Karthus - League of Legends Champion
Win Rate
52.6%
Pick Rate
0.9%

Karthusvs Kha'Zix

SMage
Patch26.14
Matches491,560
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 23, 2026
MethodologyData Methodology

Karthus vs Kha'Zix is a decisive matchup in LoL patch 26.14. Karthus wins with a 66.7% win rate (+33.3%) over Kha'Zix based on 9 games. Karthus holds the advantage in both the early and late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Kha'Zix matchup.

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Karthus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 66.7% win rate in this matchup
Karthus
66.7% WR
VS
Kha'Zix vs Karthus matchup - 33.3% win rate
Kha'Zix
33.3% WR

Who Wins the Karthus vs Kha'Zix Matchup?

Karthus wins the Karthus vs Kha'Zix matchup
Winner
Karthus
Matches: 9
66.7%
Win Rate
33.3%
1.7
CS / min
0.9
1,147
DMG / min
740
15,247
Gold / game
14,400
296
Heal / min
433
497
DMG Mitigated / min
737
0.5
CC / min
0.2
100.0%
Early Game WR
0.0%
57.1%
Late Game WR
42.9%

Karthus vs Kha'Zix Matchup Summary

The Karthus vs Kha'Zix matchup is a decisive matchup in League of Legends ranked play. Based on 9 recent matches analyzed, Karthus wins with a 66.7% win rate compared to Kha'Zix's 33.3%, giving Karthus a 33.3 percentage point advantage. Karthus dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Kha'Zix players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Karthus leads by 0.2s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Karthus players can confidently pick into Kha'Zix and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Kha'Zix away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Karthus vs Kha'Zix Laning Phase Breakdown

Karthus wins the laning phase against Kha'Zix in League of Legends

Karthus is favored during the laning phase against Kha'Zix, winning 4 out of 5 key stat categories. Karthus holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
1.7Karthus
0.9Kha'Zix
Karthus edges out Kha'Zix by 0.8 CS per minute — a moderate farming advantage that adds up to roughly 12 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Karthus.
Damage
1,147Karthus
740Kha'Zix
Karthus heavily out-damages Kha'Zix by 407 DMG/min, dominating both short trades and all-in fights. Kha'Zix should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
15,247Karthus
14,400Kha'Zix
Karthus generates a commanding 847 more gold per game than Kha'Zix. This substantial economic advantage means Karthus consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Kha'Zix should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.5Karthus
0.2Kha'Zix
Both Karthus and Kha'Zix provide similar amounts of crowd control (0.2s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
793Karthus
1,170Kha'Zix
Kha'Zix vastly out-sustains Karthus, healing and mitigating 377 more damage per minute. This massive durability gap means Kha'Zix can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Karthus Build Against Kha'Zix

Sorcerer's Shoes is the optimal boots choice against Kha'Zix, providing the mobility and stats Karthus needs most in this matchup. The top-performing core items for Karthus against Kha'Zix are Stormsurge, Shadowflame and Rabadon's Deathcap. This combination gives Karthus an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Karthus vs Kha'Zix matchup.

Early Game vs Late Game

Early Game
Karthus
100.0%
+100.0% advantage
Karthus early game win rateKarthus100.0%
Kha'Zix early game win rateKha'Zix0.0%
Late Game
Karthus
57.1%
+14.3% advantage
Karthus late game win rateKarthus57.1%
Kha'Zix late game win rateKha'Zix42.9%

Karthus dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Kha'Zix. This lopsided early game means Karthus can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Karthus is far superior in the late game (25+ minutes), boasting a 57.1% win rate — 14.3 points above Kha'Zix. Extended games heavily favor Karthus, whose kit and scaling make them a dominant force in team fights and objective control.

Karthus holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Kha'Zix players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Karthus Runes Against Kha'Zix

Domination rune tree - Karthus primary runes vs Kha'ZixDomination
Dark Harvest - best Karthus rune vs Kha'ZixCheap Shot - best Karthus rune vs Kha'ZixGrisly Mementos - best Karthus rune vs Kha'ZixUltimate Hunter - best Karthus rune vs Kha'Zix
Sorcery rune tree - Karthus secondary runes vs Kha'ZixSorcery
Axiom Arcanist - best Karthus rune vs Kha'ZixGathering Storm - best Karthus rune vs Kha'Zix
50.0% WR

Running Domination primary with Sorcery secondary allows Karthus to press their advantage against Kha'Zix, amplifying the strengths that make this a favorable matchup.


