Lissandra - League of Legends Champion
Win Rate
50.5%
Pick Rate
1.8%

Lissandravs Syndra

BMage
Patch26.10
Matches3,013,751
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 30, 2026
MethodologyData Methodology

Lissandra vs Syndra is a decisive matchup in LoL patch 26.10. Syndra wins with a 53.9% win rate (+7.7%) over Lissandra based on 52 games. Syndra holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Syndra matchup.

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Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 46.1% win rate in this matchup
Lissandra
46.1% WR
VS
Syndra vs Lissandra matchup - 53.9% win rate
Syndra
53.9% WR

Who Wins the Lissandra vs Syndra Matchup?

Syndra wins the Lissandra vs Syndra matchup
Winner
Syndra
Matches: 52
46.1%
Win Rate
53.9%
6.8
CS / min
7.1
711
DMG / min
1,025
11,155
Gold / game
12,724
155
Heal / min
76
442
DMG Mitigated / min
343
1.4
CC / min
1.5
47.8%
Early Game WR
52.2%
44.8%
Late Game WR
55.2%

Lissandra vs Syndra Matchup Summary

The Lissandra vs Syndra matchup is a decisive matchup in League of Legends ranked play. Based on 52 recent matches analyzed, Syndra wins with a 53.9% win rate compared to Lissandra's 46.1%, giving Syndra a 7.7 percentage point advantage. Syndra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in damage output, where Syndra leads by 315 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Syndra has a strong advantage in this matchup. Lissandra players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Syndra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Syndra Laning Phase Breakdown

Syndra wins the laning phase against Lissandra in League of Legends

Syndra is favored during the laning phase against Lissandra, winning 4 out of 5 key stat categories. Syndra holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
6.8Lissandra
7.1Syndra
Syndra edges out Lissandra by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Syndra.
Damage
711Lissandra
1,025Syndra
Syndra heavily out-damages Lissandra by 315 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Syndra's sustained damage advantage take over.
Economy
11,155Lissandra
12,724Syndra
Syndra generates a commanding 1,569 more gold per game than Lissandra. This substantial economic advantage means Syndra consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Lissandra should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.4Lissandra
1.5Syndra
Both Lissandra and Syndra provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
598Lissandra
420Syndra
Lissandra vastly out-sustains Syndra, healing and mitigating 178 more damage per minute. This massive durability gap means Lissandra can absorb significant punishment and remain in lane while Syndra is forced to recall. Building grievous wounds early is essential for Syndra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Lissandra Build Against Syndra

Spellslinger's Shoes is the optimal boots choice against Syndra, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Syndra are Luden's Echo, Shadowflame and Zhonya's Hourglass. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 75.0% win rate across 4 games — well above average and making it the top item path against Syndra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Syndra matchup.

Early Game vs Late Game

Early Game
Syndra
52.2%
+4.3% advantage
Lissandra early game win rateLissandra47.8%
Syndra early game win rateSyndra52.2%
Late Game
Syndra
55.2%
+10.3% advantage
Lissandra late game win rateLissandra44.8%
Syndra late game win rateSyndra55.2%

During the early laning phase (first 15 minutes), Syndra has a meaningful 52.2% win rate, outperforming Lissandra by 4.3 percentage points. Syndra players should look to press this advantage through aggressive trades, wave priority, and early jungle coordination.

Syndra is far superior in the late game (25+ minutes), boasting a 55.2% win rate — 10.3 points above Lissandra. Extended games heavily favor Syndra, whose kit and scaling make them a dominant force in team fights and objective control.

Syndra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Lissandra Runes Against Syndra

Sorcery rune tree - Lissandra primary runes vs SyndraSorcery
Arcane Comet - best Lissandra rune vs SyndraManaflow Band - best Lissandra rune vs SyndraTranscendence - best Lissandra rune vs SyndraScorch - best Lissandra rune vs Syndra
Domination rune tree - Lissandra secondary runes vs SyndraDomination
Cheap Shot - best Lissandra rune vs SyndraUltimate Hunter - best Lissandra rune vs Syndra
100.0% WR

