Nautilus - League of Legends Champion
Win Rate
47.9%
Pick Rate
4.7%

Nautilusvs Karthus

FTankSupport
Patch26.10
Matches1,492,117
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 19, 2026
MethodologyData Methodology

Nautilus vs Karthus is a decisive matchup in LoL patch 26.10. Nautilus wins with a 80.0% win rate (+60.0%) over Karthus based on 5 games. Karthus wins the early laning phase while Nautilus scales better into the late game. Below you'll find the best Nautilus build, runes, laning stats, and strategies for the Nautilus vs Karthus matchup.

Nautilus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Nautilus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 80.0% win rateKarthus(80.0%)
Nautilus - 80.0% win rate in this matchup
Nautilus
80.0% WR
VS
Karthus vs Nautilus matchup - 20.0% win rate
Karthus
20.0% WR

Who Wins the Nautilus vs Karthus Matchup?

Nautilus wins the Nautilus vs Karthus matchup
Winner
Nautilus
Matches: 5
80.0%
Win Rate
20.0%
1.3
CS / min
2.3
529
DMG / min
1,122
12,208
Gold / game
13,874
186
Heal / min
136
1,983
DMG Mitigated / min
469
2.4
CC / min
0.8
0.0%
Early Game WR
100.0%
100.0%
Late Game WR
0.0%

Nautilus vs Karthus Matchup Summary

The Nautilus vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Nautilus wins with a 80.0% win rate compared to Karthus's 20.0%, giving Nautilus a 60.0 percentage point advantage. Game phase dynamics play a critical role here: Karthus controls the early laning stage, but Nautilus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Karthus needs to press advantages before Nautilus reaches their power spikes, while Nautilus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Nautilus leads by 1,564 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Nautilus players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Nautilus vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Nautilus in League of Legends

Karthus is favored during the laning phase against Nautilus, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
1.3Nautilus
2.3Karthus
Karthus significantly out-farms Nautilus by 1.1 CS per minute, accumulating an estimated 16 CS lead by mid game. This substantial farming gap gives Karthus a major gold advantage and earlier item completions. Nautilus players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
529Nautilus
1,122Karthus
Karthus heavily out-damages Nautilus by 593 DMG/min, dominating both short trades and all-in fights. Nautilus should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
12,208Nautilus
13,874Karthus
Karthus generates a commanding 1,666 more gold per game than Nautilus. This substantial economic advantage means Karthus consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Nautilus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
2.4Nautilus
0.8Karthus
Nautilus brings significantly more crowd control than Karthus, with 1.6 more seconds of CC per minute. This large utility gap makes Nautilus far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Karthus should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
2,168Nautilus
604Karthus
Nautilus vastly out-sustains Karthus, healing and mitigating 1,564 more damage per minute. This massive durability gap means Nautilus can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Nautilus Build Against Karthus

Plated Steelcaps is the optimal boots choice against Karthus, providing the mobility and stats Nautilus needs most in this matchup. The top-performing core items for Nautilus against Karthus are Frozen Heart, Thornmail and Sunfire Aegis. This combination gives Nautilus an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Nautilus vs Karthus matchup.

Early Game vs Late Game

Early Game
Karthus
100.0%
+100.0% advantage
Nautilus early game win rateNautilus0.0%
Karthus early game win rateKarthus100.0%
Late Game
Nautilus
100.0%
+100.0% advantage
Nautilus late game win rateNautilus100.0%
Karthus late game win rateKarthus0.0%

Karthus dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Nautilus. This lopsided early game means Karthus can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Nautilus is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Karthus. Extended games heavily favor Nautilus, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Karthus must aggressively press their early advantage and close out the game before Nautilus reaches their scaling breakpoints. If Nautilus survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Nautilus Runes Against Karthus

