- Win Rate
- 49.8%
- Pick Rate
- 4.2%
- Ban Rate
- 5.0%
Vayne vs Kai'Sa
- Patch
- 26.21
- Games
- 8,410
- Lane
- All Lanes
- Tier
- All Tiers
- Last Updated
- Nov 3, 2026 UTC
- Author
- Dakota Chinnick
- Methodology
- Data Methodology
Vayne vs Kai'Sa is a very close matchup in LoL patch 26.21. Kai'Sa wins with a 50.1% win rate (+0.3%) over Vayne based on 650 games. Kai'Sa wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Kai'Sa matchup.
Vayne Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who wins Vayne vs Kai'Sa?
Vayne wins 50.2% of these games. With this many games the true rate is most likely between 46.3% and 54.1% (95% range).
- Expected
- 50.1% From both champions' overall Bot win rates
- Matchup effect
- +0.1 pts Observed minus expected
- Sample
- 626 games Lane: Bot
- vs patch 26.20
- +0.2 pts Within normal patch-to-patch noise
Lane: Bot · Ranked Solo/Duo & Flex · North America server · All ranks · Patch 26.21 · Oct 27 – Nov 3
Key takeaways
- Vayne vs Kai'Sa is an even matchup: Vayne wins 50.2% of 626 games, and the 95% range (46.3–54.1%) comfortably includes 50%.
- Both champions' overall Bot win rates predict 50.1% for Vayne; the result is within the margin of error of that, so this matchup mostly reflects the two champions' general strength.
- Kai'Sa usually wins the lane: 246 gold ahead of Vayne at 15 minutes on average (622 games with a 15-minute snapshot).
How we calculate this
Games: ranked Solo/Duo and Flex games on the North America server from the patch shown. Remakes (games under 5 minutes) are excluded.
A game only counts when Vayne and Kai'Sa played the same position on opposite teams, so roaming, lane swaps within a team or a champion merely being in the same game never count as this matchup.
The 95% range is a Wilson score interval. Confidence comes from how wide that range is: within ±3 points is very high, ±5 high, ±8 moderate, anything wider low. Below 20 games a matchup is not classified at all.
Expected win rate combines both champions’ win rates in this lane (same games and filters) with the log5 formula: E = A(1−B) / (A(1−B) + B(1−A)). Matchup effect = observed − expected.
"What changes" compares Vayne's choices in this matchup with the same champion's other games in the same lane, and lists a change only when it is at least 3 points and statistically significant (two-proportion z-test, |z| ≥ 2, 20+ games).
Results are not split by rank: the sample per rank is too small for honest per-rank matchup numbers.
Vayne vs Kai'Sa Laning Stats
At 15 minutes
Whole-game averages
Vayne vs Kai'Sa Win Rate by Game Length
Vayne's win rate against Kai'Sa by game length. The dot is the win rate, the bar its 95% range and the dashed line the champion's usual win rate at that length. Lengths with fewer than 25 games are left blank.
No game length stands out: Vayne's results against Kai'Sa in short and long games are within the margin of error of each other.
Vayne vs Kai'Sa Power Spikes
Who is ahead at each stage, measured from these games. A stage reads "Even" when the difference is inside the margin of error, and "Insufficient data" when there are too few games to tell.
- Lane (15 min)Kai'SaVayne gold at 15: −246
- First itemKai'SaVayne: 13.1 min · Kai'Sa: 10.6 min
- Games under 20 minInsufficient data
- 20–30 min gamesEvenVayne wins 48.9% of 266 games
- 30+ min gamesEvenVayne wins 50.6% of 324 games
What Vayne Changes Against Kai'Sa
Vayne players don't meaningfully change their setup against Kai'Sa: no item, rune, spell or skill order differs by 3 points or more beyond the margin of error. The usual build applies.
Best Vayne Build vs Kai'Sa
Usual Vayne build (Bot)
58.5% win rate · 410 games
Against Kai'Sa
72.1% win rate · 43 games
Limited sample: 43 of 458 games finished this exact core, so treat it as an observation rather than a recommendation.
- Vayne usually completes Blade of The Ruined King first, at 13.1 min (median of 325 games).
- Kai'Sa usually completes Kraken Slayer first, at 10.6 min (median of 394 games).
- Skill priority: Q > W > E — the same as usual.
Builds are ranked by the lower edge of their win rate range, not the raw win rate, so a build seen in a handful of wins never outranks a proven one.
Best Vayne Runes vs Kai'Sa
Usual Vayne runes (Bot)
Lethal Tempo
50.7% win rate · 3,727 games
Against Kai'Sa
Lethal Tempo48.6% win rate · 350 games
Plan your Vayne draft in Draft Lab
Draft Lab lays out both teams lane by lane with live matchup win rates, damage profiles and game-phase lean, and suggests picks and bans from current meta data.
- Full 5v5 draft board
- Lane matchup win rates
- Pick and ban suggestions
Vayne matchup data for League of Legends patch 26.21. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.
Other Vayne Matchups
Hardest for Vayne
Easiest for Vayne
Win rate and games for each matchup. Lists are ranked by the edge of the 95% range so small samples cannot top them; matchups with at least 50 games only.
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Vayne vs Kai'Sa FAQ - Patch 26.21
Who wins Vayne vs Kai'Sa?
Vayne vs Kai'Sa is an even matchup: Vayne wins 50.2% of 626 games, and the 95% range (46.3–54.1%) comfortably includes 50%.
What is Vayne's win rate against Kai'Sa?
Vayne wins 50.2% of 626 Bot games against Kai'Sa on patch 26.21 (95% range 46.3–54.1%). Based on both champions' overall Bot win rates, 50.1% would be expected.
Does Vayne counter Kai'Sa?
Not clearly. Vayne wins 50.2% of 626 games against Kai'Sa, and the 95% range (46.3–54.1%) includes 50%, so neither champion reliably counters the other on current data.
Who wins lane, Vayne or Kai'Sa?
Kai'Sa usually wins the lane: 246 gold ahead of Vayne at 15 minutes on average (622 games with a 15-minute snapshot).
Does Vayne outscale Kai'Sa?
Not measurably: Vayne's win rate against Kai'Sa in games of 25 minutes or less and in longer games is within the margin of error of each other.
When is Kai'Sa strongest against Vayne?
Kai'Sa is measurably ahead in: Lane (15 min), First item.
What should Vayne build against Kai'Sa?
The most successful Vayne core against Kai'Sa is Kraken Slayer, Blade of The Ruined King, Guinsoo's Rageblade (72.1% over 43 games).
What runes should Vayne use against Kai'Sa?
Lethal Tempo with Precision and Resolve — 48.6% over 350 games against Kai'Sa.