Samira - League of Legends Champion
Win Rate
49.6%
Pick Rate
2.8%

Samiravs Vayne

CMarksmanAssassin
Patch26.13
Matches265,623
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 14, 2026
MethodologyData Methodology

Samira vs Vayne is a decisive matchup in LoL patch 26.13. Vayne wins with a 53.6% win rate (+7.1%) over Samira based on 56 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Samira build, runes, laning stats, and strategies for the Samira vs Vayne matchup.

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Samira Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Samira performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Samira - 46.4% win rate in this matchup
Samira
46.4% WR
VS
Vayne vs Samira matchup - 53.6% win rate
Vayne
53.6% WR

Who Wins the Samira vs Vayne Matchup?

Vayne wins the Samira vs Vayne matchup
Winner
Vayne
Matches: 56
46.4%
Win Rate
53.6%
6.5
CS / min
6.0
932
DMG / min
834
14,142
Gold / game
12,857
301
Heal / min
210
574
DMG Mitigated / min
479
0.1
CC / min
0.4
46.1%
Early Game WR
53.9%
46.7%
Late Game WR
53.3%

Samira vs Vayne Matchup Summary

The Samira vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 56 recent matches analyzed, Vayne wins with a 53.6% win rate compared to Samira's 46.4%, giving Vayne a 7.1 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Samira players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Vayne leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a strong advantage in this matchup. Samira players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Vayne overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Samira vs Vayne Laning Phase Breakdown

Samira wins the laning phase against Vayne in League of Legends

Samira is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Samira holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
6.5Samira
6.0Vayne
Samira edges out Vayne by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 8 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Samira.
Damage
932Samira
834Vayne
Samira heavily out-damages Vayne by 99 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Samira's sustained damage advantage take over.
Economy
14,142Samira
12,857Vayne
Samira generates a commanding 1,285 more gold per game than Vayne. This substantial economic advantage means Samira consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.1Samira
0.4Vayne
Both Samira and Vayne provide similar amounts of crowd control (0.3s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
875Samira
689Vayne
Samira vastly out-sustains Vayne, healing and mitigating 185 more damage per minute. This massive durability gap means Samira can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Early Game vs Late Game

Early Game
Vayne
53.9%
+7.7% advantage
Samira early game win rateSamira46.1%
Vayne early game win rateVayne53.9%
Late Game
Vayne
53.3%
+6.7% advantage
Samira late game win rateSamira46.7%
Vayne late game win rateVayne53.3%

Vayne dominates the early game (first 15 minutes) with a commanding 53.9% win rate — a 7.7 percentage point lead over Samira. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 53.3% win rate — 6.7 points above Samira. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Samira players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Samira Runes Against Vayne

Precision rune tree - Samira primary runes vs VaynePrecision
Conqueror - best Samira rune vs VayneTriumph - best Samira rune vs VayneLegend: Bloodline - best Samira rune vs VayneLast Stand - best Samira rune vs Vayne
Domination rune tree - Samira secondary runes vs VayneDomination
Taste of Blood - best Samira rune vs VayneTreasure Hunter - best Samira rune vs Vayne
69.6% WR

The Precision and Domination rune setup gives Samira the best tools to compete against Vayne in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Samira matchup data for League of Legends patch 26.13. The table below shows Samira's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Samira build, runes, laning stats, and early vs late game analysis for that specific matchup.

Samira matchup win rates and stats in League of Legends patch 26.13
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
44.03%1346.585412,99842.6%45.5%
51.56%1286.090814,10645.2%57.6%
53.97%1266.393814,69849.1%57.8%
38.94%1136.379212,23643.1%34.5%
52.44%826.384613,06560.0%43.2%
48.57%706.692613,27850.0%46.4%
53.73%676.683612,97865.8%37.9%
62.69%676.590413,92861.3%63.9%
45.00%606.387913,00641.9%48.3%
46.43%566.593214,14246.1%46.7%
52.08%486.591512,72146.1%59.1%
66.67%456.189213,55371.4%62.5%
58.14%436.083114,24666.7%53.6%
55.56%366.399815,02463.2%47.1%
41.67%366.41,02715,35141.2%42.1%
50.00%326.689413,99550.0%50.0%
45.16%316.688414,87350.0%41.2%
59.26%276.587814,70550.0%64.7%
40.91%226.284114,31333.3%46.1%
36.36%226.580312,55654.5%18.2%
35.29%176.470313,44820.0%41.7%
41.18%175.791314,66125.0%46.1%
60.00%156.31,01612,95357.1%62.5%
38.46%135.890712,84625.0%60.0%
91.67%126.392715,26680.0%100.0%
25.00%126.71,01511,75612.5%50.0%
36.36%116.91,06716,66333.3%37.5%
72.73%116.998213,92775.0%71.4%
45.45%116.477214,38166.7%37.5%
55.56%96.81,11717,10550.0%57.1%
37.50%86.91,02514,26450.0%25.0%
28.57%75.61,00310,33433.3%0.0%
66.67%65.891411,44566.7%66.7%
50.00%67.162712,26466.7%33.3%
50.00%66.489415,42733.3%66.7%
60.00%56.476710,34533.3%100.0%
60.00%56.771214,86450.0%66.7%
40.00%55.35249,05633.3%50.0%
60.00%56.91,05815,28833.3%100.0%

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Samira vs Vayne - Frequently Asked Questions

How does Samira do against Vayne in League of Legends?

Vayne wins the Samira vs Vayne matchup with a 53.6% win rate compared to Samira's 46.4%, a 7.1 percentage point difference. This data is based on 56 recent ranked games in patch 26.13.

How does Samira do against Vayne in the early game?

In the early game, Vayne has the advantage against Samira with a 53.9% win rate versus 46.1%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Samira do against Vayne in the late game?

In the late game, Vayne takes over the Samira vs Vayne matchup with a 53.3% win rate compared to 46.7%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Samira vs Vayne matchup?

Vayne wins the matchup against Samira with a 53.6% win rate in League of Legends patch 26.13. The 7.1 percentage point advantage means Vayne is significantly favored in this lane matchup based on 56 games analyzed.

What is the best Samira build against Vayne?

The best Samira build against Vayne includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Samira runes against Vayne?

The best Samira runes against Vayne use the Precision primary tree with Domination secondary. This rune setup achieves a 69.6% win rate in the Samira vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Samira counter Vayne?

No, Samira struggles against Vayne with only a 46.4% win rate. Vayne has the advantage in this matchup. Samira players should focus on safe farming and avoiding extended trades to minimize Vayne's lead.

How do I play Samira against Vayne?

When playing Samira against Vayne, play cautiously and avoid Vayne's power spikes. Look for jungle assistance and team-dependent plays since Vayne has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.