Kha'Zix - League of Legends Champion
Win Rate
47.9%
Pick Rate
1.8%

Kha'ZixRunes

FAssassin
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 7, 2026
MethodologyData Methodology

Best Kha'Zix runes for LoL Patch 26.11 - First Strike from the Inspiration tree with Domination secondary (72.0% WR, 0.7% pick rate). Kha'Zix's optimal primary runes are First Strike, Magical Footwear, Triple Tonic, Cosmic Insight. Secondary tree: Sudden Impact, Treasure Hunter.

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Kha'Zix performs best with First Strike as the keystone rune from the Inspiration tree. Kha'Zix's optimal primary runes are First Strike, Magical Footwear, Triple Tonic, Cosmic Insight. Kha'Zix's secondary rune tree is Domination with Sudden Impact, Treasure Hunter. This rune setup achieves a 72.00% win rate (+24.1% win rate difference) with a 0.7% pick rate across 25 Kha'Zix games.
72.0%Win Rate
+24.1%WR Diff
0.7%Pick Rate
First StrikeFirst Strike

Attacks or abilities against an enemy champion within 0.25s of entering champion combat grant 10 gold and First Strike for 3 seconds, causing you to deal 7% extra damage against champions, and granting 50% (35% for ranged champions) of bonus damage dealt as gold.

Cooldown: 25 - 15s

Magical FootwearMagical Footwear

You get free Slightly Magical Footwear at 12 min, but you cannot buy boots before then. For each takedown you acquire the boots 45s sooner.

Slightly Magical Footwear grants you an additional 10 Move Speed.

Triple TonicTriple Tonic

Upon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.

Cosmic InsightCosmic Insight

+18 Summoner Spell Haste
+10 Item Haste

Sudden ImpactSudden Impact

Damaging basic attacks and abilities deal a bonus 20 - 80 True Damage based on level to enemy champions after using a dash, leap, blink, teleport, or when leaving stealth for 4s.

Cooldown: 10s

Treasure HunterTreasure Hunter

Gain an additional 50 gold the next time you collect a Bounty Hunter stack. Increase the gold gained by 20 gold for each Bounty Hunter stack, up to 130 gold.

Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

This alternative Kha'Zix rune build uses First Strike as the keystone from the Inspiration tree. The primary runes are First Strike, Cash Back, Triple Tonic, Cosmic Insight. Kha'Zix's secondary rune tree is Domination with Sudden Impact, Relentless Hunter. This setup achieves a 61.11% win rate (+13.2% win rate difference) with a 0.5% pick rate across 18 games.
61.1%Win Rate
+13.2%WR Diff
0.5%Pick Rate
First StrikeFirst Strike

Attacks or abilities against an enemy champion within 0.25s of entering champion combat grant 10 gold and First Strike for 3 seconds, causing you to deal 7% extra damage against champions, and granting 50% (35% for ranged champions) of bonus damage dealt as gold.

Cooldown: 25 - 15s

Cash BackCash Back

Get 7.5% Gold back when you purchase Legendary Items.

Triple TonicTriple Tonic

Upon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.

Cosmic InsightCosmic Insight

+18 Summoner Spell Haste
+10 Item Haste

Sudden ImpactSudden Impact

Damaging basic attacks and abilities deal a bonus 20 - 80 True Damage based on level to enemy champions after using a dash, leap, blink, teleport, or when leaving stealth for 4s.

Cooldown: 10s

Relentless HunterRelentless Hunter

Gain 8 Move Speed out of combat per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

These champions share at least 4 runes with Kha'Zix's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Kha'Zix's playstyle or want to learn champions with familiar rune setups.Rengar, Kassadin, Zed, Xerath, Syndra

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Kha'Zix Runes - Frequently Asked Questions

What are the best Kha'Zix runes in patch 26.11?

The best Kha'Zix runes in patch 26.11 use the Inspiration tree with First Strike, Magical Footwear, Triple Tonic, and Cosmic Insight, and the Domination tree with Sudden Impact and Treasure Hunter. This rune setup achieves a 72.0% win rate with a 0.7% pick rate.

What is the win rate for Kha'Zix's best rune page?

Kha'Zix's best rune page has a 72.0% win rate in patch 26.11, which is +24.1% compared to Kha'Zix's average win rate. This rune setup has a 0.7% pick rate among Kha'Zix players.

What keystone should I use on Kha'Zix?

First Strike from the Inspiration tree is the best keystone rune for Kha'Zix in patch 26.11. This keystone synergizes well with Kha'Zix's kit and provides a 72.0% win rate.

What is Kha'Zix's primary rune tree?

Kha'Zix's primary rune tree is Inspiration. The optimal Inspiration runes for Kha'Zix are First Strike, Magical Footwear, Triple Tonic, and Cosmic Insight, with First Strike being the keystone of choice.

What is Kha'Zix's secondary rune tree?

Kha'Zix's best secondary rune tree is Domination. The recommended Domination runes are Sudden Impact and Treasure Hunter, which complement Kha'Zix's Inspiration primary tree.

What are alternative rune setups for Kha'Zix?

An alternative Kha'Zix rune setup uses First Strike from the Inspiration tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Kha'Zix's runes?

Kha'Zix's top rune page has a 0.7% pick rate in patch 26.11. This indicates that 0.7% of Kha'Zix players use the First Strike setup with Inspiration and Domination trees.