Vayne - League of Legends Champion
Win Rate
49.3%
Pick Rate
5.3%

Vaynevs Samira

DMarksmanAssassin
Patch26.10
Matches3,169,061
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 30, 2026
MethodologyData Methodology

Vayne vs Samira is a very close matchup in LoL patch 26.10. Samira wins with a 50.8% win rate (+1.6%) over Vayne based on 189 games. Samira wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Samira matchup.

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Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 49.2% win rate in this matchup
Vayne
49.2% WR
VS
Samira vs Vayne matchup - 50.8% win rate
Samira
50.8% WR

Who Wins the Vayne vs Samira Matchup?

Samira wins the Vayne vs Samira matchup
Winner
Samira
Matches: 189
49.2%
Win Rate
50.8%
5.9
CS / min
6.4
829
DMG / min
994
12,620
Gold / game
14,683
196
Heal / min
335
464
DMG Mitigated / min
615
0.4
CC / min
0.1
48.4%
Early Game WR
51.6%
50.0%
Late Game WR
50.0%

Vayne vs Samira Matchup Summary

The Vayne vs Samira matchup is a very close matchup in League of Legends ranked play. Based on 189 recent matches analyzed, Samira wins with a 50.8% win rate compared to Vayne's 49.2%, giving Samira a 1.6 percentage point advantage. Game phase dynamics play a critical role here: Samira controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Samira needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Vayne leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. While Samira is slightly favored, Vayne can absolutely win this lane through smart trading patterns and wave management. Focus on playing around your cooldowns, conceding CS only when necessary, and capitalizing on Samira's mistakes. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Samira Laning Phase Breakdown

Samira wins the laning phase against Vayne in League of Legends

Samira is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Samira holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
5.9Vayne
6.4Samira
Samira edges out Vayne by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 7 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Samira.
Damage
829Vayne
994Samira
Samira heavily out-damages Vayne by 165 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Samira's sustained damage advantage take over.
Economy
12,620Vayne
14,683Samira
Samira generates a commanding 2,062 more gold per game than Vayne. This substantial economic advantage means Samira consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.4Vayne
0.1Samira
Both Vayne and Samira provide similar amounts of crowd control (0.3s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
660Vayne
949Samira
Samira vastly out-sustains Vayne, healing and mitigating 289 more damage per minute. This massive durability gap means Samira can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Early Game vs Late Game

Early Game
Samira
51.6%
+3.2% advantage
Vayne early game win rateVayne48.4%
Samira early game win rateSamira51.6%
Late Game
Vayne
50.0%
+0.0% advantage
Vayne late game win rateVayne50.0%
Samira late game win rateSamira50.0%

During the early laning phase (first 15 minutes), Samira has a meaningful 51.6% win rate, outperforming Vayne by 3.2 percentage points. Samira players should look to press this advantage through aggressive trades, wave priority, and early jungle coordination.

Late game (25+ minutes) is equally balanced, with Vayne at 50.0% win rate — only 0.0 points ahead of Samira. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Samira has the edge early, but Vayne gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Vayne Runes Against Samira

Precision rune tree - Vayne primary runes vs SamiraPrecision
Lethal Tempo - best Vayne rune vs SamiraTriumph - best Vayne rune vs SamiraLegend: Alacrity - best Vayne rune vs SamiraCoup de Grace - best Vayne rune vs Samira
Resolve rune tree - Vayne secondary runes vs SamiraResolve
Conditioning - best Vayne rune vs SamiraOvergrowth - best Vayne rune vs Samira
54.3% WR

The Precision primary with Resolve secondary combination helps Vayne maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Samira.


