Karthusvs Vayne
Karthus vs Vayne is a decisive matchup in LoL patch 26.7. Vayne wins with a 53.9% win rate (+7.7%) over Karthus based on 13 games. Karthus wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Vayne matchup.
Karthus Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Vayne(46.1%)Who Wins the Karthus vs Vayne Matchup?
Karthus vs Vayne Matchup Summary
The Karthus vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 13 recent matches analyzed, Vayne wins with a 53.9% win rate compared to Karthus's 46.1%, giving Vayne a 7.7 percentage point advantage. Game phase dynamics play a critical role here: Karthus controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Karthus needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Vayne leads by 399 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a strong advantage in this matchup. Karthus players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Vayne overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Karthus vs Vayne Laning Phase Breakdown
Karthus is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Karthus holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.
Best Karthus Build Against Vayne
Sorcerer's Shoes is the optimal boots choice against Vayne, providing the mobility and stats Karthus needs most in this matchup. The top-performing core items for Karthus against Vayne are Shadowflame, Malignance and Rabadon's Deathcap. This combination gives Karthus an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Karthus vs Vayne matchup.
Early Game vs Late Game
Karthus50.0%Vayne50.0%Karthus44.4%Vayne55.6%The early game (first 15 minutes) is a toss-up between Karthus and Vayne, with Karthus holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.
Vayne is far superior in the late game (25+ minutes), boasting a 55.6% win rate — 11.1 points above Karthus. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.
The power dynamics shift as the game progresses — Karthus has the edge early, but Vayne gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.
Best Karthus Runes Against Vayne
Domination
Precision
The Domination and Precision rune setup gives Karthus the best tools to compete against Vayne in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Karthus matchup data for League of Legends patch 26.7. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 48.78% | 41 | 1.5 | 1,246 | 13,634 | 64.7% | 37.5% | |
| 45.00% | 40 | 1.7 | 1,199 | 14,676 | 50.0% | 41.7% | |
| 37.84% | 37 | 1.8 | 1,203 | 13,453 | 42.9% | 34.8% | |
| 59.46% | 37 | 6.8 | 1,204 | 14,133 | 61.1% | 57.9% | |
| 58.33% | 36 | 1.4 | 1,185 | 14,863 | 46.1% | 65.2% | |
| 42.86% | 35 | 1.6 | 1,147 | 13,923 | 40.0% | 45.0% | |
| 44.12% | 34 | 1.4 | 1,122 | 14,486 | 58.3% | 36.4% | |
| 65.63% | 32 | 6.3 | 1,266 | 13,647 | 71.4% | 61.1% | |
| 50.00% | 28 | 1.6 | 1,254 | 15,999 | 71.4% | 42.9% | |
| 44.44% | 27 | 6.1 | 1,219 | 13,946 | 41.7% | 46.7% | |
| 59.26% | 27 | 6.0 | 1,248 | 14,691 | 60.0% | 58.8% | |
