70.0%
25.00%166.797510,88720.0%33.3%
40.00%156.481212,48240.0%40.0%
46.67%156.688011,31233.3%66.7%
53.33%157.075810,33175.0%28.6%
46.67%155.68379,41857.1%37.5%
60.00%156.777511,88950.0%66.7%
53.33%156.495915,25280.0%40.0%
42.86%146.584314,39960.0%33.3%
42.86%145.699912,81040.0%44.4%
57.14%146.874510,70466.7%40.0%
46.15%136.177311,11675.0%33.3%
46.15%136.275213,06525.0%55.6%
38.46%136.888612,28040.0%37.5%
38.46%136.587112,22925.0%44.4%
46.15%136.367710,36550.0%42.9%
33.33%126.584611,52540.0%28.6%
75.00%126.095312,12566.7%77.8%
33.33%127.188613,28133.3%33.3%
40.00%106.774810,25150.0%33.3%
70.00%106.276013,23466.7%71.4%
40.00%106.695112,29625.0%50.0%
30.00%105.07719,95420.0%40.0%
60.00%106.859610,76260.0%60.0%
33.33%96.66649,94340.0%25.0%
55.56%95.89409,89180.0%25.0%
55.56%96.264312,38675.0%40.0%
37.50%86.593711,12350.0%25.0%
75.00%86.869212,90166.7%80.0%
50.00%87.693613,63150.0%50.0%
62.50%85.073812,673100.0%57.1%
42.86%76.281310,95333.3%50.0%
42.86%76.79509,39650.0%33.3%
28.57%76.091914,773100.0%16.7%
42.86%76.584413,416100.0%33.3%
57.14%77.388712,39066.7%50.0%
57.14%76.783713,61266.7%50.0%
57.14%76.78359,91660.0%50.0%
42.86%74.775111,3020.0%50.0%
42.86%77.097912,94750.0%33.3%
50.00%68.572911,19875.0%0.0%
66.67%66.685711,941100.0%33.3%
50.00%65.41,10610,45266.7%33.3%
33.33%65.194012,71350.0%25.0%
50.00%66.468310,56750.0%50.0%
50.00%67.585610,70466.7%33.3%
50.00%66.01,00311,64566.7%33.3%
50.00%66.678211,7340.0%60.0%
50.00%66.880010,45850.0%50.0%
50.00%66.490011,37166.7%33.3%
80.00%55.91,14210,330100.0%75.0%
80.00%55.81,06412,017100.0%75.0%
20.00%55.86868,91825.0%0.0%
80.00%56.568811,435100.0%0.0%
40.00%57.193713,62933.3%50.0%
60.00%56.695214,593100.0%50.0%
60.00%56.262910,9320.0%100.0%
40.00%56.31,0999,66750.0%33.3%
20.00%53.55436,59525.0%0.0%
60.00%57.81,18313,86166.7%50.0%
60.00%57.797711,450100.0%33.3%
40.00%56.770313,7890.0%50.0%
40.00%56.782711,93250.0%33.3%
60.00%55.986912,342100.0%50.0%
60.00%57.479812,16550.0%66.7%
100.00%57.294613,607100.0%100.0%

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Cassiopeia vs Kai'Sa - Frequently Asked Questions

How does Cassiopeia do against Kai'Sa in League of Legends?

Cassiopeia wins the Cassiopeia vs Kai'Sa matchup with a 50.0% win rate compared to Kai'Sa's 50.0%, a 0.0 percentage point difference. This data is based on 8 recent ranked games in patch 26.10.

How does Cassiopeia do against Kai'Sa in the early game?

In the early game, Cassiopeia has the advantage against Kai'Sa with a 50.0% win rate versus 50.0%. Cassiopeia players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Cassiopeia do against Kai'Sa in the late game?

In the late game, Cassiopeia takes over the Cassiopeia vs Kai'Sa matchup with a 50.0% win rate compared to 50.0%. Cassiopeia scales better into team fights and objective contests after 25 minutes.

Who wins the Cassiopeia vs Kai'Sa matchup?

Cassiopeia wins the matchup against Kai'Sa with a 50.0% win rate in League of Legends patch 26.10. The 0.0 percentage point advantage means Cassiopeia is slightly favored in this lane matchup based on 8 games analyzed.

What is the best Cassiopeia build against Kai'Sa?

The best Cassiopeia build against Kai'Sa includes Rod of Ages, Liandry's Torment, Rylai's Crystal Scepter. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Cassiopeia runes against Kai'Sa?

The best Cassiopeia runes against Kai'Sa use the Precision primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Cassiopeia vs Kai'Sa matchup. See the full rune breakdown in the matchup comparison above.

Does Cassiopeia counter Kai'Sa?

Yes, Cassiopeia has a favorable matchup against Kai'Sa with a 50.0% win rate. Cassiopeia slightly edges out Kai'Sa in lane based on current patch 26.10 data.

How do I play Cassiopeia against Kai'Sa?

When playing Cassiopeia against Kai'Sa, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.