Vayne matchup data for League of Legends patch 26.10. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
44.98%8566.188013,32245.6%44.5%
47.13%6286.080113,00745.1%48.6%
46.70%6216.078512,96146.1%47.1%
50.57%5306.384912,93250.4%50.7%
50.76%5246.185313,57346.8%53.3%
47.62%4835.777412,89947.3%47.9%
54.67%4286.388813,11050.0%58.9%
56.75%2896.391813,74154.1%59.0%
52.53%2175.983013,24552.6%52.5%
47.64%2126.079712,59248.5%46.8%
50.25%2016.180012,89845.0%54.5%
59.07%1936.41,01613,02559.1%59.1%
49.21%1895.982912,62048.4%50.0%
57.65%1706.284213,37853.2%61.5%
50.30%1695.880812,79352.6%48.4%
46.01%1635.761111,63440.3%49.5%
50.63%1586.079012,71639.4%58.7%
53.19%1416.090311,55447.4%57.1%
48.23%1416.185313,84456.6%43.2%
48.51%1346.288911,72345.5%51.5%
50.40%1256.381313,60049.1%51.4%
48.36%1225.995612,22952.1%46.0%
47.93%1216.582512,87645.2%50.9%
44.92%1186.294013,19135.9%52.3%
34.21%1145.558610,06031.4%36.5%
58.18%1106.084912,68252.1%62.9%
57.01%1076.387313,73056.8%57.1%
41.12%1076.287513,69935.6%45.2%
52.17%926.41,15013,16150.0%53.5%
48.86%886.61,32112,55245.5%50.9%
55.95%846.098512,41950.0%60.4%
46.99%836.179811,18928.9%62.2%
48.10%796.395312,43442.4%52.2%
43.04%796.095211,62029.7%54.8%
50.67%755.992212,38256.1%44.1%
51.35%746.397611,77661.8%42.5%
50.00%726.01,06911,81957.1%43.2%
53.52%716.688511,51443.2%64.7%
49.25%676.390713,96452.0%47.6%
59.38%646.399013,18759.1%59.5%
60.66%616.31,00412,19368.0%55.6%
47.46%596.495911,86444.8%50.0%
57.14%566.184710,64350.0%68.2%
50.00%565.987413,78650.0%50.0%
49.09%556.184113,39050.0%48.4%
44.44%546.186712,81059.1%34.4%
50.00%546.274011,46557.1%42.3%
52.94%515.285311,70640.9%62.1%
48.00%506.287713,50761.9%37.9%
54.00%506.181112,06150.0%55.9%
46.94%496.283812,88340.0%51.7%
52.08%486.188411,32260.0%43.5%
48.94%475.889912,00141.2%53.3%
51.11%455.999312,34375.0%37.9%
47.62%425.885812,58830.8%55.2%
58.54%416.084411,58052.4%65.0%
50.00%406.078512,69347.1%52.2%
42.50%405.969810,78437.5%45.8%
58.97%395.779812,67073.3%50.0%
50.00%386.399612,09650.0%50.0%
47.37%385.988513,00631.3%59.1%
44.74%386.173611,74333.3%55.0%
44.44%365.371211,28642.9%46.7%
58.33%366.695011,38245.0%75.0%
58.33%366.595913,11853.9%60.9%
47.22%366.582213,31950.0%45.5%
44.12%345.479411,93460.0%31.6%
52.94%345.41,02113,00837.5%66.7%
56.25%325.287713,12653.9%57.9%
59.38%326.276712,76469.2%52.6%
51.61%316.277011,71740.0%62.5%
45.16%314.780411,86864.3%29.4%
45.16%316.397512,90940.0%50.0%
48.28%296.291211,14150.0%46.7%
34.48%296.365111,6767.1%60.0%
51.85%276.076413,31510.0%76.5%
42.31%266.486612,49436.4%46.7%
64.00%256.596311,30069.2%58.3%
54.17%246.083511,08970.0%42.9%
54.17%245.883912,11145.5%61.5%
39.13%236.173312,75144.4%35.7%
56.52%236.195613,24540.0%69.2%
54.55%226.389010,65036.4%72.7%
52.38%216.096813,25366.7%50.0%
42.86%215.684211,90333.3%46.7%
31.58%194.765612,34130.0%33.3%
57.89%196.275611,62554.5%62.5%
38.89%186.692213,23340.0%38.5%
52.94%175.064410,54650.0%60.0%
41.18%176.162213,24033.3%45.5%
52.94%176.31,02813,65371.4%40.0%
52.94%174.697413,70325.0%61.5%
64.71%176.791411,70937.5%88.9%
41.18%174.072511,37257.1%30.0%
50.00%166.186611,70344.4%57.1%
64.29%146.175910,98857.1%71.4%
42.86%145.585112,39050.0%37.5%
46.15%136.51,00712,79760.0%37.5%
46.15%131.972813,23033.3%57.1%
50.00%121.881213,51325.0%62.5%
50.00%125.787413,26350.0%50.0%
66.67%123.598413,96362.5%75.0%
45.45%115.588412,9660.0%55.6%
50.00%103.074912,60350.0%50.0%
40.00%103.864812,56333.3%50.0%
60.00%105.174412,11540.0%80.0%
50.00%106.282812,42650.0%50.0%
50.00%104.581711,97980.0%20.0%
55.56%93.372211,97566.7%50.0%
44.44%93.91,0158,79040.0%50.0%
55.56%94.967711,57450.0%60.0%
55.56%96.487212,030100.0%42.9%
50.00%85.774110,83450.0%50.0%
62.50%86.482311,94150.0%75.0%
25.00%84.481812,09133.3%20.0%
62.50%86.293312,63350.0%75.0%
42.86%74.274910,21440.0%50.0%
42.86%73.94719,22433.3%50.0%
42.86%73.879413,2380.0%60.0%
57.14%75.188615,1560.0%57.1%
42.86%75.464711,86450.0%40.0%
14.29%76.51,05310,91325.0%0.0%
33.33%63.876515,45250.0%25.0%
66.67%65.875714,611100.0%33.3%
16.67%63.267411,43350.0%0.0%
60.00%55.188813,1200.0%75.0%
60.00%55.567110,7640.0%75.0%
80.00%58.393710,89280.0%0.0%
0.00%55.16939,6540.0%0.0%
20.00%53.168912,3420.0%25.0%
60.00%54.486413,2810.0%60.0%
40.00%56.089115,5540.0%50.0%

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Vayne vs Samira - Frequently Asked Questions

How does Vayne do against Samira in League of Legends?

Samira wins the Vayne vs Samira matchup with a 50.8% win rate compared to Vayne's 49.2%, a 1.6 percentage point difference. This data is based on 189 recent ranked games in patch 26.10.

How does Vayne do against Samira in the early game?

In the early game, Samira has the advantage against Vayne with a 51.6% win rate versus 48.4%. Samira players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Samira in the late game?

In the late game, Vayne takes over the Vayne vs Samira matchup with a 50.0% win rate compared to 50.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Samira matchup?

Samira wins the matchup against Vayne with a 50.8% win rate in League of Legends patch 26.10. The 1.6 percentage point advantage means Samira is slightly favored in this lane matchup based on 189 games analyzed.

What is the best Vayne build against Samira?

The best Vayne build against Samira includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Samira?

The best Vayne runes against Samira use the Precision primary tree with Resolve secondary. This rune setup achieves a 54.3% win rate in the Vayne vs Samira matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Samira?

No, Vayne struggles against Samira with only a 49.2% win rate. Samira has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Samira's lead.

How do I play Vayne against Samira?

When playing Vayne against Samira, play cautiously and avoid Samira's power spikes. Focus on safe farming — you outscale Samira in the late game. Use the matchup-specific build and runes above to optimize your chances.