Vayne - League of Legends Champion
Win Rate
50.6%
Pick Rate
4.6%

Vaynevs Samira

AMarksmanAssassin
Patch26.4
Matches974,630
LaneAll Lanes
TierAll Tiers
Last UpdatedFeb 27, 2026
MethodologyData Methodology

Vayne vs Samira is a decisive matchup in LoL patch 26.4. Vayne wins with a 55.1% win rate (+10.3%) over Samira based on 216 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Samira matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Samira - 55.1% win rateSamira(55.1%)
Vayne - 55.1% win rate in this matchup
Vayne
55.1% WR
VS
Samira vs Vayne matchup - 44.9% win rate
Samira
44.9% WR

Who Wins the Vayne vs Samira Matchup?

Vayne wins the Vayne vs Samira matchup
Winner
Vayne
Matches: 216
55.1%
Win Rate
44.9%
6.2
CS / min
6.4
885
DMG / min
935
13,166
Gold / game
14,136
214
Heal / min
277
465
DMG Mitigated / min
607
0.4
CC / min
0.1
56.0%
Early Game WR
44.0%
54.3%
Late Game WR
45.7%

Vayne vs Samira Matchup Summary

The Vayne vs Samira matchup is a decisive matchup in League of Legends ranked play. Based on 216 recent matches analyzed, Vayne wins with a 55.1% win rate compared to Samira's 44.9%, giving Vayne a 10.3 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Samira players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Vayne leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Samira and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Samira away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Samira Laning Phase Breakdown

Samira wins the laning phase against Vayne in League of Legends

Samira is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Samira holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
6.2Vayne
6.4Samira
Vayne and Samira farm at nearly identical rates in this matchup, with only a 0.3 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
885Vayne
935Samira
Samira deals 49 more champion damage per minute than Vayne. While noticeable in extended trades, this gap can be offset by Vayne choosing favorable fight windows, such as engaging when Samira's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
13,166Vayne
14,136Samira
Samira generates a commanding 970 more gold per game than Vayne. This substantial economic advantage means Samira consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.4Vayne
0.1Samira
Both Vayne and Samira provide similar amounts of crowd control (0.3s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
679Vayne
885Samira
Samira vastly out-sustains Vayne, healing and mitigating 205 more damage per minute. This massive durability gap means Samira can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Samira

Berserker's Greaves is the optimal boots choice against Samira, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Samira are Voltaic Cyclosword, Essence Reaver and Stormrazor. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Samira matchup.

Early Game vs Late Game

Early Game
Vayne
56.0%
+11.9% advantage
Vayne early game win rateVayne56.0%
Samira early game win rateSamira44.0%
Late Game
Vayne
54.3%
+8.6% advantage
Vayne late game win rateVayne54.3%
Samira late game win rateSamira45.7%

Vayne dominates the early game (first 15 minutes) with a commanding 56.0% win rate — a 11.9 percentage point lead over Samira. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 54.3% win rate — 8.6 points above Samira. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Samira players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Samira

Precision rune tree - Vayne primary runes vs SamiraPrecision
Press the Attack - best Vayne rune vs SamiraTriumph - best Vayne rune vs SamiraLegend: Alacrity - best Vayne rune vs SamiraCoup de Grace - best Vayne rune vs Samira
Resolve rune tree - Vayne secondary runes vs SamiraResolve
Conditioning - best Vayne rune vs SamiraOvergrowth - best Vayne rune vs Samira
63.2% WR