Resolve rune tree - Nautilus primary runes vs KarthusResolve
Aftershock - best Nautilus rune vs KarthusShield Bash - best Nautilus rune vs KarthusBone Plating - best Nautilus rune vs KarthusUnflinching - best Nautilus rune vs Karthus
Inspiration rune tree - Nautilus secondary runes vs KarthusInspiration
Biscuit Delivery - best Nautilus rune vs KarthusCosmic Insight - best Nautilus rune vs Karthus
100.0% WR

Running Resolve primary with Inspiration secondary allows Nautilus to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Nautilus matchup data for League of Legends patch 26.10. The table below shows Nautilus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Nautilus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Nautilus matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
40.96%5811.13548,24637.8%44.0%
47.57%5341.13558,40545.9%49.1%
49.26%4731.13539,02547.6%50.4%
47.21%4301.13698,61247.2%47.2%
47.49%4191.13828,47148.6%46.4%
48.14%4031.13788,69144.1%51.6%
47.75%3771.13478,67343.2%51.4%
52.05%2921.14089,29047.9%55.0%
47.10%2761.13789,08445.7%48.0%
45.83%2641.13638,32047.1%44.5%
50.43%2321.13878,85350.5%50.4%
44.95%2181.13308,29442.7%47.0%
50.24%2071.13828,62550.0%50.4%
52.71%2031.03608,57050.5%54.7%
60.61%1991.13278,55161.5%59.6%
44.16%1971.14278,76542.9%45.1%
52.08%1921.14348,55150.0%54.1%
53.13%1921.13498,63451.5%54.8%
51.83%1911.13608,56054.4%49.5%
51.93%1811.03578,84038.2%61.9%
53.33%1651.13579,01950.0%55.3%
52.17%1611.14168,88346.0%57.6%
49.07%1611.13648,64055.9%44.1%
51.80%1391.13998,82451.6%52.0%
50.37%1351.14158,86842.6%56.8%
56.72%1341.23928,90652.6%59.7%
52.59%1161.13809,07453.6%51.7%
44.74%1141.13388,01144.1%45.5%
39.81%1081.13618,43141.7%38.3%
45.45%991.04028,76840.5%49.1%
49.45%911.14008,39843.2%55.3%
50.63%791.03698,32847.5%53.9%
48.00%751.14319,57144.4%50.0%
50.00%741.13898,94443.8%54.8%
40.91%661.13738,54133.3%47.2%
37.70%611.44118,89742.9%33.3%
49.12%571.13758,59443.3%55.6%
57.69%521.24069,17069.6%48.3%
46.67%451.43928,45539.1%54.5%
47.62%421.74529,16956.3%42.3%
46.34%411.23997,81045.5%47.4%
54.55%331.24568,86850.0%60.0%
21.88%321.33468,61035.3%6.7%
55.56%271.64498,78446.7%66.7%
48.00%251.54339,24844.4%50.0%
68.00%251.03758,78372.7%64.3%
64.00%251.14209,49854.5%71.4%
41.67%241.74009,90742.9%41.2%
68.18%221.23749,09680.0%58.3%
57.14%210.83368,79663.6%50.0%
60.00%202.35309,77085.7%46.1%
45.00%201.33629,13057.1%38.5%
47.37%191.13708,72360.0%33.3%
42.11%192.34358,75745.5%37.5%
57.89%191.03798,92050.0%63.6%
72.22%181.95079,91957.1%81.8%
35.29%171.23818,79227.3%50.0%
37.50%161.04469,99516.7%50.0%
40.00%151.25299,45050.0%33.3%
50.00%141.65379,41771.4%28.6%
42.86%141.33427,88533.3%50.0%
50.00%141.04338,77142.9%57.1%
71.43%141.743810,77060.0%77.8%
50.00%141.356810,23042.9%57.1%
30.77%134.25738,91428.6%33.3%
46.15%133.75179,13833.3%57.1%
58.33%120.94179,97050.0%62.5%
91.67%120.853812,37275.0%100.0%
66.67%121.856610,72960.0%71.4%
41.67%121.056511,602100.0%12.5%
50.00%121.05239,54042.9%60.0%
36.36%112.16129,16933.3%40.0%
45.45%111.55489,69560.0%33.3%
63.64%112.359710,74150.0%71.4%
45.45%111.03968,18325.0%57.1%
50.00%101.03458,28450.0%50.0%
50.00%101.74838,97950.0%50.0%
70.00%104.984810,23166.7%75.0%
40.00%101.648010,40050.0%33.3%
50.00%102.75509,26250.0%50.0%
44.44%92.34829,23760.0%25.0%
55.56%94.05808,99380.0%25.0%
77.78%91.14248,96575.0%80.0%
44.44%92.74457,99233.3%66.7%
55.56%91.750310,61525.0%80.0%
12.50%81.35148,97225.0%0.0%
62.50%81.73999,71466.7%60.0%
25.00%82.36138,15825.0%25.0%
42.86%72.373412,82650.0%40.0%
71.43%71.646811,194100.0%66.7%
57.14%71.554712,013100.0%50.0%
71.43%72.345510,547100.0%66.7%
57.14%72.062610,0280.0%80.0%
42.86%73.65539,70475.0%0.0%
42.86%71.064212,80850.0%40.0%
28.57%76.381310,6610.0%50.0%
57.14%71.13808,88950.0%66.7%
100.00%64.45538,987100.0%100.0%
100.00%61.64379,252100.0%100.0%
33.33%66.178012,7940.0%40.0%
50.00%64.559110,97250.0%50.0%
66.67%61.03585,72166.7%0.0%
50.00%61.665210,70250.0%50.0%
50.00%61.26589,97666.7%33.3%
33.33%60.95379,50425.0%50.0%
16.67%60.93258,889100.0%0.0%
20.00%51.162711,17050.0%0.0%
40.00%54.468613,3150.0%40.0%
20.00%51.35239,4180.0%25.0%
80.00%50.65349,61075.0%100.0%
40.00%50.947710,15350.0%33.3%
100.00%51.04087,721100.0%100.0%
40.00%54.759310,3920.0%66.7%
40.00%51.13216,87625.0%100.0%
60.00%52.53768,79550.0%66.7%
60.00%53.069412,46550.0%66.7%
60.00%52.75709,74066.7%50.0%
60.00%53.747310,02250.0%66.7%
80.00%51.352912,2080.0%100.0%
40.00%50.93846,50733.3%50.0%

