Vaynevs Kai'Sa
Vayne vs Kai'Sa is a decisive matchup in LoL patch 26.14. Vayne wins with a 53.1% win rate (+6.2%) over Kai'Sa based on 211 games. Kai'Sa wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Kai'Sa matchup.
Vayne Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who Wins the Vayne vs Kai'Sa Matchup?
Vayne vs Kai'Sa Matchup Summary
The Vayne vs Kai'Sa matchup is a decisive matchup in League of Legends ranked play. Based on 211 recent matches analyzed, Vayne wins with a 53.1% win rate compared to Kai'Sa's 46.9%, giving Vayne a 6.2 percentage point advantage. Game phase dynamics play a critical role here: Kai'Sa controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Kai'Sa needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Vayne leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Kai'Sa and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Kai'Sa away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Vayne vs Kai'Sa Laning Phase Breakdown
Kai'Sa is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Kai'Sa holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.
Early Game vs Late Game
Vayne43.0%
Kai'Sa57.0%Vayne61.0%Kai'Sa39.0%Kai'Sa dominates the early game (first 15 minutes) with a commanding 57.0% win rate — a 14.0 percentage point lead over Vayne. This lopsided early game means Kai'Sa can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Vayne is far superior in the late game (25+ minutes), boasting a 61.0% win rate — 22.0 points above Kai'Sa. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.
This matchup features a dramatic power shift: Kai'Sa must aggressively press their early advantage and close out the game before Vayne reaches their scaling breakpoints. If Vayne survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.
Best Vayne Runes Against Kai'Sa
Precision
Resolve
Running Precision primary with Resolve secondary allows Vayne to press their advantage against Kai'Sa, amplifying the strengths that make this a favorable matchup.
Vayne matchup data for League of Legends patch 26.14. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 48.56% | 348 | 5.8 | 847 | 12,979 | 44.1% | 50.9% | |
| 53.42% | 307 | 5.9 | 839 | 12,940 | 48.8% | 56.6% | |
| 48.20% | 278 | 6.1 | 836 | 13,470 | 41.3% | 51.6% | |
| 47.74% | 243 | 6.2 | 860 | 12,610 | 47.6% | 47.9% | |
| 53.08% | 211 | 6.3 | 878 | 12,621 | 43.0% | 61.0% | |
| 41.53% | 183 | 6.1 | 773 | 12,603 | 38.8% | 43.1% | |
| 52.78% | 144 | 6.1 | 791 | 12,829 | 55.8% | 51.1% | |
| 51.91% | 131 | 6.4 | 881 | 14,083 | 40.9% | 57.5% | |
| 41.41% | 128 | 6.1 | 892 | 12,802 | 38.3% | 43.2% | |
| 49.00% | 100 | 6.3 | 952 | 13,528 | 45.7% | 50.8% | |
| 42.86% | 98 | 6.0 | 825 | 13,131 | 40.0% | 44.1% | |
| 52.75% | 91 | 6.2 | 890 | 12,275 | 55.1% | 50.0% | |
| 50.00% | 88 | 5.7 | 727 | 12,174 | 43.8% | 53.6% | |
| 51.81% | 83 | 6.1 | 910 | 11,362 | 54.5% | 50.0% | |
| 47.50% | 80 | 6.1 | 820 | 12,475 | 45.7% | 48.9% | |
| 60.00% | 65 | 6.0 | 974 | 12,774 | 68.2% | 55.8% | |
| 50.00% | 64 | 6.0 | 847 | 11,777 | 46.1% | 52.6% | |
| 62.50% | 64 | 6.1 | 899 | 12,623 | 66.7% | 58.8% | |
| 33.33% | 60 | 5.7 | 698 | 10,500 | 28.6% | 37.5% | |
| 64.91% | 57 | 6.1 | 1,042 | 12,267 | 60.0% | 68.8% | |
