Cassiopeia - League of Legends Champion
Win Rate
55.2%
Pick Rate
0.8%

Cassiopeiavs Kai'Sa

SMage
Patch26.7
Matches508,082
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 8, 2026
MethodologyData Methodology

Cassiopeia vs Kai'Sa is a decisive matchup in LoL patch 26.7. Cassiopeia wins with a 83.3% win rate (+66.7%) over Kai'Sa based on 6 games. Cassiopeia holds the advantage in both the early and late game. Below you'll find the best Cassiopeia build, runes, laning stats, and strategies for the Cassiopeia vs Kai'Sa matchup.

Cassiopeia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Cassiopeia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Kai'Sa - 83.3% win rateKai'Sa(83.3%)
Cassiopeia - 83.3% win rate in this matchup
Cassiopeia
83.3% WR
VS
Kai'Sa vs Cassiopeia matchup - 16.7% win rate
Kai'Sa
16.7% WR

Who Wins the Cassiopeia vs Kai'Sa Matchup?

Cassiopeia wins the Cassiopeia vs Kai'Sa matchup
Winner
Cassiopeia
Matches: 6
83.3%
Win Rate
16.7%
6.7
CS / min
7.0
840
DMG / min
792
13,445
Gold / game
12,769
297
Heal / min
133
654
DMG Mitigated / min
452
1.1
CC / min
0.0
50.0%
Early Game WR
50.0%
100.0%
Late Game WR
0.0%

Cassiopeia vs Kai'Sa Matchup Summary

The Cassiopeia vs Kai'Sa matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Cassiopeia wins with a 83.3% win rate compared to Kai'Sa's 16.7%, giving Cassiopeia a 66.7 percentage point advantage. Cassiopeia dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Kai'Sa players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Cassiopeia leads by 1.0s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Cassiopeia players can confidently pick into Kai'Sa and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Kai'Sa away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Cassiopeia vs Kai'Sa Laning Phase Breakdown

Cassiopeia wins the laning phase against Kai'Sa in League of Legends

Cassiopeia is favored during the laning phase against Kai'Sa, winning 4 out of 5 key stat categories. Cassiopeia holds advantages in damage, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.7Cassiopeia
7.0Kai'Sa
Kai'Sa edges out Cassiopeia by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Kai'Sa.
Damage
840Cassiopeia
792Kai'Sa
Cassiopeia deals 49 more champion damage per minute than Kai'Sa. While noticeable in extended trades, this gap can be offset by Kai'Sa choosing favorable fight windows, such as engaging when Cassiopeia's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
13,445Cassiopeia
12,769Kai'Sa
Cassiopeia earns 676 more gold per game than Kai'Sa, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Cassiopeia slightly faster item completions.
Utility
1.1Cassiopeia
0.0Kai'Sa
Cassiopeia brings significantly more crowd control than Kai'Sa, with 1.0 more seconds of CC per minute. This large utility gap makes Cassiopeia far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Kai'Sa should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
951Cassiopeia
585Kai'Sa
Cassiopeia vastly out-sustains Kai'Sa, healing and mitigating 365 more damage per minute. This massive durability gap means Cassiopeia can absorb significant punishment and remain in lane while Kai'Sa is forced to recall. Building grievous wounds early is essential for Kai'Sa, and focusing on burst trade patterns rather than sustained fights is critical.

Best Cassiopeia Build Against Kai'Sa

Spellslinger's Shoes is the optimal boots choice against Kai'Sa, providing the mobility and stats Cassiopeia needs most in this matchup. The top-performing core items for Cassiopeia against Kai'Sa are Rod of Ages, Rylai's Crystal Scepter and Seraph's Embrace. This combination gives Cassiopeia an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 2 games — well above average and making it the top item path against Kai'Sa. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Cassiopeia vs Kai'Sa matchup.

Early Game vs Late Game

Early Game
Cassiopeia
50.0%
+0.0% advantage
Cassiopeia early game win rateCassiopeia50.0%
Kai'Sa early game win rateKai'Sa50.0%
Late Game
Cassiopeia
100.0%
+100.0% advantage
Cassiopeia late game win rateCassiopeia100.0%
Kai'Sa late game win rateKai'Sa0.0%

The early game (first 15 minutes) is a toss-up between Cassiopeia and Kai'Sa, with Cassiopeia holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Cassiopeia is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Kai'Sa. Extended games heavily favor Cassiopeia, whose kit and scaling make them a dominant force in team fights and objective control.

Cassiopeia holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Kai'Sa players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Cassiopeia Runes Against Kai'Sa

Sorcery rune tree - Cassiopeia primary runes vs Kai'SaSorcery
Phase Rush - best Cassiopeia rune vs Kai'SaManaflow Band - best Cassiopeia rune vs Kai'SaTranscendence - best Cassiopeia rune vs Kai'SaScorch - best Cassiopeia rune vs Kai'Sa
Precision rune tree - Cassiopeia secondary runes vs Kai'SaPrecision
Coup de Grace - best Cassiopeia rune vs Kai'SaPresence of Mind - best Cassiopeia rune vs Kai'Sa
100.0% WR

Running Sorcery primary with Precision secondary allows Cassiopeia to press their advantage against Kai'Sa, amplifying the strengths that make this a favorable matchup.