The Sorcery and Domination rune setup gives Lissandra the best tools to compete against Syndra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Lissandra matchup data for League of Legends patch 26.10. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.16%2326.885412,28555.5%49.6%
46.07%1786.791112,31138.9%50.9%
53.46%1596.879011,46955.3%51.8%
54.09%1596.884711,93456.3%52.6%
46.75%1546.979611,85949.2%44.9%
58.62%1456.587711,25856.5%60.5%
57.03%1286.989211,59263.1%50.8%
44.44%1086.686611,74135.4%51.7%
54.72%1066.884111,65057.1%52.6%
48.57%1056.876211,44351.1%46.5%
37.50%966.669210,74345.5%30.8%
50.00%925.973111,54850.0%50.0%
65.85%826.588511,61862.9%68.1%
47.56%826.391512,16245.7%48.9%
51.47%686.997211,35856.3%47.2%
43.75%646.677110,29351.5%35.5%
40.63%646.376711,40733.3%46.0%
49.18%616.573710,48446.7%51.6%
39.34%616.779311,92419.1%50.0%
62.71%596.992611,94168.2%59.5%
28.57%566.673011,13734.5%22.2%
47.27%557.083811,51150.0%44.8%
53.85%526.073710,64562.5%46.4%
46.15%526.871111,15547.8%44.8%
46.15%526.377911,13736.8%51.5%
51.11%456.169210,96829.4%64.3%
47.73%446.593910,51246.4%50.0%
53.49%436.887212,26041.2%61.5%
45.24%426.582811,81541.2%48.0%
47.62%426.485011,35442.9%52.4%
57.14%426.879111,77758.3%55.6%
51.22%416.879411,56650.0%52.4%
52.50%406.687312,43947.1%56.5%
52.50%406.691711,68262.5%45.8%
47.37%386.788811,10152.9%42.9%
51.52%336.478812,52555.6%50.0%
36.67%306.995312,86453.9%23.5%
40.00%256.488512,33860.0%26.7%
37.50%245.983611,91337.5%37.5%
50.00%245.379110,92660.0%42.9%
37.50%247.486011,16446.1%27.3%
39.13%237.483611,97941.7%36.4%
31.82%226.996011,81433.3%30.8%
40.91%226.991712,34041.7%40.0%
59.09%227.491511,55050.0%75.0%
52.38%216.386610,83858.3%44.4%
65.00%205.784512,16862.5%66.7%
55.00%207.087113,31950.0%57.1%
78.95%197.397414,556100.0%71.4%
50.00%185.874610,64350.0%50.0%
72.22%187.177912,73485.7%63.6%
44.44%186.791210,27940.0%50.0%
42.86%146.965810,94133.3%50.0%
64.29%147.085410,56050.0%83.3%
50.00%126.889810,59166.7%33.3%
75.00%126.788011,79180.0%71.4%
30.00%102.25439,550100.0%12.5%
40.00%103.352410,20366.7%28.6%
55.56%96.61,05610,22742.9%100.0%
66.67%93.871910,978100.0%57.1%
66.67%96.069211,35966.7%66.7%
66.67%94.27157,02275.0%0.0%
44.44%94.071210,37125.0%60.0%
33.33%96.57559,67850.0%20.0%
37.50%86.378411,75150.0%25.0%
62.50%87.287514,869100.0%57.1%
50.00%86.575512,17350.0%50.0%
75.00%83.76429,76860.0%100.0%
50.00%86.878212,26150.0%50.0%
42.86%76.28568,50840.0%50.0%
57.14%77.389910,93033.3%75.0%
42.86%76.88829,65875.0%0.0%
57.14%73.162911,52033.3%75.0%
57.14%71.55377,71075.0%33.3%
57.14%76.48009,61733.3%75.0%
71.43%76.71,03213,175100.0%60.0%
42.86%76.298712,32250.0%33.3%
85.71%76.799014,608100.0%83.3%
28.57%76.778414,28050.0%20.0%
42.86%75.873710,37220.0%100.0%
66.67%66.498713,59950.0%75.0%
66.67%66.599014,0020.0%80.0%
83.33%64.674411,181100.0%75.0%
33.33%63.775912,4310.0%33.3%
33.33%62.753510,59150.0%25.0%
100.00%57.582810,158100.0%0.0%
40.00%53.066811,17050.0%33.3%
60.00%52.560710,07266.7%50.0%
100.00%55.51,07115,048100.0%100.0%
20.00%56.473011,3550.0%33.3%
20.00%52.369211,547100.0%0.0%
40.00%55.795411,09766.7%0.0%
60.00%57.278211,57966.7%50.0%
40.00%52.75677,42950.0%0.0%
60.00%57.31,04710,8040.0%75.0%
20.00%52.160610,24650.0%0.0%
80.00%53.35659,650100.0%50.0%
80.00%54.870312,980100.0%75.0%

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Lissandra vs Syndra - Frequently Asked Questions

How does Lissandra do against Syndra in League of Legends?

Syndra wins the Lissandra vs Syndra matchup with a 53.9% win rate compared to Lissandra's 46.1%, a 7.7 percentage point difference. This data is based on 52 recent ranked games in patch 26.10.

How does Lissandra do against Syndra in the early game?

In the early game, Syndra has the advantage against Lissandra with a 52.2% win rate versus 47.8%. Syndra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Syndra in the late game?

In the late game, Syndra takes over the Lissandra vs Syndra matchup with a 55.2% win rate compared to 44.8%. Syndra scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Syndra matchup?

Syndra wins the matchup against Lissandra with a 53.9% win rate in League of Legends patch 26.10. The 7.7 percentage point advantage means Syndra is significantly favored in this lane matchup based on 52 games analyzed.

What is the best Lissandra build against Syndra?

The best Lissandra build against Syndra includes Luden's Echo, Shadowflame, Zhonya's Hourglass with Spellslinger's Shoes. This build achieves a 75.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Syndra?

The best Lissandra runes against Syndra use the Sorcery primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Syndra matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Syndra?

No, Lissandra struggles against Syndra with only a 46.1% win rate. Syndra has the advantage in this matchup. Lissandra players should focus on safe farming and avoiding extended trades to minimize Syndra's lead.

How do I play Lissandra against Syndra?

When playing Lissandra against Syndra, play cautiously and avoid Syndra's power spikes. Look for jungle assistance and team-dependent plays since Syndra has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.