Running Precision primary with Resolve secondary allows Vayne to press their advantage against Samira, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.4. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.4
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
51.15%6596.180113,24352.4%50.1%
50.60%5865.981413,66251.6%49.9%
50.09%5666.386713,36649.8%50.3%
53.30%4756.186213,38751.8%54.4%
49.40%4256.590914,01844.3%53.8%
45.15%3626.180413,21839.0%50.3%
56.70%3596.491914,03553.3%59.7%
52.94%3126.491114,09052.2%53.4%
46.40%2516.085013,49655.3%40.1%
53.42%2346.585913,17254.5%52.5%
55.14%2166.288513,16656.0%54.3%
54.55%1876.593214,48459.1%51.7%
51.61%1876.284613,36957.7%44.9%
54.14%1816.281013,07049.4%58.5%
48.82%1706.390513,44549.4%48.2%
53.70%1635.985713,74856.3%52.0%
48.70%1556.187113,65544.6%51.7%
50.42%1195.986614,05246.8%52.8%
56.19%1056.192513,93859.1%54.1%
48.98%986.184413,96447.1%50.0%
54.08%986.185411,82255.6%52.8%
61.29%946.593013,07159.5%62.8%
60.00%916.198512,31963.4%57.1%
55.81%875.81,03214,14447.1%61.5%
54.88%826.090513,50358.3%52.2%
46.91%816.385713,75443.2%50.0%
49.37%806.188313,63860.0%40.9%
51.90%796.489914,02648.5%54.4%
50.72%716.491712,08850.0%51.2%
42.03%706.288514,16529.2%48.9%
44.93%705.761511,53628.6%56.1%
43.48%696.31,39212,40937.0%47.6%
43.28%675.987911,17626.5%60.6%
56.67%615.565911,92131.6%68.3%
51.72%585.999911,10250.0%53.9%
47.37%576.71,01014,57452.0%43.8%
44.64%566.187513,78542.9%45.7%
57.14%566.11,00711,81653.9%60.0%
50.00%546.492713,26957.7%42.9%
49.06%536.31,04613,34750.0%48.5%
48.08%526.497511,85140.0%55.6%
50.98%516.489411,70642.1%56.3%
57.45%476.384712,01854.2%60.9%
47.73%446.492012,19055.0%41.7%
48.84%436.282412,11333.3%63.6%
48.78%426.497912,55350.0%47.8%
50.00%426.01,00011,70545.8%55.6%
70.73%416.892215,19371.4%70.4%
50.00%406.590010,91648.0%53.3%
51.28%397.398313,32652.6%50.0%
52.63%386.688413,01147.4%57.9%
32.43%375.971910,33620.8%53.9%
57.14%355.891514,68643.8%68.4%
45.71%355.682811,98344.4%47.1%
55.88%346.198612,04160.0%52.6%
60.61%335.980712,81150.0%68.4%
33.33%336.588813,38920.0%39.1%
46.88%326.094412,56630.0%54.5%
50.00%316.187311,55150.0%50.0%
50.00%305.972313,12238.5%58.8%
62.07%296.587112,59472.7%55.6%
48.15%286.191712,78150.0%46.7%
53.85%266.079812,54254.5%53.3%
50.00%266.280312,23140.0%56.3%
44.00%255.594411,60154.5%35.7%
50.00%246.580412,75063.6%38.5%
60.87%236.390914,13163.6%58.3%
43.48%236.589511,12741.7%45.5%
43.48%236.61,12712,56542.9%44.4%
43.48%235.287413,74262.5%33.3%
59.09%226.91,10214,21757.1%60.0%
54.55%226.185912,77960.0%50.0%
50.00%226.81,09813,97162.5%42.9%
36.84%206.486613,93240.0%33.3%
57.89%205.688114,08362.5%54.5%
52.63%195.97209,97854.5%50.0%
63.16%196.31,06115,663100.0%53.3%
50.00%185.881512,69742.9%54.5%
56.25%166.01,03012,56144.4%71.4%
50.00%166.592611,54340.0%66.7%
46.67%155.762510,93128.6%62.5%
66.67%156.780511,17863.6%75.0%
21.43%146.66639,40522.2%20.0%
38.46%136.393211,81633.3%42.9%
33.33%126.560010,67833.3%33.3%
50.00%125.789715,26533.3%55.6%
41.67%126.797615,74340.0%42.9%
58.33%125.978111,83020.0%85.7%
50.00%126.21,00412,25420.0%71.4%
41.67%126.881011,67620.0%57.1%
36.36%113.693813,26760.0%16.7%
50.00%102.41,04515,15333.3%57.1%
30.00%104.485313,51520.0%40.0%
40.00%104.877312,40933.3%50.0%
50.00%104.583010,90150.0%50.0%
40.00%106.094814,70440.0%40.0%
50.00%105.379011,45350.0%50.0%
30.00%106.676812,6370.0%37.5%
40.00%106.486611,63750.0%33.3%
44.44%94.082511,62340.0%50.0%
44.44%96.01,11312,12760.0%25.0%
25.00%84.275811,7450.0%66.7%
62.50%86.066012,870100.0%50.0%
14.29%83.25548,24016.7%0.0%
50.00%84.269712,89650.0%50.0%
42.86%74.167011,9290.0%60.0%
57.14%75.486112,5180.0%100.0%
71.43%76.684915,13250.0%80.0%
14.29%76.01,05415,4820.0%16.7%
50.00%65.195712,1060.0%60.0%
25.00%52.456711,13350.0%0.0%
60.00%56.877813,45350.0%66.7%
60.00%54.582216,075100.0%50.0%
40.00%51.385410,6460.0%100.0%
40.00%52.770614,2870.0%50.0%
40.00%53.11,07012,85150.0%0.0%
60.00%54.065111,403100.0%33.3%
60.00%56.41,09915,068100.0%33.3%
60.00%56.91,19213,2620.0%100.0%
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Vayne vs Samira - Frequently Asked Questions

How does Vayne do against Samira in League of Legends?

Vayne wins the Vayne vs Samira matchup with a 55.1% win rate compared to Samira's 44.9%, a 10.3 percentage point difference. This data is based on 216 recent ranked games in patch 26.4.

How does Vayne do against Samira in the early game?

In the early game, Vayne has the advantage against Samira with a 56.0% win rate versus 44.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Samira in the late game?

In the late game, Vayne takes over the Vayne vs Samira matchup with a 54.3% win rate compared to 45.7%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Samira matchup?

Vayne wins the matchup against Samira with a 55.1% win rate in League of Legends patch 26.4. The 10.3 percentage point advantage means Vayne is significantly favored in this lane matchup based on 216 games analyzed.

What is the best Vayne build against Samira?

The best Vayne build against Samira includes Voltaic Cyclosword, Essence Reaver, Stormrazor with Berserker's Greaves. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Samira?

The best Vayne runes against Samira use the Precision primary tree with Resolve secondary. This rune setup achieves a 63.2% win rate in the Vayne vs Samira matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Samira?

Yes, Vayne has a favorable matchup against Samira with a 55.1% win rate. Vayne strongly counters Samira in lane based on current patch 26.4 data.

How do I play Vayne against Samira?

When playing Vayne against Samira, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.