Kha'Zix - League of Legends Champion
Win Rate
49.4%
Pick Rate
1.7%

Kha'Zixvs Karthus

DAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 20, 2026
MethodologyData Methodology

Kha'Zix vs Karthus is a decisive matchup in LoL patch 26.7. Kha'Zix wins with a 64.3% win rate (+28.6%) over Karthus based on 14 games. Kha'Zix holds the advantage in both the early and late game. Below you'll find the best Kha'Zix build, runes, laning stats, and strategies for the Kha'Zix vs Karthus matchup.

Kha'Zix Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Kha'Zix performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 64.3% win rateKarthus(64.3%)
Kha'Zix - 64.3% win rate in this matchup
Kha'Zix
64.3% WR
VS
Karthus vs Kha'Zix matchup - 35.7% win rate
Karthus
35.7% WR

Who Wins the Kha'Zix vs Karthus Matchup?

Kha'Zix wins the Kha'Zix vs Karthus matchup
Winner
Kha'Zix
Matches: 14
64.3%
Win Rate
35.7%
0.9
CS / min
1.1
859
DMG / min
1,120
16,003
Gold / game
13,852
438
Heal / min
300
604
DMG Mitigated / min
469
0.2
CC / min
0.6
75.0%
Early Game WR
25.0%
50.0%
Late Game WR
50.0%

Kha'Zix vs Karthus Matchup Summary

The Kha'Zix vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 14 recent matches analyzed, Kha'Zix wins with a 64.3% win rate compared to Karthus's 35.7%, giving Kha'Zix a 28.6 percentage point advantage. Kha'Zix dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Karthus leads by 0.4s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Kha'Zix players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Kha'Zix vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Kha'Zix in League of Legends

Karthus is favored during the laning phase against Kha'Zix, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and crowd control, making them the stronger laner in this matchup.

Farming
0.9Kha'Zix
1.1Karthus
Kha'Zix and Karthus farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
859Kha'Zix
1,120Karthus
Karthus heavily out-damages Kha'Zix by 261 DMG/min, dominating both short trades and all-in fights. Kha'Zix should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
16,003Kha'Zix
13,852Karthus
Kha'Zix generates a commanding 2,151 more gold per game than Karthus. This substantial economic advantage means Kha'Zix consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Karthus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.2Kha'Zix
0.6Karthus
Karthus provides 0.4 seconds more crowd control per minute than Kha'Zix, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Karthus coordinate with their jungler and control the pace of skirmishes.
Sustain
1,042Kha'Zix
769Karthus
Kha'Zix vastly out-sustains Karthus, healing and mitigating 273 more damage per minute. This massive durability gap means Kha'Zix can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Kha'Zix Build Against Karthus

Ionian Boots of Lucidity is the optimal boots choice against Karthus, providing the mobility and stats Kha'Zix needs most in this matchup. The top-performing core items for Kha'Zix against Karthus are Profane Hydra, Edge of Night and Umbral Glaive. This combination gives Kha'Zix an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Kha'Zix vs Karthus matchup.

Early Game vs Late Game

Early Game
Kha'Zix
75.0%
+50.0% advantage
Kha'Zix early game win rateKha'Zix75.0%
Karthus early game win rateKarthus25.0%
Late Game
Kha'Zix
50.0%
+0.0% advantage
Kha'Zix late game win rateKha'Zix50.0%
Karthus late game win rateKarthus50.0%

Kha'Zix dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Karthus. This lopsided early game means Kha'Zix can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Kha'Zix at 50.0% win rate — only 0.0 points ahead of Karthus. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

Kha'Zix holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Kha'Zix Runes Against Karthus

Domination rune tree - Kha'Zix primary runes vs KarthusDomination
Dark Harvest - best Kha'Zix rune vs KarthusSudden Impact - best Kha'Zix rune vs KarthusGrisly Mementos - best Kha'Zix rune vs KarthusTreasure Hunter - best Kha'Zix rune vs Karthus
Sorcery rune tree - Kha'Zix secondary runes vs KarthusSorcery
Absolute Focus - best Kha'Zix rune vs KarthusGathering Storm - best Kha'Zix rune vs Karthus
100.0% WR

Running Domination primary with Sorcery secondary allows Kha'Zix to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Kha'Zix matchup data for League of Legends patch 26.7. The table below shows Kha'Zix's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Kha'Zix build, runes, laning stats, and early vs late game analysis for that specific matchup.