Cassiopeia matchup data for League of Legends patch 26.7. The table below shows Cassiopeia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Cassiopeia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Cassiopeia matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
56.25%326.788512,08850.0%66.7%
55.17%297.082911,66350.0%60.0%
48.00%256.776712,31650.0%47.4%
47.83%236.872911,51240.0%62.5%
45.45%226.385913,06120.0%52.9%
59.09%226.484912,54862.5%57.1%
42.11%196.986411,12127.3%62.5%
42.11%196.590810,89433.3%57.1%
57.89%196.492112,99228.6%75.0%
41.18%176.373912,06537.5%44.4%
35.29%176.773611,49814.3%50.0%
58.82%177.076110,08961.5%50.0%
43.75%166.579312,56433.3%46.1%
37.50%166.679911,96633.3%40.0%
37.50%166.769211,33728.6%44.4%
66.67%156.194812,98175.0%63.6%
66.67%157.098013,675100.0%54.5%
50.00%146.580411,93333.3%62.5%
57.14%146.565011,06250.0%62.5%
21.43%146.485812,88566.7%9.1%
46.15%136.86919,86937.5%60.0%
69.23%136.494011,61866.7%71.4%
58.33%126.984013,60150.0%66.7%
66.67%126.91,01711,75950.0%83.3%
36.36%116.262311,14260.0%16.7%
81.82%116.894211,31971.4%100.0%
54.55%116.593013,22360.0%50.0%
63.64%117.46599,84555.6%100.0%
36.36%115.583012,70025.0%42.9%
45.45%116.71,09012,21225.0%57.1%
45.45%117.179011,95850.0%42.9%
40.00%106.483613,98333.3%42.9%
20.00%107.565811,9420.0%25.0%
77.78%97.093011,929100.0%60.0%
44.44%96.11,06214,147100.0%37.5%
33.33%96.374010,38820.0%50.0%
62.50%86.293212,07075.0%50.0%
50.00%86.584011,20660.0%33.3%
62.50%87.21,06913,95450.0%66.7%
37.50%87.375311,9870.0%60.0%
62.50%86.580412,10040.0%100.0%
71.43%76.71,07712,31650.0%80.0%
42.86%76.61,02513,52950.0%40.0%
57.14%76.282511,09066.7%50.0%
28.57%76.479313,23650.0%0.0%
85.71%77.097012,450100.0%75.0%
83.33%66.864110,21075.0%100.0%
33.33%66.575210,28925.0%50.0%
83.33%66.784013,44550.0%100.0%
33.33%66.875810,81125.0%50.0%
66.67%65.987214,875100.0%60.0%
16.67%66.155810,7760.0%50.0%
83.33%66.986213,632100.0%50.0%
60.00%57.190515,4910.0%75.0%
0.00%56.91,07312,4530.0%0.0%
60.00%57.31,07713,11466.7%50.0%
80.00%56.999912,801100.0%50.0%
40.00%56.783410,90933.3%50.0%
20.00%55.77549,53133.3%0.0%
80.00%57.079611,09275.0%100.0%
40.00%56.774513,361100.0%0.0%
80.00%57.26758,508100.0%50.0%
60.00%55.91,14416,9190.0%60.0%
60.00%56.77329,347100.0%0.0%
20.00%56.895411,16633.3%0.0%

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Cassiopeia vs Kai'Sa - Frequently Asked Questions

How does Cassiopeia do against Kai'Sa in League of Legends?

Cassiopeia wins the Cassiopeia vs Kai'Sa matchup with a 83.3% win rate compared to Kai'Sa's 16.7%, a 66.7 percentage point difference. This data is based on 6 recent ranked games in patch 26.7.

How does Cassiopeia do against Kai'Sa in the early game?

In the early game, Cassiopeia has the advantage against Kai'Sa with a 50.0% win rate versus 50.0%. Cassiopeia players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Cassiopeia do against Kai'Sa in the late game?

In the late game, Cassiopeia takes over the Cassiopeia vs Kai'Sa matchup with a 100.0% win rate compared to 0.0%. Cassiopeia scales better into team fights and objective contests after 25 minutes.

Who wins the Cassiopeia vs Kai'Sa matchup?

Cassiopeia wins the matchup against Kai'Sa with a 83.3% win rate in League of Legends patch 26.7. The 66.7 percentage point advantage means Cassiopeia is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Cassiopeia build against Kai'Sa?

The best Cassiopeia build against Kai'Sa includes Rod of Ages, Rylai's Crystal Scepter, Seraph's Embrace with Spellslinger's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Cassiopeia runes against Kai'Sa?

The best Cassiopeia runes against Kai'Sa use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Cassiopeia vs Kai'Sa matchup. See the full rune breakdown in the matchup comparison above.

Does Cassiopeia counter Kai'Sa?

Yes, Cassiopeia has a favorable matchup against Kai'Sa with a 83.3% win rate. Cassiopeia strongly counters Kai'Sa in lane based on current patch 26.7 data.

How do I play Cassiopeia against Kai'Sa?

When playing Cassiopeia against Kai'Sa, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.