Karthus matchup data for League of Legends patch 26.14. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Karthus matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
50.00%341.51,21014,46054.5%47.8%
65.38%261.61,21314,12962.5%66.7%
53.85%261.71,10713,35375.0%44.4%
42.86%211.61,27314,86962.5%30.8%
57.14%216.71,27214,85833.3%66.7%
66.67%216.91,36914,65075.0%61.5%
60.00%206.21,54715,16337.5%75.0%
36.84%196.31,22212,59850.0%30.8%
63.16%191.31,18912,55066.7%61.5%
47.37%192.31,29912,04137.5%54.5%
44.44%181.598412,23128.6%54.5%
41.18%171.31,17413,39350.0%36.4%
64.71%171.41,13313,53860.0%66.7%
58.82%176.11,29612,02328.6%80.0%
31.25%161.199810,23422.2%42.9%
37.50%161.21,03611,54922.2%57.1%
56.25%161.41,29115,82233.3%61.5%
53.33%153.81,15513,36371.4%37.5%
57.14%141.51,18916,77080.0%44.4%
71.43%141.11,31714,69160.0%77.8%
38.46%132.11,36416,13750.0%33.3%
69.23%131.71,10914,29450.0%77.8%
38.46%131.61,25013,79266.7%30.0%
38.46%131.91,01213,36340.0%37.5%
50.00%121.61,10111,97450.0%50.0%
50.00%121.31,07513,07060.0%42.9%
33.33%125.81,24213,03514.3%60.0%
45.45%111.31,27013,00666.7%37.5%
36.36%111.21,17313,47040.0%33.3%
45.45%111.41,19814,74550.0%44.4%
72.73%111.71,13312,27275.0%71.4%
50.00%106.11,27114,6470.0%62.5%
50.00%107.01,11913,92733.3%57.1%
50.00%101.21,07211,23725.0%66.7%
60.00%103.81,32616,244100.0%55.6%
40.00%106.41,24514,25550.0%37.5%
66.67%91.71,14715,247100.0%57.1%
77.78%96.61,16214,76466.7%83.3%
37.50%85.91,03911,3920.0%100.0%
87.50%84.11,12512,35175.0%100.0%
57.14%76.81,18913,55850.0%60.0%
28.57%75.78099,61440.0%0.0%
57.14%71.71,40716,43933.3%75.0%
71.43%75.31,42315,6410.0%83.3%
16.67%66.81,0689,34925.0%0.0%
50.00%67.81,51610,97075.0%0.0%
16.67%67.01,14313,26333.3%0.0%
66.67%65.71,15611,1440.0%100.0%
50.00%62.51,11011,40975.0%0.0%
66.67%67.51,51118,2240.0%80.0%
60.00%51.41,36115,8020.0%75.0%
60.00%52.31,12814,9440.0%75.0%
40.00%52.11,18610,48033.3%50.0%
60.00%55.61,04712,658100.0%50.0%
40.00%57.01,62911,36466.7%0.0%
20.00%55.81,75514,34450.0%0.0%
80.00%53.31,36913,229100.0%66.7%
40.00%53.21,67613,06650.0%33.3%
60.00%51.11,23114,7290.0%75.0%
100.00%21.51,21814,599100.0%100.0%
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Karthus vs Kha'Zix - Frequently Asked Questions

How does Karthus do against Kha'Zix in League of Legends?

Karthus wins the Karthus vs Kha'Zix matchup with a 66.7% win rate compared to Kha'Zix's 33.3%, a 33.3 percentage point difference. This data is based on 9 recent ranked games in patch 26.14.

How does Karthus do against Kha'Zix in the early game?

In the early game, Karthus has the advantage against Kha'Zix with a 100.0% win rate versus 0.0%. Karthus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Karthus do against Kha'Zix in the late game?

In the late game, Karthus takes over the Karthus vs Kha'Zix matchup with a 57.1% win rate compared to 42.9%. Karthus scales better into team fights and objective contests after 25 minutes.

Who wins the Karthus vs Kha'Zix matchup?

Karthus wins the matchup against Kha'Zix with a 66.7% win rate in League of Legends patch 26.14. The 33.3 percentage point advantage means Karthus is significantly favored in this lane matchup based on 9 games analyzed.

What is the best Karthus build against Kha'Zix?

The best Karthus build against Kha'Zix includes Stormsurge, Shadowflame, Rabadon's Deathcap with Sorcerer's Shoes. Check the matchup breakdown above for the full item path and build order.

What are the best Karthus runes against Kha'Zix?

The best Karthus runes against Kha'Zix use the Domination primary tree with Sorcery secondary. This rune setup achieves a 50.0% win rate in the Karthus vs Kha'Zix matchup. See the full rune breakdown in the matchup comparison above.

Does Karthus counter Kha'Zix?

Yes, Karthus has a favorable matchup against Kha'Zix with a 66.7% win rate. Karthus strongly counters Kha'Zix in lane based on current patch 26.14 data.

How do I play Karthus against Kha'Zix?

When playing Karthus against Kha'Zix, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.