Kha'Zix matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.75%910.878714,25141.9%62.5%
46.51%860.875114,10845.2%47.7%
52.38%841.075713,82551.4%53.2%
45.00%800.877413,81544.7%45.2%
51.35%740.979314,56952.8%50.0%
46.77%620.983915,28652.6%44.2%
47.27%550.884813,65443.8%52.2%
49.09%550.983214,23046.1%51.7%
42.86%490.781812,56247.8%38.5%
48.89%450.976912,42148.0%50.0%
51.11%450.974913,86560.0%40.0%
53.66%410.886813,95750.0%57.9%
58.54%410.877113,86862.5%56.0%
40.54%370.981915,15729.4%50.0%
41.67%360.985014,52535.7%45.5%
47.22%361.072613,93050.0%45.0%
52.94%340.978715,10450.0%53.9%
58.06%310.885214,00257.1%58.8%
51.72%291.085014,90146.1%56.3%
62.07%290.986515,53471.4%59.1%
65.52%291.091715,38572.7%61.1%
42.86%280.983314,71058.3%31.3%
44.44%270.989613,69127.3%56.3%
59.26%271.074014,41863.6%56.3%
53.85%261.089015,46437.5%61.1%
45.83%240.866612,33850.0%40.0%
39.13%230.984215,77442.9%37.5%
56.52%230.881615,34242.9%62.5%
50.00%221.080614,74770.0%33.3%
42.86%211.082115,32357.1%35.7%
57.14%210.995915,30466.7%50.0%
45.00%200.973212,61440.0%50.0%
21.05%191.083313,2200.0%40.0%
52.63%191.092514,05937.5%63.6%
47.37%191.172113,89950.0%45.5%
27.78%181.075113,53420.0%37.5%
47.06%170.876014,03644.4%50.0%
56.25%161.072414,57842.9%66.7%
31.25%160.857612,01728.6%33.3%
42.86%141.175113,69450.0%33.3%
64.29%140.985916,00375.0%50.0%
46.15%130.871414,19033.3%57.1%
54.55%110.860112,83880.0%33.3%
45.45%111.167612,89725.0%57.1%
63.64%111.295616,510100.0%55.6%
80.00%100.995116,954100.0%71.4%
40.00%101.176212,82925.0%50.0%
55.56%90.868512,60766.7%33.3%
42.86%71.186914,53833.3%50.0%
57.14%71.01,14617,13250.0%60.0%
42.86%70.754212,06333.3%50.0%
42.86%70.882516,35150.0%40.0%
42.86%72.268612,04720.0%100.0%
33.33%60.779816,5740.0%40.0%
33.33%60.991613,04950.0%25.0%
66.67%60.76489,73580.0%0.0%
0.00%50.967314,8820.0%0.0%
40.00%50.651912,31350.0%33.3%
60.00%50.772413,326100.0%0.0%

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Kha'Zix vs Karthus - Frequently Asked Questions

How does Kha'Zix do against Karthus in League of Legends?

Kha'Zix wins the Kha'Zix vs Karthus matchup with a 64.3% win rate compared to Karthus's 35.7%, a 28.6 percentage point difference. This data is based on 14 recent ranked games in patch 26.7.

How does Kha'Zix do against Karthus in the early game?

In the early game, Kha'Zix has the advantage against Karthus with a 75.0% win rate versus 25.0%. Kha'Zix players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Kha'Zix do against Karthus in the late game?

In the late game, Kha'Zix takes over the Kha'Zix vs Karthus matchup with a 50.0% win rate compared to 50.0%. Kha'Zix scales better into team fights and objective contests after 25 minutes.

Who wins the Kha'Zix vs Karthus matchup?

Kha'Zix wins the matchup against Karthus with a 64.3% win rate in League of Legends patch 26.7. The 28.6 percentage point advantage means Kha'Zix is significantly favored in this lane matchup based on 14 games analyzed.

What is the best Kha'Zix build against Karthus?

The best Kha'Zix build against Karthus includes Profane Hydra, Edge of Night, Umbral Glaive with Ionian Boots of Lucidity. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Kha'Zix runes against Karthus?

The best Kha'Zix runes against Karthus use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Kha'Zix vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Kha'Zix counter Karthus?

Yes, Kha'Zix has a favorable matchup against Karthus with a 64.3% win rate. Kha'Zix strongly counters Karthus in lane based on current patch 26.7 data.

How do I play Kha'Zix against Karthus?

When playing Kha'Zix against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.