Karthus - League of Legends Champion
Win Rate
49.3%
Pick Rate
1.3%

Karthusvs Kha'Zix

DMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 22, 2026
MethodologyData Methodology

Karthus vs Kha'Zix is a decisive matchup in LoL patch 26.7. Kha'Zix wins with a 64.3% win rate (+28.6%) over Karthus based on 14 games. Kha'Zix wins the early laning phase while Karthus scales better into the late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Kha'Zix matchup.

Karthus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Kha'Zix - 35.7% win rateKha'Zix(35.7%)
Karthus - 35.7% win rate in this matchup
Karthus
35.7% WR
VS
Kha'Zix vs Karthus matchup - 64.3% win rate
Kha'Zix
64.3% WR

Who Wins the Karthus vs Kha'Zix Matchup?

Kha'Zix wins the Karthus vs Kha'Zix matchup
Winner
Kha'Zix
Matches: 14
35.7%
Win Rate
64.3%
1.1
CS / min
0.9
1,120
DMG / min
859
13,852
Gold / game
16,003
300
Heal / min
438
469
DMG Mitigated / min
604
0.6
CC / min
0.2
25.0%
Early Game WR
75.0%
50.0%
Late Game WR
50.0%

Karthus vs Kha'Zix Matchup Summary

The Karthus vs Kha'Zix matchup is a decisive matchup in League of Legends ranked play. Based on 14 recent matches analyzed, Kha'Zix wins with a 64.3% win rate compared to Karthus's 35.7%, giving Kha'Zix a 28.6 percentage point advantage. Game phase dynamics play a critical role here: Kha'Zix controls the early laning stage, but Karthus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Kha'Zix needs to press advantages before Karthus reaches their power spikes, while Karthus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Karthus leads by 0.4s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Kha'Zix has a strong advantage in this matchup. Karthus players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Kha'Zix overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Karthus vs Kha'Zix Laning Phase Breakdown

Karthus wins the laning phase against Kha'Zix in League of Legends

Karthus is favored during the laning phase against Kha'Zix, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and crowd control, making them the stronger laner in this matchup.

Farming
1.1Karthus
0.9Kha'Zix
Karthus and Kha'Zix farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
1,120Karthus
859Kha'Zix
Karthus heavily out-damages Kha'Zix by 261 DMG/min, dominating both short trades and all-in fights. Kha'Zix should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
13,852Karthus
16,003Kha'Zix
Kha'Zix generates a commanding 2,151 more gold per game than Karthus. This substantial economic advantage means Kha'Zix consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Karthus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.6Karthus
0.2Kha'Zix
Karthus provides 0.4 seconds more crowd control per minute than Kha'Zix, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Karthus coordinate with their jungler and control the pace of skirmishes.
Sustain
769Karthus
1,042Kha'Zix
Kha'Zix vastly out-sustains Karthus, healing and mitigating 273 more damage per minute. This massive durability gap means Kha'Zix can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Karthus Build Against Kha'Zix

Sorcerer's Shoes is the optimal boots choice against Kha'Zix, providing the mobility and stats Karthus needs most in this matchup. The top-performing core items for Karthus against Kha'Zix are Liandry's Torment, Rabadon's Deathcap and Blackfire Torch. This combination gives Karthus an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Kha'Zix. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Karthus vs Kha'Zix matchup.

Early Game vs Late Game

Early Game
Kha'Zix
75.0%
+50.0% advantage
Karthus early game win rateKarthus25.0%
Kha'Zix early game win rateKha'Zix75.0%
Late Game
Karthus
50.0%
+0.0% advantage
Karthus late game win rateKarthus50.0%
Kha'Zix late game win rateKha'Zix50.0%

Kha'Zix dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Karthus. This lopsided early game means Kha'Zix can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Karthus at 50.0% win rate — only 0.0 points ahead of Kha'Zix. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Kha'Zix has the edge early, but Karthus gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Karthus Runes Against Kha'Zix

Domination rune tree - Karthus primary runes vs Kha'ZixDomination
Dark Harvest - best Karthus rune vs Kha'ZixCheap Shot - best Karthus rune vs Kha'ZixSixth Sense - best Karthus rune vs Kha'ZixTreasure Hunter - best Karthus rune vs Kha'Zix
Precision rune tree - Karthus secondary runes vs Kha'ZixPrecision
Triumph - best Karthus rune vs Kha'ZixLast Stand - best Karthus rune vs Kha'Zix
100.0% WR