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Nautilus vs Karthus - Frequently Asked Questions

How does Nautilus do against Karthus in League of Legends?

Nautilus wins the Nautilus vs Karthus matchup with a 80.0% win rate compared to Karthus's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.

How does Nautilus do against Karthus in the early game?

In the early game, Karthus has the advantage against Nautilus with a 100.0% win rate versus 0.0%. Karthus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Nautilus do against Karthus in the late game?

In the late game, Nautilus takes over the Nautilus vs Karthus matchup with a 100.0% win rate compared to 0.0%. Nautilus scales better into team fights and objective contests after 25 minutes.

Who wins the Nautilus vs Karthus matchup?

Nautilus wins the matchup against Karthus with a 80.0% win rate in League of Legends patch 26.10. The 60.0 percentage point advantage means Nautilus is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Nautilus build against Karthus?

The best Nautilus build against Karthus includes Frozen Heart, Thornmail, Sunfire Aegis with Plated Steelcaps. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Nautilus runes against Karthus?

The best Nautilus runes against Karthus use the Resolve primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Nautilus vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Nautilus counter Karthus?

Yes, Nautilus has a favorable matchup against Karthus with a 80.0% win rate. Nautilus strongly counters Karthus in lane based on current patch 26.10 data.

How do I play Nautilus against Karthus?

When playing Nautilus against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Karthus. Build the recommended items and runes for this specific matchup for the best results.