| 50.88% | 57 | 6.1 | 787 | 12,253 | 54.8% | 46.1% | |
| 53.57% | 56 | 5.8 | 725 | 12,485 | 43.5% | 60.6% | |
| 47.17% | 53 | 6.4 | 721 | 12,526 | 33.3% | 58.6% | |
| 45.28% | 53 | 5.7 | 745 | 11,425 | 48.1% | 42.3% | |
| 40.38% | 52 | 6.0 | 807 | 12,805 | 42.9% | 38.7% | |
| 52.00% | 50 | 5.6 | 757 | 10,827 | 71.4% | 37.9% | |
| 24.00% | 50 | 5.5 | 593 | 10,367 | 10.5% | 32.3% | |
| 50.00% | 48 | 6.3 | 804 | 12,299 | 37.5% | 62.5% | |
| 43.48% | 46 | 5.9 | 831 | 13,246 | 40.0% | 46.1% | |
| 64.44% | 45 | 6.6 | 1,356 | 13,355 | 52.9% | 71.4% | |
| 44.19% | 43 | 6.5 | 783 | 12,296 | 42.9% | 45.5% | |
| 48.78% | 41 | 6.2 | 879 | 13,464 | 28.6% | 59.3% | |
| 52.94% | 34 | 6.7 | 896 | 13,048 | 50.0% | 55.6% | |
| 63.64% | 33 | 6.5 | 1,116 | 12,112 | 53.3% | 72.2% | |
| 62.50% | 32 | 6.3 | 819 | 12,631 | 45.5% | 71.4% | |
| 59.38% | 32 | 6.1 | 854 | 12,126 | 88.9% | 47.8% | |
| 38.71% | 31 | 5.7 | 1,025 | 11,464 | 27.3% | 45.0% | |
| 54.84% | 31 | 5.8 | 820 | 11,578 | 20.0% | 71.4% | |
| 67.74% | 31 | 6.0 | 1,055 | 12,463 | 54.5% | 75.0% | |
| 43.33% | 30 | 6.2 | 879 | 12,495 | 36.4% | 47.4% | |
| 53.33% | 30 | 6.5 | 1,296 | 14,350 | 44.4% | 57.1% | |
| 42.86% | 28 | 5.9 | 832 | 12,552 | 36.4% | 47.1% | |
| 66.67% | 27 | 6.3 | 893 | 10,712 | 69.2% | 64.3% | |
| 62.96% | 27 | 6.3 | 1,010 | 10,804 | 57.1% | 69.2% | |
| 51.85% | 27 | 6.6 | 827 | 11,719 | 60.0% | 47.1% | |
| 40.00% | 25 | 5.9 | 1,076 | 12,666 | 55.6% | 31.3% | |
| 66.67% | 24 | 6.3 | 851 | 11,368 | 75.0% | 58.3% | |
| 41.67% | 24 | 6.5 | 982 | 11,958 | 53.9% | 27.3% | |
| 39.13% | 23 | 5.3 | 808 | 11,110 | 11.1% | 57.1% | |
| 43.48% | 23 | 5.9 | 903 | 12,039 | 40.0% | 44.4% | |
| 52.17% | 23 | 6.3 | 716 | 12,158 | 50.0% | 53.3% | |
| 50.00% | 22 | 6.3 | 786 | 12,373 | 50.0% | 50.0% | |
| 50.00% | 22 | 6.3 | 877 | 11,269 | 33.3% | 61.5% | |
| 54.55% | 22 | 6.1 | 944 | 13,476 | 50.0% | 56.3% | |
| 50.00% | 22 | 5.7 | 857 | 10,867 | 66.7% | 38.5% | |
| 61.90% | 21 | 5.7 | 807 | 11,322 | 55.6% | 66.7% | |
| 38.10% | 21 | 6.1 | 885 | 12,478 | 66.7% | 26.7% | |
| 47.62% | 21 | 6.3 | 794 | 14,046 | 33.3% | 50.0% | |
| 40.00% | 20 | 6.1 | 896 | 12,759 | 40.0% | 40.0% | |
| 68.42% | 19 | 6.1 | 951 | 10,335 | 75.0% | 63.6% | |
| 57.89% | 19 | 6.3 | 813 | 12,245 | 50.0% | 63.6% | |
| 50.00% | 18 | 5.8 | 938 | 11,873 | 55.6% | 44.4% | |
| 70.59% | 17 | 6.4 | 1,041 | 13,115 | 80.0% | 66.7% | |
| 56.25% | 16 | 6.5 | 811 | 14,119 | 50.0% | 58.3% | |
| 43.75% | 16 | 5.6 | 733 | 11,696 | 28.6% | 55.6% | |
| 31.25% | 16 | 6.0 | 738 | 11,878 | 40.0% | 27.3% | |
| 62.50% | 16 | 6.2 | 946 | 12,972 | 50.0% | 70.0% | |
| 46.67% | 15 | 6.0 | 661 | 9,616 | 55.6% | 33.3% | |
| 66.67% | 15 | 6.2 | 938 | 14,618 | 25.0% | 81.8% | |
| 78.57% | 14 | 6.8 | 918 | 15,770 | 100.0% | 70.0% | |
| 35.71% | 14 | 6.2 | 906 | 9,942 | 33.3% | 37.5% | |
| 71.43% | 14 | 6.4 | 846 | 13,112 | 42.9% | 100.0% | |
| 64.29% | 14 | 6.1 | 1,149 | 12,061 | 57.1% | 71.4% | |
| 53.85% | 13 | 5.9 | 810 | 13,109 | 33.3% | 60.0% | |
| 53.85% | 13 | 5.4 | 1,017 | 13,231 | 50.0% | 57.1% | |
| 53.85% | 13 | 5.8 | 757 | 10,865 | 75.0% | 20.0% | |
| 50.00% | 12 | 6.3 | 894 | 13,153 | 25.0% | 62.5% | |
| 58.33% | 12 | 6.5 | 863 | 10,158 | 33.3% | 83.3% | |