| 60.00% | 25 | 1.5 | 1,208 | 14,135 | 45.5% | 71.4% | |
| 63.64% | 22 | 2.0 | 1,412 | 15,520 | 85.7% | 53.3% | |
| 63.64% | 22 | 6.0 | 1,331 | 15,661 | 62.5% | 64.3% | |
| 57.89% | 19 | 1.2 | 1,111 | 13,727 | 37.5% | 72.7% | |
| 36.84% | 19 | 6.5 | 1,280 | 14,545 | 16.7% | 46.1% | |
| 42.11% | 19 | 1.5 | 1,295 | 15,863 | 40.0% | 42.9% | |
| 57.89% | 19 | 1.4 | 1,150 | 14,330 | 71.4% | 50.0% | |
| 47.06% | 17 | 6.4 | 1,294 | 15,528 | 50.0% | 46.1% | |
| 76.47% | 17 | 1.2 | 1,066 | 13,394 | 66.7% | 87.5% | |
| 47.06% | 17 | 1.8 | 1,198 | 14,513 | 50.0% | 46.1% | |
| 75.00% | 16 | 1.4 | 1,298 | 14,714 | 66.7% | 80.0% | |
| 56.25% | 16 | 1.5 | 1,140 | 13,022 | 50.0% | 62.5% | |
| 26.67% | 15 | 1.3 | 1,034 | 12,146 | 27.3% | 25.0% | |
| 33.33% | 15 | 2.1 | 1,142 | 13,213 | 20.0% | 40.0% | |
| 35.71% | 14 | 1.1 | 1,120 | 13,852 | 25.0% | 50.0% | |
| 38.46% | 13 | 1.2 | 1,083 | 13,389 | 16.7% | 57.1% | |
| 38.46% | 13 | 1.4 | 1,186 | 14,427 | 40.0% | 37.5% | |
| 23.08% | 13 | 2.2 | 1,010 | 10,855 | 22.2% | 25.0% | |
| 46.15% | 13 | 6.0 | 1,246 | 13,804 | 50.0% | 44.4% | |
| 53.85% | 13 | 7.1 | 1,164 | 13,192 | 42.9% | 66.7% | |
| 50.00% | 12 | 3.7 | 1,319 | 14,921 | 80.0% | 28.6% | |
| 50.00% | 12 | 1.2 | 1,228 | 14,553 | 25.0% | 62.5% | |
| 25.00% | 12 | 6.5 | 1,364 | 14,041 | 33.3% | 16.7% | |
| 83.33% | 12 | 1.4 | 1,238 | 15,117 | 66.7% | 88.9% | |
| 25.00% | 12 | 1.6 | 1,126 | 15,193 | 25.0% | 25.0% | |
| 66.67% | 12 | 7.3 | 1,539 | 18,810 | 100.0% | 60.0% | |
| 25.00% | 12 | 1.2 | 1,076 | 13,887 | 0.0% | 60.0% | |
| 50.00% | 12 | 1.3 | 1,038 | 11,954 | 50.0% | 50.0% | |
| 63.64% | 11 | 6.8 | 1,405 | 15,260 | 60.0% | 66.7% | |
| 63.64% | 11 | 2.9 | 1,092 | 13,992 | 66.7% | 62.5% | |
| 27.27% | 11 | 1.3 | 1,125 | 12,250 | 20.0% | 33.3% | |
| 18.18% | 11 | 1.5 | 1,183 | 12,730 | 25.0% | 14.3% | |
| 45.45% | 11 | 6.7 | 1,230 | 14,914 | 40.0% | 50.0% | |
| 70.00% | 10 | 5.9 | 1,269 | 12,687 | 60.0% | 80.0% | |
| 60.00% | 10 | 7.0 | 1,168 | 13,689 | 60.0% | 60.0% | |
| 60.00% | 10 | 1.4 | 1,388 | 13,386 | 60.0% | 60.0% | |
| 70.00% | 10 | 7.1 | 1,333 | 14,530 | 75.0% | 66.7% | |
| 33.33% | 9 | 7.3 | 1,212 | 13,578 | 20.0% | 50.0% | |
| 44.44% | 9 | 3.8 | 990 | 13,717 | 100.0% | 28.6% | |
| 22.22% | 9 | 6.8 | 1,088 | 12,891 | 20.0% | 25.0% | |
| 66.67% | 9 | 1.6 | 1,569 | 15,986 | 75.0% | 60.0% | |
| 66.67% | 9 | 1.8 | 1,227 | 14,337 | 80.0% | 50.0% | |
| 33.33% | 9 | 4.8 | 1,072 | 13,644 | 25.0% | 40.0% | |
| 50.00% | 8 | 6.7 | 1,221 | 14,594 | 60.0% | 33.3% | |
| 37.50% | 8 | 1.8 | 1,338 | 16,668 | 100.0% | 28.6% | |
| 42.86% | 7 | 2.1 | 1,106 | 12,567 | 33.3% | 50.0% | |
| 42.86% | 7 | 2.2 | 1,172 | 11,380 | 60.0% | 0.0% | |
| 42.86% | 7 | 2.0 | 1,374 | 13,477 | 50.0% | 33.3% | |
| 42.86% | 7 | 7.2 | 1,125 | 12,970 | 33.3% | 50.0% | |
| 71.43% | 7 | 5.7 | 1,054 | 13,552 | 0.0% | 100.0% | |
| 71.43% | 7 | 1.2 | 1,496 | 15,885 | 0.0% | 83.3% | |
| 14.29% | 7 | 2.9 | 1,232 | 13,716 | 0.0% | 33.3% | |
| 57.14% | 7 | 2.0 | 1,191 | 12,954 | 66.7% | 50.0% | |
| 42.86% | 7 | 2.1 | 1,193 | 15,035 | 50.0% | 40.0% | |