The Domination and Precision rune setup gives Karthus the best tools to compete against Kha'Zix in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Karthus matchup data for League of Legends patch 26.7. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Karthus matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
48.78%411.51,24613,63464.7%37.5%
45.00%401.71,19914,67650.0%41.7%
37.84%371.81,20313,45342.9%34.8%
59.46%376.81,20414,13361.1%57.9%
58.33%361.41,18514,86346.1%65.2%
42.86%351.61,14713,92340.0%45.0%
44.12%341.41,12214,48658.3%36.4%
65.63%326.31,26613,64771.4%61.1%
50.00%281.61,25415,99971.4%42.9%
44.44%276.11,21913,94641.7%46.7%
59.26%276.01,24814,69160.0%58.8%
60.00%251.51,20814,13545.5%71.4%
63.64%222.01,41215,52085.7%53.3%
63.64%226.01,33115,66162.5%64.3%
57.89%191.21,11113,72737.5%72.7%
36.84%196.51,28014,54516.7%46.1%
42.11%191.51,29515,86340.0%42.9%
57.89%191.41,15014,33071.4%50.0%
47.06%176.41,29415,52850.0%46.1%
76.47%171.21,06613,39466.7%87.5%
47.06%171.81,19814,51350.0%46.1%
75.00%161.41,29814,71466.7%80.0%
56.25%161.51,14013,02250.0%62.5%
26.67%151.31,03412,14627.3%25.0%
33.33%152.11,14213,21320.0%40.0%
35.71%141.11,12013,85225.0%50.0%
38.46%131.21,08313,38916.7%57.1%
38.46%131.41,18614,42740.0%37.5%
23.08%132.21,01010,85522.2%25.0%
46.15%136.01,24613,80450.0%44.4%
53.85%137.11,16413,19242.9%66.7%
50.00%123.71,31914,92180.0%28.6%
50.00%121.21,22814,55325.0%62.5%
25.00%126.51,36414,04133.3%16.7%
83.33%121.41,23815,11766.7%88.9%
25.00%121.61,12615,19325.0%25.0%
66.67%127.31,53918,810100.0%60.0%
25.00%121.21,07613,8870.0%60.0%
50.00%121.31,03811,95450.0%50.0%
63.64%116.81,40515,26060.0%66.7%
63.64%112.91,09213,99266.7%62.5%
27.27%111.31,12512,25020.0%33.3%
18.18%111.51,18312,73025.0%14.3%
45.45%116.71,23014,91440.0%50.0%
70.00%105.91,26912,68760.0%80.0%
60.00%107.01,16813,68960.0%60.0%
60.00%101.41,38813,38660.0%60.0%
70.00%107.11,33314,53075.0%66.7%
33.33%97.31,21213,57820.0%50.0%
44.44%93.899013,717100.0%28.6%
22.22%96.81,08812,89120.0%25.0%
66.67%91.61,56915,98675.0%60.0%
66.67%91.81,22714,33780.0%50.0%
33.33%94.81,07213,64425.0%40.0%
50.00%86.71,22114,59460.0%33.3%
37.50%81.81,33816,668100.0%28.6%
42.86%72.11,10612,56733.3%50.0%
42.86%72.21,17211,38060.0%0.0%
42.86%72.01,37413,47750.0%33.3%
42.86%77.21,12512,97033.3%50.0%
71.43%75.71,05413,5520.0%100.0%
71.43%71.21,49615,8850.0%83.3%
14.29%72.91,23213,7160.0%33.3%
57.14%72.01,19112,95466.7%50.0%
42.86%72.11,19315,03550.0%40.0%
85.71%71.61,34617,646100.0%80.0%
57.14%72.81,23515,411100.0%40.0%
50.00%66.91,27912,34425.0%100.0%
66.67%61.31,38414,20166.7%66.7%
66.67%61.396311,486100.0%50.0%
33.33%65.41,55214,5320.0%33.3%
33.33%62.481311,29650.0%0.0%
66.67%64.01,15114,6630.0%80.0%
16.67%61.41,19215,1100.0%20.0%
50.00%61.61,26817,2400.0%60.0%
60.00%55.91,19113,24966.7%50.0%
40.00%51.61,10312,8790.0%66.7%
40.00%56.81,00311,9160.0%50.0%
60.00%55.11,47719,353100.0%50.0%
20.00%52.81,10312,98150.0%0.0%
60.00%53.17289,38375.0%0.0%
60.00%57.11,03414,8450.0%75.0%
20.00%58.21,15513,53650.0%0.0%
60.00%52.382213,48466.7%50.0%

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Karthus vs Kha'Zix - Frequently Asked Questions

How does Karthus do against Kha'Zix in League of Legends?

Kha'Zix wins the Karthus vs Kha'Zix matchup with a 64.3% win rate compared to Karthus's 35.7%, a 28.6 percentage point difference. This data is based on 14 recent ranked games in patch 26.7.

How does Karthus do against Kha'Zix in the early game?

In the early game, Kha'Zix has the advantage against Karthus with a 75.0% win rate versus 25.0%. Kha'Zix players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Karthus do against Kha'Zix in the late game?

In the late game, Karthus takes over the Karthus vs Kha'Zix matchup with a 50.0% win rate compared to 50.0%. Karthus scales better into team fights and objective contests after 25 minutes.

Who wins the Karthus vs Kha'Zix matchup?

Kha'Zix wins the matchup against Karthus with a 64.3% win rate in League of Legends patch 26.7. The 28.6 percentage point advantage means Kha'Zix is significantly favored in this lane matchup based on 14 games analyzed.

What is the best Karthus build against Kha'Zix?

The best Karthus build against Kha'Zix includes Liandry's Torment, Rabadon's Deathcap, Blackfire Torch with Sorcerer's Shoes. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Karthus runes against Kha'Zix?

The best Karthus runes against Kha'Zix use the Domination primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Karthus vs Kha'Zix matchup. See the full rune breakdown in the matchup comparison above.

Does Karthus counter Kha'Zix?

No, Karthus struggles against Kha'Zix with only a 35.7% win rate. Kha'Zix has the advantage in this matchup. Karthus players should focus on safe farming and avoiding extended trades to minimize Kha'Zix's lead.

How do I play Karthus against Kha'Zix?

When playing Karthus against Kha'Zix, play cautiously and avoid Kha'Zix's power spikes. Focus on safe farming — you outscale Kha'Zix in the late game. Use the matchup-specific build and runes above to optimize your chances.