| 41.67% | 12 | 4.4 | 890 | 10,679 | 50.0% | 25.0% | |
| 54.55% | 11 | 5.7 | 764 | 12,344 | 33.3% | 62.5% | |
| 50.00% | 10 | 6.4 | 838 | 12,063 | 66.7% | 42.9% | |
| 80.00% | 10 | 6.0 | 847 | 12,029 | 100.0% | 66.7% | |
| 33.33% | 9 | 5.0 | 723 | 12,686 | 0.0% | 50.0% | |
| 22.22% | 9 | 4.0 | 782 | 13,444 | 0.0% | 33.3% | |
| 66.67% | 9 | 4.3 | 882 | 14,962 | 100.0% | 62.5% | |
| 77.78% | 9 | 5.5 | 792 | 15,017 | 100.0% | 71.4% | |
| 25.00% | 8 | 6.4 | 866 | 11,042 | 50.0% | 0.0% | |
| 37.50% | 8 | 4.5 | 780 | 11,842 | 50.0% | 33.3% | |
| 12.50% | 8 | 4.4 | 823 | 11,955 | 25.0% | 0.0% | |
| 71.43% | 7 | 6.4 | 795 | 13,702 | 50.0% | 80.0% | |
| 42.86% | 7 | 4.8 | 522 | 10,756 | 33.3% | 50.0% | |
| 33.33% | 6 | 6.0 | 825 | 14,164 | 0.0% | 40.0% | |
| 50.00% | 6 | 3.2 | 462 | 10,339 | 66.7% | 33.3% | |
| 16.67% | 6 | 5.1 | 933 | 11,156 | 33.3% | 0.0% | |
| 50.00% | 6 | 4.0 | 739 | 8,973 | 50.0% | 50.0% | |
| 50.00% | 6 | 3.1 | 630 | 7,383 | 50.0% | 50.0% | |
| 83.33% | 6 | 5.5 | 718 | 14,890 | 100.0% | 80.0% | |
| 66.67% | 6 | 5.9 | 979 | 16,504 | 0.0% | 66.7% | |
| 16.67% | 6 | 4.7 | 846 | 11,283 | 0.0% | 25.0% | |
| 40.00% | 5 | 0.7 | 512 | 11,183 | 33.3% | 50.0% | |
| 0.00% | 5 | 5.7 | 822 | 10,600 | 0.0% | 0.0% | |
| 60.00% | 5 | 6.9 | 792 | 12,100 | 50.0% | 66.7% | |
| 60.00% | 5 | 4.2 | 988 | 15,386 | 0.0% | 60.0% | |
| 40.00% | 5 | 4.5 | 714 | 9,282 | 66.7% | 0.0% | |
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Vayne vs Kai'Sa - Frequently Asked Questions
How does Vayne do against Kai'Sa in League of Legends?
Vayne wins the Vayne vs Kai'Sa matchup with a 53.1% win rate compared to Kai'Sa's 46.9%, a 6.2 percentage point difference. This data is based on 211 recent ranked games in patch 26.14.
How does Vayne do against Kai'Sa in the early game?
In the early game, Kai'Sa has the advantage against Vayne with a 57.0% win rate versus 43.0%. Kai'Sa players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Vayne do against Kai'Sa in the late game?
In the late game, Vayne takes over the Vayne vs Kai'Sa matchup with a 61.0% win rate compared to 39.0%. Vayne scales better into team fights and objective contests after 25 minutes.
Who wins the Vayne vs Kai'Sa matchup?
Vayne wins the matchup against Kai'Sa with a 53.1% win rate in League of Legends patch 26.14. The 6.2 percentage point advantage means Vayne is significantly favored in this lane matchup based on 211 games analyzed.
What is the best Vayne build against Kai'Sa?
The best Vayne build against Kai'Sa includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Vayne runes against Kai'Sa?
The best Vayne runes against Kai'Sa use the Precision primary tree with Resolve secondary. This rune setup achieves a 58.8% win rate in the Vayne vs Kai'Sa matchup. See the full rune breakdown in the matchup comparison above.
Does Vayne counter Kai'Sa?
Yes, Vayne has a favorable matchup against Kai'Sa with a 53.1% win rate. Vayne strongly counters Kai'Sa in lane based on current patch 26.14 data.
How do I play Vayne against Kai'Sa?
When playing Vayne against Kai'Sa, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Kai'Sa. Build the recommended items and runes for this specific matchup for the best results.