| 85.71% | 7 | 1.6 | 1,346 | 17,646 | 100.0% | 80.0% | |
| 57.14% | 7 | 2.8 | 1,235 | 15,411 | 100.0% | 40.0% | |
| 50.00% | 6 | 6.9 | 1,279 | 12,344 | 25.0% | 100.0% | |
| 66.67% | 6 | 1.3 | 1,384 | 14,201 | 66.7% | 66.7% | |
| 66.67% | 6 | 1.3 | 963 | 11,486 | 100.0% | 50.0% | |
| 33.33% | 6 | 5.4 | 1,552 | 14,532 | 0.0% | 33.3% | |
| 33.33% | 6 | 2.4 | 813 | 11,296 | 50.0% | 0.0% | |
| 66.67% | 6 | 4.0 | 1,151 | 14,663 | 0.0% | 80.0% | |
| 16.67% | 6 | 1.4 | 1,192 | 15,110 | 0.0% | 20.0% | |
| 50.00% | 6 | 1.6 | 1,268 | 17,240 | 0.0% | 60.0% | |
| 60.00% | 5 | 5.9 | 1,191 | 13,249 | 66.7% | 50.0% | |
| 40.00% | 5 | 1.6 | 1,103 | 12,879 | 0.0% | 66.7% | |
| 40.00% | 5 | 6.8 | 1,003 | 11,916 | 0.0% | 50.0% | |
| 60.00% | 5 | 5.1 | 1,477 | 19,353 | 100.0% | 50.0% | |
| 20.00% | 5 | 2.8 | 1,103 | 12,981 | 50.0% | 0.0% | |
| 60.00% | 5 | 3.1 | 728 | 9,383 | 75.0% | 0.0% | |
| 60.00% | 5 | 7.1 | 1,034 | 14,845 | 0.0% | 75.0% | |
| 20.00% | 5 | 8.2 | 1,155 | 13,536 | 50.0% | 0.0% | |
| 60.00% | 5 | 2.3 | 822 | 13,484 | 66.7% | 50.0% | |
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Karthus vs Vayne - Frequently Asked Questions
How does Karthus do against Vayne in League of Legends?
Vayne wins the Karthus vs Vayne matchup with a 53.9% win rate compared to Karthus's 46.1%, a 7.7 percentage point difference. This data is based on 13 recent ranked games in patch 26.7.
How does Karthus do against Vayne in the early game?
In the early game, Karthus has the advantage against Vayne with a 50.0% win rate versus 50.0%. Karthus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Karthus do against Vayne in the late game?
In the late game, Vayne takes over the Karthus vs Vayne matchup with a 55.6% win rate compared to 44.4%. Vayne scales better into team fights and objective contests after 25 minutes.
Who wins the Karthus vs Vayne matchup?
Vayne wins the matchup against Karthus with a 53.9% win rate in League of Legends patch 26.7. The 7.7 percentage point advantage means Vayne is significantly favored in this lane matchup based on 13 games analyzed.
What is the best Karthus build against Vayne?
The best Karthus build against Vayne includes Shadowflame, Malignance, Rabadon's Deathcap with Sorcerer's Shoes. Check the matchup breakdown above for the full item path and build order.
What are the best Karthus runes against Vayne?
The best Karthus runes against Vayne use the Domination primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Karthus vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Karthus counter Vayne?
No, Karthus struggles against Vayne with only a 46.1% win rate. Vayne has the advantage in this matchup. Karthus players should focus on safe farming and avoiding extended trades to minimize Vayne's lead.
How do I play Karthus against Vayne?
When playing Karthus against Vayne, play cautiously and avoid Vayne's power spikes. Look for jungle assistance and team-dependent plays since Vayne has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.